Click here to switch to the map view.

The map label for this gene is lpxA [H]

Identifier: 54295784

GI number: 54295784

Start: 3279845

End: 3280675

Strand: Reverse

Name: lpxA [H]

Synonym: lpl2874

Alternate gene names: 54295784

Gene position: 3280675-3279845 (Counterclockwise)

Preceding gene: 54295785

Following gene: 54295783

Centisome position: 98.06

GC content: 37.67

Gene sequence:

>831_bases
ATGCAAGTGAGTCCGTTAGATCATAGTCATGTGTCTAGTAAAGTTGTTTCATTTTCACAATTGATTCATCCTACAGCGCT
TATATCTCCTTACGCAAAAATTGGACCTAATGTTAGCATAGGTCCTTATTCCATTATTGGGGATAATGTCAGCATTGGTC
AGGGAACAACAATAGGGTCCCATGTTTCTATTCAAGGATGGACACAAATAGGTGAGGATAATCAAATCGAAACCGGGGCA
ATTATTGGCGCTGTTCCCCAGGATCTGAAATTTGCAGGTGAAAAAAGTACGGTTTTTATTGGTAACAATAATATTATTCG
AGAATATGTGACTATTAACCGAGGAACTGCTGGCGGAGGAGGAGAAACGCATGTCGGTAATCATAATTTAATCATGACTT
CAGTCCATGTAGCCCACGATGTTCAAATGGGAAACAATAACATTATCGCTAATGCGGTTGCCATTGGCGGACATGTAGTT
ATTGATGATTGGGTGACTATTGGCGCTTTGTGCGGGATTCATCAATTTGTTCAGTTAGGCAGAATGAGTATGATTGGTGC
ACAAAGCAAAATTACAAAAGATGTTTTGCCTTATACTTTGGTTTCTGGAAATCCTCCCAAACGATTTGGCATCAATGTTG
AGAGATTGCGTCGAAATGGATACAGTTCTTCAGAAAGAATAGATATTCAGAGGGCTTATAAAATTCTCTTTCAGGAAGGC
CAAACGTTAACTGATACTATTGAAATGCTTAAAAAAGAGTTTCAAAAAAGCATGGATGTAAATTATATTCTCAAATTCCT
TGAAAATTCTAAACGTAGCTTTTATCGTTAA

Upstream 100 bases:

>100_bases
TGTAGCCAATTGATTAGTAATATGGAATTTCAGAAATCTTCGGTTGCTTAGATTGTTAATAGAGTCTAATTTTTGTATTT
GTTTTTTTGGAGGTACCCTC

Downstream 100 bases:

>100_bases
TTTTTTAGAGTGTGTATGTCAAATTACCAATTTACAAAACCTGCAGGACCATTTTATTTAGCGGAATTAGCCGAGATTTC
TGGCTCTACCCTGTATGAAG

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MQVSPLDHSHVSSKVVSFSQLIHPTALISPYAKIGPNVSIGPYSIIGDNVSIGQGTTIGSHVSIQGWTQIGEDNQIETGA
IIGAVPQDLKFAGEKSTVFIGNNNIIREYVTINRGTAGGGGETHVGNHNLIMTSVHVAHDVQMGNNNIIANAVAIGGHVV
IDDWVTIGALCGIHQFVQLGRMSMIGAQSKITKDVLPYTLVSGNPPKRFGINVERLRRNGYSSSERIDIQRAYKILFQEG
QTLTDTIEMLKKEFQKSMDVNYILKFLENSKRSFYR

Sequences:

>Translated_276_residues
MQVSPLDHSHVSSKVVSFSQLIHPTALISPYAKIGPNVSIGPYSIIGDNVSIGQGTTIGSHVSIQGWTQIGEDNQIETGA
IIGAVPQDLKFAGEKSTVFIGNNNIIREYVTINRGTAGGGGETHVGNHNLIMTSVHVAHDVQMGNNNIIANAVAIGGHVV
IDDWVTIGALCGIHQFVQLGRMSMIGAQSKITKDVLPYTLVSGNPPKRFGINVERLRRNGYSSSERIDIQRAYKILFQEG
QTLTDTIEMLKKEFQKSMDVNYILKFLENSKRSFYR
>Mature_276_residues
MQVSPLDHSHVSSKVVSFSQLIHPTALISPYAKIGPNVSIGPYSIIGDNVSIGQGTTIGSHVSIQGWTQIGEDNQIETGA
IIGAVPQDLKFAGEKSTVFIGNNNIIREYVTINRGTAGGGGETHVGNHNLIMTSVHVAHDVQMGNNNIIANAVAIGGHVV
IDDWVTIGALCGIHQFVQLGRMSMIGAQSKITKDVLPYTLVSGNPPKRFGINVERLRRNGYSSSERIDIQRAYKILFQEG
QTLTDTIEMLKKEFQKSMDVNYILKFLENSKRSFYR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=258, Percent_Identity=43.0232558139535, Blast_Score=223, Evalue=7e-60,
Organism=Escherichia coli, GI1786376, Length=177, Percent_Identity=31.0734463276836, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 30132; Mature: 30132

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVSPLDHSHVSSKVVSFSQLIHPTALISPYAKIGPNVSIGPYSIIGDNVSIGQGTTIGS
CCCCCCCHHHHHHHHHHHHHHHCHHHHHCCHHHHCCCCCCCCEEEECCCEECCCCCCCCC
HVSIQGWTQIGEDNQIETGAIIGAVPQDLKFAGEKSTVFIGNNNIIREYVTINRGTAGGG
EEEEEHHHCCCCCCCCCCCEEEECCCHHHHCCCCCCEEEECCCCEEEEEEEEECCCCCCC
GETHVGNHNLIMTSVHVAHDVQMGNNNIIANAVAIGGHVVIDDWVTIGALCGIHQFVQLG
CCCCCCCCCEEEEEEEEEEEEEECCCCEEEEEEEECCEEEEEHHHHHHHHHHHHHHHHHH
RMSMIGAQSKITKDVLPYTLVSGNPPKRFGINVERLRRNGYSSSERIDIQRAYKILFQEG
HHHHHCCHHHHHHHHCCEEEECCCCCHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCC
QTLTDTIEMLKKEFQKSMDVNYILKFLENSKRSFYR
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQVSPLDHSHVSSKVVSFSQLIHPTALISPYAKIGPNVSIGPYSIIGDNVSIGQGTTIGS
CCCCCCCHHHHHHHHHHHHHHHCHHHHHCCHHHHCCCCCCCCEEEECCCEECCCCCCCCC
HVSIQGWTQIGEDNQIETGAIIGAVPQDLKFAGEKSTVFIGNNNIIREYVTINRGTAGGG
EEEEEHHHCCCCCCCCCCCEEEECCCHHHHCCCCCCEEEECCCCEEEEEEEEECCCCCCC
GETHVGNHNLIMTSVHVAHDVQMGNNNIIANAVAIGGHVVIDDWVTIGALCGIHQFVQLG
CCCCCCCCCEEEEEEEEEEEEEECCCCEEEEEEEECCEEEEEHHHHHHHHHHHHHHHHHH
RMSMIGAQSKITKDVLPYTLVSGNPPKRFGINVERLRRNGYSSSERIDIQRAYKILFQEG
HHHHHCCHHHHHHHHCCEEEECCCCCHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCC
QTLTDTIEMLKKEFQKSMDVNYILKFLENSKRSFYR
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA