Click here to switch to the map view.

The map label for this gene is lysAC [H]

Identifier: 54294698

GI number: 54294698

Start: 1982759

End: 1985338

Strand: Direct

Name: lysAC [H]

Synonym: lpl1775

Alternate gene names: 54294698

Gene position: 1982759-1985338 (Clockwise)

Preceding gene: 54294696

Following gene: 54294699

Centisome position: 59.26

GC content: 41.4

Gene sequence:

>2580_bases
TTGAGCGGAATACTAATCATGCAACAAGTAGTCATCAAATTTGGAGGCACTAGTGTTTCAACCAGAGCCACTTGGAATAA
TATTGCTGCAATTACCCAAAAACATCTGAATACAGGTGTTCAACCCGTTATAGTCTGTTCTGCTTTAACTCAAATTTCCA
ACAAACTTGAAAAAGCCATAGAGGCAGCCCTTCTTGACGAGCATCATAGCCTTTTCAATGACATTCAGAGCAGTCACCTG
AATCTGGCAGAACAATTAGAAGTAAACCATCAATTAATTGCTAATGATTTGCACCAATTACAGCAATGGCTAACCGGGAT
CTCCTTGCTCAAACAAGCGCCTGCAAAAACACATGCGCAAATTTTAAGTTTAGGTGAATTGATGATGACCCGCATGGGCC
ACGCCTTTCTTGAAAGGCATGAGATTAAAGTGAAATGGTATGATGCCAGAGAATTGTTAACAAGCACACCGACCCTTGGT
GGAGAAACAATGAACTATCTCTCTGCCCGTTGTGAGAGTGAATACGACCCGGGATTGGTAGAAAAATTTCTCTCCAGCGG
AGCTCAAGCCATTATTACCCAAGGTTTTTTTGCTGCCAATCCTCATGGTGAAACCGTTTTGCTTGGTCGAGGAGGCTCTG
ATACTTCAGCAGCACTACTTGCGGGCAAACTACAGGCCGCCTCTTGTGAAATATGGACTGATGTTCCAGGTATTTATACC
GCTAACCCGCATCAACTACCCCATGCCCGATTATTAAAGCAATTAAATTACGATGAAGCACAGGAAATTGCCTCAATGGG
GGCCAAAGTCTTACACCCCAATTGCATACCGCCTGTTCGAAAAGCCAATATCCCTATGGTAGTCAAATACACTCACCTGC
CAGAACATTCAGGAACATTGATTACCAAAGACATTGATGAATCAGCACCCTTAATAAAATCCATCCAGGTTAAACACAGC
ATACTGCTAATTTCTATAGACACTTTGAATATGTGGCAACAAGTAGGATTTCTGGCTGATGTATTCGCCGCCTTTAAGAA
GCATGGATTTTCAGTTGATTTGCTTTCTTCTTCTGAATTCAATGTCACCCTATCCCTGGATGTTAATGCCAAAATACATG
ATAGACCAGCAATTAATGCCTTGCTCGACGATTTAAACCAATTTGGACGCGCCAAACTGATAGAACCCTGTAGTGCTGTC
AGTTTGGTAGGACATCACATCCGAACTGTATTACCTCATCTTGGCCCGGCTTTGGAAGTATTTGAGGCAAAACAAGTATA
CCTGATGTCTCTGGCCTCGAATGACCTTAATTTGACTTTTGTTGTTGATGAATCACATGCCGATAAATTATGCCAAAGAT
TGCATCATCTACTAATCGAAAGTAATCCTCAAATCTTTTATTACTCCAAAAGCTGGCATGAAGAATTTGGCAAACCCAAT
GTTCGCCCAACACCTTGGTGGGAAATTGAAAGAGACCGCTTGCTGACAACCAGCGCAATACATTCTCCTTGCTATGTTTA
CCATAGTCCCACCCAGGCAATTCGTGCAAGACAATTATCTGCTCTGGAGTCAATTGATAGCTTGTTTTACGCTGTTAAAG
CGAATCCATTCCCTTCCATTTTAAAAACTTTGGAAAAAGAAGGGATAGGTTTTGAATGCGTTTCTATTCAGGAATTGGAA
TTGGTGTTAAAACTGTTCCCCAATATTAAAAAAGAAAGAATTTTATTCACACCCAATTTTGCTCCGAAATCCGAGTATGA
ATTCGCTCTGCAAACAGGCTGCTATGTGACTATTGACAGTTTGTATCCCTTGGAAAACTGGCCTGAATTGTTTAAAAACC
GTGAAGTAATCGTTCGCATAGATCCTGGCACCGGAGCTGGCCATCATAAACATGTTTCTACGGGTGGGAATGAATCCAAA
TTTGGTATCACACAAAATGACATAAGCAAGATTCTATCACTTACCAAATCCAACCACATTAAGGTCATAGGCTTACATGC
TCACTCTGGTAGCGGCATACTCTCAACCGATTTATGGCAACAAACTGCTGTGATGCTTGCCTCCCTAACCGATCAATTTC
CTGAAGTACGTTCAATTAATTTAGGTGGCGGCCTAGGTATTGTAGAAAAACCGGGCCAACACCCTATTGATTTTGCAGCA
CTTGATGCGCAATTAATGGCAGTAAAATCTCAATATCCAGGATTGGCAATCTGGCTTGAACCAGGCCGCTTCTTTGTAGC
TGAAAGTGGTGTCATTCTTGCCAAAGTAACGCAATGTAAAGAAAAAGGAAAAGTAAAATTTATTGGTATTGAAACAGGAA
TGAACTCATTGATAAGGCCTTCCTTATATGGTGCGTATCATGAAATTGTCAATTTAACTCGACTACATGAAGAAAAGGCC
GGGTTTGCTCATATAGTTGGCCCAATCTGTGAATCAGGAGATACATTGGGTTATGACCGCTTATTACCAGTTACCAAGGA
AGGAGATGTGATATTAATTGCAAACACTGGGGCCTATGGTCACTGTATGAGTTCACACTACAATTTAAGACCACCTGCTC
AGGAAATAGTTCTGGAATAA

Upstream 100 bases:

>100_bases
TCCAATGCATTCTCTCAGTGTTTCCTGAAAAATTCTTTTTTAAATTAGAAGCGTAATCTACTTGTCTAAATACTTTAGTC
CATGCTAAGGTGTATTAATT

Downstream 100 bases:

>100_bases
TGGCATGCAGTTAATTGATAGTGAACAAAGGAGACAAGCGACAGATCCTGCTGAATCATTTATAGTCCAGGCTCCTGCCG
GGTCAGGAAAAACAGAGATT

Product: bifunctional aspartate kinase/diaminopimelate decarboxylase protein

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 859; Mature: 858

Protein sequence:

>859_residues
MSGILIMQQVVIKFGGTSVSTRATWNNIAAITQKHLNTGVQPVIVCSALTQISNKLEKAIEAALLDEHHSLFNDIQSSHL
NLAEQLEVNHQLIANDLHQLQQWLTGISLLKQAPAKTHAQILSLGELMMTRMGHAFLERHEIKVKWYDARELLTSTPTLG
GETMNYLSARCESEYDPGLVEKFLSSGAQAIITQGFFAANPHGETVLLGRGGSDTSAALLAGKLQAASCEIWTDVPGIYT
ANPHQLPHARLLKQLNYDEAQEIASMGAKVLHPNCIPPVRKANIPMVVKYTHLPEHSGTLITKDIDESAPLIKSIQVKHS
ILLISIDTLNMWQQVGFLADVFAAFKKHGFSVDLLSSSEFNVTLSLDVNAKIHDRPAINALLDDLNQFGRAKLIEPCSAV
SLVGHHIRTVLPHLGPALEVFEAKQVYLMSLASNDLNLTFVVDESHADKLCQRLHHLLIESNPQIFYYSKSWHEEFGKPN
VRPTPWWEIERDRLLTTSAIHSPCYVYHSPTQAIRARQLSALESIDSLFYAVKANPFPSILKTLEKEGIGFECVSIQELE
LVLKLFPNIKKERILFTPNFAPKSEYEFALQTGCYVTIDSLYPLENWPELFKNREVIVRIDPGTGAGHHKHVSTGGNESK
FGITQNDISKILSLTKSNHIKVIGLHAHSGSGILSTDLWQQTAVMLASLTDQFPEVRSINLGGGLGIVEKPGQHPIDFAA
LDAQLMAVKSQYPGLAIWLEPGRFFVAESGVILAKVTQCKEKGKVKFIGIETGMNSLIRPSLYGAYHEIVNLTRLHEEKA
GFAHIVGPICESGDTLGYDRLLPVTKEGDVILIANTGAYGHCMSSHYNLRPPAQEIVLE

Sequences:

>Translated_859_residues
MSGILIMQQVVIKFGGTSVSTRATWNNIAAITQKHLNTGVQPVIVCSALTQISNKLEKAIEAALLDEHHSLFNDIQSSHL
NLAEQLEVNHQLIANDLHQLQQWLTGISLLKQAPAKTHAQILSLGELMMTRMGHAFLERHEIKVKWYDARELLTSTPTLG
GETMNYLSARCESEYDPGLVEKFLSSGAQAIITQGFFAANPHGETVLLGRGGSDTSAALLAGKLQAASCEIWTDVPGIYT
ANPHQLPHARLLKQLNYDEAQEIASMGAKVLHPNCIPPVRKANIPMVVKYTHLPEHSGTLITKDIDESAPLIKSIQVKHS
ILLISIDTLNMWQQVGFLADVFAAFKKHGFSVDLLSSSEFNVTLSLDVNAKIHDRPAINALLDDLNQFGRAKLIEPCSAV
SLVGHHIRTVLPHLGPALEVFEAKQVYLMSLASNDLNLTFVVDESHADKLCQRLHHLLIESNPQIFYYSKSWHEEFGKPN
VRPTPWWEIERDRLLTTSAIHSPCYVYHSPTQAIRARQLSALESIDSLFYAVKANPFPSILKTLEKEGIGFECVSIQELE
LVLKLFPNIKKERILFTPNFAPKSEYEFALQTGCYVTIDSLYPLENWPELFKNREVIVRIDPGTGAGHHKHVSTGGNESK
FGITQNDISKILSLTKSNHIKVIGLHAHSGSGILSTDLWQQTAVMLASLTDQFPEVRSINLGGGLGIVEKPGQHPIDFAA
LDAQLMAVKSQYPGLAIWLEPGRFFVAESGVILAKVTQCKEKGKVKFIGIETGMNSLIRPSLYGAYHEIVNLTRLHEEKA
GFAHIVGPICESGDTLGYDRLLPVTKEGDVILIANTGAYGHCMSSHYNLRPPAQEIVLE
>Mature_858_residues
SGILIMQQVVIKFGGTSVSTRATWNNIAAITQKHLNTGVQPVIVCSALTQISNKLEKAIEAALLDEHHSLFNDIQSSHLN
LAEQLEVNHQLIANDLHQLQQWLTGISLLKQAPAKTHAQILSLGELMMTRMGHAFLERHEIKVKWYDARELLTSTPTLGG
ETMNYLSARCESEYDPGLVEKFLSSGAQAIITQGFFAANPHGETVLLGRGGSDTSAALLAGKLQAASCEIWTDVPGIYTA
NPHQLPHARLLKQLNYDEAQEIASMGAKVLHPNCIPPVRKANIPMVVKYTHLPEHSGTLITKDIDESAPLIKSIQVKHSI
LLISIDTLNMWQQVGFLADVFAAFKKHGFSVDLLSSSEFNVTLSLDVNAKIHDRPAINALLDDLNQFGRAKLIEPCSAVS
LVGHHIRTVLPHLGPALEVFEAKQVYLMSLASNDLNLTFVVDESHADKLCQRLHHLLIESNPQIFYYSKSWHEEFGKPNV
RPTPWWEIERDRLLTTSAIHSPCYVYHSPTQAIRARQLSALESIDSLFYAVKANPFPSILKTLEKEGIGFECVSIQELEL
VLKLFPNIKKERILFTPNFAPKSEYEFALQTGCYVTIDSLYPLENWPELFKNREVIVRIDPGTGAGHHKHVSTGGNESKF
GITQNDISKILSLTKSNHIKVIGLHAHSGSGILSTDLWQQTAVMLASLTDQFPEVRSINLGGGLGIVEKPGQHPIDFAAL
DAQLMAVKSQYPGLAIWLEPGRFFVAESGVILAKVTQCKEKGKVKFIGIETGMNSLIRPSLYGAYHEIVNLTRLHEEKAG
FAHIVGPICESGDTLGYDRLLPVTKEGDVILIANTGAYGHCMSSHYNLRPPAQEIVLE

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=360, Percent_Identity=26.9444444444444, Blast_Score=82, Evalue=3e-15,
Organism=Escherichia coli, GI1790455, Length=462, Percent_Identity=30.7359307359307, Blast_Score=192, Evalue=7e-50,
Organism=Escherichia coli, GI1789203, Length=376, Percent_Identity=31.9148936170213, Blast_Score=191, Evalue=2e-49,
Organism=Escherichia coli, GI1786183, Length=483, Percent_Identity=30.0207039337474, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1790376, Length=302, Percent_Identity=27.8145695364238, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6320893, Length=498, Percent_Identity=26.9076305220884, Blast_Score=150, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24586472, Length=343, Percent_Identity=27.1137026239067, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24586474, Length=367, Percent_Identity=27.5204359673025, Blast_Score=72, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 94908; Mature: 94777

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00324 ASPARTOKINASE ; PS00878 ODR_DC_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGILIMQQVVIKFGGTSVSTRATWNNIAAITQKHLNTGVQPVIVCSALTQISNKLEKAI
CCCHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EAALLDEHHSLFNDIQSSHLNLAEQLEVNHQLIANDLHQLQQWLTGISLLKQAPAKTHAQ
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ILSLGELMMTRMGHAFLERHEIKVKWYDARELLTSTPTLGGETMNYLSARCESEYDPGLV
HHHHHHHHHHHHHHHHHHCCEEEEEEECHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHH
EKFLSSGAQAIITQGFFAANPHGETVLLGRGGSDTSAALLAGKLQAASCEIWTDVPGIYT
HHHHHCCCCEEHHCCCEEECCCCCEEEEECCCCCCHHHHHHHCCCCCCEEEEECCCCCEE
ANPHQLPHARLLKQLNYDEAQEIASMGAKVLHPNCIPPVRKANIPMVVKYTHLPEHSGTL
CCCCCCCHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEE
ITKDIDESAPLIKSIQVKHSILLISIDTLNMWQQVGFLADVFAAFKKHGFSVDLLSSSEF
EEECCCCCCCHHHHHEEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCE
NVTLSLDVNAKIHDRPAINALLDDLNQFGRAKLIEPCSAVSLVGHHIRTVLPHLGPALEV
EEEEEEEECCEECCCHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHCCCHHHH
FEAKQVYLMSLASNDLNLTFVVDESHADKLCQRLHHLLIESNPQIFYYSKSWHEEFGKPN
HHHHHEEEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHCCCC
VRPTPWWEIERDRLLTTSAIHSPCYVYHSPTQAIRARQLSALESIDSLFYAVKANPFPSI
CCCCCCCCCCCCCEEEHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHEEEEECCCHHHH
LKTLEKEGIGFECVSIQELELVLKLFPNIKKERILFTPNFAPKSEYEFALQTGCYVTIDS
HHHHHHCCCCEEEECHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEECCCEEEECC
LYPLENWPELFKNREVIVRIDPGTGAGHHKHVSTGGNESKFGITQNDISKILSLTKSNHI
CCCCCCCHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCE
KVIGLHAHSGSGILSTDLWQQTAVMLASLTDQFPEVRSINLGGGLGIVEKPGQHPIDFAA
EEEEEEECCCCCCEEHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCHHH
LDAQLMAVKSQYPGLAIWLEPGRFFVAESGVILAKVTQCKEKGKVKFIGIETGMNSLIRP
HHHHHHHHHHCCCCEEEEECCCEEEEECCCEEEEEHHHHHHCCCEEEEEEECCCHHHHCH
SLYGAYHEIVNLTRLHEEKAGFAHIVGPICESGDTLGYDRLLPVTKEGDVILIANTGAYG
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCH
HCMSSHYNLRPPAQEIVLE
HHHCCCCCCCCCHHHHCCC
>Mature Secondary Structure 
SGILIMQQVVIKFGGTSVSTRATWNNIAAITQKHLNTGVQPVIVCSALTQISNKLEKAI
CCHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EAALLDEHHSLFNDIQSSHLNLAEQLEVNHQLIANDLHQLQQWLTGISLLKQAPAKTHAQ
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ILSLGELMMTRMGHAFLERHEIKVKWYDARELLTSTPTLGGETMNYLSARCESEYDPGLV
HHHHHHHHHHHHHHHHHHCCEEEEEEECHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHH
EKFLSSGAQAIITQGFFAANPHGETVLLGRGGSDTSAALLAGKLQAASCEIWTDVPGIYT
HHHHHCCCCEEHHCCCEEECCCCCEEEEECCCCCCHHHHHHHCCCCCCEEEEECCCCCEE
ANPHQLPHARLLKQLNYDEAQEIASMGAKVLHPNCIPPVRKANIPMVVKYTHLPEHSGTL
CCCCCCCHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEE
ITKDIDESAPLIKSIQVKHSILLISIDTLNMWQQVGFLADVFAAFKKHGFSVDLLSSSEF
EEECCCCCCCHHHHHEEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCE
NVTLSLDVNAKIHDRPAINALLDDLNQFGRAKLIEPCSAVSLVGHHIRTVLPHLGPALEV
EEEEEEEECCEECCCHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHCCCHHHH
FEAKQVYLMSLASNDLNLTFVVDESHADKLCQRLHHLLIESNPQIFYYSKSWHEEFGKPN
HHHHHEEEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHCCCC
VRPTPWWEIERDRLLTTSAIHSPCYVYHSPTQAIRARQLSALESIDSLFYAVKANPFPSI
CCCCCCCCCCCCCEEEHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHEEEEECCCHHHH
LKTLEKEGIGFECVSIQELELVLKLFPNIKKERILFTPNFAPKSEYEFALQTGCYVTIDS
HHHHHHCCCCEEEECHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEECCCEEEECC
LYPLENWPELFKNREVIVRIDPGTGAGHHKHVSTGGNESKFGITQNDISKILSLTKSNHI
CCCCCCCHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCE
KVIGLHAHSGSGILSTDLWQQTAVMLASLTDQFPEVRSINLGGGLGIVEKPGQHPIDFAA
EEEEEEECCCCCCEEHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCHHH
LDAQLMAVKSQYPGLAIWLEPGRFFVAESGVILAKVTQCKEKGKVKFIGIETGMNSLIRP
HHHHHHHHHHCCCCEEEEECCCEEEEECCCEEEEEHHHHHHCCCEEEEEEECCCHHHHCH
SLYGAYHEIVNLTRLHEEKAGFAHIVGPICESGDTLGYDRLLPVTKEGDVILIANTGAYG
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCH
HCMSSHYNLRPPAQEIVLE
HHHCCCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]