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The map label for this gene is gpi

Identifier: 54296786

GI number: 54296786

Start: 922386

End: 923885

Strand: Direct

Name: gpi

Synonym: lpp0825

Alternate gene names: 54296786

Gene position: 922386-923885 (Clockwise)

Preceding gene: 54296785

Following gene: 54296787

Centisome position: 26.33

GC content: 35.27

Gene sequence:

>1500_bases
ATGATTAGAAATAGCATGAAGTCTCACACAGAATTATTGTCATGGAATTTGCTTCAAAAAGAAGCGGATAGAGTGCGTCT
AAATTCAGATTCTCTAACATGCGTTGTTCCGGATTCCAACAATTATGAATCCAGTAAACAGATCAATTGTATTGAGTACG
ACTATTCCAGGCAGAGAGTAAACAGAACCATCATTGATTTGCTTATCGATTTGGCTAATGAAGTCAAATTACAAGAAAAA
ATTGATAACTTAATCAATGGTAAAAAAATCAATATCAGCGAAAACAGGCCTGCACTACATACTGCACTTAGGGACTTAGG
TAATAAATCGATAATGATTGATGGACTGGATATTATGTCCGCAGTTATAAATACTCGTGAAAAAATTAAAGTTATATCCA
ATCAGATCAGAGAAAAGAAGTGGCTGGGCCATTCAGGTCTACCAATAACTGATATTGTAAACATAGGTATTGGCGGCTCG
GATTTAGGTCCTCGTGTATGCATCAATGCCCTGTCTAATTATATTTCCAAAGAATTTAATTATCATTTTATCTCAGATGT
TGATCCGGCCAGTTTTAACGATGTTATTGCAAAAATTAATCCGCAAACCACCTTATTTATTGTTTCTTCCAAATCATTTA
CTACAAAAGAAACTCTATTAAATGCCAGAAAAGCTTTTGCATTGTATGAGGATACGGCCTCTATCGATCAACATTTTATA
GCTGTAACCGCACATCCGGAAAGAGCTTATCAAATGGGTATTAAAACTGTTTTACCGATTTGGGATTGGGTTGGTGGTCG
ATTTTCTTTTTGTTCCGCAGTTAATTTAATTACTGCGATTGCAATTGGTTATGAACAATTTGTTGAATTGCTGGCTGGTG
CCCATGATGTCGATACTCATGTCCAATTTACTGATTTTAAAAATAATATTCCTGTGCTAATGGCTTTAATCGGTATATGG
AATAACAATTTTTTGAATATTCATAATTTACTTATTCTTACCTATTCAAAAAAACTGGAGTACTTTGTTCCTTATGTACA
ACAGCTGGATATGGAGAGTAATGGGAAGTCCATTGATGTGAATGGAAGTATGGTAGATTACGCCACTGGACCTATCGTTT
GGGGTGGATTAGGAAATCAGGCACAGCATAGCTATTTTCAATTATTATGTCAGGGTACGCATCGATGTGTTGGTGATTTT
ATTACTTTGAAAACTAATGATGAGCATGAGATTAATTCCATGTGTCATTATAAAATGAAAGTTTTAAGTGAGGGAATTCA
AACAATTGAAAATCCTTATGGGTATATTCCTGGCAATATGCCAATGAATCATCTCATTTTGTCAGATTGTTCTCCTTATA
CATTAGGGGCTCTGGTGGCACTCTATGAACATAAGATTTTTGTACAAAGTGTGATATGGAATATTAACCCATTCGATCAG
CCCGGTATTGAAAGCGCCAAGAGTGCTCACAGAGAAATCACATTATCAAGCGAATCATAA

Upstream 100 bases:

>100_bases
ATAAATTATCAAATACAGTTCATCATTACTTAACACGGTATGAGCGCGAAATTAATATTTAATAAATTGAAAATAATCAG
GTAACATAGACTTTATTTTG

Downstream 100 bases:

>100_bases
AGGGGCGCTCAATGCTATAAATTAGTTTAATTATTAAACTAAACTTTATATTTTATTGACATTATCAACGTATTTTAATG
TATTACTTCAATAAACTTGA

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MIRNSMKSHTELLSWNLLQKEADRVRLNSDSLTCVVPDSNNYESSKQINCIEYDYSRQRVNRTIIDLLIDLANEVKLQEK
IDNLINGKKINISENRPALHTALRDLGNKSIMIDGLDIMSAVINTREKIKVISNQIREKKWLGHSGLPITDIVNIGIGGS
DLGPRVCINALSNYISKEFNYHFISDVDPASFNDVIAKINPQTTLFIVSSKSFTTKETLLNARKAFALYEDTASIDQHFI
AVTAHPERAYQMGIKTVLPIWDWVGGRFSFCSAVNLITAIAIGYEQFVELLAGAHDVDTHVQFTDFKNNIPVLMALIGIW
NNNFLNIHNLLILTYSKKLEYFVPYVQQLDMESNGKSIDVNGSMVDYATGPIVWGGLGNQAQHSYFQLLCQGTHRCVGDF
ITLKTNDEHEINSMCHYKMKVLSEGIQTIENPYGYIPGNMPMNHLILSDCSPYTLGALVALYEHKIFVQSVIWNINPFDQ
PGIESAKSAHREITLSSES

Sequences:

>Translated_499_residues
MIRNSMKSHTELLSWNLLQKEADRVRLNSDSLTCVVPDSNNYESSKQINCIEYDYSRQRVNRTIIDLLIDLANEVKLQEK
IDNLINGKKINISENRPALHTALRDLGNKSIMIDGLDIMSAVINTREKIKVISNQIREKKWLGHSGLPITDIVNIGIGGS
DLGPRVCINALSNYISKEFNYHFISDVDPASFNDVIAKINPQTTLFIVSSKSFTTKETLLNARKAFALYEDTASIDQHFI
AVTAHPERAYQMGIKTVLPIWDWVGGRFSFCSAVNLITAIAIGYEQFVELLAGAHDVDTHVQFTDFKNNIPVLMALIGIW
NNNFLNIHNLLILTYSKKLEYFVPYVQQLDMESNGKSIDVNGSMVDYATGPIVWGGLGNQAQHSYFQLLCQGTHRCVGDF
ITLKTNDEHEINSMCHYKMKVLSEGIQTIENPYGYIPGNMPMNHLILSDCSPYTLGALVALYEHKIFVQSVIWNINPFDQ
PGIESAKSAHREITLSSES
>Mature_499_residues
MIRNSMKSHTELLSWNLLQKEADRVRLNSDSLTCVVPDSNNYESSKQINCIEYDYSRQRVNRTIIDLLIDLANEVKLQEK
IDNLINGKKINISENRPALHTALRDLGNKSIMIDGLDIMSAVINTREKIKVISNQIREKKWLGHSGLPITDIVNIGIGGS
DLGPRVCINALSNYISKEFNYHFISDVDPASFNDVIAKINPQTTLFIVSSKSFTTKETLLNARKAFALYEDTASIDQHFI
AVTAHPERAYQMGIKTVLPIWDWVGGRFSFCSAVNLITAIAIGYEQFVELLAGAHDVDTHVQFTDFKNNIPVLMALIGIW
NNNFLNIHNLLILTYSKKLEYFVPYVQQLDMESNGKSIDVNGSMVDYATGPIVWGGLGNQAQHSYFQLLCQGTHRCVGDF
ITLKTNDEHEINSMCHYKMKVLSEGIQTIENPYGYIPGNMPMNHLILSDCSPYTLGALVALYEHKIFVQSVIWNINPFDQ
PGIESAKSAHREITLSSES

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=506, Percent_Identity=37.3517786561265, Blast_Score=356, Evalue=3e-98,
Organism=Homo sapiens, GI296080693, Length=473, Percent_Identity=34.8837209302326, Blast_Score=305, Evalue=8e-83,
Organism=Escherichia coli, GI1790457, Length=509, Percent_Identity=40.0785854616896, Blast_Score=374, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI71996708, Length=505, Percent_Identity=37.029702970297, Blast_Score=342, Evalue=3e-94,
Organism=Caenorhabditis elegans, GI71996703, Length=505, Percent_Identity=37.029702970297, Blast_Score=342, Evalue=4e-94,
Organism=Saccharomyces cerevisiae, GI6319673, Length=496, Percent_Identity=37.5, Blast_Score=328, Evalue=1e-90,
Organism=Drosophila melanogaster, GI24651916, Length=473, Percent_Identity=39.9577167019027, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24651914, Length=473, Percent_Identity=39.9577167019027, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI17737445, Length=473, Percent_Identity=39.9577167019027, Blast_Score=356, Evalue=2e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_LEGPA (Q5X6Y8)

Other databases:

- EMBL:   CR628336
- RefSeq:   YP_123155.1
- ProteinModelPortal:   Q5X6Y8
- SMR:   Q5X6Y8
- STRING:   Q5X6Y8
- GeneID:   3117706
- GenomeReviews:   CR628336_GR
- KEGG:   lpp:lpp0825
- LegioList:   lpp0825
- eggNOG:   COG0166
- HOGENOM:   HBG352954
- OMA:   GPKIVSQ
- ProtClustDB:   CLSK832387
- BioCyc:   LPNE297246:LPP0825-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR018189
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 56153; Mature: 56153

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 352-352 ACT_SITE 383-383 ACT_SITE 487-487

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRNSMKSHTELLSWNLLQKEADRVRLNSDSLTCVVPDSNNYESSKQINCIEYDYSRQRV
CCCCCHHHHHHHHHHHHHHHHHHHEEECCCCEEEEECCCCCCCCCCCCEEEEECHHHHHH
NRTIIDLLIDLANEVKLQEKIDNLINGKKINISENRPALHTALRDLGNKSIMIDGLDIMS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCCEEEEECHHHHH
AVINTREKIKVISNQIREKKWLGHSGLPITDIVNIGIGGSDLGPRVCINALSNYISKEFN
HHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHEECCCCCCCCCHHHHHHHHHHHHHHCCC
YHFISDVDPASFNDVIAKINPQTTLFIVSSKSFTTKETLLNARKAFALYEDTASIDQHFI
EEEECCCCCCCCHHHHEEECCCEEEEEEECCCCCHHHHHHHHHHHHEEECCHHCCCCEEE
AVTAHPERAYQMGIKTVLPIWDWVGGRFSFCSAVNLITAIAIGYEQFVELLAGAHDVDTH
EEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCC
VQFTDFKNNIPVLMALIGIWNNNFLNIHNLLILTYSKKLEYFVPYVQQLDMESNGKSIDV
EEEECCCCCHHHHHHHHHHHCCCEEEEEEEEEEEECHHHHHHHHHHHHCCCCCCCCEEEC
NGSMVDYATGPIVWGGLGNQAQHSYFQLLCQGTHRCVGDFITLKTNDEHEINSMCHYKMK
CCCEEECCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHH
VLSEGIQTIENPYGYIPGNMPMNHLILSDCSPYTLGALVALYEHKIFVQSVIWNINPFDQ
HHHHHHHHHCCCCCCCCCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PGIESAKSAHREITLSSES
CCCHHHHHHCCEEEECCCC
>Mature Secondary Structure
MIRNSMKSHTELLSWNLLQKEADRVRLNSDSLTCVVPDSNNYESSKQINCIEYDYSRQRV
CCCCCHHHHHHHHHHHHHHHHHHHEEECCCCEEEEECCCCCCCCCCCCEEEEECHHHHHH
NRTIIDLLIDLANEVKLQEKIDNLINGKKINISENRPALHTALRDLGNKSIMIDGLDIMS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCCEEEEECHHHHH
AVINTREKIKVISNQIREKKWLGHSGLPITDIVNIGIGGSDLGPRVCINALSNYISKEFN
HHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHEECCCCCCCCCHHHHHHHHHHHHHHCCC
YHFISDVDPASFNDVIAKINPQTTLFIVSSKSFTTKETLLNARKAFALYEDTASIDQHFI
EEEECCCCCCCCHHHHEEECCCEEEEEEECCCCCHHHHHHHHHHHHEEECCHHCCCCEEE
AVTAHPERAYQMGIKTVLPIWDWVGGRFSFCSAVNLITAIAIGYEQFVELLAGAHDVDTH
EEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCC
VQFTDFKNNIPVLMALIGIWNNNFLNIHNLLILTYSKKLEYFVPYVQQLDMESNGKSIDV
EEEECCCCCHHHHHHHHHHHCCCEEEEEEEEEEEECHHHHHHHHHHHHCCCCCCCCEEEC
NGSMVDYATGPIVWGGLGNQAQHSYFQLLCQGTHRCVGDFITLKTNDEHEINSMCHYKMK
CCCEEECCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHH
VLSEGIQTIENPYGYIPGNMPMNHLILSDCSPYTLGALVALYEHKIFVQSVIWNINPFDQ
HHHHHHHHHCCCCCCCCCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PGIESAKSAHREITLSSES
CCCHHHHHHCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA