| Definition | Legionella pneumophila str. Lens, complete genome. |
|---|---|
| Accession | NC_006369 |
| Length | 3,345,687 |
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The map label for this gene is gra-orf6 [H]
Identifier: 54295687
GI number: 54295687
Start: 3173181
End: 3173960
Strand: Reverse
Name: gra-orf6 [H]
Synonym: lpl2775
Alternate gene names: 54295687
Gene position: 3173960-3173181 (Counterclockwise)
Preceding gene: 54295692
Following gene: 54295686
Centisome position: 94.87
GC content: 43.46
Gene sequence:
>780_bases CTGTTACCATATGGGGAACGTACCTTGAATCAGACAAACACGCAAGAAGCCAAGGTTGCTTTAGTGACTGGAGGCGCTAA ACGAATCGGCGCAGCAATTGTTAAAAAATTACATCTCTCTGGATATCAGGTAGCCATCCATTGTCGTTCTGCTTTGCATG AAGCCGATATTCTGGCCAAAGATTTGAATCGGTTGCGTACGAATAGCGCCATTGTCACGCAAAAAGAATTAACTGAGCCT GATGCAGCAGAAGAGATCATATCCAAAGTGAAACATTGGGCCGGTCGTTTGGATTTGCTAGTGAATAATGCTTCTGTTTT TAAACGAACGGATTGCCATTTATTGAATGAGGCAGACTGGCAATATCTGTTTGCAGTGAATGTCCAGGTCCCCTTTCTAC TGAGTATGGCAGCATGTCCTTTACTGGCTCCATGCAAGGGTTCCATTATTAACATAACTGATATTCATGCAGATAAGCCA CTTAAAGGATATTCGGTATATTGTCAAACTAAAGCCGCATTGGAGATGCAAACGAGGTCGCTTGCTCGTGAGCTGGCACC AGAAATAAGAGTCAATGCCGTTGCGCCTGGTGCCATTGCCTGGCCTGAGAATGACAATAGTTTAACTGCGGAAGCACAAC AAAAAATTATCGAGAAAACACCGTTAAAAAGCCATGGCAAACCCGATTTTATCGCTCAGGCTGTTCTTGCTCTGGCTGAA AATTCATTTATCACTGGTCAAACATTGAAAGTAGATGGAGGTAGAAGTTTGACAAGCTAG
Upstream 100 bases:
>100_bases TGCAAGGAGAAACAAAGAAAATACTGAAGTGTACACAATAATACTTGAGGATTCGAGCATCCTGGCTGATTACTTTTTGC AGTGAGGTTGCGAAAGGAGT
Downstream 100 bases:
>100_bases AGTTGTATACTGGATTTCATTGCAAACAATCAATTTACTGTATAGGGATTACTATTATGTCAAAATGGATTTTATTATCT GGCTCCTTGTTTTTATGCTT
Product: pteridine reductase
Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]
Alternate protein names: ORF6 [H]
Number of amino acids: Translated: 259; Mature: 259
Protein sequence:
>259_residues MLPYGERTLNQTNTQEAKVALVTGGAKRIGAAIVKKLHLSGYQVAIHCRSALHEADILAKDLNRLRTNSAIVTQKELTEP DAAEEIISKVKHWAGRLDLLVNNASVFKRTDCHLLNEADWQYLFAVNVQVPFLLSMAACPLLAPCKGSIINITDIHADKP LKGYSVYCQTKAALEMQTRSLARELAPEIRVNAVAPGAIAWPENDNSLTAEAQQKIIEKTPLKSHGKPDFIAQAVLALAE NSFITGQTLKVDGGRSLTS
Sequences:
>Translated_259_residues MLPYGERTLNQTNTQEAKVALVTGGAKRIGAAIVKKLHLSGYQVAIHCRSALHEADILAKDLNRLRTNSAIVTQKELTEP DAAEEIISKVKHWAGRLDLLVNNASVFKRTDCHLLNEADWQYLFAVNVQVPFLLSMAACPLLAPCKGSIINITDIHADKP LKGYSVYCQTKAALEMQTRSLARELAPEIRVNAVAPGAIAWPENDNSLTAEAQQKIIEKTPLKSHGKPDFIAQAVLALAE NSFITGQTLKVDGGRSLTS >Mature_259_residues MLPYGERTLNQTNTQEAKVALVTGGAKRIGAAIVKKLHLSGYQVAIHCRSALHEADILAKDLNRLRTNSAIVTQKELTEP DAAEEIISKVKHWAGRLDLLVNNASVFKRTDCHLLNEADWQYLFAVNVQVPFLLSMAACPLLAPCKGSIINITDIHADKP LKGYSVYCQTKAALEMQTRSLARELAPEIRVNAVAPGAIAWPENDNSLTAEAQQKIIEKTPLKSHGKPDFIAQAVLALAE NSFITGQTLKVDGGRSLTS
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI15277342, Length=259, Percent_Identity=32.046332046332, Blast_Score=88, Evalue=7e-18, Organism=Homo sapiens, GI40254992, Length=247, Percent_Identity=31.9838056680162, Blast_Score=86, Evalue=4e-17, Organism=Homo sapiens, GI19923817, Length=253, Percent_Identity=31.6205533596838, Blast_Score=85, Evalue=5e-17, Organism=Homo sapiens, GI32483357, Length=251, Percent_Identity=30.2788844621514, Blast_Score=84, Evalue=2e-16, Organism=Homo sapiens, GI7705925, Length=240, Percent_Identity=30, Blast_Score=82, Evalue=5e-16, Organism=Homo sapiens, GI5031737, Length=244, Percent_Identity=30.327868852459, Blast_Score=81, Evalue=1e-15, Organism=Homo sapiens, GI33667109, Length=184, Percent_Identity=33.695652173913, Blast_Score=80, Evalue=1e-15, Organism=Homo sapiens, GI31542939, Length=258, Percent_Identity=26.3565891472868, Blast_Score=74, Evalue=2e-13, Organism=Homo sapiens, GI4758504, Length=253, Percent_Identity=28.0632411067194, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI66933014, Length=172, Percent_Identity=30.2325581395349, Blast_Score=67, Evalue=2e-11, Organism=Escherichia coli, GI1787335, Length=248, Percent_Identity=32.6612903225806, Blast_Score=99, Evalue=3e-22, Organism=Escherichia coli, GI2367365, Length=241, Percent_Identity=30.7053941908714, Blast_Score=97, Evalue=1e-21, Organism=Escherichia coli, GI1788459, Length=254, Percent_Identity=33.4645669291339, Blast_Score=96, Evalue=2e-21, Organism=Escherichia coli, GI1789378, Length=264, Percent_Identity=32.9545454545455, Blast_Score=83, Evalue=1e-17, Organism=Escherichia coli, GI1787891, Length=240, Percent_Identity=27.9166666666667, Blast_Score=81, Evalue=7e-17, Organism=Escherichia coli, GI87082160, Length=247, Percent_Identity=29.5546558704453, Blast_Score=81, Evalue=7e-17, Organism=Escherichia coli, GI1789208, Length=250, Percent_Identity=26.8, Blast_Score=79, Evalue=2e-16, Organism=Escherichia coli, GI1790717, Length=253, Percent_Identity=30.4347826086957, Blast_Score=79, Evalue=3e-16, Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=28.6821705426357, Blast_Score=79, Evalue=3e-16, Organism=Escherichia coli, GI2367175, Length=249, Percent_Identity=26.9076305220884, Blast_Score=75, Evalue=4e-15, Organism=Escherichia coli, GI1787905, Length=249, Percent_Identity=31.3253012048193, Blast_Score=75, Evalue=5e-15, Organism=Escherichia coli, GI1786812, Length=179, Percent_Identity=33.5195530726257, Blast_Score=71, Evalue=8e-14, Organism=Caenorhabditis elegans, GI71994600, Length=249, Percent_Identity=30.9236947791165, Blast_Score=110, Evalue=6e-25, Organism=Caenorhabditis elegans, GI71994604, Length=251, Percent_Identity=30.6772908366534, Blast_Score=104, Evalue=5e-23, Organism=Caenorhabditis elegans, GI115534694, Length=249, Percent_Identity=34.9397590361446, Blast_Score=103, Evalue=1e-22, Organism=Caenorhabditis elegans, GI17555706, Length=255, Percent_Identity=30.1960784313725, Blast_Score=91, Evalue=4e-19, Organism=Caenorhabditis elegans, GI17562910, Length=266, Percent_Identity=29.3233082706767, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17560676, Length=243, Percent_Identity=30.8641975308642, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI17560332, Length=260, Percent_Identity=31.1538461538462, Blast_Score=87, Evalue=6e-18, Organism=Caenorhabditis elegans, GI17559104, Length=266, Percent_Identity=31.5789473684211, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17538480, Length=278, Percent_Identity=29.8561151079137, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17562904, Length=262, Percent_Identity=30.1526717557252, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17561402, Length=249, Percent_Identity=31.7269076305221, Blast_Score=85, Evalue=3e-17, Organism=Caenorhabditis elegans, GI72000259, Length=264, Percent_Identity=29.5454545454545, Blast_Score=85, Evalue=5e-17, Organism=Caenorhabditis elegans, GI17544670, Length=272, Percent_Identity=27.2058823529412, Blast_Score=84, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17538486, Length=267, Percent_Identity=29.5880149812734, Blast_Score=83, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17551412, Length=263, Percent_Identity=30.7984790874525, Blast_Score=83, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17562990, Length=264, Percent_Identity=30.3030303030303, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI25147288, Length=253, Percent_Identity=30.0395256916996, Blast_Score=81, Evalue=4e-16, Organism=Caenorhabditis elegans, GI17562906, Length=262, Percent_Identity=29.0076335877863, Blast_Score=81, Evalue=5e-16, Organism=Caenorhabditis elegans, GI17560150, Length=271, Percent_Identity=29.520295202952, Blast_Score=80, Evalue=8e-16, Organism=Caenorhabditis elegans, GI17563726, Length=264, Percent_Identity=29.9242424242424, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17538182, Length=250, Percent_Identity=29.2, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17531453, Length=265, Percent_Identity=30.5660377358491, Blast_Score=74, Evalue=7e-14, Organism=Caenorhabditis elegans, GI17508651, Length=258, Percent_Identity=29.4573643410853, Blast_Score=73, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17562908, Length=262, Percent_Identity=28.6259541984733, Blast_Score=72, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17565030, Length=263, Percent_Identity=27.3764258555133, Blast_Score=72, Evalue=4e-13, Organism=Caenorhabditis elegans, GI193204405, Length=263, Percent_Identity=30.7984790874525, Blast_Score=71, Evalue=6e-13, Organism=Caenorhabditis elegans, GI17560220, Length=269, Percent_Identity=29.7397769516729, Blast_Score=66, Evalue=1e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=248, Percent_Identity=27.0161290322581, Blast_Score=63, Evalue=6e-11, Organism=Drosophila melanogaster, GI23397609, Length=246, Percent_Identity=30.4878048780488, Blast_Score=98, Evalue=6e-21, Organism=Drosophila melanogaster, GI24644339, Length=248, Percent_Identity=30.241935483871, Blast_Score=94, Evalue=7e-20, Organism=Drosophila melanogaster, GI28571526, Length=248, Percent_Identity=30.6451612903226, Blast_Score=92, Evalue=4e-19, Organism=Drosophila melanogaster, GI21357041, Length=246, Percent_Identity=30.4878048780488, Blast_Score=89, Evalue=3e-18, Organism=Drosophila melanogaster, GI21355319, Length=252, Percent_Identity=31.3492063492063, Blast_Score=87, Evalue=1e-17, Organism=Drosophila melanogaster, GI24644337, Length=192, Percent_Identity=32.8125, Blast_Score=85, Evalue=4e-17, Organism=Drosophila melanogaster, GI24643142, Length=246, Percent_Identity=30.4878048780488, Blast_Score=85, Evalue=6e-17, Organism=Drosophila melanogaster, GI24639444, Length=248, Percent_Identity=28.6290322580645, Blast_Score=72, Evalue=3e-13,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100 [C]
Molecular weight: Translated: 28215; Mature: 28215
Theoretical pI: Translated: 8.48; Mature: 8.48
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.9 %Cys (Translated Protein) 1.2 %Met (Translated Protein) 3.1 %Cys+Met (Translated Protein) 1.9 %Cys (Mature Protein) 1.2 %Met (Mature Protein) 3.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLPYGERTLNQTNTQEAKVALVTGGAKRIGAAIVKKLHLSGYQVAIHCRSALHEADILAK CCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHH DLNRLRTNSAIVTQKELTEPDAAEEIISKVKHWAGRLDLLVNNASVFKRTDCHLLNEADW HHHHHHCCCEEEEHHHCCCCHHHHHHHHHHHHHHCCEEEEECCCHHHCCCCCCEECCCCC QYLFAVNVQVPFLLSMAACPLLAPCKGSIINITDIHADKPLKGYSVYCQTKAALEMQTRS EEEEEEECCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEHHHHHHHHHHH LARELAPEIRVNAVAPGAIAWPENDNSLTAEAQQKIIEKTPLKSHGKPDFIAQAVLALAE HHHHHCCHHEEEEECCCCEECCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHC NSFITGQTLKVDGGRSLTS CCEECCCEEEECCCCCCCC >Mature Secondary Structure MLPYGERTLNQTNTQEAKVALVTGGAKRIGAAIVKKLHLSGYQVAIHCRSALHEADILAK CCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHH DLNRLRTNSAIVTQKELTEPDAAEEIISKVKHWAGRLDLLVNNASVFKRTDCHLLNEADW HHHHHHCCCEEEEHHHCCCCHHHHHHHHHHHHHHCCEEEEECCCHHHCCCCCCEECCCCC QYLFAVNVQVPFLLSMAACPLLAPCKGSIINITDIHADKPLKGYSVYCQTKAALEMQTRS EEEEEEECCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEHHHHHHHHHHH LARELAPEIRVNAVAPGAIAWPENDNSLTAEAQQKIIEKTPLKSHGKPDFIAQAVLALAE HHHHHCCHHEEEEECCCCEECCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHC NSFITGQTLKVDGGRSLTS CCEECCCEEEECCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NADPH [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]
Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 2583128; 9831526 [H]