Click here to switch to the map view.

The map label for this gene is proC [H]

Identifier: 54294913

GI number: 54294913

Start: 2232571

End: 2233359

Strand: Direct

Name: proC [H]

Synonym: lpl1992

Alternate gene names: 54294913

Gene position: 2232571-2233359 (Clockwise)

Preceding gene: 54294912

Following gene: 54294914

Centisome position: 66.73

GC content: 40.43

Gene sequence:

>789_bases
ATGAATATCAGTTTTATTGGTTATGGGAATATGGCAAAAGCAATTGCCTGCCACTTACAAAAGCAAAATAAATACTCATT
GTCAGCTGCCTCACCATCCTTATCTGCGGGCATTAGTAAAGAAAATATTCGCACTCATTACGATAATAAAGAAGTGGCCA
AAGACGCAAACGTCATTATATTGGCAGTAAAACCCGCACAAATGCGTGAGGTAATCAATGAGATTAACCCTTTTATTTCA
TCAGGTTGCCTTCTAGTCTCAGTGGCAGCGGGATTGTCCCTGACCTGGTTTGCCAAATATTGTAAAAAAGGACAAGCGGT
CGTAAGAACCATGCCTAATACCCCGGCTATAGTTGGATTTGCAGCAACATCAATGATTGCAAATGAATTTGTAAACGAGA
AACAAAAAAAATGGGCAGAACAATTATTTTCAAGCATTGGGATTACTGATTGGGTTAAAGATGAAGAAGACATGGACACC
CTGACAGCTCTTTCTGGCAGTGGCCCTGCTTACGTATTTTTGTTTCTTGAGGCGATGATTAATGCAGGGATCCAATTGGG
CCTGGAAGAAACAGTTGCCAAACACTTTGCCATACAGACATTTTCAGGATCGCTTCAATTAGCTCAACATAGCCAGTTAA
GTTTGACTGAACTGAGAAAAAAAGTAACTTCTCCGGGAGGTACAACAGCCGCAGCTTTGGAAATCCTGCATGGAGATTTG
GATGAGCTCATTTTTTCTGCTATGAAAGCTGCGAAACAAAAAGCCCATCAATTAGGAAAAGTTGAATAA

Upstream 100 bases:

>100_bases
CAATGGGTATGAGTGATGATTTGGTTCCGGCAATTAAAGCAGGTTCGACCATAGTTCGAATTGGAAGAGCAATTTTTGGC
GAACGAAAAGGTAAATTATT

Downstream 100 bases:

>100_bases
CTCTTTTGAGTTAACAAAAATTCTATCGCAAGAAGTCCTCCGTTGACTTCTTTTATTTTAATATCAGTCAGGATTTACAA
ACACCCCAAGGTCAAGGCAA

Product: hypothetical protein

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MNISFIGYGNMAKAIACHLQKQNKYSLSAASPSLSAGISKENIRTHYDNKEVAKDANVIILAVKPAQMREVINEINPFIS
SGCLLVSVAAGLSLTWFAKYCKKGQAVVRTMPNTPAIVGFAATSMIANEFVNEKQKKWAEQLFSSIGITDWVKDEEDMDT
LTALSGSGPAYVFLFLEAMINAGIQLGLEETVAKHFAIQTFSGSLQLAQHSQLSLTELRKKVTSPGGTTAAALEILHGDL
DELIFSAMKAAKQKAHQLGKVE

Sequences:

>Translated_262_residues
MNISFIGYGNMAKAIACHLQKQNKYSLSAASPSLSAGISKENIRTHYDNKEVAKDANVIILAVKPAQMREVINEINPFIS
SGCLLVSVAAGLSLTWFAKYCKKGQAVVRTMPNTPAIVGFAATSMIANEFVNEKQKKWAEQLFSSIGITDWVKDEEDMDT
LTALSGSGPAYVFLFLEAMINAGIQLGLEETVAKHFAIQTFSGSLQLAQHSQLSLTELRKKVTSPGGTTAAALEILHGDL
DELIFSAMKAAKQKAHQLGKVE
>Mature_262_residues
MNISFIGYGNMAKAIACHLQKQNKYSLSAASPSLSAGISKENIRTHYDNKEVAKDANVIILAVKPAQMREVINEINPFIS
SGCLLVSVAAGLSLTWFAKYCKKGQAVVRTMPNTPAIVGFAATSMIANEFVNEKQKKWAEQLFSSIGITDWVKDEEDMDT
LTALSGSGPAYVFLFLEAMINAGIQLGLEETVAKHFAIQTFSGSLQLAQHSQLSLTELRKKVTSPGGTTAAALEILHGDL
DELIFSAMKAAKQKAHQLGKVE

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=270, Percent_Identity=31.4814814814815, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI24797095, Length=270, Percent_Identity=31.4814814814815, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI198041662, Length=268, Percent_Identity=31.7164179104478, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI21361454, Length=270, Percent_Identity=31.4814814814815, Blast_Score=123, Evalue=2e-28,
Organism=Escherichia coli, GI1786585, Length=265, Percent_Identity=32.4528301886792, Blast_Score=125, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17569021, Length=267, Percent_Identity=30.3370786516854, Blast_Score=130, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17540664, Length=285, Percent_Identity=25.9649122807018, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6320861, Length=226, Percent_Identity=32.7433628318584, Blast_Score=115, Evalue=7e-27,
Organism=Drosophila melanogaster, GI21358587, Length=245, Percent_Identity=34.2857142857143, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI24648116, Length=276, Percent_Identity=29.7101449275362, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24647700, Length=147, Percent_Identity=34.0136054421769, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28324; Mature: 28324

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNISFIGYGNMAKAIACHLQKQNKYSLSAASPSLSAGISKENIRTHYDNKEVAKDANVII
CCEEEEECCCHHHHHHHHHHHCCCEEECCCCCCHHCCCCHHHHHHHCCCHHHHCCCCEEE
LAVKPAQMREVINEINPFISSGCLLVSVAAGLSLTWFAKYCKKGQAVVRTMPNTPAIVGF
EEECCHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCCCCCHHH
AATSMIANEFVNEKQKKWAEQLFSSIGITDWVKDEEDMDTLTALSGSGPAYVFLFLEAMI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHH
NAGIQLGLEETVAKHFAIQTFSGSLQLAQHSQLSLTELRKKVTSPGGTTAAALEILHGDL
HCCHHCCHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCH
DELIFSAMKAAKQKAHQLGKVE
HHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNISFIGYGNMAKAIACHLQKQNKYSLSAASPSLSAGISKENIRTHYDNKEVAKDANVII
CCEEEEECCCHHHHHHHHHHHCCCEEECCCCCCHHCCCCHHHHHHHCCCHHHHCCCCEEE
LAVKPAQMREVINEINPFISSGCLLVSVAAGLSLTWFAKYCKKGQAVVRTMPNTPAIVGF
EEECCHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCCCCCHHH
AATSMIANEFVNEKQKKWAEQLFSSIGITDWVKDEEDMDTLTALSGSGPAYVFLFLEAMI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHH
NAGIQLGLEETVAKHFAIQTFSGSLQLAQHSQLSLTELRKKVTSPGGTTAAALEILHGDL
HCCHHCCHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCH
DELIFSAMKAAKQKAHQLGKVE
HHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]