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The map label for this gene is czcD [H]

Identifier: 54295577

GI number: 54295577

Start: 3035281

End: 3036204

Strand: Reverse

Name: czcD [H]

Synonym: lpl2664

Alternate gene names: 54295577

Gene position: 3036204-3035281 (Counterclockwise)

Preceding gene: 54295578

Following gene: 54295572

Centisome position: 90.75

GC content: 38.85

Gene sequence:

>924_bases
ATGAGTAGGCATTCGCATGATGGAGCACACCATCATGAGCATGGGGAAGTGACTTATGACAAGGCTTTTATAATTGCAAT
TACTGCGAATGGCCTTTTTGTTGTGATGCAAATTATTTTTGCCTATTTAGCGAATTCTACCAGTTTGCTAGCAGATGCTT
TTCATAATCTAGGTGATGTATTAGGGTTGATTTTAGCATGGGTAGCAACCGGATTAATGAAGAGAAAACCTACCCATAAA
GCAACTTATGGATTTAAAAAAACCTCTATTTTAGCGGCATTGGCCAATGGAGCGTTACTGGTATTTACTTGCGGGATCAT
AGCGACAGATGCTATGTATAAGTTATTTTCACCGACTGAAATTCAAGCCGTCTCTGTGATGATAGTCGCCGCGATTGGTA
TAGTCGTGAACTTCTCTACAGCGCTCTTGTTTTTACGGGGTTCCGATGATCTCAATATTCGAGGAGCTTATTTACATTTA
TTTTATGATGCCTTGATCTCGGTAGGTGTTGTTTTATCAGCGGGTGTATTATACCTGACGGGTTGGGTATGGATAGATCC
GGTTGTCGGACTATTAATTGCATTAGTGATTTTGAAGGGCACTTGGTCACTATTTGCTGATAGTTTCAGATTAATTATTG
ATGGTGTTCCCCGGGATATATCCTGGATTAAAGTCAGTGATTTTCTCTTGGCTATACCTGGCGTAAAATCTATTCATGAT
TTACATATTTGGGCAATCAGTACGAAAGAAAATGCACTTTCTGTTCATTTATTTATGCCGGAGGAGTCATTATCTGATGA
TTTGCGTAGAGAGCTGGTTGAAAAATTAAAGCATGATTTCAGTATTCAGCATGTCACTATCCAAGTTGAAAAAACAGAAG
CAGAATGCAATGACGCATGTCATAATCCCAGGATAATCATTTAA

Upstream 100 bases:

>100_bases
ATTCTTTACGAGATACGAATGCCTGGCGCAAGCAAAATACAAGAGATCGTATTAAAATTGGACTTAATTATTACTCTGAA
AGCAAGAATGAAGGAGAATT

Downstream 100 bases:

>100_bases
TTGAGGCTGGATTTACGACCCCTAATTTCTTTGTTTAAAAAAGAGTTTAATTGATTCATTAATTGTATCTAAACGCCCTT
ATTAAAAACATTTTTTGCCT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MSRHSHDGAHHHEHGEVTYDKAFIIAITANGLFVVMQIIFAYLANSTSLLADAFHNLGDVLGLILAWVATGLMKRKPTHK
ATYGFKKTSILAALANGALLVFTCGIIATDAMYKLFSPTEIQAVSVMIVAAIGIVVNFSTALLFLRGSDDLNIRGAYLHL
FYDALISVGVVLSAGVLYLTGWVWIDPVVGLLIALVILKGTWSLFADSFRLIIDGVPRDISWIKVSDFLLAIPGVKSIHD
LHIWAISTKENALSVHLFMPEESLSDDLRRELVEKLKHDFSIQHVTIQVEKTEAECNDACHNPRIII

Sequences:

>Translated_307_residues
MSRHSHDGAHHHEHGEVTYDKAFIIAITANGLFVVMQIIFAYLANSTSLLADAFHNLGDVLGLILAWVATGLMKRKPTHK
ATYGFKKTSILAALANGALLVFTCGIIATDAMYKLFSPTEIQAVSVMIVAAIGIVVNFSTALLFLRGSDDLNIRGAYLHL
FYDALISVGVVLSAGVLYLTGWVWIDPVVGLLIALVILKGTWSLFADSFRLIIDGVPRDISWIKVSDFLLAIPGVKSIHD
LHIWAISTKENALSVHLFMPEESLSDDLRRELVEKLKHDFSIQHVTIQVEKTEAECNDACHNPRIII
>Mature_306_residues
SRHSHDGAHHHEHGEVTYDKAFIIAITANGLFVVMQIIFAYLANSTSLLADAFHNLGDVLGLILAWVATGLMKRKPTHKA
TYGFKKTSILAALANGALLVFTCGIIATDAMYKLFSPTEIQAVSVMIVAAIGIVVNFSTALLFLRGSDDLNIRGAYLHLF
YDALISVGVVLSAGVLYLTGWVWIDPVVGLLIALVILKGTWSLFADSFRLIIDGVPRDISWIKVSDFLLAIPGVKSIHDL
HIWAISTKENALSVHLFMPEESLSDDLRRELVEKLKHDFSIQHVTIQVEKTEAECNDACHNPRIII

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=288, Percent_Identity=25, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI289803013, Length=317, Percent_Identity=26.813880126183, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI289803009, Length=317, Percent_Identity=26.813880126183, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI289803007, Length=317, Percent_Identity=26.813880126183, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI289803003, Length=317, Percent_Identity=26.813880126183, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI64762489, Length=317, Percent_Identity=26.813880126183, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI21361112, Length=301, Percent_Identity=25.5813953488372, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI21359890, Length=301, Percent_Identity=25.2491694352159, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI14210520, Length=231, Percent_Identity=25.1082251082251, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI20070323, Length=308, Percent_Identity=25, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI52351208, Length=175, Percent_Identity=28.5714285714286, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1786966, Length=287, Percent_Identity=29.616724738676, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI193210990, Length=326, Percent_Identity=28.8343558282209, Blast_Score=141, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17555794, Length=323, Percent_Identity=24.4582043343653, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17555796, Length=322, Percent_Identity=22.9813664596273, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI32564488, Length=285, Percent_Identity=27.0175438596491, Blast_Score=107, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6320411, Length=167, Percent_Identity=30.5389221556886, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323899, Length=128, Percent_Identity=35.9375, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324892, Length=146, Percent_Identity=33.5616438356164, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24656728, Length=329, Percent_Identity=27.0516717325228, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24656724, Length=329, Percent_Identity=27.0516717325228, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24656720, Length=329, Percent_Identity=27.0516717325228, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24656715, Length=329, Percent_Identity=27.0516717325228, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21357035, Length=329, Percent_Identity=27.0516717325228, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24583858, Length=338, Percent_Identity=23.6686390532544, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24584409, Length=162, Percent_Identity=27.1604938271605, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28574430, Length=162, Percent_Identity=27.1604938271605, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24585900, Length=147, Percent_Identity=29.2517006802721, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24585898, Length=147, Percent_Identity=29.2517006802721, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24585896, Length=147, Percent_Identity=29.2517006802721, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI19921672, Length=147, Percent_Identity=29.2517006802721, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33783; Mature: 33652

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRHSHDGAHHHEHGEVTYDKAFIIAITANGLFVVMQIIFAYLANSTSLLADAFHNLGDV
CCCCCCCCCCCCCCCCEEECCEEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LGLILAWVATGLMKRKPTHKATYGFKKTSILAALANGALLVFTCGIIATDAMYKLFSPTE
HHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHCCCCH
IQAVSVMIVAAIGIVVNFSTALLFLRGSDDLNIRGAYLHLFYDALISVGVVLSAGVLYLT
HHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHCCHHHHH
GWVWIDPVVGLLIALVILKGTWSLFADSFRLIIDGVPRDISWIKVSDFLLAIPGVKSIHD
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEEECCCCCCEEEEECHHEEECCCCCCEEE
LHIWAISTKENALSVHLFMPEESLSDDLRRELVEKLKHDFSIQHVTIQVEKTEAECNDAC
EEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHCC
HNPRIII
CCCEEEC
>Mature Secondary Structure 
SRHSHDGAHHHEHGEVTYDKAFIIAITANGLFVVMQIIFAYLANSTSLLADAFHNLGDV
CCCCCCCCCCCCCCCEEECCEEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LGLILAWVATGLMKRKPTHKATYGFKKTSILAALANGALLVFTCGIIATDAMYKLFSPTE
HHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHCCCCH
IQAVSVMIVAAIGIVVNFSTALLFLRGSDDLNIRGAYLHLFYDALISVGVVLSAGVLYLT
HHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHCCHHHHH
GWVWIDPVVGLLIALVILKGTWSLFADSFRLIIDGVPRDISWIKVSDFLLAIPGVKSIHD
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEEECCCCCCEEEEECHHEEECCCCCCEEE
LHIWAISTKENALSVHLFMPEESLSDDLRRELVEKLKHDFSIQHVTIQVEKTEAECNDAC
EEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHCC
HNPRIII
CCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]