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The map label for this gene is nuoN

Identifier: 54295605

GI number: 54295605

Start: 3072242

End: 3073684

Strand: Reverse

Name: nuoN

Synonym: lpl2692

Alternate gene names: 54295605

Gene position: 3073684-3072242 (Counterclockwise)

Preceding gene: 54295606

Following gene: 54295604

Centisome position: 91.87

GC content: 37.42

Gene sequence:

>1443_bases
ATGATGACATTACTAGAAAATATCCATGTAGCAATACCAGAAATGATTATTTTAATAACCGCGTGTTTGGCGTTGCTTTC
TGATTTGTTCTTTCGTCATAAATTAAAATCAATTGCGTTTTACATATCTTGTGTAGGAATTATAGTTTCTGCAGCAGTAA
GCTTTGTATTTATAGGAAGCTACAAGTTACTTATATTCAACAAATTATTTATAAGTGATGATATAAGTCATTTAATGAAA
CTGTTTATTGATATCACGGTTTTATTAAGTTTTGTCTATTCCCAAAACTATCTGGATGAACGGCAAATGCCTACAGGTGA
TTATTATGTTCTGGGGCTGTTTTCAACACTAGGTATGATGATTCTTGTTTCAGCACACTCGCTGTTAACCCTTTATCTAG
GTTTGGAGTTAATGTCATTGCCGCTCTATGCAATGACCGCCATCCGCCGAACTGATAGCGATGCATCTGAAGCGGCAATG
AAATATTTTGTTATGGGTGCTATTGCTTCTGGTATGCTGTTATATGGAATATCCTTGGTGTATGGTGCAACAGGAAAACT
TGATTTGTTAGATGTTGCTAATGCAGTGGCAGTCAATTGGCAGCAACAAAATACTCTTTTTGCGTTTGCAATGGTATTTA
TACTTGCCGGCGTAGGATTCAAACTGGCTGCTGTCCCTTTCCATATGTGGGCTCCAGACGTATATCAAGGGGCACCAAGC
TCTGTAACACTTTTTATTAGTACAGCACCCAAGATTGCTGCACTGGGGATGGCACTGCGATTTTTAACTATTGGCTTAGT
CGACATCACCATGCAATGGCAGCAAATTATTTTAGTAATGGCTCTTCTTTCTACCGGCATAGGTAATTTGTTAGCAGTGA
TTCAAACCAGAATCAAACGCCTGTTAGCTTATTCTGCAATTTCTCATATAGGATATGCTTTATTTGGAGTTTTAGCCGCC
AGCTCTGCTGGCTATGCCGCAGCACTGTATTATATTTTAATCTATGCTGTAATGTCAGCGGCTGCTTTTGGTTTAGTTGT
ATTGATGTCAAATCATGGAATGGAAATTGATAGTATTGATGACTTAAAGGGCTTGAATAAAAGAAACCCGTGGTTGGCAT
TTATGATGCTATTAGTCATGTTCTCAATGGCTGGCGTGCCGCCAACGGTTGGCTTCTTTACAAAATTATTGGTATTGAAG
GCATTGGTAGATGTTCACATGACTTGGTTAGCTGTTGTGGGTTTGCTATTTACAGTTATAGGTGCCTATTATTATTTGCG
AATTGTTAAAATTATGTATTTTGATCAACCTGAAAATGAAGCTATAGTAAAAATTGGTACAGGCAATACCATAGTTTATT
CACTTAATTGCCTCTCCTTACTATATTTAGGTATTTTCCCAGGCGCTTTAATTGCAGCCTGTATTAATGCATTTGCAAAT
TAA

Upstream 100 bases:

>100_bases
AAACTGTAAGTCATACTTTGGCATTGGCTGATAAATCTAAACTCTAACAAAGAACTGCGATAGGCTTAAATTGCAATCAA
GTTCCTTAGCAAGGTTAAAT

Downstream 100 bases:

>100_bases
TTAATAAACTTTAACAAAAGTACTTGCTTAGGGACCCAAGTATCAGTATACTTGCCCTCAGTTGACGCGGGGTGGAGCAG
CCTGGTAGCTCGTCGGGCTC

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MMTLLENIHVAIPEMIILITACLALLSDLFFRHKLKSIAFYISCVGIIVSAAVSFVFIGSYKLLIFNKLFISDDISHLMK
LFIDITVLLSFVYSQNYLDERQMPTGDYYVLGLFSTLGMMILVSAHSLLTLYLGLELMSLPLYAMTAIRRTDSDASEAAM
KYFVMGAIASGMLLYGISLVYGATGKLDLLDVANAVAVNWQQQNTLFAFAMVFILAGVGFKLAAVPFHMWAPDVYQGAPS
SVTLFISTAPKIAALGMALRFLTIGLVDITMQWQQIILVMALLSTGIGNLLAVIQTRIKRLLAYSAISHIGYALFGVLAA
SSAGYAAALYYILIYAVMSAAAFGLVVLMSNHGMEIDSIDDLKGLNKRNPWLAFMMLLVMFSMAGVPPTVGFFTKLLVLK
ALVDVHMTWLAVVGLLFTVIGAYYYLRIVKIMYFDQPENEAIVKIGTGNTIVYSLNCLSLLYLGIFPGALIAACINAFAN

Sequences:

>Translated_480_residues
MMTLLENIHVAIPEMIILITACLALLSDLFFRHKLKSIAFYISCVGIIVSAAVSFVFIGSYKLLIFNKLFISDDISHLMK
LFIDITVLLSFVYSQNYLDERQMPTGDYYVLGLFSTLGMMILVSAHSLLTLYLGLELMSLPLYAMTAIRRTDSDASEAAM
KYFVMGAIASGMLLYGISLVYGATGKLDLLDVANAVAVNWQQQNTLFAFAMVFILAGVGFKLAAVPFHMWAPDVYQGAPS
SVTLFISTAPKIAALGMALRFLTIGLVDITMQWQQIILVMALLSTGIGNLLAVIQTRIKRLLAYSAISHIGYALFGVLAA
SSAGYAAALYYILIYAVMSAAAFGLVVLMSNHGMEIDSIDDLKGLNKRNPWLAFMMLLVMFSMAGVPPTVGFFTKLLVLK
ALVDVHMTWLAVVGLLFTVIGAYYYLRIVKIMYFDQPENEAIVKIGTGNTIVYSLNCLSLLYLGIFPGALIAACINAFAN
>Mature_480_residues
MMTLLENIHVAIPEMIILITACLALLSDLFFRHKLKSIAFYISCVGIIVSAAVSFVFIGSYKLLIFNKLFISDDISHLMK
LFIDITVLLSFVYSQNYLDERQMPTGDYYVLGLFSTLGMMILVSAHSLLTLYLGLELMSLPLYAMTAIRRTDSDASEAAM
KYFVMGAIASGMLLYGISLVYGATGKLDLLDVANAVAVNWQQQNTLFAFAMVFILAGVGFKLAAVPFHMWAPDVYQGAPS
SVTLFISTAPKIAALGMALRFLTIGLVDITMQWQQIILVMALLSTGIGNLLAVIQTRIKRLLAYSAISHIGYALFGVLAA
SSAGYAAALYYILIYAVMSAAAFGLVVLMSNHGMEIDSIDDLKGLNKRNPWLAFMMLLVMFSMAGVPPTVGFFTKLLVLK
ALVDVHMTWLAVVGLLFTVIGAYYYLRIVKIMYFDQPENEAIVKIGTGNTIVYSLNCLSLLYLGIFPGALIAACINAFAN

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family

Homologues:

Organism=Homo sapiens, GI251831108, Length=307, Percent_Identity=25.7328990228013, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI145693160, Length=475, Percent_Identity=33.0526315789474, Blast_Score=229, Evalue=4e-61,
Organism=Escherichia coli, GI1788614, Length=358, Percent_Identity=29.0502793296089, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1788831, Length=305, Percent_Identity=25.9016393442623, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1788613, Length=389, Percent_Identity=25.9640102827763, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788827, Length=347, Percent_Identity=23.342939481268, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI2367154, Length=269, Percent_Identity=25.2788104089219, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUON_LEGPL (Q5WT33)

Other databases:

- EMBL:   CR628337
- RefSeq:   YP_128020.1
- STRING:   Q5WT33
- GeneID:   3115022
- GenomeReviews:   CR628337_GR
- KEGG:   lpf:lpl2692
- NMPDR:   fig|297245.3.peg.1281
- LegioList:   lpl2692
- HOGENOM:   HBG747830
- OMA:   MDMNTLL
- PhylomeDB:   Q5WT33
- ProtClustDB:   PRK05777
- BioCyc:   LPNE297245:LPL2692-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_00445
- InterPro:   IPR010096
- InterPro:   IPR001750
- TIGRFAMs:   TIGR01770

Pfam domain/function: PF00361 Oxidored_q1

EC number: =1.6.99.5

Molecular weight: Translated: 52506; Mature: 52506

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe6f545c)-; HASH(0x14ad47a0)-; HASH(0x15e96604)-; HASH(0x10f67634)-; HASH(0x15576128)-; HASH(0x15b7d0f8)-; HASH(0x161cfbc4)-; HASH(0x15308208)-; HASH(0x15ab37c8)-; HASH(0x1582a108)-; HASH(0x15c2c0a4)-; HASH(0x1501e928)-; HASH(0x15ea3d64)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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>Mature Secondary Structure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PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA