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The map label for this gene is nadC [H]

Identifier: 54296828

GI number: 54296828

Start: 978623

End: 979465

Strand: Direct

Name: nadC [H]

Synonym: lpp0869

Alternate gene names: 54296828

Gene position: 978623-979465 (Clockwise)

Preceding gene: 54296827

Following gene: 54296829

Centisome position: 27.93

GC content: 39.74

Gene sequence:

>843_bases
ATGAATAATGTTTTATCGCAAGTTACATTTGATGTAAAACGTGCTTTGCAAGAGGACGTGGGCAATGGTGATGTTACTGC
GGCTTTGTTGCCTCAGCAGCTGATTGTAGAAGCAGAAATTATATCAAGAGAACCTATGCTTGTTTGTGGGCAGCCCTGGG
TAAATGAGGTTTTTAAGCAAGTTGATAATACAGTTGAAATGGAGTGGCGGGTTTCTGAAGGAGATTTTTTAAGCACGCCA
GCTACTTTATGTATTATTCATGGTACTGCCAGTAGTATTTTAACGGCAGAGCGTACTGCGTTAAATTTTTTGCAAACCCT
TTCAGCTACTGCAACACAAACTTATCACTATGTTCAGAAATTAAAAGGTACCAAGGCAAAGCTGTTAGACACACGCAAAA
CAATTCCAGGACTTCGGTTAGCGCAAAAATACGCTGTCTATTGTGGTGGCGGGTTAAATCATCGTATGGGACTTTATGAT
GCGTTTCTAATCAAAGAAAATCATATCAAAGCCTGTGGTTCAGTTGCTCATGCTATCAGTCTGGCAAGGAAAACCGATAA
ACACTTACTGGTTGAGATTGAAGTGGAAACCCTTGAGGAGTTGCAAGAGGCTTTGGATGCTCACCCTGACAGGATATTAT
TAGATAATTTCACTCAAGATATGCTTGAGCAAGCAGTCAAAATGAATCATCCCAAGTACTGTGAATTGGAAGCCTCTGGC
GGCATTAATATCAATAATATTGCAGACATTGCTCAAACCGGAGTGGATTTTATTTCAGTTGGATCCATCACCAAATCAAT
TCAAGCAATTGATTTGAGCTTATTGATTAGGGAAACATTATGA

Upstream 100 bases:

>100_bases
ATCTGTTTACCGCAATTGTATTGATGATCATGATCACAACCTTTATTGCGCCACCTTTATTAAAGATGCGATATGCCAAA
CCAAAAGAGGATAGGAATGC

Downstream 100 bases:

>100_bases
GCCCAAGTATTGTTTTTACCGGGGGAGGAACTGCCGGACATGTAACGCCTAATATCGCTTTGATTAAGGAATTTCGAAAA
GAAGGCTGGAATGTAGAATA

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MNNVLSQVTFDVKRALQEDVGNGDVTAALLPQQLIVEAEIISREPMLVCGQPWVNEVFKQVDNTVEMEWRVSEGDFLSTP
ATLCIIHGTASSILTAERTALNFLQTLSATATQTYHYVQKLKGTKAKLLDTRKTIPGLRLAQKYAVYCGGGLNHRMGLYD
AFLIKENHIKACGSVAHAISLARKTDKHLLVEIEVETLEELQEALDAHPDRILLDNFTQDMLEQAVKMNHPKYCELEASG
GININNIADIAQTGVDFISVGSITKSIQAIDLSLLIRETL

Sequences:

>Translated_280_residues
MNNVLSQVTFDVKRALQEDVGNGDVTAALLPQQLIVEAEIISREPMLVCGQPWVNEVFKQVDNTVEMEWRVSEGDFLSTP
ATLCIIHGTASSILTAERTALNFLQTLSATATQTYHYVQKLKGTKAKLLDTRKTIPGLRLAQKYAVYCGGGLNHRMGLYD
AFLIKENHIKACGSVAHAISLARKTDKHLLVEIEVETLEELQEALDAHPDRILLDNFTQDMLEQAVKMNHPKYCELEASG
GININNIADIAQTGVDFISVGSITKSIQAIDLSLLIRETL
>Mature_280_residues
MNNVLSQVTFDVKRALQEDVGNGDVTAALLPQQLIVEAEIISREPMLVCGQPWVNEVFKQVDNTVEMEWRVSEGDFLSTP
ATLCIIHGTASSILTAERTALNFLQTLSATATQTYHYVQKLKGTKAKLLDTRKTIPGLRLAQKYAVYCGGGLNHRMGLYD
AFLIKENHIKACGSVAHAISLARKTDKHLLVEIEVETLEELQEALDAHPDRILLDNFTQDMLEQAVKMNHPKYCELEASG
GININNIADIAQTGVDFISVGSITKSIQAIDLSLLIRETL

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=269, Percent_Identity=33.457249070632, Blast_Score=135, Evalue=6e-32,
Organism=Escherichia coli, GI1786299, Length=286, Percent_Identity=48.951048951049, Blast_Score=237, Evalue=7e-64,
Organism=Saccharomyces cerevisiae, GI6321162, Length=279, Percent_Identity=36.9175627240143, Blast_Score=152, Evalue=8e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30917; Mature: 30917

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNVLSQVTFDVKRALQEDVGNGDVTAALLPQQLIVEAEIISREPMLVCGQPWVNEVFKQ
CCCHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHH
VDNTVEMEWRVSEGDFLSTPATLCIIHGTASSILTAERTALNFLQTLSATATQTYHYVQK
CCCCEEEEEEECCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKGTKAKLLDTRKTIPGLRLAQKYAVYCGGGLNHRMGLYDAFLIKENHIKACGSVAHAIS
HCCCHHHHHHHHHCCCCHHHHHHHHEEECCCCCCCCCHHHHEEEECCHHHHHHHHHHHHH
LARKTDKHLLVEIEVETLEELQEALDAHPDRILLDNFTQDMLEQAVKMNHPKYCELEASG
HHHHCCCEEEEEEEHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCEEEEECCC
GININNIADIAQTGVDFISVGSITKSIQAIDLSLLIRETL
CCCCHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNNVLSQVTFDVKRALQEDVGNGDVTAALLPQQLIVEAEIISREPMLVCGQPWVNEVFKQ
CCCHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHH
VDNTVEMEWRVSEGDFLSTPATLCIIHGTASSILTAERTALNFLQTLSATATQTYHYVQK
CCCCEEEEEEECCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKGTKAKLLDTRKTIPGLRLAQKYAVYCGGGLNHRMGLYDAFLIKENHIKACGSVAHAIS
HCCCHHHHHHHHHCCCCHHHHHHHHEEECCCCCCCCCHHHHEEEECCHHHHHHHHHHHHH
LARKTDKHLLVEIEVETLEELQEALDAHPDRILLDNFTQDMLEQAVKMNHPKYCELEASG
HHHHCCCEEEEEEEHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCEEEEECCC
GININNIADIAQTGVDFISVGSITKSIQAIDLSLLIRETL
CCCCHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]