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The map label for this gene is tpiA [H]

Identifier: 54295620

GI number: 54295620

Start: 3087535

End: 3088284

Strand: Reverse

Name: tpiA [H]

Synonym: lpl2707

Alternate gene names: 54295620

Gene position: 3088284-3087535 (Counterclockwise)

Preceding gene: 54295622

Following gene: 54295619

Centisome position: 92.31

GC content: 41.33

Gene sequence:

>750_bases
GTGAGGCAAAAGATAGTTGCTGGTAACTGGAAAATGAATGGCCAGATTCAACAGGTGACTGAATTGGTTTCGCAAATTGA
GAAATTAATTGGCTTTGATTGCGCAGCACAGGTTGCTGTAATGCCTCCCAGCATTTATATACCCAAGGTAAGAGACTGCT
TAAGGACGGGGAAGATTGTAGTAGGTGCGCAAAATGTTTATCCGAAAGATTATGGTGCCTACACAGGTGAACTGTCAGCT
CCCATGCTTAAAGATTTTGATTGCCGATATGTTCTGGTGGGGCACTCGGAGCGCAGGCAATTTTTTCATGAAGATGAAAA
TTTTGTGGCGCAAAAATTCCACCATGTCAAAGATCATGGTATGATACCTGTTCTTTGTGTTGGTGAAACTCTTTCTGAAA
GAGAGAATGGAAAAACAGAGCAGGTTATTGCTCAACAGGTGCTCGCAGTGAGTGCAAAAGGGAAAGATTGTTTTCGTGAT
TGCGTAGTGGCTTATGAGCCTGTATGGGCAATTGGGACAGGAAAAACTGCTACACCTGAACAGGCACAAAAAATACACCA
GTTTATTAGAGATCTGGTTGGAGAAATAAATGATAGCGATGCGAAACATTTGACGCTCATATATGGTGGCAGTGTTAATG
AAAATAATGCAAAAGCCTTATTTTCCATGCCAGATATTGATGGAGGGTTAGTGGGTGGAGCATCGTTGAATGCAAAACAA
TTTGTGGAAATTGTGAAATGTATCAATTGA

Upstream 100 bases:

>100_bases
TCGGTATATTGCACAGCTGCACACTATCAGTTGTTTACTGATAGGCTGGAAATAATAGAAAGGATTTTGTCCGCCTATAC
TAGAAATTATTGGAGGGAGT

Downstream 100 bases:

>100_bases
TATTAATGATTCATGTCTTAATTGCTGTAATTTTAATAGGCTTGGTTCTTATCCAACATGGTAAGGGTGCTGATATTGGT
GCTGCTTTTGGTTCTGGCGC

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MRQKIVAGNWKMNGQIQQVTELVSQIEKLIGFDCAAQVAVMPPSIYIPKVRDCLRTGKIVVGAQNVYPKDYGAYTGELSA
PMLKDFDCRYVLVGHSERRQFFHEDENFVAQKFHHVKDHGMIPVLCVGETLSERENGKTEQVIAQQVLAVSAKGKDCFRD
CVVAYEPVWAIGTGKTATPEQAQKIHQFIRDLVGEINDSDAKHLTLIYGGSVNENNAKALFSMPDIDGGLVGGASLNAKQ
FVEIVKCIN

Sequences:

>Translated_249_residues
MRQKIVAGNWKMNGQIQQVTELVSQIEKLIGFDCAAQVAVMPPSIYIPKVRDCLRTGKIVVGAQNVYPKDYGAYTGELSA
PMLKDFDCRYVLVGHSERRQFFHEDENFVAQKFHHVKDHGMIPVLCVGETLSERENGKTEQVIAQQVLAVSAKGKDCFRD
CVVAYEPVWAIGTGKTATPEQAQKIHQFIRDLVGEINDSDAKHLTLIYGGSVNENNAKALFSMPDIDGGLVGGASLNAKQ
FVEIVKCIN
>Mature_249_residues
MRQKIVAGNWKMNGQIQQVTELVSQIEKLIGFDCAAQVAVMPPSIYIPKVRDCLRTGKIVVGAQNVYPKDYGAYTGELSA
PMLKDFDCRYVLVGHSERRQFFHEDENFVAQKFHHVKDHGMIPVLCVGETLSERENGKTEQVIAQQVLAVSAKGKDCFRD
CVVAYEPVWAIGTGKTATPEQAQKIHQFIRDLVGEINDSDAKHLTLIYGGSVNENNAKALFSMPDIDGGLVGGASLNAKQ
FVEIVKCIN

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI4507645, Length=245, Percent_Identity=44.8979591836735, Blast_Score=198, Evalue=4e-51,
Organism=Homo sapiens, GI226529917, Length=245, Percent_Identity=44.8979591836735, Blast_Score=198, Evalue=4e-51,
Organism=Escherichia coli, GI1790353, Length=248, Percent_Identity=49.5967741935484, Blast_Score=251, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI17536593, Length=247, Percent_Identity=43.7246963562753, Blast_Score=196, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6320255, Length=249, Percent_Identity=43.3734939759036, Blast_Score=199, Evalue=3e-52,
Organism=Drosophila melanogaster, GI28572008, Length=245, Percent_Identity=44.8979591836735, Blast_Score=206, Evalue=8e-54,
Organism=Drosophila melanogaster, GI28572006, Length=245, Percent_Identity=44.8979591836735, Blast_Score=206, Evalue=8e-54,
Organism=Drosophila melanogaster, GI28572004, Length=245, Percent_Identity=44.8979591836735, Blast_Score=205, Evalue=2e-53,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 27513; Mature: 27513

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQKIVAGNWKMNGQIQQVTELVSQIEKLIGFDCAAQVAVMPPSIYIPKVRDCLRTGKIV
CCCCEEECCCEECCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHCCCEE
VGAQNVYPKDYGAYTGELSAPMLKDFDCRYVLVGHSERRQFFHEDENFVAQKFHHVKDHG
EECCCCCCCCCCCCCCCCCCCHHCCCCCCEEEECCHHHHHHHCCCHHHHHHHHHHHHHCC
MIPVLCVGETLSERENGKTEQVIAQQVLAVSAKGKDCFRDCVVAYEPVWAIGTGKTATPE
CEEEEECCCHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEECCCCCCCHH
QAQKIHQFIRDLVGEINDSDAKHLTLIYGGSVNENNAKALFSMPDIDGGLVGGASLNAKQ
HHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCEECCCCCCHHH
FVEIVKCIN
HHHHHHHCC
>Mature Secondary Structure
MRQKIVAGNWKMNGQIQQVTELVSQIEKLIGFDCAAQVAVMPPSIYIPKVRDCLRTGKIV
CCCCEEECCCEECCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHCCCEE
VGAQNVYPKDYGAYTGELSAPMLKDFDCRYVLVGHSERRQFFHEDENFVAQKFHHVKDHG
EECCCCCCCCCCCCCCCCCCCHHCCCCCCEEEECCHHHHHHHCCCHHHHHHHHHHHHHCC
MIPVLCVGETLSERENGKTEQVIAQQVLAVSAKGKDCFRDCVVAYEPVWAIGTGKTATPE
CEEEEECCCHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEECCCCCCCHH
QAQKIHQFIRDLVGEINDSDAKHLTLIYGGSVNENNAKALFSMPDIDGGLVGGASLNAKQ
HHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCEECCCCCCHHH
FVEIVKCIN
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA