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The map label for this gene is folP [H]

Identifier: 54295623

GI number: 54295623

Start: 3093387

End: 3094181

Strand: Reverse

Name: folP [H]

Synonym: lpl2710

Alternate gene names: 54295623

Gene position: 3094181-3093387 (Counterclockwise)

Preceding gene: 54295624

Following gene: 54295622

Centisome position: 92.48

GC content: 38.99

Gene sequence:

>795_bases
ATGGGTGTCTTAAATGTTACCTCGGACTCATTTTATGATGGTGGCAAGTATCTGTCTGTTGATAGAGCCTGTGATCAGGC
TTTAAAATTAATTGCATGTGGAGCTGATCTCATTGATATAGGTGGGGAATCAACCAAACCTGGTGCGCCGCCAGTCCCTT
TAGATGTTGAACTATCAAGAGTTCTTCCCGTAATCAAACAACTTCGTGCCCTCGCAGATGTGTGTATTTCTATTGATACT
AATAAGCCTGAAGTGATGGAAGCGGCAATCGATGCTGGTGCGAATGTTATAAATGATGTTTATGCTTTAAGAAGGGATGG
TGCTTTGAATGTTGCTGCGCAGTTAGATGTTCCTGTTTGTTTAATGCACATGAAAGGAGAGCCTCGAACTATGCAAGAAA
ATCCTTCTTACCCAGAAGGAATAATGAAGGAATTACAGCATTTTTTTGAAGAGCGCATCGATAAATGCCAGAAAGCCGGG
CTGAATAAGAATAAATTAATTCTTGACCCTGGCTTTGGTTTTGGAAAGCGCATTAAAGATAACCTAAAATTAATTTATCA
TCTGAACGAATTGCGTTCTTTTGGATTGCCAATTCTTTTGGGCGTTTCACGCAAAAGCACAATTGGTGCTGTATTGAATA
ATGAAGTTGAGCAACGTTTGATTGGAAGTATTACGCTAGGAATATATGCTGCTCTTAAAGGCACTGCAATTATCAGGACA
CATGATGTGGATGAAACGAATCAAGCATTAACTATGATTAATGCAATTTATCAAGCTGCTAAAGAAATCAGTTAA

Upstream 100 bases:

>100_bases
TATTTATCGAGAGTACCCTGTGAATTCTGAACAGTTCCTAGGTTGGCTTGAGCGAAAGAGCCAACCTCCTTCCTCCTTAG
TTTTTGAAAAGCCATTAATT

Downstream 100 bases:

>100_bases
TGGCTCATGAAATGATCAGAAGACAACTGAGATTAGAAAAATTAAATAATAAGGTAGGTAAGGATGAGTCAACGTAAATA
TTTTGGTACGGATGGAATAC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MGVLNVTSDSFYDGGKYLSVDRACDQALKLIACGADLIDIGGESTKPGAPPVPLDVELSRVLPVIKQLRALADVCISIDT
NKPEVMEAAIDAGANVINDVYALRRDGALNVAAQLDVPVCLMHMKGEPRTMQENPSYPEGIMKELQHFFEERIDKCQKAG
LNKNKLILDPGFGFGKRIKDNLKLIYHLNELRSFGLPILLGVSRKSTIGAVLNNEVEQRLIGSITLGIYAALKGTAIIRT
HDVDETNQALTMINAIYQAAKEIS

Sequences:

>Translated_264_residues
MGVLNVTSDSFYDGGKYLSVDRACDQALKLIACGADLIDIGGESTKPGAPPVPLDVELSRVLPVIKQLRALADVCISIDT
NKPEVMEAAIDAGANVINDVYALRRDGALNVAAQLDVPVCLMHMKGEPRTMQENPSYPEGIMKELQHFFEERIDKCQKAG
LNKNKLILDPGFGFGKRIKDNLKLIYHLNELRSFGLPILLGVSRKSTIGAVLNNEVEQRLIGSITLGIYAALKGTAIIRT
HDVDETNQALTMINAIYQAAKEIS
>Mature_263_residues
GVLNVTSDSFYDGGKYLSVDRACDQALKLIACGADLIDIGGESTKPGAPPVPLDVELSRVLPVIKQLRALADVCISIDTN
KPEVMEAAIDAGANVINDVYALRRDGALNVAAQLDVPVCLMHMKGEPRTMQENPSYPEGIMKELQHFFEERIDKCQKAGL
NKNKLILDPGFGFGKRIKDNLKLIYHLNELRSFGLPILLGVSRKSTIGAVLNNEVEQRLIGSITLGIYAALKGTAIIRTH
DVDETNQALTMINAIYQAAKEIS

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=259, Percent_Identity=47.8764478764479, Blast_Score=256, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6324073, Length=317, Percent_Identity=26.813880126183, Blast_Score=110, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 28746; Mature: 28614

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS50972 PTERIN_BINDING ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVLNVTSDSFYDGGKYLSVDRACDQALKLIACGADLIDIGGESTKPGAPPVPLDVELSR
CCEEECCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCHHH
VLPVIKQLRALADVCISIDTNKPEVMEAAIDAGANVINDVYALRRDGALNVAAQLDVPVC
HHHHHHHHHHHHHHHEECCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCEE
LMHMKGEPRTMQENPSYPEGIMKELQHFFEERIDKCQKAGLNKNKLILDPGFGFGKRIKD
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHH
NLKLIYHLNELRSFGLPILLGVSRKSTIGAVLNNEVEQRLIGSITLGIYAALKGTAIIRT
HHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
HDVDETNQALTMINAIYQAAKEIS
CCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GVLNVTSDSFYDGGKYLSVDRACDQALKLIACGADLIDIGGESTKPGAPPVPLDVELSR
CEEECCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCHHH
VLPVIKQLRALADVCISIDTNKPEVMEAAIDAGANVINDVYALRRDGALNVAAQLDVPVC
HHHHHHHHHHHHHHHEECCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCEE
LMHMKGEPRTMQENPSYPEGIMKELQHFFEERIDKCQKAGLNKNKLILDPGFGFGKRIKD
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHH
NLKLIYHLNELRSFGLPILLGVSRKSTIGAVLNNEVEQRLIGSITLGIYAALKGTAIIRT
HHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
HDVDETNQALTMINAIYQAAKEIS
CCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]