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The map label for this gene is sdaC [H]

Identifier: 54295161

GI number: 54295161

Start: 2557981

End: 2559276

Strand: Direct

Name: sdaC [H]

Synonym: lpl2241

Alternate gene names: 54295161

Gene position: 2557981-2559276 (Clockwise)

Preceding gene: 54295159

Following gene: 54295167

Centisome position: 76.46

GC content: 36.34

Gene sequence:

>1296_bases
ATGTCATCAAATGAATCTGCAGCTATAGTATCTCCGATAGTCAACCAAAAACTATCGCAATGGAAAAAACAAGATACGAT
TTGGATGTTAAGCCTCTATGGCACAGCAATTGGTGCCGGAACTCTTTTCCTTCCTATAGATGCTGGTCTTAATGGCATTT
TGCCTTTAATCATTATGACAATTCTGGCCTTCCCCATGACTTATTATTCTCATAGGGCTTTATGTCGTTTTGTCCTTTCA
GGCTCGTCCTCACACAATGACATCACTGATGTTGTAGAAGAACACTTTGGCTCATTTGCGGGTAATATGCTGACTATCCT
GTACTTTTTTGCGATTTATCCAATTTTGCTTATGTACAGTGTCGCAATAACAAATACCACGGAAAGTTTCCTGATTAATC
AAATGGGAATTACCCCTCCGCCACGAGCTCTTTTAGCAATCATATTAATTCTTGGGTTAATGGGTATCGTGCGTTTAGGA
CAAGAAATTATTGTCAAATCGATGTCGGTATTGGTATATCCTTTTGCCACTATTCTATTTCTGCTTTCGCTTTATTTAAT
TCCAAATTGGAATAACGCTATTTTTATCCAAAGCAATTCCTTACATGCCAATGGAGGGCATGGACTATTAATGACTTTAT
GGTTAATTATTCCAGTGATGGTGTTCTCCTTTAACCATTCTCCTATCATTTCATCTTTTGCTGTGAATCAAAAGCAGCAA
TATGGTAGCCAAGCTGACGAGAAAAGCTCATTAATTATGAAATACAGCCACTTGATGATGGTTTTCTCTGTGATGTTTTT
TGTATTTAGCTGTGTGTTGAGCCTGTCACCTCAAGATCTTTTGCAAGCAAGGCAACAAAATATTTCCATTTTGTCTTATC
TGGCGAATCATTTTAATACCCCTATTATGGCCTATATTGCACCGGTTATTGCATTCATAGCCATTTCAAAATCTTTTCTG
GGACATTATTTAGGTGCCAAGGAAGGTTTAAGTGGAATTATTGTTAAGTCATTAAAATCAACAACAGGCAAAACAATTAA
TAAGAATTCCCTGCACAGAATCATTGAAATCTTTATGATTCTGACTTGTTGGGTTGTTGCTACAATTAATCCTAATATTT
TAAAAATGATTGAAACATTAGGAGGCCCCATCATAGCTGTCTTATTATTTATCATGCCAATGTATGCCATTGCTAAAGTG
CCAGCCATGAAAAAATACAACAACCAAATCAGTAACGTATTTGTTACCGTCATGGGCATTATTTCTATCTCAGCCATCAT
TTATGGCTTAATTTAA

Upstream 100 bases:

>100_bases
TTTAGTTCGCAATTGTTGAAATATTGTCTTTGTAGTGTTAATATTGATCAACTTGCGAGGCGCTATTTTATTAGTTAGTA
ATAAAACGAGGATGTTTTTC

Downstream 100 bases:

>100_bases
CAATCAATCTGGTAGTTGCATATATTTATTAAGGCGTATATTACGCCTTAATAATATTGCTAAACATCGGTATTTTTCTC
AATAGAATGAACTTAGATTT

Product: hypothetical protein

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MSSNESAAIVSPIVNQKLSQWKKQDTIWMLSLYGTAIGAGTLFLPIDAGLNGILPLIIMTILAFPMTYYSHRALCRFVLS
GSSSHNDITDVVEEHFGSFAGNMLTILYFFAIYPILLMYSVAITNTTESFLINQMGITPPPRALLAIILILGLMGIVRLG
QEIIVKSMSVLVYPFATILFLLSLYLIPNWNNAIFIQSNSLHANGGHGLLMTLWLIIPVMVFSFNHSPIISSFAVNQKQQ
YGSQADEKSSLIMKYSHLMMVFSVMFFVFSCVLSLSPQDLLQARQQNISILSYLANHFNTPIMAYIAPVIAFIAISKSFL
GHYLGAKEGLSGIIVKSLKSTTGKTINKNSLHRIIEIFMILTCWVVATINPNILKMIETLGGPIIAVLLFIMPMYAIAKV
PAMKKYNNQISNVFVTVMGIISISAIIYGLI

Sequences:

>Translated_431_residues
MSSNESAAIVSPIVNQKLSQWKKQDTIWMLSLYGTAIGAGTLFLPIDAGLNGILPLIIMTILAFPMTYYSHRALCRFVLS
GSSSHNDITDVVEEHFGSFAGNMLTILYFFAIYPILLMYSVAITNTTESFLINQMGITPPPRALLAIILILGLMGIVRLG
QEIIVKSMSVLVYPFATILFLLSLYLIPNWNNAIFIQSNSLHANGGHGLLMTLWLIIPVMVFSFNHSPIISSFAVNQKQQ
YGSQADEKSSLIMKYSHLMMVFSVMFFVFSCVLSLSPQDLLQARQQNISILSYLANHFNTPIMAYIAPVIAFIAISKSFL
GHYLGAKEGLSGIIVKSLKSTTGKTINKNSLHRIIEIFMILTCWVVATINPNILKMIETLGGPIIAVLLFIMPMYAIAKV
PAMKKYNNQISNVFVTVMGIISISAIIYGLI
>Mature_430_residues
SSNESAAIVSPIVNQKLSQWKKQDTIWMLSLYGTAIGAGTLFLPIDAGLNGILPLIIMTILAFPMTYYSHRALCRFVLSG
SSSHNDITDVVEEHFGSFAGNMLTILYFFAIYPILLMYSVAITNTTESFLINQMGITPPPRALLAIILILGLMGIVRLGQ
EIIVKSMSVLVYPFATILFLLSLYLIPNWNNAIFIQSNSLHANGGHGLLMTLWLIIPVMVFSFNHSPIISSFAVNQKQQY
GSQADEKSSLIMKYSHLMMVFSVMFFVFSCVLSLSPQDLLQARQQNISILSYLANHFNTPIMAYIAPVIAFIAISKSFLG
HYLGAKEGLSGIIVKSLKSTTGKTINKNSLHRIIEIFMILTCWVVATINPNILKMIETLGGPIIAVLLFIMPMYAIAKVP
AMKKYNNQISNVFVTVMGIISISAIIYGLI

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=432, Percent_Identity=63.8888888888889, Blast_Score=556, Evalue=1e-160,
Organism=Escherichia coli, GI1789504, Length=446, Percent_Identity=46.6367713004484, Blast_Score=390, Evalue=1e-109,
Organism=Escherichia coli, GI1789211, Length=411, Percent_Identity=37.956204379562, Blast_Score=291, Evalue=8e-80,
Organism=Escherichia coli, GI145693183, Length=405, Percent_Identity=26.1728395061728, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1789961, Length=400, Percent_Identity=27.5, Blast_Score=123, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 47612; Mature: 47480

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNESAAIVSPIVNQKLSQWKKQDTIWMLSLYGTAIGAGTLFLPIDAGLNGILPLIIMT
CCCCCCHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHCCCEEEEEECCCCCHHHHHHHHH
ILAFPMTYYSHRALCRFVLSGSSSHNDITDVVEEHFGSFAGNMLTILYFFAIYPILLMYS
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAITNTTESFLINQMGITPPPRALLAIILILGLMGIVRLGQEIIVKSMSVLVYPFATILF
HHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLSLYLIPNWNNAIFIQSNSLHANGGHGLLMTLWLIIPVMVFSFNHSPIISSFAVNQKQQ
HHHHHHCCCCCCEEEEECCCEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
YGSQADEKSSLIMKYSHLMMVFSVMFFVFSCVLSLSPQDLLQARQQNISILSYLANHFNT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
PIMAYIAPVIAFIAISKSFLGHYLGAKEGLSGIIVKSLKSTTGKTINKNSLHRIIEIFMI
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LTCWVVATINPNILKMIETLGGPIIAVLLFIMPMYAIAKVPAMKKYNNQISNVFVTVMGI
HHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
ISISAIIYGLI
HHHHHHHHHCC
>Mature Secondary Structure 
SSNESAAIVSPIVNQKLSQWKKQDTIWMLSLYGTAIGAGTLFLPIDAGLNGILPLIIMT
CCCCCHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHCCCEEEEEECCCCCHHHHHHHHH
ILAFPMTYYSHRALCRFVLSGSSSHNDITDVVEEHFGSFAGNMLTILYFFAIYPILLMYS
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAITNTTESFLINQMGITPPPRALLAIILILGLMGIVRLGQEIIVKSMSVLVYPFATILF
HHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLSLYLIPNWNNAIFIQSNSLHANGGHGLLMTLWLIIPVMVFSFNHSPIISSFAVNQKQQ
HHHHHHCCCCCCEEEEECCCEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
YGSQADEKSSLIMKYSHLMMVFSVMFFVFSCVLSLSPQDLLQARQQNISILSYLANHFNT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
PIMAYIAPVIAFIAISKSFLGHYLGAKEGLSGIIVKSLKSTTGKTINKNSLHRIIEIFMI
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LTCWVVATINPNILKMIETLGGPIIAVLLFIMPMYAIAKVPAMKKYNNQISNVFVTVMGI
HHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
ISISAIIYGLI
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]