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The map label for this gene is icd [H]

Identifier: 54296837

GI number: 54296837

Start: 986554

End: 987810

Strand: Direct

Name: icd [H]

Synonym: lpp0878

Alternate gene names: 54296837

Gene position: 986554-987810 (Clockwise)

Preceding gene: 54296836

Following gene: 54296838

Centisome position: 28.16

GC content: 41.37

Gene sequence:

>1257_bases
ATGACATACGATAAAATCAAAGTGCCTGCCCAAGGCGAAGCTATTACTGTTGCTGCTGACCATTCACTTCATGTTCCTGA
TAATCCAATTATTCCTTTTATTGAGGGTGATGGTATCGGTGTTGATGTAACACCTCCGATGATCCGTGTTGTTGATGCTG
CAGTTCAAAAAGCATATGGCAACAAGAGAAAAATTTCCTGGATGGAGGTTTATGCCGGGGAAAAGGCTACTAAGGTTTAT
GGTGGCGATCAATGGCTTCCCAAAGAGACTCTGGATGCCATGAAAAAATATGTGGTTTCAATTAAAGGTCCTTTAACTAC
TCCTGTTGGTGGCGGTATACGTTCATTGAATGTCGCTATTCGCCAAGACATGGATCTCTATGTTTGTTTACGTCCAATTC
GCTATTTTAATGGTGTTCCAAGTCCGGTTCGGGAGCCATGGAAAACCGATATGGTCATTTTCAGGGAAAATTCTGAAGAT
ATTTATGCCGGTATTGAATGGCAGGCAGATACCCCGGAAGCTAAAAAAGTGATTCAATTTTTAACTAAGGAAATGGGTGT
TAAGAAAATTCGTTTTCCTGAGCATTGTGGTATAGGTGTGAAGCCTGTTTCCAGAGAAGGTACCACTCGACTTGTCAAAG
CGGCCATTCAGTATGCGATAGATAATGACCGCAGTACAGTGACTTTGGTACATAAAGGCAATATCATGAAGTTTACTGAA
GGGGCTTTTAAAGATTGGGGATATCAAGTTGCTCGCGATTCTTTTGGAGCAAAAGAATATCAAGGTGGGCCATGGATGGA
ATTTAAAAATCCTAAAACCGGTAAGCAGATTATCATTAATGATGTGATCGCTGATGCCTTTTTGCAACAAATCCTGTTAA
GACCTGAAGACTATAGTGTCATTGCTACATTAAATTTGAATGGTGATTATATTTCTGATGCTTTGGCTGCTCAGGTTGGT
GGAATAGGTATAGCTCCCGGAGCGAACATTAGTGATCAAATGGCTGTGTTTGAAGCAACTCATGGAACTGCGCCTAAATA
TGCTGGGCAGAATAAAGTGAACCCCGGTTCTATTATTCTTTCTGCCGAAATGATGTTACGTCATATGGGGTGGTATGAAG
CAGCTGATTTGATTATCAGAGGTATGGAAGGCGCGATAGAAGCCAAAACCGTAACTTATGATTTTGAACGTGGTATGCAA
GGAGCAACGTTAGTCAGCAGCTCTGGTTTTGCAGATGCCATGATTAAGCATATGTAA

Upstream 100 bases:

>100_bases
GAGCTAATTTAGCTAAAAATAATTAATAGTCGTAATTGATATTTGGGAAACCCGATTATCACATGCTATCATTAATTTCT
CTAAATTTATGGAGTCGTCA

Downstream 100 bases:

>100_bases
ACCGGGGAGTTATCACATGGTCTTTCTGAACAACGCGTATTGACAATATAGCACTTACAGCTTTACTCAGTGCCAATGCG
TTGTTCATGAAAGACTGGGA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MTYDKIKVPAQGEAITVAADHSLHVPDNPIIPFIEGDGIGVDVTPPMIRVVDAAVQKAYGNKRKISWMEVYAGEKATKVY
GGDQWLPKETLDAMKKYVVSIKGPLTTPVGGGIRSLNVAIRQDMDLYVCLRPIRYFNGVPSPVREPWKTDMVIFRENSED
IYAGIEWQADTPEAKKVIQFLTKEMGVKKIRFPEHCGIGVKPVSREGTTRLVKAAIQYAIDNDRSTVTLVHKGNIMKFTE
GAFKDWGYQVARDSFGAKEYQGGPWMEFKNPKTGKQIIINDVIADAFLQQILLRPEDYSVIATLNLNGDYISDALAAQVG
GIGIAPGANISDQMAVFEATHGTAPKYAGQNKVNPGSIILSAEMMLRHMGWYEAADLIIRGMEGAIEAKTVTYDFERGMQ
GATLVSSSGFADAMIKHM

Sequences:

>Translated_418_residues
MTYDKIKVPAQGEAITVAADHSLHVPDNPIIPFIEGDGIGVDVTPPMIRVVDAAVQKAYGNKRKISWMEVYAGEKATKVY
GGDQWLPKETLDAMKKYVVSIKGPLTTPVGGGIRSLNVAIRQDMDLYVCLRPIRYFNGVPSPVREPWKTDMVIFRENSED
IYAGIEWQADTPEAKKVIQFLTKEMGVKKIRFPEHCGIGVKPVSREGTTRLVKAAIQYAIDNDRSTVTLVHKGNIMKFTE
GAFKDWGYQVARDSFGAKEYQGGPWMEFKNPKTGKQIIINDVIADAFLQQILLRPEDYSVIATLNLNGDYISDALAAQVG
GIGIAPGANISDQMAVFEATHGTAPKYAGQNKVNPGSIILSAEMMLRHMGWYEAADLIIRGMEGAIEAKTVTYDFERGMQ
GATLVSSSGFADAMIKHM
>Mature_417_residues
TYDKIKVPAQGEAITVAADHSLHVPDNPIIPFIEGDGIGVDVTPPMIRVVDAAVQKAYGNKRKISWMEVYAGEKATKVYG
GDQWLPKETLDAMKKYVVSIKGPLTTPVGGGIRSLNVAIRQDMDLYVCLRPIRYFNGVPSPVREPWKTDMVIFRENSEDI
YAGIEWQADTPEAKKVIQFLTKEMGVKKIRFPEHCGIGVKPVSREGTTRLVKAAIQYAIDNDRSTVTLVHKGNIMKFTEG
AFKDWGYQVARDSFGAKEYQGGPWMEFKNPKTGKQIIINDVIADAFLQQILLRPEDYSVIATLNLNGDYISDALAAQVGG
IGIAPGANISDQMAVFEATHGTAPKYAGQNKVNPGSIILSAEMMLRHMGWYEAADLIIRGMEGAIEAKTVTYDFERGMQG
ATLVSSSGFADAMIKHM

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=369, Percent_Identity=31.4363143631436, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI28178816, Length=352, Percent_Identity=27.2727272727273, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI28178821, Length=352, Percent_Identity=27.2727272727273, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI28178838, Length=366, Percent_Identity=25.6830601092896, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI4758582, Length=391, Percent_Identity=25.8312020460358, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI28178819, Length=181, Percent_Identity=33.1491712707182, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1787381, Length=414, Percent_Identity=75.3623188405797, Blast_Score=663, Evalue=0.0,
Organism=Escherichia coli, GI1788101, Length=346, Percent_Identity=29.1907514450867, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI87081683, Length=402, Percent_Identity=23.8805970149254, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71986051, Length=396, Percent_Identity=33.3333333333333, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI25144293, Length=350, Percent_Identity=28.5714285714286, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17505779, Length=365, Percent_Identity=27.3972602739726, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17550882, Length=344, Percent_Identity=25.5813953488372, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324709, Length=391, Percent_Identity=28.9002557544757, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6322097, Length=372, Percent_Identity=27.9569892473118, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6324291, Length=370, Percent_Identity=27.027027027027, Blast_Score=120, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24643270, Length=369, Percent_Identity=33.6043360433604, Blast_Score=174, Evalue=8e-44,
Organism=Drosophila melanogaster, GI24643268, Length=369, Percent_Identity=33.6043360433604, Blast_Score=174, Evalue=8e-44,
Organism=Drosophila melanogaster, GI24661184, Length=391, Percent_Identity=29.923273657289, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI161078635, Length=290, Percent_Identity=28.2758620689655, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI161078637, Length=290, Percent_Identity=28.2758620689655, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI161078633, Length=290, Percent_Identity=28.2758620689655, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24650122, Length=290, Percent_Identity=28.2758620689655, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI161078639, Length=290, Percent_Identity=28.2758620689655, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI20130355, Length=348, Percent_Identity=24.4252873563218, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI281362242, Length=327, Percent_Identity=26.9113149847095, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24648872, Length=327, Percent_Identity=26.9113149847095, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45983; Mature: 45852

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYDKIKVPAQGEAITVAADHSLHVPDNPIIPFIEGDGIGVDVTPPMIRVVDAAVQKAYG
CCCCCEECCCCCCEEEEEECCEEECCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHCC
NKRKISWMEVYAGEKATKVYGGDQWLPKETLDAMKKYVVSIKGPLTTPVGGGIRSLNVAI
CCCCEEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHEEECCCCCCCCCCCHHEEEEEE
RQDMDLYVCLRPIRYFNGVPSPVREPWKTDMVIFRENSEDIYAGIEWQADTPEAKKVIQF
CCCCCEEHHHHHHHHHCCCCCHHCCCCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHH
LTKEMGVKKIRFPEHCGIGVKPVSREGTTRLVKAAIQYAIDNDRSTVTLVHKGNIMKFTE
HHHHCCCEECCCCHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCEEEECC
GAFKDWGYQVARDSFGAKEYQGGPWMEFKNPKTGKQIIINDVIADAFLQQILLRPEDYSV
CHHHHCCHHHHHHCCCCCCCCCCCCEECCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCEE
IATLNLNGDYISDALAAQVGGIGIAPGANISDQMAVFEATHGTAPKYAGQNKVNPGSIIL
EEEEECCCCHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEE
SAEMMLRHMGWYEAADLIIRGMEGAIEAKTVTYDFERGMQGATLVSSSGFADAMIKHM
EHHHHHHHCCHHHHHHHHHHCCCCCEEEEEEEEEHHCCCCCCEEEECCCHHHHHHHCC
>Mature Secondary Structure 
TYDKIKVPAQGEAITVAADHSLHVPDNPIIPFIEGDGIGVDVTPPMIRVVDAAVQKAYG
CCCCEECCCCCCEEEEEECCEEECCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHCC
NKRKISWMEVYAGEKATKVYGGDQWLPKETLDAMKKYVVSIKGPLTTPVGGGIRSLNVAI
CCCCEEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHEEECCCCCCCCCCCHHEEEEEE
RQDMDLYVCLRPIRYFNGVPSPVREPWKTDMVIFRENSEDIYAGIEWQADTPEAKKVIQF
CCCCCEEHHHHHHHHHCCCCCHHCCCCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHH
LTKEMGVKKIRFPEHCGIGVKPVSREGTTRLVKAAIQYAIDNDRSTVTLVHKGNIMKFTE
HHHHCCCEECCCCHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCEEEECC
GAFKDWGYQVARDSFGAKEYQGGPWMEFKNPKTGKQIIINDVIADAFLQQILLRPEDYSV
CHHHHCCHHHHHHCCCCCCCCCCCCEECCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCEE
IATLNLNGDYISDALAAQVGGIGIAPGANISDQMAVFEATHGTAPKYAGQNKVNPGSIIL
EEEEECCCCHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEE
SAEMMLRHMGWYEAADLIIRGMEGAIEAKTVTYDFERGMQGATLVSSSGFADAMIKHM
EHHHHHHHCCHHHHHHHHHHCCCCCEEEEEEEEEHHCCCCCCEEEECCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3112144; 8905232; 9278503; 9352899; 9298646; 2204109; 2682654; 10623532 [H]