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The map label for this gene is bioA [H]

Identifier: 54294488

GI number: 54294488

Start: 1734058

End: 1735392

Strand: Direct

Name: bioA [H]

Synonym: lpl1557

Alternate gene names: 54294488

Gene position: 1734058-1735392 (Clockwise)

Preceding gene: 54294478

Following gene: 54294490

Centisome position: 51.83

GC content: 38.8

Gene sequence:

>1335_bases
ATGGTAAACACAGATCAACTGATTGCAAAAGATTTAAAGCACATTTGGCATCCTTGTTCACAAATGAAAGATTTCGAAAC
ATTCCCCCCTATCGTTGTCAACAAAGCACAAGGTAGCTATCTCTATACCAATAAGGGCCCTGTGATTGATGCAATTTCCA
GTTGGTGGTGCAAATCATTAGGGCATGGTCATCCAGCAGTGATAGCTGCTATCAAGAACCAACTGGACTGTTTTGAACAT
GTGATTGGTGCCAATACAACTCATACTGCTGCAGTGGAATTAGCTGAAAAATTAAGCGAAATTACAGGAAAACAGCATGT
GTTTTTTGCCAGTGATGGTTCCAGTGCTGTTGAAATTGCCATGAAATTAGCTATTCATGCTTCACAAATAAAAGGGCACA
AAAATAAAAACCAATTCATTGCCTTAAAAAATGGCTACCACGGAGAAACTATTGGCACCATGAGTGTCAGTGATTTGGGA
CTCTATAAGACTCCCTATGCATCGTTTGGCGTGCAATGCCATTACATCGATGATATTCCCTATGTCTCAGGCCTTAAGGA
TCCCTTATGGACAAATTGCGATGCTTATTGGAATAACGTCGTACAACAATTGAATAAAATTTGCGATAAAGTTTGCGCGA
TACTTCTGGAGCCTATCATTCAGGGTGCTGGAGGTATGCTATGTTACAGTGCAGATTTTCTCTCAAAAATCTCGTCATGG
GCTAAGGAAAAAGACATTTATTTAATTGCTGATGAGATTATGACTGGTATAGGCAGAACTGGAGAATGGCTAGCCTGTGA
TCATGCAAGGATACAACCTGATCTGATTTGTCTATCAAAAGGATTAACTTCCGGCTCAATACCATTTAGCTGTGTCATGA
TTGACAGTGCCTTATTTGATCTTTTTTATGATGATTACCATACAGGGAAATCTTTTTTGCACTCACATACCTATAGCGGT
AATCCACTTGCTATAGTCGCTGCTTTAGCAACTATTAAAACAATAGAACAAGATAATTTACTCATGCATAGCCAGGAACT
TGGTAAAATCATGTTTTCCTATCTGCAGGATATAGCAAGGGACAGTAGAAAACTTGTAAATGTTCGTGGTGTTGGAGCAG
TTGTTGCGGCTGATCTCATAGAGAGCAGTCAGGCAAGAATTGGATTTAAAATTTATCAGGAAGCAATAAAACAAGGCGCA
CTGATTCGCCCAATTGGAAATACTCTCTATTGGTTACCACCTCTTAACACAGATAAAGAAATCATTGGGAAATTAGCAGA
AATCACATTAAACTCTATAGAAAAAGCCTATAACAAAGCTCAAGGATATGAGTAA

Upstream 100 bases:

>100_bases
TTGACCACTGTTTTTTTTCTTCAGACACGGCTACCCCCTTTAATTCAGAATAGTGAACATGATAAAGTCGCGCCTATACT
TGTCAACCAAAATTTTTAAA

Downstream 100 bases:

>100_bases
GGTTATTCACAAATAGTTTAAAGACAAATCGGTTCGCCAATCTAACCTAACTCTTCTTTCGTTTGAATCTAAACTGGGCA
CTATGTTGACGACAAAATCA

Product: adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MVNTDQLIAKDLKHIWHPCSQMKDFETFPPIVVNKAQGSYLYTNKGPVIDAISSWWCKSLGHGHPAVIAAIKNQLDCFEH
VIGANTTHTAAVELAEKLSEITGKQHVFFASDGSSAVEIAMKLAIHASQIKGHKNKNQFIALKNGYHGETIGTMSVSDLG
LYKTPYASFGVQCHYIDDIPYVSGLKDPLWTNCDAYWNNVVQQLNKICDKVCAILLEPIIQGAGGMLCYSADFLSKISSW
AKEKDIYLIADEIMTGIGRTGEWLACDHARIQPDLICLSKGLTSGSIPFSCVMIDSALFDLFYDDYHTGKSFLHSHTYSG
NPLAIVAALATIKTIEQDNLLMHSQELGKIMFSYLQDIARDSRKLVNVRGVGAVVAADLIESSQARIGFKIYQEAIKQGA
LIRPIGNTLYWLPPLNTDKEIIGKLAEITLNSIEKAYNKAQGYE

Sequences:

>Translated_444_residues
MVNTDQLIAKDLKHIWHPCSQMKDFETFPPIVVNKAQGSYLYTNKGPVIDAISSWWCKSLGHGHPAVIAAIKNQLDCFEH
VIGANTTHTAAVELAEKLSEITGKQHVFFASDGSSAVEIAMKLAIHASQIKGHKNKNQFIALKNGYHGETIGTMSVSDLG
LYKTPYASFGVQCHYIDDIPYVSGLKDPLWTNCDAYWNNVVQQLNKICDKVCAILLEPIIQGAGGMLCYSADFLSKISSW
AKEKDIYLIADEIMTGIGRTGEWLACDHARIQPDLICLSKGLTSGSIPFSCVMIDSALFDLFYDDYHTGKSFLHSHTYSG
NPLAIVAALATIKTIEQDNLLMHSQELGKIMFSYLQDIARDSRKLVNVRGVGAVVAADLIESSQARIGFKIYQEAIKQGA
LIRPIGNTLYWLPPLNTDKEIIGKLAEITLNSIEKAYNKAQGYE
>Mature_444_residues
MVNTDQLIAKDLKHIWHPCSQMKDFETFPPIVVNKAQGSYLYTNKGPVIDAISSWWCKSLGHGHPAVIAAIKNQLDCFEH
VIGANTTHTAAVELAEKLSEITGKQHVFFASDGSSAVEIAMKLAIHASQIKGHKNKNQFIALKNGYHGETIGTMSVSDLG
LYKTPYASFGVQCHYIDDIPYVSGLKDPLWTNCDAYWNNVVQQLNKICDKVCAILLEPIIQGAGGMLCYSADFLSKISSW
AKEKDIYLIADEIMTGIGRTGEWLACDHARIQPDLICLSKGLTSGSIPFSCVMIDSALFDLFYDDYHTGKSFLHSHTYSG
NPLAIVAALATIKTIEQDNLLMHSQELGKIMFSYLQDIARDSRKLVNVRGVGAVVAADLIESSQARIGFKIYQEAIKQGA
LIRPIGNTLYWLPPLNTDKEIIGKLAEITLNSIEKAYNKAQGYE

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=438, Percent_Identity=27.6255707762557, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI284507298, Length=322, Percent_Identity=29.1925465838509, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI13994255, Length=378, Percent_Identity=25.3968253968254, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI24119277, Length=439, Percent_Identity=25.9681093394077, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI37574042, Length=387, Percent_Identity=24.2894056847545, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI226442709, Length=339, Percent_Identity=23.598820058997, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI226442705, Length=387, Percent_Identity=23.5142118863049, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1786991, Length=425, Percent_Identity=34.3529411764706, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI145693181, Length=373, Percent_Identity=30.0268096514745, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1787560, Length=381, Percent_Identity=30.1837270341207, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1788044, Length=395, Percent_Identity=27.8481012658228, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1789759, Length=382, Percent_Identity=28.2722513089005, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1789016, Length=420, Percent_Identity=28.0952380952381, Blast_Score=139, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI25144271, Length=409, Percent_Identity=26.4058679706601, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71992977, Length=389, Percent_Identity=26.7352185089974, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI32564660, Length=445, Percent_Identity=26.0674157303371, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI25144274, Length=320, Percent_Identity=27.5, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324386, Length=472, Percent_Identity=29.8728813559322, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6323470, Length=422, Percent_Identity=28.9099526066351, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6324432, Length=421, Percent_Identity=25.41567695962, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6321456, Length=400, Percent_Identity=23, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357415, Length=407, Percent_Identity=25.0614250614251, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI161085790, Length=442, Percent_Identity=26.0180995475113, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI28574759, Length=420, Percent_Identity=25.952380952381, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21356575, Length=396, Percent_Identity=24.7474747474747, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI281366494, Length=382, Percent_Identity=22.7748691099476, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24667139, Length=382, Percent_Identity=22.7748691099476, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24667143, Length=382, Percent_Identity=22.7748691099476, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 48980; Mature: 48980

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNTDQLIAKDLKHIWHPCSQMKDFETFPPIVVNKAQGSYLYTNKGPVIDAISSWWCKSL
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEECCCCHHHHHHHHHHHHH
GHGHPAVIAAIKNQLDCFEHVIGANTTHTAAVELAEKLSEITGKQHVFFASDGSSAVEIA
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHH
MKLAIHASQIKGHKNKNQFIALKNGYHGETIGTMSVSDLGLYKTPYASFGVQCHYIDDIP
HHHHHHHHHHCCCCCCCCEEEEECCCCCCEEECEECCCCCCCCCCCHHHCEEEEEECCCC
YVSGLKDPLWTNCDAYWNNVVQQLNKICDKVCAILLEPIIQGAGGMLCYSADFLSKISSW
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHH
AKEKDIYLIADEIMTGIGRTGEWLACDHARIQPDLICLSKGLTSGSIPFSCVMIDSALFD
HHHCCEEEEHHHHHHHCCCCCCEEEECCCCCCCHHHHHHCCCCCCCCCEEEEHHHHHHHH
LFYDDYHTGKSFLHSHTYSGNPLAIVAALATIKTIEQDNLLMHSQELGKIMFSYLQDIAR
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
DSRKLVNVRGVGAVVAADLIESSQARIGFKIYQEAIKQGALIRPIGNTLYWLPPLNTDKE
HHHHEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCEEECCCCCCCHH
IIGKLAEITLNSIEKAYNKAQGYE
HHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVNTDQLIAKDLKHIWHPCSQMKDFETFPPIVVNKAQGSYLYTNKGPVIDAISSWWCKSL
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEECCCCHHHHHHHHHHHHH
GHGHPAVIAAIKNQLDCFEHVIGANTTHTAAVELAEKLSEITGKQHVFFASDGSSAVEIA
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHH
MKLAIHASQIKGHKNKNQFIALKNGYHGETIGTMSVSDLGLYKTPYASFGVQCHYIDDIP
HHHHHHHHHHCCCCCCCCEEEEECCCCCCEEECEECCCCCCCCCCCHHHCEEEEEECCCC
YVSGLKDPLWTNCDAYWNNVVQQLNKICDKVCAILLEPIIQGAGGMLCYSADFLSKISSW
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHH
AKEKDIYLIADEIMTGIGRTGEWLACDHARIQPDLICLSKGLTSGSIPFSCVMIDSALFD
HHHCCEEEEHHHHHHHCCCCCCEEEECCCCCCCHHHHHHCCCCCCCCCEEEEHHHHHHHH
LFYDDYHTGKSFLHSHTYSGNPLAIVAALATIKTIEQDNLLMHSQELGKIMFSYLQDIAR
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
DSRKLVNVRGVGAVVAADLIESSQARIGFKIYQEAIKQGALIRPIGNTLYWLPPLNTDKE
HHHHEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCEEECCCCCCCHH
IIGKLAEITLNSIEKAYNKAQGYE
HHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]