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The map label for this gene is aroB

Identifier: 54296954

GI number: 54296954

Start: 1101203

End: 1102312

Strand: Direct

Name: aroB

Synonym: lpp0995

Alternate gene names: 54296954

Gene position: 1101203-1102312 (Clockwise)

Preceding gene: 54296953

Following gene: 54296955

Centisome position: 31.43

GC content: 38.11

Gene sequence:

>1110_bases
ATGGCGAAGTTTGAACTTTATGCCGAGGTTGATGTTTCGATTTCAGGGCATCAATATCCAATAATTATTTGCCGCAATGG
TTTAATTGATCCTGATTTAATTAATCGTTTTATCACTTCAAAACAGGTGCTTATTGTTACTAATCGAACAGTGGCACCTT
TGTATCTAGGCCATTTGCAATCTGTTTTACCATCAAAACAATGCGATGTTGTTATTCTGGAAGACGGTGAAGAGCATAAA
AATCAGCGCAGTTTATTTACTATTTATGACTCTTTGATTCAAAACAAACATCATAGAGATACCTCCATCATTGCTTTGGG
CGGGGGAGTGATTGGTGATATGGCTGGTTTTGCAGCTTCTACGTATCAACGAGGTGTGCGATTTATTCAGCTGCCTACTA
CGTTACTGGCTCAGGTTGATGCTTCAGTTGGTGGTAAAACAGCGATTAATCATCCTGCCGGTAAAAATATGATTGGCAGT
TTTTACCAACCTCAAGCGGTCATAATTGATTTAAATACCTTAAAAACATTACCTGAGCGTGAGTTTCGTGCAGGTATTGC
CGAGATGATAAAATACGCTTTGTTGGTTGGTGGCTCTTTTTTTGAACGAATTCAAGAGGTTCTGCAACAAGGATTAACGG
TACATAGTCCGGAGCTACCACTACTGATAGCAGAATGTTGCCAAGTTAAAGCTAAAATTGTAGAGCAAGATGAAAGGGAG
TCCGGGTTGCGTGCTTTGCTTAATCTGGGGCATACTTTTGCTCATGCGCTGGAAACGTATACCGATTATAAAAAGTGGTT
ACATGGAGAAGCCGTTGCCATAGGTTTATATTGTGCGGCTGTATTATCAGAGAAGAAGGGCTTGTTGGATAAACCAATTG
TAGACCAGGTAGAAAAGATGCTCATACATGCAGGTTTGCCTCATAAAATTCCAAATTCCATAGATTTAATTCAATTAAGA
GAGTTGATGAGTTTGGATAAGAAAATTAAAAATAATTGTTTACGTTTTGTAATGATTAAAAAGCCAGGTGCTTGTTATAT
TGATGATTCAGTTACTGAAGATTGTTTGCACAATACACTGATTAATGTGGTAGAAGGAGAACAAAAATGA

Upstream 100 bases:

>100_bases
GATGAGCGAGAACCTTTTTATGATGAATTGGCGGATGTCAGTTTTGAAACAGATAAACTGACTGTAAAAGCTGTTGCAAA
CAATATAATAAAATACTTAT

Downstream 100 bases:

>100_bases
TAGATGGAAAGGAGCCTCTTGATGAGGGAGTTGCCAATCAGCCCAGAACTCTATTCAAACCAGGAGCCTGGCTTGCGAAA
GTTGATTTCATTAATCATTT

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MAKFELYAEVDVSISGHQYPIIICRNGLIDPDLINRFITSKQVLIVTNRTVAPLYLGHLQSVLPSKQCDVVILEDGEEHK
NQRSLFTIYDSLIQNKHHRDTSIIALGGGVIGDMAGFAASTYQRGVRFIQLPTTLLAQVDASVGGKTAINHPAGKNMIGS
FYQPQAVIIDLNTLKTLPEREFRAGIAEMIKYALLVGGSFFERIQEVLQQGLTVHSPELPLLIAECCQVKAKIVEQDERE
SGLRALLNLGHTFAHALETYTDYKKWLHGEAVAIGLYCAAVLSEKKGLLDKPIVDQVEKMLIHAGLPHKIPNSIDLIQLR
ELMSLDKKIKNNCLRFVMIKKPGACYIDDSVTEDCLHNTLINVVEGEQK

Sequences:

>Translated_369_residues
MAKFELYAEVDVSISGHQYPIIICRNGLIDPDLINRFITSKQVLIVTNRTVAPLYLGHLQSVLPSKQCDVVILEDGEEHK
NQRSLFTIYDSLIQNKHHRDTSIIALGGGVIGDMAGFAASTYQRGVRFIQLPTTLLAQVDASVGGKTAINHPAGKNMIGS
FYQPQAVIIDLNTLKTLPEREFRAGIAEMIKYALLVGGSFFERIQEVLQQGLTVHSPELPLLIAECCQVKAKIVEQDERE
SGLRALLNLGHTFAHALETYTDYKKWLHGEAVAIGLYCAAVLSEKKGLLDKPIVDQVEKMLIHAGLPHKIPNSIDLIQLR
ELMSLDKKIKNNCLRFVMIKKPGACYIDDSVTEDCLHNTLINVVEGEQK
>Mature_368_residues
AKFELYAEVDVSISGHQYPIIICRNGLIDPDLINRFITSKQVLIVTNRTVAPLYLGHLQSVLPSKQCDVVILEDGEEHKN
QRSLFTIYDSLIQNKHHRDTSIIALGGGVIGDMAGFAASTYQRGVRFIQLPTTLLAQVDASVGGKTAINHPAGKNMIGSF
YQPQAVIIDLNTLKTLPEREFRAGIAEMIKYALLVGGSFFERIQEVLQQGLTVHSPELPLLIAECCQVKAKIVEQDERES
GLRALLNLGHTFAHALETYTDYKKWLHGEAVAIGLYCAAVLSEKKGLLDKPIVDQVEKMLIHAGLPHKIPNSIDLIQLRE
LMSLDKKIKNNCLRFVMIKKPGACYIDDSVTEDCLHNTLINVVEGEQK

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=353, Percent_Identity=45.6090651558074, Blast_Score=310, Evalue=1e-85,
Organism=Saccharomyces cerevisiae, GI6320332, Length=349, Percent_Identity=36.3896848137536, Blast_Score=196, Evalue=4e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_LEGPA (Q5X6H0)

Other databases:

- EMBL:   CR628336
- RefSeq:   YP_123323.1
- ProteinModelPortal:   Q5X6H0
- SMR:   Q5X6H0
- STRING:   Q5X6H0
- GeneID:   3116389
- GenomeReviews:   CR628336_GR
- KEGG:   lpp:lpp0995
- LegioList:   lpp0995
- eggNOG:   COG0337
- HOGENOM:   HBG632303
- OMA:   CEIKAEV
- ProtClustDB:   PRK00002
- BioCyc:   LPNE297246:LPP0995-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455
- TIGRFAMs:   TIGR01357

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 40977; Mature: 40846

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKFELYAEVDVSISGHQYPIIICRNGLIDPDLINRFITSKQVLIVTNRTVAPLYLGHLQ
CCCEEEEEEEEEEECCCCEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHH
SVLPSKQCDVVILEDGEEHKNQRSLFTIYDSLIQNKHHRDTSIIALGGGVIGDMAGFAAS
HHCCCCCCCEEEECCCHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHH
TYQRGVRFIQLPTTLLAQVDASVGGKTAINHPAGKNMIGSFYQPQAVIIDLNTLKTLPER
HHHCCCEEEECHHHHHHHHHHCCCCCCCCCCCCCCCHHCCCCCCCEEEEECHHHHCCCCH
EFRAGIAEMIKYALLVGGSFFERIQEVLQQGLTVHSPELPLLIAECCQVKAKIVEQDERE
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHHCHHHH
SGLRALLNLGHTFAHALETYTDYKKWLHGEAVAIGLYCAAVLSEKKGLLDKPIVDQVEKM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LIHAGLPHKIPNSIDLIQLRELMSLDKKIKNNCLRFVMIKKPGACYIDDSVTEDCLHNTL
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEECCHHHHHHHHHHH
INVVEGEQK
HHHHCCCCC
>Mature Secondary Structure 
AKFELYAEVDVSISGHQYPIIICRNGLIDPDLINRFITSKQVLIVTNRTVAPLYLGHLQ
CCEEEEEEEEEEECCCCEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHH
SVLPSKQCDVVILEDGEEHKNQRSLFTIYDSLIQNKHHRDTSIIALGGGVIGDMAGFAAS
HHCCCCCCCEEEECCCHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHH
TYQRGVRFIQLPTTLLAQVDASVGGKTAINHPAGKNMIGSFYQPQAVIIDLNTLKTLPER
HHHCCCEEEECHHHHHHHHHHCCCCCCCCCCCCCCCHHCCCCCCCEEEEECHHHHCCCCH
EFRAGIAEMIKYALLVGGSFFERIQEVLQQGLTVHSPELPLLIAECCQVKAKIVEQDERE
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHHCHHHH
SGLRALLNLGHTFAHALETYTDYKKWLHGEAVAIGLYCAAVLSEKKGLLDKPIVDQVEKM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LIHAGLPHKIPNSIDLIQLRELMSLDKKIKNNCLRFVMIKKPGACYIDDSVTEDCLHNTL
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEECCHHHHHHHHHHH
INVVEGEQK
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA