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The map label for this gene is purC [H]

Identifier: 54294564

GI number: 54294564

Start: 1827120

End: 1828058

Strand: Reverse

Name: purC [H]

Synonym: lpl1640

Alternate gene names: 54294564

Gene position: 1828058-1827120 (Counterclockwise)

Preceding gene: 54294565

Following gene: 54294563

Centisome position: 54.64

GC content: 39.4

Gene sequence:

>939_bases
TTGCCTTTTTGCTTAACCGAAACCTCTTTACCTTTCGGCAAAAAGTATAAGGGGAAAGTAAGGGATACCTATGATCTTGG
CGATCAGTTGATTTTAGTAACTACAGATAGACAAAGTGCCTTTGATCGATGTCTTGCTGCTGTACCTTATAAAGGACAAG
TATTGAATTTGACTTCAGTATGGTGGTTTAAAAACACTCAATCGATTGTACCTAACCATTTAATTGCCGTACCTGATCCC
AATGTAGCGATAGCCAAAAAATGCAAAATATTCCCTGTTGAATTTGTTGTTCGTGGGTATATTTCGGGAAGTACAAGTAC
GTCTTTATGGACGCAATACCAAAAAGGGGTTCGTGAGTACTGTGGCATAACATTTCCTGATGGGTTAAGAAAAAATCAAA
AACTTGAGAGCCCAGTGATAACCCCTACTACCAAAGAAACGATCCATGACAGGCCGATTAGCCCACACGAAATCGTCGCA
GAAGGCTGGATGACCCAAGAAGACTGGGATGAAACCAGCAGTTATGCTTTAAGGTTATTTCAACATGGAATGGAAGTAGC
TCAGCAACATGGTTTGATTTTGGTGGATACCAAATATGAATTTGGCCGTGATGCGGAAGGAAGAATTGTATTAGTGGATG
AAATTCATACTCCAGATTCCAGTCGTTATTGGTTATTTAACGGCTATCAAGAGCGATTTGATGCGGGTAAGGAGCCGGAG
AATATAGATAAAGAATTTTTGCGCTTGTGGTTTGTTGATCACTGCGATCCTTATAAGGATGAAGTATTGCCTCAAGCACC
ACAGGAGTTAATTGTTACTTTAGCATCAAGATATATCCAACTATATGAAATGATTACAGGTGAATCGTTTGTGTATGACA
GTAATCCTGGGCCAGTAAATGATAGGATTTTGCATAACATACAACATTGGTTAGGTTAA

Upstream 100 bases:

>100_bases
TTGGCAGAATCCATTTTAGCTACTAATATTATCTTTAACCCTAATGCTCATATCTGCTATGAATACCAATGTCCCTAGTC
AAGAGGAGCTTTTTGCTGCG

Downstream 100 bases:

>100_bases
TTTTTAGCCGGGGGAAAGGCTTATGTGTGGCATTGTAGGAATTTACAGTCATGAACCCGTTGCTGCTGAGCTTTATGATA
GCTTGATTCATTTACAGCAC

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MPFCLTETSLPFGKKYKGKVRDTYDLGDQLILVTTDRQSAFDRCLAAVPYKGQVLNLTSVWWFKNTQSIVPNHLIAVPDP
NVAIAKKCKIFPVEFVVRGYISGSTSTSLWTQYQKGVREYCGITFPDGLRKNQKLESPVITPTTKETIHDRPISPHEIVA
EGWMTQEDWDETSSYALRLFQHGMEVAQQHGLILVDTKYEFGRDAEGRIVLVDEIHTPDSSRYWLFNGYQERFDAGKEPE
NIDKEFLRLWFVDHCDPYKDEVLPQAPQELIVTLASRYIQLYEMITGESFVYDSNPGPVNDRILHNIQHWLG

Sequences:

>Translated_312_residues
MPFCLTETSLPFGKKYKGKVRDTYDLGDQLILVTTDRQSAFDRCLAAVPYKGQVLNLTSVWWFKNTQSIVPNHLIAVPDP
NVAIAKKCKIFPVEFVVRGYISGSTSTSLWTQYQKGVREYCGITFPDGLRKNQKLESPVITPTTKETIHDRPISPHEIVA
EGWMTQEDWDETSSYALRLFQHGMEVAQQHGLILVDTKYEFGRDAEGRIVLVDEIHTPDSSRYWLFNGYQERFDAGKEPE
NIDKEFLRLWFVDHCDPYKDEVLPQAPQELIVTLASRYIQLYEMITGESFVYDSNPGPVNDRILHNIQHWLG
>Mature_311_residues
PFCLTETSLPFGKKYKGKVRDTYDLGDQLILVTTDRQSAFDRCLAAVPYKGQVLNLTSVWWFKNTQSIVPNHLIAVPDPN
VAIAKKCKIFPVEFVVRGYISGSTSTSLWTQYQKGVREYCGITFPDGLRKNQKLESPVITPTTKETIHDRPISPHEIVAE
GWMTQEDWDETSSYALRLFQHGMEVAQQHGLILVDTKYEFGRDAEGRIVLVDEIHTPDSSRYWLFNGYQERFDAGKEPEN
IDKEFLRLWFVDHCDPYKDEVLPQAPQELIVTLASRYIQLYEMITGESFVYDSNPGPVNDRILHNIQHWLG

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6319326, Length=299, Percent_Identity=33.7792642140468, Blast_Score=145, Evalue=1e-35,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 35911; Mature: 35780

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFCLTETSLPFGKKYKGKVRDTYDLGDQLILVTTDRQSAFDRCLAAVPYKGQVLNLTSV
CCEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCEEEEEEEE
WWFKNTQSIVPNHLIAVPDPNVAIAKKCKIFPVEFVVRGYISGSTSTSLWTQYQKGVREY
EEECCCCHHCCCCEEECCCCCEEEHHHCEECHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
CGITFPDGLRKNQKLESPVITPTTKETIHDRPISPHEIVAEGWMTQEDWDETSSYALRLF
CCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHH
QHGMEVAQQHGLILVDTKYEFGRDAEGRIVLVDEIHTPDSSRYWLFNGYQERFDAGKEPE
HHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCCEEEECCHHHHHCCCCCCC
NIDKEFLRLWFVDHCDPYKDEVLPQAPQELIVTLASRYIQLYEMITGESFVYDSNPGPVN
HHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCH
DRILHNIQHWLG
HHHHHHHHHHCC
>Mature Secondary Structure 
PFCLTETSLPFGKKYKGKVRDTYDLGDQLILVTTDRQSAFDRCLAAVPYKGQVLNLTSV
CEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCEEEEEEEE
WWFKNTQSIVPNHLIAVPDPNVAIAKKCKIFPVEFVVRGYISGSTSTSLWTQYQKGVREY
EEECCCCHHCCCCEEECCCCCEEEHHHCEECHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
CGITFPDGLRKNQKLESPVITPTTKETIHDRPISPHEIVAEGWMTQEDWDETSSYALRLF
CCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHH
QHGMEVAQQHGLILVDTKYEFGRDAEGRIVLVDEIHTPDSSRYWLFNGYQERFDAGKEPE
HHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCCEEEECCHHHHHCCCCCCC
NIDKEFLRLWFVDHCDPYKDEVLPQAPQELIVTLASRYIQLYEMITGESFVYDSNPGPVN
HHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCH
DRILHNIQHWLG
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA