Click here to switch to the map view.

The map label for this gene is dtd [H]

Identifier: 54294732

GI number: 54294732

Start: 2025282

End: 2025719

Strand: Direct

Name: dtd [H]

Synonym: lpl1809

Alternate gene names: 54294732

Gene position: 2025282-2025719 (Clockwise)

Preceding gene: 54294731

Following gene: 54294733

Centisome position: 60.53

GC content: 36.76

Gene sequence:

>438_bases
ATGTTAACTGTATTACAAAGAGTAAAGGAAGCCAGGGTTGATATTGATGGTCAAACTGTTGGCAAAATAAACCATGGCTT
GCTGATACTTTGTGGTTTTGAACCTAATGATTCGCTAGAAAATATTAAACGAATGCTGGATAAATGCATTAATTATCGCA
TTTTTGAAGACCCGAGTGGCAAAATGAACTTGAGCTTAAAGGATGTAAATGGCGGTTTGCTATTAGTACCACAATTTACT
CTCATGGCAGATACCCAAAAAGGATTACGTCCAAGTTTTTCAAATGCAGCTTCTCCAGAACTTGGGCGTGAACTTTTTGA
TAACTTATTAACTCTTGCCCAGAAATGCCACCAAAATACTCAAAGTGGTTGCTTTGGAGCGAACATGCAAGTTTATTTAT
GTAATGATGGGCCTGTGACATTTCTGTTACAATTTTAA

Upstream 100 bases:

>100_bases
TAAGAATTGTCAGAGATGCCGGTCACTCTGATAGAGAATCGGGAATTATTGATGCACTTATTTATGCCAGTAAGGACATC
TCAAAGCAGGGTCTTGATGC

Downstream 100 bases:

>100_bases
TCAGCTTTTGCTGTATTAAATTTTTGTATAACCTGGATTGTCGAGCGAAGTATAATCAACATTCATCATTGGGATTCATT
GCGGCCAAAAAAAAAGCATG

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 145; Mature: 145

Protein sequence:

>145_residues
MLTVLQRVKEARVDIDGQTVGKINHGLLILCGFEPNDSLENIKRMLDKCINYRIFEDPSGKMNLSLKDVNGGLLLVPQFT
LMADTQKGLRPSFSNAASPELGRELFDNLLTLAQKCHQNTQSGCFGANMQVYLCNDGPVTFLLQF

Sequences:

>Translated_145_residues
MLTVLQRVKEARVDIDGQTVGKINHGLLILCGFEPNDSLENIKRMLDKCINYRIFEDPSGKMNLSLKDVNGGLLLVPQFT
LMADTQKGLRPSFSNAASPELGRELFDNLLTLAQKCHQNTQSGCFGANMQVYLCNDGPVTFLLQF
>Mature_145_residues
MLTVLQRVKEARVDIDGQTVGKINHGLLILCGFEPNDSLENIKRMLDKCINYRIFEDPSGKMNLSLKDVNGGLLLVPQFT
LMADTQKGLRPSFSNAASPELGRELFDNLLTLAQKCHQNTQSGCFGANMQVYLCNDGPVTFLLQF

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine [H]

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family [H]

Homologues:

Organism=Homo sapiens, GI30795227, Length=147, Percent_Identity=36.0544217687075, Blast_Score=87, Evalue=7e-18,
Organism=Escherichia coli, GI1790320, Length=144, Percent_Identity=46.5277777777778, Blast_Score=149, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI115533292, Length=143, Percent_Identity=34.965034965035, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319982, Length=146, Percent_Identity=38.3561643835616, Blast_Score=108, Evalue=2e-25,
Organism=Drosophila melanogaster, GI281361569, Length=146, Percent_Identity=36.986301369863, Blast_Score=92, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003732 [H]

Pfam domain/function: PF02580 Tyr_Deacylase [H]

EC number: NA

Molecular weight: Translated: 16122; Mature: 16122

Theoretical pI: Translated: 6.49; Mature: 6.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTVLQRVKEARVDIDGQTVGKINHGLLILCGFEPNDSLENIKRMLDKCINYRIFEDPSG
CCHHHHHHHHHHCCCCCCEECEECCCEEEEEECCCCCHHHHHHHHHHHHHCCEEEECCCC
KMNLSLKDVNGGLLLVPQFTLMADTQKGLRPSFSNAASPELGRELFDNLLTLAQKCHQNT
CEEEEEEECCCCEEEEECEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
QSGCFGANMQVYLCNDGPVTFLLQF
CCCCCCCCCEEEEECCCCEEEEEEC
>Mature Secondary Structure
MLTVLQRVKEARVDIDGQTVGKINHGLLILCGFEPNDSLENIKRMLDKCINYRIFEDPSG
CCHHHHHHHHHHCCCCCCEECEECCCEEEEEECCCCCHHHHHHHHHHHHHCCEEEECCCC
KMNLSLKDVNGGLLLVPQFTLMADTQKGLRPSFSNAASPELGRELFDNLLTLAQKCHQNT
CEEEEEEECCCCEEEEECEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
QSGCFGANMQVYLCNDGPVTFLLQF
CCCCCCCCCEEEEECCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA