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The map label for this gene is nuoD [H]

Identifier: 54295615

GI number: 54295615

Start: 3084013

End: 3085266

Strand: Reverse

Name: nuoD [H]

Synonym: lpl2702

Alternate gene names: 54295615

Gene position: 3085266-3084013 (Counterclockwise)

Preceding gene: 54295616

Following gene: 54295614

Centisome position: 92.22

GC content: 41.15

Gene sequence:

>1254_bases
ATGATTGAACTTAAAAATTATACCTTGAATTTTGGCCCACAACATCCTGCTGCACATGGTGTTTTAAGATTGGTTCTTGA
GTTAGAAGGTGAAACTATCGTTCGTGCTGATCCACATATTGGATTGCTTCATCGTGCAACGGAAAAATTGGCTGAGACCA
AGCCTTACATTCAAAGCATTGGTTACATGGACAGATTAGATTATGTCTCAATGATGTGCAATGAACATGCTTATGTCATG
GCGATTGAGAAGTTATTGGGTATAGAACCGCCTTTGCGAGCCAAGTATATAAGAACTATGTTTGATGAGGTGACTCGAAT
TCTGAACCATCTCTTGTGGTTAGGAGCTACTGCATTGGATATTGGTGCAATGACAGTGTTTCTTTATTGTTTCAGAGAGA
GAGAAGATTTGTTTGATTGCTACGAGGCAGTTTCAGGAGCACGTATGCATGCTACCTACTATAGGCCAGGAGGGGTAGCA
AGAGACTTACCAGACACTATGCCTCAATACAAACCGTCAAGATGGCATAGCGAAAGAGAGATTGAAAAAAAGAATCACAA
TCGTCAGGGCAGTCTTTTGGATTTTCTTTGGGACTTTACTGAACGATTTCCCCACTGTGTGGATGAATACGAAACATTGT
TGACCGATAATCGTATATGGAAGCAACGTACTGTAGATATTGGTGTCGTTTCACCTGAAAATGCACTGCAATGGGGATTT
ACCGGACCAATGTTAAGAGGCTCCGGTATTGCCTGGGATTTACGCAAGAAACAAAGCTATGCTGCTTACGACAGGGTTGA
ATTTGATATTCCTGTTGGCAAGACAGGGGATTGTTATGATCGATACTTGGTAAGAGTCGAGGAATTGAGACAATCCAATC
GAATTATAAGGCAATGTATTGAGTGGTTGCGCAAGCATCCTGGTCCAGTAAAAGTCGATGATTATAAAGTGTCGCCTCCA
CGTCGTGTAGTAATGAAACATGACATGGAAGCATTAATTCATCACTTTAAATTATTTACCGAAGGCTTTTGTTTACCGCG
AGGTGAAGTTTATTCATCTGTTGAGGCGCCAAAGGGCGAGTTTGGTATCTATATGGTGTCAGATGGAGCTAATAAACCTT
ACCGTCTGAAAATAAGAGCTCCAGGCTTTGCTCATTTATCAAGCTTTGATGATATGGTTAGAGGTCACATGCTAGCTGAT
GGAGTGGCTATATTGGCAAGTCAAGATATAGTGTTTGGAGAGATTGATCGTTAA

Upstream 100 bases:

>100_bases
CAAAAGGTAATATATGCCCCTGTAGACATTGTGCCAAGAATTGTAGTTCCAAAGGTTATTCGTAACGATAACCGCTACAT
AGGTAATGAAGGTAGCAAAA

Downstream 100 bases:

>100_bases
TTTAACGACATGCTTGCTTAAAGTGTATTAAGAGATAATAAACGATATAAAGGTTTCGAAATGTCTGCTAATTCAGCAAA
AATATTAAATCAATTGATGC

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MIELKNYTLNFGPQHPAAHGVLRLVLELEGETIVRADPHIGLLHRATEKLAETKPYIQSIGYMDRLDYVSMMCNEHAYVM
AIEKLLGIEPPLRAKYIRTMFDEVTRILNHLLWLGATALDIGAMTVFLYCFREREDLFDCYEAVSGARMHATYYRPGGVA
RDLPDTMPQYKPSRWHSEREIEKKNHNRQGSLLDFLWDFTERFPHCVDEYETLLTDNRIWKQRTVDIGVVSPENALQWGF
TGPMLRGSGIAWDLRKKQSYAAYDRVEFDIPVGKTGDCYDRYLVRVEELRQSNRIIRQCIEWLRKHPGPVKVDDYKVSPP
RRVVMKHDMEALIHHFKLFTEGFCLPRGEVYSSVEAPKGEFGIYMVSDGANKPYRLKIRAPGFAHLSSFDDMVRGHMLAD
GVAILASQDIVFGEIDR

Sequences:

>Translated_417_residues
MIELKNYTLNFGPQHPAAHGVLRLVLELEGETIVRADPHIGLLHRATEKLAETKPYIQSIGYMDRLDYVSMMCNEHAYVM
AIEKLLGIEPPLRAKYIRTMFDEVTRILNHLLWLGATALDIGAMTVFLYCFREREDLFDCYEAVSGARMHATYYRPGGVA
RDLPDTMPQYKPSRWHSEREIEKKNHNRQGSLLDFLWDFTERFPHCVDEYETLLTDNRIWKQRTVDIGVVSPENALQWGF
TGPMLRGSGIAWDLRKKQSYAAYDRVEFDIPVGKTGDCYDRYLVRVEELRQSNRIIRQCIEWLRKHPGPVKVDDYKVSPP
RRVVMKHDMEALIHHFKLFTEGFCLPRGEVYSSVEAPKGEFGIYMVSDGANKPYRLKIRAPGFAHLSSFDDMVRGHMLAD
GVAILASQDIVFGEIDR
>Mature_417_residues
MIELKNYTLNFGPQHPAAHGVLRLVLELEGETIVRADPHIGLLHRATEKLAETKPYIQSIGYMDRLDYVSMMCNEHAYVM
AIEKLLGIEPPLRAKYIRTMFDEVTRILNHLLWLGATALDIGAMTVFLYCFREREDLFDCYEAVSGARMHATYYRPGGVA
RDLPDTMPQYKPSRWHSEREIEKKNHNRQGSLLDFLWDFTERFPHCVDEYETLLTDNRIWKQRTVDIGVVSPENALQWGF
TGPMLRGSGIAWDLRKKQSYAAYDRVEFDIPVGKTGDCYDRYLVRVEELRQSNRIIRQCIEWLRKHPGPVKVDDYKVSPP
RRVVMKHDMEALIHHFKLFTEGFCLPRGEVYSSVEAPKGEFGIYMVSDGANKPYRLKIRAPGFAHLSSFDDMVRGHMLAD
GVAILASQDIVFGEIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=414, Percent_Identity=60.6280193236715, Blast_Score=512, Evalue=1e-145,
Organism=Homo sapiens, GI260898743, Length=408, Percent_Identity=59.8039215686275, Blast_Score=495, Evalue=1e-140,
Organism=Escherichia coli, GI145693162, Length=410, Percent_Identity=38.2926829268293, Blast_Score=293, Evalue=1e-80,
Organism=Escherichia coli, GI1789076, Length=415, Percent_Identity=28.6746987951807, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1788832, Length=408, Percent_Identity=26.4705882352941, Blast_Score=108, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17568379, Length=415, Percent_Identity=58.3132530120482, Blast_Score=493, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17555284, Length=415, Percent_Identity=58.7951807228916, Blast_Score=491, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24638644, Length=414, Percent_Identity=59.1787439613527, Blast_Score=513, Evalue=1e-146,
Organism=Drosophila melanogaster, GI221459469, Length=409, Percent_Identity=54.0342298288509, Blast_Score=454, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 48178; Mature: 48178

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELKNYTLNFGPQHPAAHGVLRLVLELEGETIVRADPHIGLLHRATEKLAETKPYIQSI
CEEEECCEEECCCCCCHHHHHHHHHHEECCCEEEECCCCCHHHHHHHHHHHHCCHHHHHC
GYMDRLDYVSMMCNEHAYVMAIEKLLGIEPPLRAKYIRTMFDEVTRILNHLLWLGATALD
CHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGAMTVFLYCFREREDLFDCYEAVSGARMHATYYRPGGVARDLPDTMPQYKPSRWHSERE
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHCCCCCCCCCCCHHH
IEKKNHNRQGSLLDFLWDFTERFPHCVDEYETLLTDNRIWKQRTVDIGVVSPENALQWGF
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEEEEEEECCCCCEECCC
TGPMLRGSGIAWDLRKKQSYAAYDRVEFDIPVGKTGDCYDRYLVRVEELRQSNRIIRQCI
CCCCCCCCCCEEEHHHCCCHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EWLRKHPGPVKVDDYKVSPPRRVVMKHDMEALIHHFKLFTEGFCLPRGEVYSSVEAPKGE
HHHHCCCCCCEECCEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCC
FGIYMVSDGANKPYRLKIRAPGFAHLSSFDDMVRGHMLADGVAILASQDIVFGEIDR
EEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCEEEEECCCEEEECCCC
>Mature Secondary Structure
MIELKNYTLNFGPQHPAAHGVLRLVLELEGETIVRADPHIGLLHRATEKLAETKPYIQSI
CEEEECCEEECCCCCCHHHHHHHHHHEECCCEEEECCCCCHHHHHHHHHHHHCCHHHHHC
GYMDRLDYVSMMCNEHAYVMAIEKLLGIEPPLRAKYIRTMFDEVTRILNHLLWLGATALD
CHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGAMTVFLYCFREREDLFDCYEAVSGARMHATYYRPGGVARDLPDTMPQYKPSRWHSERE
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHCCCCCCCCCCCHHH
IEKKNHNRQGSLLDFLWDFTERFPHCVDEYETLLTDNRIWKQRTVDIGVVSPENALQWGF
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEEEEEEECCCCCEECCC
TGPMLRGSGIAWDLRKKQSYAAYDRVEFDIPVGKTGDCYDRYLVRVEELRQSNRIIRQCI
CCCCCCCCCCEEEHHHCCCHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EWLRKHPGPVKVDDYKVSPPRRVVMKHDMEALIHHFKLFTEGFCLPRGEVYSSVEAPKGE
HHHHCCCCCCEECCEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCC
FGIYMVSDGANKPYRLKIRAPGFAHLSSFDDMVRGHMLADGVAILASQDIVFGEIDR
EEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCEEEEECCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA