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The map label for this gene is pth [H]

Identifier: 54295491

GI number: 54295491

Start: 2946521

End: 2947090

Strand: Direct

Name: pth [H]

Synonym: lpl2578

Alternate gene names: 54295491

Gene position: 2946521-2947090 (Clockwise)

Preceding gene: 54295490

Following gene: 54295492

Centisome position: 88.07

GC content: 39.82

Gene sequence:

>570_bases
ATGGCCATTAAACTAATTGTCGGTTTACGCAATCCCGGATCGGCTTATGAACAAACCAGACACAACGCAGGTGCGTGGTT
AGTGACCGCTTTGGCCCAAAGACATAATTCGCATTTTAAGATTGACAAGAAAATGCAAGCGGAATTAACTGAAATTGATA
TTAACAACCACCCATGTCGACTATTGCTTCCTTTGACTTTTATGAATCATAGTGGTCAAACAACAAGAATAATCAGTCAA
TTCTATAAAATTGAACCCGGTGAAATATTAATTGTTCATGACGAGTTGGATTTACCTGTTGGACGAATCAAATTAAAAAC
AGGTGGTGGCCATGGTGGGCATAATGGTTTGAGAGACATAACTGCTCAATTGGGAACAGGTGAGTTTCATCGATTACGTA
TAGGGATAGGTCATCCTGGACATAAAGATCTAGTCCATCAATACGTACTCAGCAGGCCTTCTATGCACGACAGGCAACAA
ATTTATGATGCAATAGACAGAGGTATAGCGATAATACCTATAGTATTGTCAGGGGATATAGCCCGAGCAATGAATCAAGT
AAACGCTTAA

Upstream 100 bases:

>100_bases
TTTATGCAAATATTCAGAGCTTAATTCAGAGTATTTGCATAAAATCTAGTGCTAGAATAGTCAACACAAATCCGCTTAAT
TCAAATTTTATAGAAAATCT

Downstream 100 bases:

>100_bases
CATAATGAGGTATGACTCATGGGATTTAAATGTGGAATAGTAGGATTGCCCAATGTAGGGAAATCGACTCTTTTTAATGC
ATTGACTAAGGCTGGGATAG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 189; Mature: 188

Protein sequence:

>189_residues
MAIKLIVGLRNPGSAYEQTRHNAGAWLVTALAQRHNSHFKIDKKMQAELTEIDINNHPCRLLLPLTFMNHSGQTTRIISQ
FYKIEPGEILIVHDELDLPVGRIKLKTGGGHGGHNGLRDITAQLGTGEFHRLRIGIGHPGHKDLVHQYVLSRPSMHDRQQ
IYDAIDRGIAIIPIVLSGDIARAMNQVNA

Sequences:

>Translated_189_residues
MAIKLIVGLRNPGSAYEQTRHNAGAWLVTALAQRHNSHFKIDKKMQAELTEIDINNHPCRLLLPLTFMNHSGQTTRIISQ
FYKIEPGEILIVHDELDLPVGRIKLKTGGGHGGHNGLRDITAQLGTGEFHRLRIGIGHPGHKDLVHQYVLSRPSMHDRQQ
IYDAIDRGIAIIPIVLSGDIARAMNQVNA
>Mature_188_residues
AIKLIVGLRNPGSAYEQTRHNAGAWLVTALAQRHNSHFKIDKKMQAELTEIDINNHPCRLLLPLTFMNHSGQTTRIISQF
YKIEPGEILIVHDELDLPVGRIKLKTGGGHGGHNGLRDITAQLGTGEFHRLRIGIGHPGHKDLVHQYVLSRPSMHDRQQI
YDAIDRGIAIIPIVLSGDIARAMNQVNA

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=170, Percent_Identity=32.9411764705882, Blast_Score=96, Evalue=2e-20,
Organism=Escherichia coli, GI1787455, Length=190, Percent_Identity=46.8421052631579, Blast_Score=157, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 21031; Mature: 20899

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIKLIVGLRNPGSAYEQTRHNAGAWLVTALAQRHNSHFKIDKKMQAELTEIDINNHPCR
CEEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHCCCCEEECHHHHCEEEEEECCCCCEE
LLLPLTFMNHSGQTTRIISQFYKIEPGEILIVHDELDLPVGRIKLKTGGGHGGHNGLRDI
EEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCHHHH
TAQLGTGEFHRLRIGIGHPGHKDLVHQYVLSRPSMHDRQQIYDAIDRGIAIIPIVLSGDI
HHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEEEEECCHH
ARAMNQVNA
HHHHHHCCC
>Mature Secondary Structure 
AIKLIVGLRNPGSAYEQTRHNAGAWLVTALAQRHNSHFKIDKKMQAELTEIDINNHPCR
EEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHCCCCEEECHHHHCEEEEEECCCCCEE
LLLPLTFMNHSGQTTRIISQFYKIEPGEILIVHDELDLPVGRIKLKTGGGHGGHNGLRDI
EEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCHHHH
TAQLGTGEFHRLRIGIGHPGHKDLVHQYVLSRPSMHDRQQIYDAIDRGIAIIPIVLSGDI
HHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEEEEECCHH
ARAMNQVNA
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA