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The map label for this gene is clcA [H]

Identifier: 54294621

GI number: 54294621

Start: 1893318

End: 1894601

Strand: Reverse

Name: clcA [H]

Synonym: lpl1697

Alternate gene names: 54294621

Gene position: 1894601-1893318 (Counterclockwise)

Preceding gene: 54294622

Following gene: 54294619

Centisome position: 56.63

GC content: 40.58

Gene sequence:

>1284_bases
ATGGGTAAAAAAATACTGATTTTATATTTTGTATCAGTTCTATTAGGGATATTAACAGGCGCAATTGCTTCATTATTGCA
ACTTACTATTCAACAGATGGATCATCTGCTGGAGCTATTATTTCATATCACAGAAAGTTATGGACTTCCTGTAGGAATCG
TTTCCGCTATGATATCGATGATGATGTTATTTATTGCCTGGATGATGGTGAAGTACATCGCCCCGGAAGCAGCAGGAAGT
GGTGTGCAAGAAATTGAAGGCACCTTGCTTCATGTAAGACCAATATTTTGGAAGCGTCTGATACCAGTAAAATTTTTGGG
GGGTGTGTTATCCATATCGGCAAAAATGGTTATGGGAAGAGAAGGGCCTACTATTCAGATGGGCGGTAACCTTGGACAGA
TGCTTGGAGAGTTGTTTCGGCTTACACGCCGTCGCCGTGATACTTTAATAGCCGCTGGTTCTGCCGCTGGTTTGGCTGCA
GCATTTAATGCGCCTCTGGCTGGTGTACTGTTTGTCATGGAGGAAATGCGTAACCAGTTTAATTATTCATTTACCAATTT
TAAAATGGTCGTTATTTGTTGTGTCATGGCAACGATTGTTTTGCATCTTATTATTGGCTCACAACCGGCTATTCAAATGG
AGGTTTTTGAACTACCTACACTGGGCTCTTTGTGGCTGTTCTTTGTTTTTGGAATATTAATGGGGTTGGCTGGTTTATTA
TTCAACGTTACACTCATGAGAACTGTTGGATGGTTGGATAAACAAAACCCCAAAAATAAAAAATATTATATTTTAGCTGT
TGGATTTTTAGTCGGCTATCTGGCGTACTCCTACCCTGCTACTGTTGGGGGTGGTTATGTTATCATCAGTGAAGCACTGA
CTATGTCACCTGCATTTAGCGTGTTATGCAGTCTTATTGTAATCAGGTTTATCATGACCATGTTATCCTATTCAACTGGC
GTACCTGGCGGTATCTTTGCACCAATGCTGGCTTTGGGAACACTGTTTGGATTAGGTTTTTTCCATTTATTTCAATGGTT
GAGTATGGATTTTTCAATTGAACCTGGTATGTTTGCAGTTGCAGGTATGGGAGCGCTTTTCGCAGCTGCAGTAAGATCAC
CAATTACTGGTGTGGTATTGGTTGTTGAAATGACAAAAAATTACTCTCTAATTCTACCCCTTATGATCTCCTGCATTACT
GCAACGATTGTGGTGCAACTAGCACGTAATGAGCCGATTTACACTCAATTGTTAGAGCGAACTTTACGGCTCAATGCAAA
ATGA

Upstream 100 bases:

>100_bases
CCTGTGCATGCGGTTCAATTTCATCCAGAGACAATTTTGTCTTTATCGGATCAAGTGGGTTTAAGAATAATCATCAATTT
GATGAACATGGTGAAGGACA

Downstream 100 bases:

>100_bases
GTCTAAATATCTCAATATGTATTGATAGTTCAGCTATGGAGAATAAGGATAAAAGTAAGAAGAGCTCTTGATTTATCTAC
CAAAAACACGAACTCACTGG

Product: chloride channel protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MGKKILILYFVSVLLGILTGAIASLLQLTIQQMDHLLELLFHITESYGLPVGIVSAMISMMMLFIAWMMVKYIAPEAAGS
GVQEIEGTLLHVRPIFWKRLIPVKFLGGVLSISAKMVMGREGPTIQMGGNLGQMLGELFRLTRRRRDTLIAAGSAAGLAA
AFNAPLAGVLFVMEEMRNQFNYSFTNFKMVVICCVMATIVLHLIIGSQPAIQMEVFELPTLGSLWLFFVFGILMGLAGLL
FNVTLMRTVGWLDKQNPKNKKYYILAVGFLVGYLAYSYPATVGGGYVIISEALTMSPAFSVLCSLIVIRFIMTMLSYSTG
VPGGIFAPMLALGTLFGLGFFHLFQWLSMDFSIEPGMFAVAGMGALFAAAVRSPITGVVLVVEMTKNYSLILPLMISCIT
ATIVVQLARNEPIYTQLLERTLRLNAK

Sequences:

>Translated_427_residues
MGKKILILYFVSVLLGILTGAIASLLQLTIQQMDHLLELLFHITESYGLPVGIVSAMISMMMLFIAWMMVKYIAPEAAGS
GVQEIEGTLLHVRPIFWKRLIPVKFLGGVLSISAKMVMGREGPTIQMGGNLGQMLGELFRLTRRRRDTLIAAGSAAGLAA
AFNAPLAGVLFVMEEMRNQFNYSFTNFKMVVICCVMATIVLHLIIGSQPAIQMEVFELPTLGSLWLFFVFGILMGLAGLL
FNVTLMRTVGWLDKQNPKNKKYYILAVGFLVGYLAYSYPATVGGGYVIISEALTMSPAFSVLCSLIVIRFIMTMLSYSTG
VPGGIFAPMLALGTLFGLGFFHLFQWLSMDFSIEPGMFAVAGMGALFAAAVRSPITGVVLVVEMTKNYSLILPLMISCIT
ATIVVQLARNEPIYTQLLERTLRLNAK
>Mature_426_residues
GKKILILYFVSVLLGILTGAIASLLQLTIQQMDHLLELLFHITESYGLPVGIVSAMISMMMLFIAWMMVKYIAPEAAGSG
VQEIEGTLLHVRPIFWKRLIPVKFLGGVLSISAKMVMGREGPTIQMGGNLGQMLGELFRLTRRRRDTLIAAGSAAGLAAA
FNAPLAGVLFVMEEMRNQFNYSFTNFKMVVICCVMATIVLHLIIGSQPAIQMEVFELPTLGSLWLFFVFGILMGLAGLLF
NVTLMRTVGWLDKQNPKNKKYYILAVGFLVGYLAYSYPATVGGGYVIISEALTMSPAFSVLCSLIVIRFIMTMLSYSTGV
PGGIFAPMLALGTLFGLGFFHLFQWLSMDFSIEPGMFAVAGMGALFAAAVRSPITGVVLVVEMTKNYSLILPLMISCITA
TIVVQLARNEPIYTQLLERTLRLNAK

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557473, Length=428, Percent_Identity=25.7009345794392, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI189217923, Length=428, Percent_Identity=25.7009345794392, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI189217921, Length=428, Percent_Identity=25.7009345794392, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI55770838, Length=423, Percent_Identity=26.241134751773, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI55770840, Length=423, Percent_Identity=26.241134751773, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI153252026, Length=419, Percent_Identity=23.8663484486874, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1786350, Length=425, Percent_Identity=41.1764705882353, Blast_Score=272, Evalue=3e-74,
Organism=Escherichia coli, GI87081943, Length=322, Percent_Identity=29.5031055900621, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71985148, Length=468, Percent_Identity=27.991452991453, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71985141, Length=464, Percent_Identity=28.0172413793103, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17532615, Length=413, Percent_Identity=24.455205811138, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17559050, Length=495, Percent_Identity=25.0505050505051, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71980828, Length=477, Percent_Identity=23.0607966457023, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71980820, Length=482, Percent_Identity=22.6141078838174, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71980824, Length=477, Percent_Identity=23.0607966457023, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322500, Length=388, Percent_Identity=26.8041237113402, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24665008, Length=418, Percent_Identity=23.9234449760766, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 46739; Mature: 46608

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
6.6 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
6.3 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKKILILYFVSVLLGILTGAIASLLQLTIQQMDHLLELLFHITESYGLPVGIVSAMISM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
MMLFIAWMMVKYIAPEAAGSGVQEIEGTLLHVRPIFWKRLIPVKFLGGVLSISAKMVMGR
HHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EGPTIQMGGNLGQMLGELFRLTRRRRDTLIAAGSAAGLAAAFNAPLAGVLFVMEEMRNQF
CCCEEEECCCHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHH
NYSFTNFKMVVICCVMATIVLHLIIGSQPAIQMEVFELPTLGSLWLFFVFGILMGLAGLL
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
FNVTLMRTVGWLDKQNPKNKKYYILAVGFLVGYLAYSYPATVGGGYVIISEALTMSPAFS
HHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCEEEEEHHHHCCHHHH
VLCSLIVIRFIMTMLSYSTGVPGGIFAPMLALGTLFGLGFFHLFQWLSMDFSIEPGMFAV
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
AGMGALFAAAVRSPITGVVLVVEMTKNYSLILPLMISCITATIVVQLARNEPIYTQLLER
HHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
TLRLNAK
HHHCCCC
>Mature Secondary Structure 
GKKILILYFVSVLLGILTGAIASLLQLTIQQMDHLLELLFHITESYGLPVGIVSAMISM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
MMLFIAWMMVKYIAPEAAGSGVQEIEGTLLHVRPIFWKRLIPVKFLGGVLSISAKMVMGR
HHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EGPTIQMGGNLGQMLGELFRLTRRRRDTLIAAGSAAGLAAAFNAPLAGVLFVMEEMRNQF
CCCEEEECCCHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHH
NYSFTNFKMVVICCVMATIVLHLIIGSQPAIQMEVFELPTLGSLWLFFVFGILMGLAGLL
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
FNVTLMRTVGWLDKQNPKNKKYYILAVGFLVGYLAYSYPATVGGGYVIISEALTMSPAFS
HHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCEEEEEHHHHCCHHHH
VLCSLIVIRFIMTMLSYSTGVPGGIFAPMLALGTLFGLGFFHLFQWLSMDFSIEPGMFAV
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
AGMGALFAAAVRSPITGVVLVVEMTKNYSLILPLMISCITATIVVQLARNEPIYTQLLER
HHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
TLRLNAK
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA