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The map label for this gene is hemA [H]

Identifier: 54295176

GI number: 54295176

Start: 2573452

End: 2574726

Strand: Direct

Name: hemA [H]

Synonym: lpl2256

Alternate gene names: 54295176

Gene position: 2573452-2574726 (Clockwise)

Preceding gene: 54295175

Following gene: 54295177

Centisome position: 76.92

GC content: 41.33

Gene sequence:

>1275_bases
ATGGTATTTGTAGCTTGCGGGCTTAATCATAAAACTGCTCCAATTCATGTGCGTGAAAAAGTCGCACTGCAGCCAGCCAT
GCAAGATTCTCTATTGAGCAGTCTGCTTGATTTACCTGAAGTTAATGAAGCGGCTATTTTATCTACATGCAACCGGACTG
AAATCTACTGTGATACCAATACCCCTGAGGTTCTTGGAAACTGGTTAGCTCATGAACACCAATTATCAGAGGAATTATTA
TCTCAATTTTTGTATATCCATCAGGGAAAAGAAGGAATCAAACATACCTTGCGTGTTGCCAGCGGTTTGGATTCCATGAT
GATAGGCGAACCACAAATCCTTGGCCAAATGAAACAGGCGTATCAACATGCTTGTCGTCTTGGCACAGTAAAAACACAAT
TGCGGCCTGTGTTTGAATATATTTTCAGAGCGTCCAAACGCATCAGAACTCGTAGCGGAATTGGAGCTAATCCCGTATCG
ATTGCCTATGCTGCGGTACAACTGATAGGGCAATTATTTAAAAACTATCATTCCTTAAGTGTCTTTTTAATTGGTTCCGG
AGAAACAGCCTCTCTGGTTGCTAAATACCTGCATCAGCATGGTGTCCATCGTTTTTTGATAGCGAGCCGCACTCTGGAAA
ATGCTCAAAAATTAGCTGAAACTTTCGATGGAAAAACACTGTCCATTGGTGATATCCCGCAATATTTACCTCTGGCCGAT
GTTGTTATTTCTGCCACAGCATGCCCGCTCCCATTCATCAATAAAAGCCTGGTTGAGCATGCCTTAGAGCAAAGAAACCA
TGCCCCTATGTTTCTATTGGATTTGGCCGTTCCTCGTGATATTGAAGGAAATGTCAATGAGTTGGAACAAGTTCATCTCT
ATAATGTAGATGATTTACAATCCATGATAGAAAAAGGGATGGATGAAAGGCGAAATGCGGCATTACAAGCAGAACAATTG
ATCGAAAGCGAACTGGATAACTACATTAGATGGCATCGCTCGCTTAGAGCCAAAGACGTCATTTGCGATTACCGCAATCA
AATGCACACTTTGGCTCAACAGGAATTACAACGTGCTTTGAAAAAAATATCCGCTGGTCAAAATCAGCAAGACGTTTTAA
ATGAATTCAGTATGCGCTTGGTCAACAAGCTAACTCATAATCCCACCATAGGTTTAAGACAAATGGCATGGGATAACAGA
GAAGACTTACTTGACCTCGCACGATATCTCTTTGATACAACAGCCAATCAATCATTATATGAAGAAATCTCTTGA

Upstream 100 bases:

>100_bases
AAGAAACAGAAATACAAGGAACCTTGCCTTTTTCTCTACAAATTTTACAATGAATCGTTTACAATTCGTTAATTCCCTTA
AACAAATAAATCAAGATTCT

Downstream 100 bases:

>100_bases
GTTAAAATTACAGCAAATGTTGGAGCGATACGAGGAAGTAGGTCGCTTACTGTCCGAAGCATCCATTATTGCCGATCAAA
ATCAATTTAAGTCTTTATCA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MVFVACGLNHKTAPIHVREKVALQPAMQDSLLSSLLDLPEVNEAAILSTCNRTEIYCDTNTPEVLGNWLAHEHQLSEELL
SQFLYIHQGKEGIKHTLRVASGLDSMMIGEPQILGQMKQAYQHACRLGTVKTQLRPVFEYIFRASKRIRTRSGIGANPVS
IAYAAVQLIGQLFKNYHSLSVFLIGSGETASLVAKYLHQHGVHRFLIASRTLENAQKLAETFDGKTLSIGDIPQYLPLAD
VVISATACPLPFINKSLVEHALEQRNHAPMFLLDLAVPRDIEGNVNELEQVHLYNVDDLQSMIEKGMDERRNAALQAEQL
IESELDNYIRWHRSLRAKDVICDYRNQMHTLAQQELQRALKKISAGQNQQDVLNEFSMRLVNKLTHNPTIGLRQMAWDNR
EDLLDLARYLFDTTANQSLYEEIS

Sequences:

>Translated_424_residues
MVFVACGLNHKTAPIHVREKVALQPAMQDSLLSSLLDLPEVNEAAILSTCNRTEIYCDTNTPEVLGNWLAHEHQLSEELL
SQFLYIHQGKEGIKHTLRVASGLDSMMIGEPQILGQMKQAYQHACRLGTVKTQLRPVFEYIFRASKRIRTRSGIGANPVS
IAYAAVQLIGQLFKNYHSLSVFLIGSGETASLVAKYLHQHGVHRFLIASRTLENAQKLAETFDGKTLSIGDIPQYLPLAD
VVISATACPLPFINKSLVEHALEQRNHAPMFLLDLAVPRDIEGNVNELEQVHLYNVDDLQSMIEKGMDERRNAALQAEQL
IESELDNYIRWHRSLRAKDVICDYRNQMHTLAQQELQRALKKISAGQNQQDVLNEFSMRLVNKLTHNPTIGLRQMAWDNR
EDLLDLARYLFDTTANQSLYEEIS
>Mature_424_residues
MVFVACGLNHKTAPIHVREKVALQPAMQDSLLSSLLDLPEVNEAAILSTCNRTEIYCDTNTPEVLGNWLAHEHQLSEELL
SQFLYIHQGKEGIKHTLRVASGLDSMMIGEPQILGQMKQAYQHACRLGTVKTQLRPVFEYIFRASKRIRTRSGIGANPVS
IAYAAVQLIGQLFKNYHSLSVFLIGSGETASLVAKYLHQHGVHRFLIASRTLENAQKLAETFDGKTLSIGDIPQYLPLAD
VVISATACPLPFINKSLVEHALEQRNHAPMFLLDLAVPRDIEGNVNELEQVHLYNVDDLQSMIEKGMDERRNAALQAEQL
IESELDNYIRWHRSLRAKDVICDYRNQMHTLAQQELQRALKKISAGQNQQDVLNEFSMRLVNKLTHNPTIGLRQMAWDNR
EDLLDLARYLFDTTANQSLYEEIS

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=412, Percent_Identity=41.2621359223301, Blast_Score=328, Evalue=3e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 47961; Mature: 47961

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFVACGLNHKTAPIHVREKVALQPAMQDSLLSSLLDLPEVNEAAILSTCNRTEIYCDTN
CEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCEEEECCC
TPEVLGNWLAHEHQLSEELLSQFLYIHQGKEGIKHTLRVASGLDSMMIGEPQILGQMKQA
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHH
YQHACRLGTVKTQLRPVFEYIFRASKRIRTRSGIGANPVSIAYAAVQLIGQLFKNYHSLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEE
VFLIGSGETASLVAKYLHQHGVHRFLIASRTLENAQKLAETFDGKTLSIGDIPQYLPLAD
EEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHH
VVISATACPLPFINKSLVEHALEQRNHAPMFLLDLAVPRDIEGNVNELEQVHLYNVDDLQ
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCHHHHH
SMIEKGMDERRNAALQAEQLIESELDNYIRWHRSLRAKDVICDYRNQMHTLAQQELQRAL
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKISAGQNQQDVLNEFSMRLVNKLTHNPTIGLRQMAWDNREDLLDLARYLFDTTANQSLY
HHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCHHHH
EEIS
HHCC
>Mature Secondary Structure
MVFVACGLNHKTAPIHVREKVALQPAMQDSLLSSLLDLPEVNEAAILSTCNRTEIYCDTN
CEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCEEEECCC
TPEVLGNWLAHEHQLSEELLSQFLYIHQGKEGIKHTLRVASGLDSMMIGEPQILGQMKQA
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHH
YQHACRLGTVKTQLRPVFEYIFRASKRIRTRSGIGANPVSIAYAAVQLIGQLFKNYHSLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEE
VFLIGSGETASLVAKYLHQHGVHRFLIASRTLENAQKLAETFDGKTLSIGDIPQYLPLAD
EEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHH
VVISATACPLPFINKSLVEHALEQRNHAPMFLLDLAVPRDIEGNVNELEQVHLYNVDDLQ
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCHHHHH
SMIEKGMDERRNAALQAEQLIESELDNYIRWHRSLRAKDVICDYRNQMHTLAQQELQRAL
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKISAGQNQQDVLNEFSMRLVNKLTHNPTIGLRQMAWDNREDLLDLARYLFDTTANQSLY
HHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCHHHH
EEIS
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA