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The map label for this gene is rir2 [H]

Identifier: 54294662

GI number: 54294662

Start: 1943732

End: 1944835

Strand: Direct

Name: rir2 [H]

Synonym: lpl1739

Alternate gene names: 54294662

Gene position: 1943732-1944835 (Clockwise)

Preceding gene: 54294661

Following gene: 54294663

Centisome position: 58.1

GC content: 40.13

Gene sequence:

>1104_bases
ATGAACTACAATGATACTCAAGAAATTGTCGTAACTCCTCTTATGGGCGCGACAGGGCTCGAGGCTTTAGAAATGGGAGC
GGCACGCATTCATGTCGATGATAAGCAAATCATTAATTGCCGCGCTGACTTAAATCAATTGGTGCCCTTCAAATACAAAT
GGGCTTGGGATAAATACTTGACAGCCTGTGCTAATCATTGGATGCCCAATGAAATCAGTATGAGTGCCGATGTCGCTTTA
TGGAAAGATCCTTATGGTCTTACAGAAGATGAGCGTTTAATCATTAAGCGTAATTTGGGATTTTTCTCAACCGCCGATTC
ACTCGTTGCGAATAATCTGGTTCTTGCTGTTTACAGACATATTACTAATCCAGAGTGTCGTCAATATCTTCTAAGGCAAG
CTTTTGAAGAAGCGTTACACACTCATGCTTATCAATACATTATAGAGAGTTTGGGGCTGGATGAAGCTGAAGTATTTAAT
ATGTATAGAGAAATACCTTCTGTATCCAGAAAAGCGGTATGGGCATTGCCATTTACTCAAAGCTTAGGCGATGAGACCTT
CCATACAGGAACTCCGGAAAACGATCAACGTCTGCTACGCGATTTAATTGCATTTTATGTTGTGTTTGAGGGTATTTTCT
TTTATGTCGGATTTACTCAAATTCTCTCCATGGGACGTCGTAACAAAATGGTAGGAACATCAGAACAGTTCCAATATATA
CTGCGCGATGAGTCCATGCATATGAATTTCGGTATTGATGTGATTAATCAAATCAAAATCGAAAATCCTCATTTATGGAC
ACCTGAATTTAAGAATGAAATAATTCAACTCATCAGAGAAGGCGTTGAGCTCGAATACCAATACGCCAGAGACACTATGC
CTCATGGCATTCTCGGAATGAACGCCGAGATGTTTGAAGAATATTTGCACTTTATTGCAAACCGTCGTTTAAATCAAATA
GGTCTGCCGGATCAATACCCTGGTGCTGAAAACCCATTCCCCTGGATGAGTGAAATGCTGGATCTCAAAAAAGAGAAAAA
CTTTTTTGAAACTCGTGTTATTGAATATCAGGCTGGCGGTACTCTAAGCTGGGATGATGAATAA

Upstream 100 bases:

>100_bases
GACGGGGCACTTAACGCAGTCAAATTAATAGATACCGAACCAAAGGCTTGTTCTATTACTGATCCAGACTGCGAGGCTTG
CCAATAATCAGGAGAAATTT

Downstream 100 bases:

>100_bases
AGTTTAATCATGTTACTTCGAGCAAAGTAAGGGAGTTTATTTAGAGAAATCCCTTACTTTGTGAAAAAGGTCATGCCCCA
GTCTTCAACTTAACCAAACT

Product: ribonucleotide-diphosphate reductase subunit beta

Products: NA

Alternate protein names: Ribonucleotide reductase small subunit [H]

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MNYNDTQEIVVTPLMGATGLEALEMGAARIHVDDKQIINCRADLNQLVPFKYKWAWDKYLTACANHWMPNEISMSADVAL
WKDPYGLTEDERLIIKRNLGFFSTADSLVANNLVLAVYRHITNPECRQYLLRQAFEEALHTHAYQYIIESLGLDEAEVFN
MYREIPSVSRKAVWALPFTQSLGDETFHTGTPENDQRLLRDLIAFYVVFEGIFFYVGFTQILSMGRRNKMVGTSEQFQYI
LRDESMHMNFGIDVINQIKIENPHLWTPEFKNEIIQLIREGVELEYQYARDTMPHGILGMNAEMFEEYLHFIANRRLNQI
GLPDQYPGAENPFPWMSEMLDLKKEKNFFETRVIEYQAGGTLSWDDE

Sequences:

>Translated_367_residues
MNYNDTQEIVVTPLMGATGLEALEMGAARIHVDDKQIINCRADLNQLVPFKYKWAWDKYLTACANHWMPNEISMSADVAL
WKDPYGLTEDERLIIKRNLGFFSTADSLVANNLVLAVYRHITNPECRQYLLRQAFEEALHTHAYQYIIESLGLDEAEVFN
MYREIPSVSRKAVWALPFTQSLGDETFHTGTPENDQRLLRDLIAFYVVFEGIFFYVGFTQILSMGRRNKMVGTSEQFQYI
LRDESMHMNFGIDVINQIKIENPHLWTPEFKNEIIQLIREGVELEYQYARDTMPHGILGMNAEMFEEYLHFIANRRLNQI
GLPDQYPGAENPFPWMSEMLDLKKEKNFFETRVIEYQAGGTLSWDDE
>Mature_367_residues
MNYNDTQEIVVTPLMGATGLEALEMGAARIHVDDKQIINCRADLNQLVPFKYKWAWDKYLTACANHWMPNEISMSADVAL
WKDPYGLTEDERLIIKRNLGFFSTADSLVANNLVLAVYRHITNPECRQYLLRQAFEEALHTHAYQYIIESLGLDEAEVFN
MYREIPSVSRKAVWALPFTQSLGDETFHTGTPENDQRLLRDLIAFYVVFEGIFFYVGFTQILSMGRRNKMVGTSEQFQYI
LRDESMHMNFGIDVINQIKIENPHLWTPEFKNEIIQLIREGVELEYQYARDTMPHGILGMNAEMFEEYLHFIANRRLNQI
GLPDQYPGAENPFPWMSEMLDLKKEKNFFETRVIEYQAGGTLSWDDE

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0208

COG function: function code F; Ribonucleotide reductase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase small chain family [H]

Homologues:

Organism=Homo sapiens, GI4557845, Length=344, Percent_Identity=29.0697674418605, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI42544136, Length=320, Percent_Identity=29.375, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI289177074, Length=320, Percent_Identity=29.375, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI260064013, Length=344, Percent_Identity=29.0697674418605, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI289177076, Length=297, Percent_Identity=29.2929292929293, Blast_Score=126, Evalue=3e-29,
Organism=Escherichia coli, GI1788567, Length=296, Percent_Identity=24.3243243243243, Blast_Score=86, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17551968, Length=319, Percent_Identity=28.5266457680251, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI193206379, Length=304, Percent_Identity=24.6710526315789, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17567153, Length=227, Percent_Identity=28.1938325991189, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322434, Length=331, Percent_Identity=31.4199395770393, Blast_Score=159, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6321619, Length=320, Percent_Identity=23.75, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI18079279, Length=320, Percent_Identity=30.9375, Blast_Score=153, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009078
- InterPro:   IPR012348
- InterPro:   IPR000358 [H]

Pfam domain/function: PF00268 Ribonuc_red_sm [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 42773; Mature: 42773

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYNDTQEIVVTPLMGATGLEALEMGAARIHVDDKQIINCRADLNQLVPFKYKWAWDKYL
CCCCCCCCEEEECCCCCCCHHHHHCCCEEEEECHHHHHHHHHHHHHCCCCEEEHHHHHHH
TACANHWMPNEISMSADVALWKDPYGLTEDERLIIKRNLGFFSTADSLVANNLVLAVYRH
HHHHHCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
ITNPECRQYLLRQAFEEALHTHAYQYIIESLGLDEAEVFNMYREIPSVSRKAVWALPFTQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHCCEEEECCCHH
SLGDETFHTGTPENDQRLLRDLIAFYVVFEGIFFYVGFTQILSMGRRNKMVGTSEQFQYI
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
LRDESMHMNFGIDVINQIKIENPHLWTPEFKNEIIQLIREGVELEYQYARDTMPHGILGM
HHCCCEEEECCCHHHHHEEECCCCCCCHHHHHHHHHHHHHCCCEEEHHHHCCCCCCCCCC
NAEMFEEYLHFIANRRLNQIGLPDQYPGAENPFPWMSEMLDLKKEKNFFETRVIEYQAGG
CHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHEEEEECCC
TLSWDDE
CCCCCCC
>Mature Secondary Structure
MNYNDTQEIVVTPLMGATGLEALEMGAARIHVDDKQIINCRADLNQLVPFKYKWAWDKYL
CCCCCCCCEEEECCCCCCCHHHHHCCCEEEEECHHHHHHHHHHHHHCCCCEEEHHHHHHH
TACANHWMPNEISMSADVALWKDPYGLTEDERLIIKRNLGFFSTADSLVANNLVLAVYRH
HHHHHCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
ITNPECRQYLLRQAFEEALHTHAYQYIIESLGLDEAEVFNMYREIPSVSRKAVWALPFTQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHCCEEEECCCHH
SLGDETFHTGTPENDQRLLRDLIAFYVVFEGIFFYVGFTQILSMGRRNKMVGTSEQFQYI
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
LRDESMHMNFGIDVINQIKIENPHLWTPEFKNEIIQLIREGVELEYQYARDTMPHGILGM
HHCCCEEEECCCHHHHHEEECCCCCCCHHHHHHHHHHHHHCCCEEEHHHHCCCCCCCCCC
NAEMFEEYLHFIANRRLNQIGLPDQYPGAENPFPWMSEMLDLKKEKNFFETRVIEYQAGG
CHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHEEEEECCC
TLSWDDE
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]