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The map label for this gene is nuoL [H]

Identifier: 54295607

GI number: 54295607

Start: 3075259

End: 3077232

Strand: Reverse

Name: nuoL [H]

Synonym: lpl2694

Alternate gene names: 54295607

Gene position: 3077232-3075259 (Counterclockwise)

Preceding gene: 54295608

Following gene: 54295606

Centisome position: 91.98

GC content: 40.48

Gene sequence:

>1974_bases
GTGAGTATTCAACAAGTCTGCTTAGTAATCGTTTTGACTCCCCTTGTTGGTTCTGCTATAGCAGGATTTTTTAGAAACCA
GATTGGACGAGTCGGAGCACATACTGTAACTATTTTAGGCGTAGCTATTTCTTTAGCCTGTTCAATTTTTCTTGCGTGGG
GCCTGTTTTCTGGTTCAATCCCAAACAGTAATAGCCTTGTTTACCACTGGGCTAGCGGGGGGGCGTTAATTCCCTACGAA
TTTAATATTGGTTTTTTAATAGACCCTCTAAGCGTTGTGATGCTGGTTATAGTTAATTTTGTTTCTTTGTTAGTCCATGT
CTACAGTATTGGGTACATGGCAGATGATGATGGTTATCAGCGATTTTTTAGTTATATCTCTTTATTTACATTCATGATGC
TCATGTTAGTTAGCGCAAACAACTTTCTGCAGTTATTTTTTGGCTGGGAAGGGGTTGGGCTTGTTTCTTATTTATTAATC
GGATTTTGGTATCAAAAGGAATCTGCAATAGAAGGCAGCCTGAAAGCATTTCTTGTAAACCGTGTAGGAGATTTTGGATT
TGTATTAGGAATAGGTTTAATTTTTGCTTATGCTGGAAGCCTTGATTATGAAAAAGTATTTACCAGCGCAAATTATTTAG
CAAGCCAGAACATAGAGTTATTTAGCGGCTACTCCTGGTCCCTGATTACAGTGATTTGCCTGCTGCTTTTTGTTGGCGCC
ATGGGCAAATCAGCACAGGTACCACTTCACGTTTGGTTACCTGAGTCAATGGAGGGTCCAACCCCTATTTCAGCACTAAT
CCATGCGGCGACAATGGTGACAGCGGGTGTTTTCATGATTGCTCGCATCTCACCTTTAATTGAATTGTCTACAGCTGCGC
TTAGTACAGTATTAGTAATTGGGGCTACAGGAGCATTGTTTACAGGAATACTGGCTTTGGTTATGAACGACATAAAGCGC
GTGGTAGCATACTCTACTTTATCACAACTAGGCTATATGATGGTGGCAATGGGTGCCTCAGCCTATAGTGCCGGTATGTT
TCATTTATTGACGCATGCTTGCTTTAAAGCGCTATTGTTCCTTGGTGCTGGTTCAGTCATTATTGGCATGCATCATGAAC
AAGATATGCGGAAAATGGGTGGGTTGTGGAATAAAATGCCGATTACCTATGTAACCTATGTCATAGGCAGTTTGGCATTG
TGTGCATTTCCTCCTTTTGCTGGTTTTTACTCAAAAGATACCATTATTGAAGCAGCGCAGCTTTCCCAGATACCCGGCAG
CAGTTATGCTTATTTTTGTGTAACAGCAGGCGCTATGGTTACAGCATTATATACTTTCAGATCCTTATTCATGACATTTC
ATGGTAAGCCACGTATGGATGAACATACATTAAGTCATCTACATGAATCTCCATGGGTAGTATGGTTACCATTAGTATTG
CTCGCTATCCCATCAATAATTTTAGGCTATGTGCTTTACATGCCTATTCTATTTGATACACCAAGCCTCTTAGGCTCATC
AATTTTTGTTTTACCTGAGCATAATGTTTTAGCCGAACTTGCTCATGAAGTAAGTTCGCCATTTGCAAGTGCTGTTCACG
CGATTTATTCTTTGCCATTTTGGATTACAGTACTCGGAGCAGTTATTGCCTGGATTTGTTATATCGCTGTCCCATCTATT
CCCGGTTATTTAGCTAGGTATTTTTCAATTGTTTATTCTATTTTACTCAATAAATACGGGTTTGATCGCTTTAACGAGTT
GTTCTTTGTGAAAGGGGCTAGAGGATTAGGCATTGCTTTTTACAAGATTGGTGATCAAAAACTAATCGATGGTGCAGTTG
TCAATGGTAGTGGACGCCTGGTTCGCTGGTTCTCTGGAAAAGGGCGAAAGATACAAAGTGGGTACATCTATCATTATGCG
ACAGTAATGGTGTTTGGATTGCTGGCCTTTTTATGCTGGTTAATCCTGGACTGA

Upstream 100 bases:

>100_bases
GCAGCGGAAGCAGCAATAGGTTTGGCCATAGTCATGTTGCTTTATAGAAATAGAGGCAATATTGACGTTGATAAAATGAA
TCATTTAAAAGGTTAAAATC

Downstream 100 bases:

>100_bases
AGATAAGGTGAAGGTATGCATTATTTGCTCAATTTATTAATTTGGTTACCGATATTGGGTGGCGTTTTTGTTTTGCTGAC
TGGGGATGATAAAAATCCAA

Product: NADH-quinone oxidoreductase chain L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 657; Mature: 656

Protein sequence:

>657_residues
MSIQQVCLVIVLTPLVGSAIAGFFRNQIGRVGAHTVTILGVAISLACSIFLAWGLFSGSIPNSNSLVYHWASGGALIPYE
FNIGFLIDPLSVVMLVIVNFVSLLVHVYSIGYMADDDGYQRFFSYISLFTFMMLMLVSANNFLQLFFGWEGVGLVSYLLI
GFWYQKESAIEGSLKAFLVNRVGDFGFVLGIGLIFAYAGSLDYEKVFTSANYLASQNIELFSGYSWSLITVICLLLFVGA
MGKSAQVPLHVWLPESMEGPTPISALIHAATMVTAGVFMIARISPLIELSTAALSTVLVIGATGALFTGILALVMNDIKR
VVAYSTLSQLGYMMVAMGASAYSAGMFHLLTHACFKALLFLGAGSVIIGMHHEQDMRKMGGLWNKMPITYVTYVIGSLAL
CAFPPFAGFYSKDTIIEAAQLSQIPGSSYAYFCVTAGAMVTALYTFRSLFMTFHGKPRMDEHTLSHLHESPWVVWLPLVL
LAIPSIILGYVLYMPILFDTPSLLGSSIFVLPEHNVLAELAHEVSSPFASAVHAIYSLPFWITVLGAVIAWICYIAVPSI
PGYLARYFSIVYSILLNKYGFDRFNELFFVKGARGLGIAFYKIGDQKLIDGAVVNGSGRLVRWFSGKGRKIQSGYIYHYA
TVMVFGLLAFLCWLILD

Sequences:

>Translated_657_residues
MSIQQVCLVIVLTPLVGSAIAGFFRNQIGRVGAHTVTILGVAISLACSIFLAWGLFSGSIPNSNSLVYHWASGGALIPYE
FNIGFLIDPLSVVMLVIVNFVSLLVHVYSIGYMADDDGYQRFFSYISLFTFMMLMLVSANNFLQLFFGWEGVGLVSYLLI
GFWYQKESAIEGSLKAFLVNRVGDFGFVLGIGLIFAYAGSLDYEKVFTSANYLASQNIELFSGYSWSLITVICLLLFVGA
MGKSAQVPLHVWLPESMEGPTPISALIHAATMVTAGVFMIARISPLIELSTAALSTVLVIGATGALFTGILALVMNDIKR
VVAYSTLSQLGYMMVAMGASAYSAGMFHLLTHACFKALLFLGAGSVIIGMHHEQDMRKMGGLWNKMPITYVTYVIGSLAL
CAFPPFAGFYSKDTIIEAAQLSQIPGSSYAYFCVTAGAMVTALYTFRSLFMTFHGKPRMDEHTLSHLHESPWVVWLPLVL
LAIPSIILGYVLYMPILFDTPSLLGSSIFVLPEHNVLAELAHEVSSPFASAVHAIYSLPFWITVLGAVIAWICYIAVPSI
PGYLARYFSIVYSILLNKYGFDRFNELFFVKGARGLGIAFYKIGDQKLIDGAVVNGSGRLVRWFSGKGRKIQSGYIYHYA
TVMVFGLLAFLCWLILD
>Mature_656_residues
SIQQVCLVIVLTPLVGSAIAGFFRNQIGRVGAHTVTILGVAISLACSIFLAWGLFSGSIPNSNSLVYHWASGGALIPYEF
NIGFLIDPLSVVMLVIVNFVSLLVHVYSIGYMADDDGYQRFFSYISLFTFMMLMLVSANNFLQLFFGWEGVGLVSYLLIG
FWYQKESAIEGSLKAFLVNRVGDFGFVLGIGLIFAYAGSLDYEKVFTSANYLASQNIELFSGYSWSLITVICLLLFVGAM
GKSAQVPLHVWLPESMEGPTPISALIHAATMVTAGVFMIARISPLIELSTAALSTVLVIGATGALFTGILALVMNDIKRV
VAYSTLSQLGYMMVAMGASAYSAGMFHLLTHACFKALLFLGAGSVIIGMHHEQDMRKMGGLWNKMPITYVTYVIGSLALC
AFPPFAGFYSKDTIIEAAQLSQIPGSSYAYFCVTAGAMVTALYTFRSLFMTFHGKPRMDEHTLSHLHESPWVVWLPLVLL
AIPSIILGYVLYMPILFDTPSLLGSSIFVLPEHNVLAELAHEVSSPFASAVHAIYSLPFWITVLGAVIAWICYIAVPSIP
GYLARYFSIVYSILLNKYGFDRFNELFFVKGARGLGIAFYKIGDQKLIDGAVVNGSGRLVRWFSGKGRKIQSGYIYHYAT
VMVFGLLAFLCWLILD

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=425, Percent_Identity=39.5294117647059, Blast_Score=298, Evalue=1e-80,
Organism=Escherichia coli, GI1788614, Length=656, Percent_Identity=37.6524390243902, Blast_Score=349, Evalue=3e-97,
Organism=Escherichia coli, GI1788829, Length=351, Percent_Identity=31.9088319088319, Blast_Score=149, Evalue=6e-37,
Organism=Escherichia coli, GI1788827, Length=438, Percent_Identity=28.9954337899543, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1788831, Length=347, Percent_Identity=28.2420749279539, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI2367154, Length=444, Percent_Identity=25.2252252252252, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1788613, Length=395, Percent_Identity=26.5822784810127, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI145693160, Length=309, Percent_Identity=24.2718446601942, Blast_Score=81, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 71915; Mature: 71784

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIQQVCLVIVLTPLVGSAIAGFFRNQIGRVGAHTVTILGVAISLACSIFLAWGLFSGSI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PNSNSLVYHWASGGALIPYEFNIGFLIDPLSVVMLVIVNFVSLLVHVYSIGYMADDDGYQ
CCCCCEEEEEECCCEEEEEEECCCEEECHHHHHHHHHHHHHHHHHHHHHHCCEECCHHHH
RFFSYISLFTFMMLMLVSANNFLQLFFGWEGVGLVSYLLIGFWYQKESAIEGSLKAFLVN
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVGDFGFVLGIGLIFAYAGSLDYEKVFTSANYLASQNIELFSGYSWSLITVICLLLFVGA
HCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHCC
MGKSAQVPLHVWLPESMEGPTPISALIHAATMVTAGVFMIARISPLIELSTAALSTVLVI
CCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GATGALFTGILALVMNDIKRVVAYSTLSQLGYMMVAMGASAYSAGMFHLLTHACFKALLF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LGAGSVIIGMHHEQDMRKMGGLWNKMPITYVTYVIGSLALCAFPPFAGFYSKDTIIEAAQ
HCCCCEEEEECCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
LSQIPGSSYAYFCVTAGAMVTALYTFRSLFMTFHGKPRMDEHTLSHLHESPWVVWLPLVL
HHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHH
LAIPSIILGYVLYMPILFDTPSLLGSSIFVLPEHNVLAELAHEVSSPFASAVHAIYSLPF
HHHHHHHHHHHHHHHHHHCCHHHHCCEEEEEECHHHHHHHHHHHHCHHHHHHHHHHHHHH
WITVLGAVIAWICYIAVPSIPGYLARYFSIVYSILLNKYGFDRFNELFFVKGARGLGIAF
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHCCEEEEECCCCCEEEE
YKIGDQKLIDGAVVNGSGRLVRWFSGKGRKIQSGYIYHYATVMVFGLLAFLCWLILD
EEECCCCEECCEEECCCCCEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SIQQVCLVIVLTPLVGSAIAGFFRNQIGRVGAHTVTILGVAISLACSIFLAWGLFSGSI
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PNSNSLVYHWASGGALIPYEFNIGFLIDPLSVVMLVIVNFVSLLVHVYSIGYMADDDGYQ
CCCCCEEEEEECCCEEEEEEECCCEEECHHHHHHHHHHHHHHHHHHHHHHCCEECCHHHH
RFFSYISLFTFMMLMLVSANNFLQLFFGWEGVGLVSYLLIGFWYQKESAIEGSLKAFLVN
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVGDFGFVLGIGLIFAYAGSLDYEKVFTSANYLASQNIELFSGYSWSLITVICLLLFVGA
HCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHCC
MGKSAQVPLHVWLPESMEGPTPISALIHAATMVTAGVFMIARISPLIELSTAALSTVLVI
CCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GATGALFTGILALVMNDIKRVVAYSTLSQLGYMMVAMGASAYSAGMFHLLTHACFKALLF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LGAGSVIIGMHHEQDMRKMGGLWNKMPITYVTYVIGSLALCAFPPFAGFYSKDTIIEAAQ
HCCCCEEEEECCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
LSQIPGSSYAYFCVTAGAMVTALYTFRSLFMTFHGKPRMDEHTLSHLHESPWVVWLPLVL
HHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHH
LAIPSIILGYVLYMPILFDTPSLLGSSIFVLPEHNVLAELAHEVSSPFASAVHAIYSLPF
HHHHHHHHHHHHHHHHHHCCHHHHCCEEEEEECHHHHHHHHHHHHCHHHHHHHHHHHHHH
WITVLGAVIAWICYIAVPSIPGYLARYFSIVYSILLNKYGFDRFNELFFVKGARGLGIAF
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHCCEEEEECCCCCEEEE
YKIGDQKLIDGAVVNGSGRLVRWFSGKGRKIQSGYIYHYATVMVFGLLAFLCWLILD
EEECCCCEECCEEECCCCCEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]