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The map label for this gene is fadD [C]

Identifier: 54296974

GI number: 54296974

Start: 1127769

End: 1129436

Strand: Direct

Name: fadD [C]

Synonym: lpp1015

Alternate gene names: 54296974

Gene position: 1127769-1129436 (Clockwise)

Preceding gene: 54296973

Following gene: 54296979

Centisome position: 32.19

GC content: 37.71

Gene sequence:

>1668_bases
ATGCAAAAAGAATCCAATTCCAATTCATTATTTAACTTACTGTTGAAAAATGAAAAAAATTCGGCAGACCATGTGTATTT
AAGACAACCAAAAAGTGGAGTTTGGCATGAATATACCTGGTCGGCCGTGATGCTGCAGGCCCGAAAAGTAGCTGGTTTTT
TACACCATCTGGGGTTAAAAAAAGGCGATCATATTTCCATTATCTCCAAGAATTGCGCGGAATGGTTTATCGCTGATTTT
GGAATTCATATTGCTGGAATGGTCAATGTCCCGTTATTTGCTAATCAAAATGAAGAAAGTGCGCATTATGTTTTAGATCA
TGGGGATGTGAAACTGGTTTTTGTTGGAAAATTAGATGATCATCAGCGGGTCAGACAATTTATCCCTAAAAGTTATCCTA
CAATTGGTTTTGATTACCATAAAGATTTGCAAGTTGATTACGAATGGTCTGATGTTTTGAAAAGTGACCCTATGATTAAC
CTGGTGGAACCAGAGCCAGATGCGTTGTATACCATTATTTATTCATCCGGGACTTCGGGGGCACCTAAAGGAGCTATGTA
TACCAATCGGTCCATAGCCAATTACTTGACAGTTTTCCCCAAGGACTTGCTCAGAATCAGAGAGTTGGAACATTATAAAT
TAATATCTTATCTTCCCCTGGCCCATGTCTATGAACGCTCTGCCATCCAATTAGGCAGTGTTGCTATTAATGCATCGGTA
TCTTTTGTTGAAAGTCTGGAGAAGTTTGCAGAGAACTTAAGAGAAGTGAGTCCTACCTTTTTCACTGCAGTTCCACGCAT
TTGGGGAGTATTTAAGCAGAAAATTGAACAAAAACTGCCACCAGCCAAATTGAATTTTTTATTAAAAATTCCTCTTATAT
CCAGTTTGATAAAAAGAAAAATCATTCACAGTTTAGGATTAAGCGAGTGTACTAATTGTTTTAGCGGAGCATCTCATCTG
CCAATATCCATTATTGATTTTTTTGAAAAATTGGGAATTTATATTCAGGAAGGATATGGTCAGTCTGAGAATTTGGCTTA
TGCTACCTTATCGATGTTAAATGAGAGAAAACGTGGTTACGTTGGTACTCCGAGGCTGGAGGTTGAGATAAAAATAGGCG
AAGAGAATGAATTACTAATGAAGTGCCCTTGTCTAATGTCAGGTTATTATAAAAATGAACAAGCGACTAAAAATGCCTTT
ACGGAAGAGGGTTGGTTGCGAACAGGAGATGTCGTTGATGTTGATAATGAAGACAGAGTTAAAATATTAGGAAGACTTTC
TGAGAACTTTAAAAATCAGACAGGAGAGTTCATTGCTCCTTCACCAATAGAAAAACTGTTTTCAGTGAACTCTATGCTAG
AACAACTGTGCCTGGTAGGTAGAGAGTTACCTAATAACGTTTTGTTAGTTACCTTGAATGAAGGAGTGCGTTTGGGTATG
CCAAAAGAGGAGATCACTCACTCATTGCAAGAAACCTTAAAGCAAGTCAATTCGAAATTGGTTAAATACGAAAAAGTCAG
TCACATCCTTGTGCTGAAAGATGTCTGGACAACTGAAAATGATAAATTAACACCTACACTGAAAGTAAAGAGAAGGGTAG
TTGAAAAAGATTATGCCGAGTTAATCCAAAAGGCACTGCAGCAATCTCAGTCAATCGTTTGGGAATGA

Upstream 100 bases:

>100_bases
AGGCGATTCATGAAGGTGAAAATTGTGTTTTGCGAGAAAAAAATAATATTTTACAACTAGTTGGTCTAGAATAGTAATTA
AACAAGCTTAAGGAAGAGCC

Downstream 100 bases:

>100_bases
GGAGACAGTTTATTTAATAAAGAACTGATTTCAAATATTCGTTCCTCTGCTGACGTGCTGTCTAGAGTAAAACGCAGACG
TTGCGGTCCTTCCATTTGAT

Product: hypothetical protein

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MQKESNSNSLFNLLLKNEKNSADHVYLRQPKSGVWHEYTWSAVMLQARKVAGFLHHLGLKKGDHISIISKNCAEWFIADF
GIHIAGMVNVPLFANQNEESAHYVLDHGDVKLVFVGKLDDHQRVRQFIPKSYPTIGFDYHKDLQVDYEWSDVLKSDPMIN
LVEPEPDALYTIIYSSGTSGAPKGAMYTNRSIANYLTVFPKDLLRIRELEHYKLISYLPLAHVYERSAIQLGSVAINASV
SFVESLEKFAENLREVSPTFFTAVPRIWGVFKQKIEQKLPPAKLNFLLKIPLISSLIKRKIIHSLGLSECTNCFSGASHL
PISIIDFFEKLGIYIQEGYGQSENLAYATLSMLNERKRGYVGTPRLEVEIKIGEENELLMKCPCLMSGYYKNEQATKNAF
TEEGWLRTGDVVDVDNEDRVKILGRLSENFKNQTGEFIAPSPIEKLFSVNSMLEQLCLVGRELPNNVLLVTLNEGVRLGM
PKEEITHSLQETLKQVNSKLVKYEKVSHILVLKDVWTTENDKLTPTLKVKRRVVEKDYAELIQKALQQSQSIVWE

Sequences:

>Translated_555_residues
MQKESNSNSLFNLLLKNEKNSADHVYLRQPKSGVWHEYTWSAVMLQARKVAGFLHHLGLKKGDHISIISKNCAEWFIADF
GIHIAGMVNVPLFANQNEESAHYVLDHGDVKLVFVGKLDDHQRVRQFIPKSYPTIGFDYHKDLQVDYEWSDVLKSDPMIN
LVEPEPDALYTIIYSSGTSGAPKGAMYTNRSIANYLTVFPKDLLRIRELEHYKLISYLPLAHVYERSAIQLGSVAINASV
SFVESLEKFAENLREVSPTFFTAVPRIWGVFKQKIEQKLPPAKLNFLLKIPLISSLIKRKIIHSLGLSECTNCFSGASHL
PISIIDFFEKLGIYIQEGYGQSENLAYATLSMLNERKRGYVGTPRLEVEIKIGEENELLMKCPCLMSGYYKNEQATKNAF
TEEGWLRTGDVVDVDNEDRVKILGRLSENFKNQTGEFIAPSPIEKLFSVNSMLEQLCLVGRELPNNVLLVTLNEGVRLGM
PKEEITHSLQETLKQVNSKLVKYEKVSHILVLKDVWTTENDKLTPTLKVKRRVVEKDYAELIQKALQQSQSIVWE
>Mature_555_residues
MQKESNSNSLFNLLLKNEKNSADHVYLRQPKSGVWHEYTWSAVMLQARKVAGFLHHLGLKKGDHISIISKNCAEWFIADF
GIHIAGMVNVPLFANQNEESAHYVLDHGDVKLVFVGKLDDHQRVRQFIPKSYPTIGFDYHKDLQVDYEWSDVLKSDPMIN
LVEPEPDALYTIIYSSGTSGAPKGAMYTNRSIANYLTVFPKDLLRIRELEHYKLISYLPLAHVYERSAIQLGSVAINASV
SFVESLEKFAENLREVSPTFFTAVPRIWGVFKQKIEQKLPPAKLNFLLKIPLISSLIKRKIIHSLGLSECTNCFSGASHL
PISIIDFFEKLGIYIQEGYGQSENLAYATLSMLNERKRGYVGTPRLEVEIKIGEENELLMKCPCLMSGYYKNEQATKNAF
TEEGWLRTGDVVDVDNEDRVKILGRLSENFKNQTGEFIAPSPIEKLFSVNSMLEQLCLVGRELPNNVLLVTLNEGVRLGM
PKEEITHSLQETLKQVNSKLVKYEKVSHILVLKDVWTTENDKLTPTLKVKRRVVEKDYAELIQKALQQSQSIVWE

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42794756, Length=583, Percent_Identity=26.7581475128645, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI42794760, Length=583, Percent_Identity=26.7581475128645, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI42794758, Length=583, Percent_Identity=26.7581475128645, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI40807491, Length=531, Percent_Identity=25.9887005649718, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI57165412, Length=576, Percent_Identity=27.0833333333333, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI57165410, Length=580, Percent_Identity=26.7241379310345, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI83745141, Length=577, Percent_Identity=25.3032928942808, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI27477105, Length=606, Percent_Identity=22.6072607260726, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI42794754, Length=597, Percent_Identity=23.785594639866, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI42794752, Length=597, Percent_Identity=23.785594639866, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI12669909, Length=609, Percent_Identity=22.824302134647, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI4758332, Length=609, Percent_Identity=22.824302134647, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI156151445, Length=475, Percent_Identity=22.1052631578947, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1788107, Length=457, Percent_Identity=23.4135667396061, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17556552, Length=606, Percent_Identity=25.9075907590759, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17510401, Length=581, Percent_Identity=26.8502581755594, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17541856, Length=588, Percent_Identity=26.0204081632653, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI193204819, Length=612, Percent_Identity=26.4705882352941, Blast_Score=148, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17564090, Length=542, Percent_Identity=22.6937269372694, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25147511, Length=601, Percent_Identity=22.4625623960067, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17553312, Length=620, Percent_Identity=22.258064516129, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17558820, Length=470, Percent_Identity=25.3191489361702, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI133901848, Length=235, Percent_Identity=28.5106382978723, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI32563687, Length=502, Percent_Identity=25.8964143426295, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17531443, Length=520, Percent_Identity=22.1153846153846, Blast_Score=85, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6320852, Length=571, Percent_Identity=24.5183887915937, Blast_Score=143, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6322182, Length=433, Percent_Identity=26.3279445727483, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323903, Length=433, Percent_Identity=25.635103926097, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324893, Length=451, Percent_Identity=24.390243902439, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI281366413, Length=569, Percent_Identity=25.3075571177504, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24666501, Length=569, Percent_Identity=25.3075571177504, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24666497, Length=569, Percent_Identity=25.3075571177504, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI17933690, Length=620, Percent_Identity=23.7096774193548, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI62471681, Length=596, Percent_Identity=24.1610738255034, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI62471687, Length=596, Percent_Identity=24.1610738255034, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24586634, Length=596, Percent_Identity=24.1610738255034, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI22026970, Length=596, Percent_Identity=24.1610738255034, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI62471689, Length=596, Percent_Identity=24.1610738255034, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI62471679, Length=596, Percent_Identity=24.1610738255034, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI62471683, Length=596, Percent_Identity=24.1610738255034, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI62471685, Length=596, Percent_Identity=24.1610738255034, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24586636, Length=596, Percent_Identity=24.1610738255034, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI19921316, Length=628, Percent_Identity=23.2484076433121, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI21355181, Length=572, Percent_Identity=23.4265734265734, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 63197; Mature: 63197

