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The map label for this gene is fabG2 [H]

Identifier: 54296926

GI number: 54296926

Start: 1073653

End: 1074396

Strand: Direct

Name: fabG2 [H]

Synonym: lpp0967

Alternate gene names: 54296926

Gene position: 1073653-1074396 (Clockwise)

Preceding gene: 54296925

Following gene: 54296930

Centisome position: 30.64

GC content: 42.34

Gene sequence:

>744_bases
ATGAATTTCGATAATCAGATTGCACTAGTAACTGGTGGTGTCTCAGGTATGGGTAAGGCTTGTGTACAATATTTACAACA
GCATGGCATGAAAGTTGTGGTCTGGGATAAACAGGAAGGCACCTCAAATGAAGCGGAACTGTATGTTGCTTGTGATGTAA
CCAGTGATGAATCTGTTGAAAAGGCAATGCGACAAACTATCTCTCAGGTAGGAGTACCAAGGGTTTGTATCAATTGTGCG
GGAATTGCTCCGGCAAAACGCATGGTAGGAAAAGAAGGGCCAATGCCTTTGGAATCATTTAGACAAGTAATAGATGTCAA
TTTAATAGGTACCTTCAATGTCATGCGAATAGCTGCACATGCCATGTCAGGATTGGAGTTGGACAACAAATCTCAGGAGC
GGGGTGTCATAATCAATACAGCTTCCATTGCTGCTTTTGAAGGACAAATAGGACAGTCTGCTTATAGTGCGTCAAAGGGT
GGAATAGTATCAATGACCTTGCCAGCAGCACGTGAATTAGCTCAATTTGCAATAAGAGTAAATACAATTGCGCCGGGGTT
AATAGCAACTCCTTTACTTTTAAATATGCCTCAAGAAGTTCAGGACAGTTTGGTTGCAACAGTGACTTTTCCCAAACGCC
TGGGTAGACCAGAGGAATTTGCTTCACTAGTAGGTCATATTATTGAAAACCAGATGATTAATGGAGAGGTAATTCGTTTG
GATGCGGCTCTCCGTATGCGTTGA

Upstream 100 bases:

>100_bases
CTTAAAAAAATAAGCAGGTTTGCCAAGGGGTCTAATAGAATACTGTTTTTAAGTGGAATAAGAAAATTGGAAATTGAAAC
CGTAGAATTTTGGAGAGAAA

Downstream 100 bases:

>100_bases
GTAGCTATGCCTGGCGCATCATACTGGAGAGCTATTTTAACCAGGGGTTATATTTCTTATGCTTCTTCATGGTGACTGCT
TTCGGAAGGGGTTTCCAAAT

Product: hypothetical protein

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MNFDNQIALVTGGVSGMGKACVQYLQQHGMKVVVWDKQEGTSNEAELYVACDVTSDESVEKAMRQTISQVGVPRVCINCA
GIAPAKRMVGKEGPMPLESFRQVIDVNLIGTFNVMRIAAHAMSGLELDNKSQERGVIINTASIAAFEGQIGQSAYSASKG
GIVSMTLPAARELAQFAIRVNTIAPGLIATPLLLNMPQEVQDSLVATVTFPKRLGRPEEFASLVGHIIENQMINGEVIRL
DAALRMR

Sequences:

>Translated_247_residues
MNFDNQIALVTGGVSGMGKACVQYLQQHGMKVVVWDKQEGTSNEAELYVACDVTSDESVEKAMRQTISQVGVPRVCINCA
GIAPAKRMVGKEGPMPLESFRQVIDVNLIGTFNVMRIAAHAMSGLELDNKSQERGVIINTASIAAFEGQIGQSAYSASKG
GIVSMTLPAARELAQFAIRVNTIAPGLIATPLLLNMPQEVQDSLVATVTFPKRLGRPEEFASLVGHIIENQMINGEVIRL
DAALRMR
>Mature_247_residues
MNFDNQIALVTGGVSGMGKACVQYLQQHGMKVVVWDKQEGTSNEAELYVACDVTSDESVEKAMRQTISQVGVPRVCINCA
GIAPAKRMVGKEGPMPLESFRQVIDVNLIGTFNVMRIAAHAMSGLELDNKSQERGVIINTASIAAFEGQIGQSAYSASKG
GIVSMTLPAARELAQFAIRVNTIAPGLIATPLLLNMPQEVQDSLVATVTFPKRLGRPEEFASLVGHIIENQMINGEVIRL
DAALRMR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=250, Percent_Identity=50.8, Blast_Score=223, Evalue=1e-58,
Organism=Homo sapiens, GI83715985, Length=250, Percent_Identity=48, Blast_Score=203, Evalue=1e-52,
Organism=Homo sapiens, GI15277342, Length=260, Percent_Identity=32.3076923076923, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI40254992, Length=249, Percent_Identity=28.1124497991968, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI59889578, Length=177, Percent_Identity=32.7683615819209, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI31542939, Length=262, Percent_Identity=26.3358778625954, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=28, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI10190704, Length=236, Percent_Identity=28.3898305084746, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI4504505, Length=240, Percent_Identity=27.5, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1787335, Length=255, Percent_Identity=27.4509803921569, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788459, Length=234, Percent_Identity=29.4871794871795, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI87082160, Length=261, Percent_Identity=26.8199233716475, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787905, Length=234, Percent_Identity=27.3504273504274, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786812, Length=236, Percent_Identity=27.1186440677966, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI87082100, Length=244, Percent_Identity=24.1803278688525, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI2367175, Length=248, Percent_Identity=29.8387096774194, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1789208, Length=264, Percent_Identity=25, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=247, Percent_Identity=48.9878542510121, Blast_Score=221, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI25147288, Length=252, Percent_Identity=33.3333333333333, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17555706, Length=232, Percent_Identity=31.4655172413793, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17562910, Length=273, Percent_Identity=26.7399267399267, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17559104, Length=251, Percent_Identity=25.0996015936255, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17561402, Length=263, Percent_Identity=27.7566539923954, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17568967, Length=248, Percent_Identity=25, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=253, Percent_Identity=24.901185770751, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17538480, Length=205, Percent_Identity=25.3658536585366, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=257, Percent_Identity=22.9571984435798, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=205, Percent_Identity=32.6829268292683, Blast_Score=79, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6320089, Length=226, Percent_Identity=28.7610619469027, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17737361, Length=251, Percent_Identity=45.8167330677291, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24639444, Length=253, Percent_Identity=34.3873517786561, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI21355319, Length=246, Percent_Identity=27.6422764227642, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI23397609, Length=208, Percent_Identity=27.8846153846154, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28571526, Length=246, Percent_Identity=25.2032520325203, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24644339, Length=231, Percent_Identity=25.5411255411255, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21357041, Length=231, Percent_Identity=25.5411255411255, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 26586; Mature: 26586

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFDNQIALVTGGVSGMGKACVQYLQQHGMKVVVWDKQEGTSNEAELYVACDVTSDESVE
CCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEECCCCHHHH
KAMRQTISQVGVPRVCINCAGIAPAKRMVGKEGPMPLESFRQVIDVNLIGTFNVMRIAAH
HHHHHHHHHCCCCEEEEEECCCCHHHHHHCCCCCCCHHHHHHHHHHHEECHHHHHHHHHH
AMSGLELDNKSQERGVIINTASIAAFEGQIGQSAYSASKGGIVSMTLPAARELAQFAIRV
HHHCCCCCCCCCCCCEEEEECCEEEECCCCCHHHHCCCCCCEEEEECHHHHHHHHHHHHH
NTIAPGLIATPLLLNMPQEVQDSLVATVTFPKRLGRPEEFASLVGHIIENQMINGEVIRL
HHCCCCHHHHHHHHCCCHHHHHHHEEEEECHHHCCCHHHHHHHHHHHHHCCCCCCEEEEE
DAALRMR
ECEECCC
>Mature Secondary Structure
MNFDNQIALVTGGVSGMGKACVQYLQQHGMKVVVWDKQEGTSNEAELYVACDVTSDESVE
CCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEECCCCHHHH
KAMRQTISQVGVPRVCINCAGIAPAKRMVGKEGPMPLESFRQVIDVNLIGTFNVMRIAAH
HHHHHHHHHCCCCEEEEEECCCCHHHHHHCCCCCCCHHHHHHHHHHHEECHHHHHHHHHH
AMSGLELDNKSQERGVIINTASIAAFEGQIGQSAYSASKGGIVSMTLPAARELAQFAIRV
HHHCCCCCCCCCCCCEEEEECCEEEECCCCCHHHHCCCCCCEEEEECHHHHHHHHHHHHH
NTIAPGLIATPLLLNMPQEVQDSLVATVTFPKRLGRPEEFASLVGHIIENQMINGEVIRL
HHCCCCHHHHHHHHCCCHHHHHHHEEEEECHHHCCCHHHHHHHHHHHHHCCCCCCEEEEE
DAALRMR
ECEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]