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The map label for this gene is treA [H]

Identifier: 54294764

GI number: 54294764

Start: 2061969

End: 2063498

Strand: Direct

Name: treA [H]

Synonym: lpl1841

Alternate gene names: 54294764

Gene position: 2061969-2063498 (Clockwise)

Preceding gene: 54294763

Following gene: 54294767

Centisome position: 61.63

GC content: 36.41

Gene sequence:

>1530_bases
ATGCAGCGTGTTTTAATCTATATTATTTTCTTCTCTTACTTTAAACTTGGCTTTACCCATCCCCAGATGGAGTTTCAATC
GAACATGCAGGAAATTAATCAATACATAGAAAAGACCTGGAGTATACTAACCAGAGATAATACCAATCTCTTGGCTGACT
CAGATGAAAAACTACCTCACACTCAATCAATCATTTACTTACCGCCAGAAGAAAATCTCAATAAAATAAAAAACAAGGTC
ACCCAAAATTGGCCTGAGTGGAAAAAAAAGAAAGTCATTTTTAAATACATTCCCCAGGACATTTCAACAATAAAACAGCA
TGGTTTGCTGTATTTACCTCATCCCTATATTGTACCCGGAGGAAGATTTAATGAAATGTATGGTTGGGATAGCTATTTTA
TAGAATTGGGGCTAATAGAGCATAATCGTCTGACAATGGCTCGACACATGATCGATAACCTCATCTACGAAATTAACCAT
TACGGAACTATCCTGAATGCAAATAGAACTTACTACCTCCAACGTTCACAACCCCCTTTACTCACAGCAATGATTTTAGC
TTATTATGACAAAACCCAAGATAAAAAATGGCTTGCATCGACTTTACCAGCCATCAAAAAACTTCATACATACTGGACAA
TACCTCCACGCCTAATCCCTGATCTTGGTTTGTCTCGTTATTATGCTGGTGGCCAGGGAAAGCCTCCAGAAGAATCGGCA
GTCTATTATGAAAAAGTTTTAAATTATTTTAAAACCCATGAGATTGATGATTATGATAAATCCCTTTTTTATAGTGAAGC
ATCAAACCAGTTAACAGAACTATTTTATATTGCTGACCGAACAGTCAGAGAATCCGGTTTCGACATTACTGCCAAATTTG
GCCCTTTCAGTGCGGGTATTCTGGATTATGCACCAGTAGATTTGAATGTACTAATTTATCAAATGGAAAATGATCTGGGT
ATAATTTATAAAATTCTTGATAATAAAGAAAATGCTGACATTTGGACTCAAAAAGCCCAAGTGCGGGCAGCATTAATCAA
CCATTACCTTTGGGATAATAAGGCCGGCTATTATTTTGATTATAACTTTAAAACAAAACAACTAAGACCTTATATTTATG
CAACCACGTTCTATCCCTTGTGGGCAGGTATTGCATCCAAAGACCAAGCTCAATCAATCGTGAATAACCTGCCTGTTCTA
TTAACCAGAGGAGGGTTATTAACCAGTTGTTATATTCAGGGAGTGCAATGGGATGCGCCTTTCGGATGGGCTCCTTTACA
ATATTTTGCCGTACTCGGTTTGAATAGATATGGGTATAAAGAGTTAGCATTGGATATTGCTAACCGCTTTGTCAGCACAA
TTCATAAAGGATTCCAGGAAGCCCATACTCTTTTTGAAAAATATGATGTTCAAAAAATGAGCATTCATACCGAAAACAAA
ATTCAATACAGTTATAGTACAAATGTCGTAGGTTTTGGATGGACTAATGGTGTGTATCTTGTCTTCATGAGATTAATTAA
TGCAAGTTAA

Upstream 100 bases:

>100_bases
GAGACAGGCTAAGCAAAAAGTCTAATAAACATCAGACTTTAAATTCTGTTTAAGTCAGGAAAGTTAAACATTTTTTAATC
ACAAAATTACAGGGAAACGG

Downstream 100 bases:

>100_bases
TTAGCTTATAAACCATTCTTTTTATTAAAGTGAAAAAGTAGAGCAAGTGCTTTCAAAACCACAGCTAGATATCTCTGGAG
AATTATGTGAAATATTCCAT

Product: hypothetical protein

Products: NA

Alternate protein names: Alpha,alpha-trehalase; Alpha,alpha-trehalose glucohydrolase [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MQRVLIYIIFFSYFKLGFTHPQMEFQSNMQEINQYIEKTWSILTRDNTNLLADSDEKLPHTQSIIYLPPEENLNKIKNKV
TQNWPEWKKKKVIFKYIPQDISTIKQHGLLYLPHPYIVPGGRFNEMYGWDSYFIELGLIEHNRLTMARHMIDNLIYEINH
YGTILNANRTYYLQRSQPPLLTAMILAYYDKTQDKKWLASTLPAIKKLHTYWTIPPRLIPDLGLSRYYAGGQGKPPEESA
VYYEKVLNYFKTHEIDDYDKSLFYSEASNQLTELFYIADRTVRESGFDITAKFGPFSAGILDYAPVDLNVLIYQMENDLG
IIYKILDNKENADIWTQKAQVRAALINHYLWDNKAGYYFDYNFKTKQLRPYIYATTFYPLWAGIASKDQAQSIVNNLPVL
LTRGGLLTSCYIQGVQWDAPFGWAPLQYFAVLGLNRYGYKELALDIANRFVSTIHKGFQEAHTLFEKYDVQKMSIHTENK
IQYSYSTNVVGFGWTNGVYLVFMRLINAS

Sequences:

>Translated_509_residues
MQRVLIYIIFFSYFKLGFTHPQMEFQSNMQEINQYIEKTWSILTRDNTNLLADSDEKLPHTQSIIYLPPEENLNKIKNKV
TQNWPEWKKKKVIFKYIPQDISTIKQHGLLYLPHPYIVPGGRFNEMYGWDSYFIELGLIEHNRLTMARHMIDNLIYEINH
YGTILNANRTYYLQRSQPPLLTAMILAYYDKTQDKKWLASTLPAIKKLHTYWTIPPRLIPDLGLSRYYAGGQGKPPEESA
VYYEKVLNYFKTHEIDDYDKSLFYSEASNQLTELFYIADRTVRESGFDITAKFGPFSAGILDYAPVDLNVLIYQMENDLG
IIYKILDNKENADIWTQKAQVRAALINHYLWDNKAGYYFDYNFKTKQLRPYIYATTFYPLWAGIASKDQAQSIVNNLPVL
LTRGGLLTSCYIQGVQWDAPFGWAPLQYFAVLGLNRYGYKELALDIANRFVSTIHKGFQEAHTLFEKYDVQKMSIHTENK
IQYSYSTNVVGFGWTNGVYLVFMRLINAS
>Mature_509_residues
MQRVLIYIIFFSYFKLGFTHPQMEFQSNMQEINQYIEKTWSILTRDNTNLLADSDEKLPHTQSIIYLPPEENLNKIKNKV
TQNWPEWKKKKVIFKYIPQDISTIKQHGLLYLPHPYIVPGGRFNEMYGWDSYFIELGLIEHNRLTMARHMIDNLIYEINH
YGTILNANRTYYLQRSQPPLLTAMILAYYDKTQDKKWLASTLPAIKKLHTYWTIPPRLIPDLGLSRYYAGGQGKPPEESA
VYYEKVLNYFKTHEIDDYDKSLFYSEASNQLTELFYIADRTVRESGFDITAKFGPFSAGILDYAPVDLNVLIYQMENDLG
IIYKILDNKENADIWTQKAQVRAALINHYLWDNKAGYYFDYNFKTKQLRPYIYATTFYPLWAGIASKDQAQSIVNNLPVL
LTRGGLLTSCYIQGVQWDAPFGWAPLQYFAVLGLNRYGYKELALDIANRFVSTIHKGFQEAHTLFEKYDVQKMSIHTENK
IQYSYSTNVVGFGWTNGVYLVFMRLINAS

Specific function: Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system [H]

COG id: COG1626

COG function: function code G; Neutral trehalase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 37 family [H]

Homologues:

Organism=Homo sapiens, GI116284412, Length=437, Percent_Identity=31.350114416476, Blast_Score=188, Evalue=1e-47,
Organism=Escherichia coli, GI1787447, Length=444, Percent_Identity=33.1081081081081, Blast_Score=221, Evalue=7e-59,
Organism=Escherichia coli, GI1789936, Length=443, Percent_Identity=32.9571106094808, Blast_Score=216, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17542196, Length=464, Percent_Identity=28.448275862069, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17565078, Length=437, Percent_Identity=28.8329519450801, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI25148109, Length=434, Percent_Identity=28.8018433179723, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI25141398, Length=431, Percent_Identity=27.6102088167053, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71987755, Length=438, Percent_Identity=24.4292237442922, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320204, Length=434, Percent_Identity=39.1705069124424, Blast_Score=282, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6319473, Length=433, Percent_Identity=38.1062355658199, Blast_Score=264, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24656680, Length=420, Percent_Identity=30.2380952380952, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24656675, Length=420, Percent_Identity=30.2380952380952, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24656685, Length=420, Percent_Identity=30.2380952380952, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24656661, Length=420, Percent_Identity=30.2380952380952, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI17933716, Length=420, Percent_Identity=30.2380952380952, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24656670, Length=420, Percent_Identity=30.2380952380952, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI22024178, Length=420, Percent_Identity=26.1904761904762, Blast_Score=132, Evalue=8e-31,
Organism=Drosophila melanogaster, GI45551104, Length=379, Percent_Identity=25.5936675461741, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI28573474, Length=101, Percent_Identity=35.6435643564356, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008928
- InterPro:   IPR001661
- InterPro:   IPR018232 [H]

Pfam domain/function: PF01204 Trehalase [H]

EC number: =3.2.1.28 [H]

Molecular weight: Translated: 59554; Mature: 59554

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS00927 TREHALASE_1 ; PS00928 TREHALASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRVLIYIIFFSYFKLGFTHPQMEFQSNMQEINQYIEKTWSILTRDNTNLLADSDEKLPH
CCCEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCEECCCCCCCCC
TQSIIYLPPEENLNKIKNKVTQNWPEWKKKKVIFKYIPQDISTIKQHGLLYLPHPYIVPG
CCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHCCEEECCCCEEECC
GRFNEMYGWDSYFIELGLIEHNRLTMARHMIDNLIYEINHYGTILNANRTYYLQRSQPPL
CCCCCCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHCCEEEEECCEEEEEECCCCCH
LTAMILAYYDKTQDKKWLASTLPAIKKLHTYWTIPPRLIPDLGLSRYYAGGQGKPPEESA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHEECCCCCCCCCHHH
VYYEKVLNYFKTHEIDDYDKSLFYSEASNQLTELFYIADRTVRESGFDITAKFGPFSAGI
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
LDYAPVDLNVLIYQMENDLGIIYKILDNKENADIWTQKAQVRAALINHYLWDNKAGYYFD
CCCCCCCEEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEE
YNFKTKQLRPYIYATTFYPLWAGIASKDQAQSIVNNLPVLLTRGGLLTSCYIQGVQWDAP
ECCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHCCCEEEECCCCEEEHEEECEEECCC
FGWAPLQYFAVLGLNRYGYKELALDIANRFVSTIHKGFQEAHTLFEKYDVQKMSIHTENK
CCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCE
IQYSYSTNVVGFGWTNGVYLVFMRLINAS
EEEEECCCEEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MQRVLIYIIFFSYFKLGFTHPQMEFQSNMQEINQYIEKTWSILTRDNTNLLADSDEKLPH
CCCEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCEECCCCCCCCC
TQSIIYLPPEENLNKIKNKVTQNWPEWKKKKVIFKYIPQDISTIKQHGLLYLPHPYIVPG
CCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHCCEEECCCCEEECC
GRFNEMYGWDSYFIELGLIEHNRLTMARHMIDNLIYEINHYGTILNANRTYYLQRSQPPL
CCCCCCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHCCEEEEECCEEEEEECCCCCH
LTAMILAYYDKTQDKKWLASTLPAIKKLHTYWTIPPRLIPDLGLSRYYAGGQGKPPEESA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHEECCCCCCCCCHHH
VYYEKVLNYFKTHEIDDYDKSLFYSEASNQLTELFYIADRTVRESGFDITAKFGPFSAGI
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
LDYAPVDLNVLIYQMENDLGIIYKILDNKENADIWTQKAQVRAALINHYLWDNKAGYYFD
CCCCCCCEEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEE
YNFKTKQLRPYIYATTFYPLWAGIASKDQAQSIVNNLPVLLTRGGLLTSCYIQGVQWDAP
ECCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHCCCEEEECCCCEEEHEEECEEECCC
FGWAPLQYFAVLGLNRYGYKELALDIANRFVSTIHKGFQEAHTLFEKYDVQKMSIHTENK
CCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCE
IQYSYSTNVVGFGWTNGVYLVFMRLINAS
EEEEECCCEEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]