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKESNSNSLFNLLLKNEKNSADHVYLRQPKSGVWHEYTWSAVMLQARKVAGFLHHLGLK
CCCCCCCCHHEEHEEECCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
KGDHISIISKNCAEWFIADFGIHIAGMVNVPLFANQNEESAHYVLDHGDVKLVFVGKLDD
CCCEEEEEHHHHHHHHHHHCCEEEEEEEECCEEECCCCCCCEEEEECCCEEEEEEECCCC
HQRVRQFIPKSYPTIGFDYHKDLQVDYEWSDVLKSDPMINLVEPEPDALYTIIYSSGTSG
HHHHHHHCCCCCCCCCCCCCCCCEEECCHHHHHCCCCCEEEECCCCCEEEEEEEECCCCC
APKGAMYTNRSIANYLTVFPKDLLRIRELEHYKLISYLPLAHVYERSAIQLGSVAINASV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEECHH
SFVESLEKFAENLREVSPTFFTAVPRIWGVFKQKIEQKLPPAKLNFLLKIPLISSLIKRK
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEECHHHHHHHHHH
IIHSLGLSECTNCFSGASHLPISIIDFFEKLGIYIQEGYGQSENLAYATLSMLNERKRGY
HHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHCEEEEECCCCCCCHHHHHHHHHHHHCCCC
VGTPRLEVEIKIGEENELLMKCPCLMSGYYKNEQATKNAFTEEGWLRTGDVVDVDNEDRV
CCCCEEEEEEEECCCCCEEEECCHHHCCCCCCCHHHHHHCCCCCCEECCCEEECCCCCHH
KILGRLSENFKNQTGEFIAPSPIEKLFSVNSMLEQLCLVGRELPNNVLLVTLNEGVRLGM
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
PKEEITHSLQETLKQVNSKLVKYEKVSHILVLKDVWTTENDKLTPTLKVKRRVVEKDYAE
CHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
LIQKALQQSQSIVWE
HHHHHHHHHHCCCCC
>Mature Secondary Structure
MQKESNSNSLFNLLLKNEKNSADHVYLRQPKSGVWHEYTWSAVMLQARKVAGFLHHLGLK
CCCCCCCCHHEEHEEECCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
KGDHISIISKNCAEWFIADFGIHIAGMVNVPLFANQNEESAHYVLDHGDVKLVFVGKLDD
CCCEEEEEHHHHHHHHHHHCCEEEEEEEECCEEECCCCCCCEEEEECCCEEEEEEECCCC
HQRVRQFIPKSYPTIGFDYHKDLQVDYEWSDVLKSDPMINLVEPEPDALYTIIYSSGTSG
HHHHHHHCCCCCCCCCCCCCCCCEEECCHHHHHCCCCCEEEECCCCCEEEEEEEECCCCC
APKGAMYTNRSIANYLTVFPKDLLRIRELEHYKLISYLPLAHVYERSAIQLGSVAINASV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEECHH
SFVESLEKFAENLREVSPTFFTAVPRIWGVFKQKIEQKLPPAKLNFLLKIPLISSLIKRK
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEECHHHHHHHHHH
IIHSLGLSECTNCFSGASHLPISIIDFFEKLGIYIQEGYGQSENLAYATLSMLNERKRGY
HHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHCEEEEECCCCCCCHHHHHHHHHHHHCCCC
VGTPRLEVEIKIGEENELLMKCPCLMSGYYKNEQATKNAFTEEGWLRTGDVVDVDNEDRV
CCCCEEEEEEEECCCCCEEEECCHHHCCCCCCCHHHHHHCCCCCCEECCCEEECCCCCHH
KILGRLSENFKNQTGEFIAPSPIEKLFSVNSMLEQLCLVGRELPNNVLLVTLNEGVRLGM
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
PKEEITHSLQETLKQVNSKLVKYEKVSHILVLKDVWTTENDKLTPTLKVKRRVVEKDYAE
CHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
LIQKALQQSQSIVWE
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]