| Definition | Legionella pneumophila str. Paris, complete genome. |
|---|---|
| Accession | NC_006368 |
| Length | 3,503,610 |
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The map label for this gene is murE [H]
Identifier: 54296937
GI number: 54296937
Start: 1082676
End: 1084127
Strand: Direct
Name: murE [H]
Synonym: lpp0978
Alternate gene names: 54296937
Gene position: 1082676-1084127 (Clockwise)
Preceding gene: 54296936
Following gene: 54296940
Centisome position: 30.9
GC content: 41.12
Gene sequence:
>1452_bases GTGAAATTAACCCAATTATTAGAACCGTGGATTAAAAGGGACATTATTGATGGCACTGTGAGTGACATAAAAAATGACAG CCGCTTGGTGAAAGAAGGGGATTTATTTGTCGCCTATCCAGGGGCAGCTTCCGATGGTCGATTATATATAGAAAAAGCCG TGGCATCAGGTGCTGTCGCTGTGGTTTATGAGCCCAATAATTTACCTCAGGGAATTACTTTGCCAACAGGAATTCCCTGT ATAGCCATTCCCCAATTAGCTGAAAAATTAGGGGAAATAGCGAAACGGTTTTTTAATAACCCATCCCAATTTCTTGGTTT AACTGGGGTAACTGGCACAAATGGTAAGACGACTATTGCTTATCAGTTGGCACAGGCACATGATTTACTCGGGCAGCACT CGGCTTACATCGGGACTATAGGGCAAGGAAAGGTGGATGCCTTAAAACCTTTGGAAAATACTACGCCAGATGCTCTTTGT TTGCAGAGGTTAATGCATCAGTATAAAGAAGGAGGCATTAAACAGGTTTGTATGGAGGTATCCTCTCATGCGCTGAGCCA GCATAGAGTCGACTCTCTCGAATTTAGTCAGGCTATCTTTACCAATTTAACGCTCGATCATTTAGATTATCACCAGACAA TGCAAGCTTATGGGGCTGCAAAGTCGAGGTTGTTTGAACGAGCAGAGTTGCAATGGGCTATTATTAATCAGGATGATGAC TTTCAAGATCTCATGAGCAATGTGCTAAAGACTCATGTAAAAAAAGTGACTTACGGTATGCATCAAAATTGCGATGTGAA AGCGCTCCAATGGAATATGGATATCACCGGAACAGAAATTGAAGTCAAATCTCCTTGGGGGCACCACCTTCTAAAGATTA AAGCACTGGGTAAGTTTAATATTTATAATAGCCTGGCTGTTTATAGCAGTTTGCTTGCCAGCGGGTATAATCCAGAAAAA GTAGTGCAAGTTATGGCCGAATTAAAAGCGGCTCCTGGCCGAATGGAAATTGTCGCTCAATCCCCATATGTTCTTGTTGA TTATGCTCATACTCCCGATGCATTGGAAAATGTTCTTATCACCTTAAAACAAATAAAAAAAGGGAGATTGTGGGTTGTAT TTGGTTGTGGTGGGGACAGAGATAAAACCAAACGGCCCATTATGGGAAAGGCAGCCAGCATGTACGCTGATAATATTGTC ATTACCAGCGATAATCCAAGAAGTGAAGATCCGGAAATTATTCTAAATGAAATTGCTTGTGGCATTCCTGCCTCTGCGCC TGTCTCTAAACTGGTGAATAGAGAAGAGGCAATTGCTTATGCTTTAAGAAAGGCTGAGCATAACGATATCATATTAATAG CAGGAAAAGGACATGAATCGTATCAGCAGATTGGGAATACAAAACATGTTTTTTCTGATCAGGAAGTTGTAAGACGTTTG ATGAATAATTAA
Upstream 100 bases:
>100_bases TGGCAGGGCCCTTATTTGCGAAAGTCATGTCAGGTGCTTTACGCTTATTCAATATTCCTACTGATGAGCCAGTTAGTTAA AGAGAATAGGAGCCAATTTT
Downstream 100 bases:
>100_bases AATTTCGGGACAGGGGTTAATTATTAGAAACAGACATCAACACCTTAACCTAATAATGGATACTTTTTTATTGAGTCAGA ATCAAAATAAGTTGTGAAAT
Product: hypothetical protein
Products: NA
Alternate protein names: Meso-A2pm-adding enzyme; Meso-diaminopimelate-adding enzyme; UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase; UDP-MurNAc-tripeptide synthetase; UDP-N-acetylmuramyl-tripeptide synthetase [H]
Number of amino acids: Translated: 483; Mature: 483
Protein sequence:
>483_residues MKLTQLLEPWIKRDIIDGTVSDIKNDSRLVKEGDLFVAYPGAASDGRLYIEKAVASGAVAVVYEPNNLPQGITLPTGIPC IAIPQLAEKLGEIAKRFFNNPSQFLGLTGVTGTNGKTTIAYQLAQAHDLLGQHSAYIGTIGQGKVDALKPLENTTPDALC LQRLMHQYKEGGIKQVCMEVSSHALSQHRVDSLEFSQAIFTNLTLDHLDYHQTMQAYGAAKSRLFERAELQWAIINQDDD FQDLMSNVLKTHVKKVTYGMHQNCDVKALQWNMDITGTEIEVKSPWGHHLLKIKALGKFNIYNSLAVYSSLLASGYNPEK VVQVMAELKAAPGRMEIVAQSPYVLVDYAHTPDALENVLITLKQIKKGRLWVVFGCGGDRDKTKRPIMGKAASMYADNIV ITSDNPRSEDPEIILNEIACGIPASAPVSKLVNREEAIAYALRKAEHNDIILIAGKGHESYQQIGNTKHVFSDQEVVRRL MNN
Sequences:
>Translated_483_residues MKLTQLLEPWIKRDIIDGTVSDIKNDSRLVKEGDLFVAYPGAASDGRLYIEKAVASGAVAVVYEPNNLPQGITLPTGIPC IAIPQLAEKLGEIAKRFFNNPSQFLGLTGVTGTNGKTTIAYQLAQAHDLLGQHSAYIGTIGQGKVDALKPLENTTPDALC LQRLMHQYKEGGIKQVCMEVSSHALSQHRVDSLEFSQAIFTNLTLDHLDYHQTMQAYGAAKSRLFERAELQWAIINQDDD FQDLMSNVLKTHVKKVTYGMHQNCDVKALQWNMDITGTEIEVKSPWGHHLLKIKALGKFNIYNSLAVYSSLLASGYNPEK VVQVMAELKAAPGRMEIVAQSPYVLVDYAHTPDALENVLITLKQIKKGRLWVVFGCGGDRDKTKRPIMGKAASMYADNIV ITSDNPRSEDPEIILNEIACGIPASAPVSKLVNREEAIAYALRKAEHNDIILIAGKGHESYQQIGNTKHVFSDQEVVRRL MNN >Mature_483_residues MKLTQLLEPWIKRDIIDGTVSDIKNDSRLVKEGDLFVAYPGAASDGRLYIEKAVASGAVAVVYEPNNLPQGITLPTGIPC IAIPQLAEKLGEIAKRFFNNPSQFLGLTGVTGTNGKTTIAYQLAQAHDLLGQHSAYIGTIGQGKVDALKPLENTTPDALC LQRLMHQYKEGGIKQVCMEVSSHALSQHRVDSLEFSQAIFTNLTLDHLDYHQTMQAYGAAKSRLFERAELQWAIINQDDD FQDLMSNVLKTHVKKVTYGMHQNCDVKALQWNMDITGTEIEVKSPWGHHLLKIKALGKFNIYNSLAVYSSLLASGYNPEK VVQVMAELKAAPGRMEIVAQSPYVLVDYAHTPDALENVLITLKQIKKGRLWVVFGCGGDRDKTKRPIMGKAASMYADNIV ITSDNPRSEDPEIILNEIACGIPASAPVSKLVNREEAIAYALRKAEHNDIILIAGKGHESYQQIGNTKHVFSDQEVVRRL MNN
Specific function: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan [H]
COG id: COG0769
COG function: function code M; UDP-N-acetylmuramyl tripeptide synthase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the MurCDEF family. MurE subfamily [H]
Homologues:
Organism=Escherichia coli, GI1786273, Length=491, Percent_Identity=41.3441955193483, Blast_Score=330, Evalue=1e-91,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004101 - InterPro: IPR013221 - InterPro: IPR000713 - InterPro: IPR005761 [H]
Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]
EC number: =6.3.2.13 [H]
Molecular weight: Translated: 53376; Mature: 53376
Theoretical pI: Translated: 7.06; Mature: 7.06
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.2 %Cys (Translated Protein) 2.5 %Met (Translated Protein) 3.7 %Cys+Met (Translated Protein) 1.2 %Cys (Mature Protein) 2.5 %Met (Mature Protein) 3.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKLTQLLEPWIKRDIIDGTVSDIKNDSRLVKEGDLFVAYPGAASDGRLYIEKAVASGAVA CCHHHHHHHHHHHHHCCCHHHHCCCCCCEEECCCEEEEECCCCCCCEEEEEEHHCCCCEE VVYEPNNLPQGITLPTGIPCIAIPQLAEKLGEIAKRFFNNPSQFLGLTGVTGTNGKTTIA EEECCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCHHHHEEEECCCCCCCCEEEE YQLAQAHDLLGQHSAYIGTIGQGKVDALKPLENTTPDALCLQRLMHQYKEGGIKQVCMEV EHHHHHHHHHHCCCCEEEECCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHH SSHALSQHRVDSLEFSQAIFTNLTLDHLDYHQTMQAYGAAKSRLFERAELQWAIINQDDD HHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCC FQDLMSNVLKTHVKKVTYGMHQNCDVKALQWNMDITGTEIEVKSPWGHHLLKIKALGKFN HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCEEEEECCCCCEEEEEEECCCCC IYNSLAVYSSLLASGYNPEKVVQVMAELKAAPGRMEIVAQSPYVLVDYAHTPDALENVLI HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCHHHHHHHH TLKQIKKGRLWVVFGCGGDRDKTKRPIMGKAASMYADNIVITSDNPRSEDPEIILNEIAC HHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHCCCEEEECCCCCCCCHHHHHHHHHC GIPASAPVSKLVNREEAIAYALRKAEHNDIILIAGKGHESYQQIGNTKHVFSDQEVVRRL CCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHCCCCCCCCCHHHHHHHH MNN HCC >Mature Secondary Structure MKLTQLLEPWIKRDIIDGTVSDIKNDSRLVKEGDLFVAYPGAASDGRLYIEKAVASGAVA CCHHHHHHHHHHHHHCCCHHHHCCCCCCEEECCCEEEEECCCCCCCEEEEEEHHCCCCEE VVYEPNNLPQGITLPTGIPCIAIPQLAEKLGEIAKRFFNNPSQFLGLTGVTGTNGKTTIA EEECCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCHHHHEEEECCCCCCCCEEEE YQLAQAHDLLGQHSAYIGTIGQGKVDALKPLENTTPDALCLQRLMHQYKEGGIKQVCMEV EHHHHHHHHHHCCCCEEEECCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHH SSHALSQHRVDSLEFSQAIFTNLTLDHLDYHQTMQAYGAAKSRLFERAELQWAIINQDDD HHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCC FQDLMSNVLKTHVKKVTYGMHQNCDVKALQWNMDITGTEIEVKSPWGHHLLKIKALGKFN HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCEEEEECCCCCEEEEEEECCCCC IYNSLAVYSSLLASGYNPEKVVQVMAELKAAPGRMEIVAQSPYVLVDYAHTPDALENVLI HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCHHHHHHHH TLKQIKKGRLWVVFGCGGDRDKTKRPIMGKAASMYADNIVITSDNPRSEDPEIILNEIAC HHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHCCCEEEECCCCCCCCHHHHHHHHHC GIPASAPVSKLVNREEAIAYALRKAEHNDIILIAGKGHESYQQIGNTKHVFSDQEVVRRL CCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHCCCCCCCCCHHHHHHHH MNN HCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 10761919 [H]