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The map label for this gene is mutH [H]

Identifier: 54294479

GI number: 54294479

Start: 1724119

End: 1724793

Strand: Reverse

Name: mutH [H]

Synonym: lpl1548

Alternate gene names: 54294479

Gene position: 1724793-1724119 (Counterclockwise)

Preceding gene: 54294480

Following gene: 54294476

Centisome position: 51.55

GC content: 37.78

Gene sequence:

>675_bases
GTGATTTTAGCCTTAAAAAACAAACCACCGAAGAATGAAAAAGAACTTTTGGAGCAATGCCAACGAATTGAGGGGTTGAG
TTTCGCTCAGTTAGCTCTTGAATTAGGTTTATTTACCCCTGTAAACCCTGTGCATCGAAAAGGATGGGTTGGACAAGCTC
TCGAGTTAGCTTTAGGTGCTGATGCAAAAAATGAGTCGCTACCTGATTTCAAGCATTTGGGCATTGAATTAAAAACGATA
CCTATTAATAAATCAGGGAAACCGGCTGAGTCCACATTTATTGTTTCTATTCCACTACTGACCATTCATCAACAAAGTTG
GGAGTCTTCTCAATGTTACGCTAAATTAAAAAAGGTATTATGGATTCCTATAGAGGGAGATACAGATATTCCCTTTCCTC
ACAGAAGAATTGGATGTGGGTTTTTATGGTCTCCGAATAAAGATCAGGAATCTGTTCTTGCAGAAGATTGGAATTATTTA
ACAAATCAAATAGTTCTGGGACAATTAGAAACATTAAATTCTTCTTCGGGAGAGTATCTTCAAGTGAGGCCTAAGGCTGC
CAATGGAAAATCTTTATGTTATGGTTATGACCCAGAGGGTAATCGTATAAGAACGTTACCACGAGGATTTTATTTACGCT
CCTGTTTTACATCCGTAATTTTAAGTCAATCCTGA

Upstream 100 bases:

>100_bases
GTAAGGTCAAAAGTCTTGTTTGCCATAACTGCACAGTTTAAAGCGGCAGGAATACAGCCGCCAATTGAGCCTATTACTGT
TGAACTAAAAGAGAGCTCCA

Downstream 100 bases:

>100_bases
TTTTAAGGATAAATTAAGCACCATCTGTTTACCAGTATTATGATAAATTTTACAGATATTAGGGAAAGCTCATTATAGCT
TTTGTCTATTAGTATACATG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: Methyl-directed mismatch repair protein [H]

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MILALKNKPPKNEKELLEQCQRIEGLSFAQLALELGLFTPVNPVHRKGWVGQALELALGADAKNESLPDFKHLGIELKTI
PINKSGKPAESTFIVSIPLLTIHQQSWESSQCYAKLKKVLWIPIEGDTDIPFPHRRIGCGFLWSPNKDQESVLAEDWNYL
TNQIVLGQLETLNSSSGEYLQVRPKAANGKSLCYGYDPEGNRIRTLPRGFYLRSCFTSVILSQS

Sequences:

>Translated_224_residues
MILALKNKPPKNEKELLEQCQRIEGLSFAQLALELGLFTPVNPVHRKGWVGQALELALGADAKNESLPDFKHLGIELKTI
PINKSGKPAESTFIVSIPLLTIHQQSWESSQCYAKLKKVLWIPIEGDTDIPFPHRRIGCGFLWSPNKDQESVLAEDWNYL
TNQIVLGQLETLNSSSGEYLQVRPKAANGKSLCYGYDPEGNRIRTLPRGFYLRSCFTSVILSQS
>Mature_224_residues
MILALKNKPPKNEKELLEQCQRIEGLSFAQLALELGLFTPVNPVHRKGWVGQALELALGADAKNESLPDFKHLGIELKTI
PINKSGKPAESTFIVSIPLLTIHQQSWESSQCYAKLKKVLWIPIEGDTDIPFPHRRIGCGFLWSPNKDQESVLAEDWNYL
TNQIVLGQLETLNSSSGEYLQVRPKAANGKSLCYGYDPEGNRIRTLPRGFYLRSCFTSVILSQS

Specific function: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair [H]

COG id: COG3066

COG function: function code L; DNA mismatch repair protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mutH family [H]

Homologues:

Organism=Escherichia coli, GI1789196, Length=215, Percent_Identity=48.3720930232558, Blast_Score=219, Evalue=1e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004230
- InterPro:   IPR011337
- InterPro:   IPR011335 [H]

Pfam domain/function: PF02976 MutH [H]

EC number: NA

Molecular weight: Translated: 25106; Mature: 25106

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILALKNKPPKNEKELLEQCQRIEGLSFAQLALELGLFTPVNPVHRKGWVGQALELALGA
CEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHCCC
DAKNESLPDFKHLGIELKTIPINKSGKPAESTFIVSIPLLTIHQQSWESSQCYAKLKKVL
CCCCCCCCCHHHCCEEEEEEECCCCCCCCCCEEEEEEEEEEEECCCCCCHHHHHHHHHEE
WIPIEGDTDIPFPHRRIGCGFLWSPNKDQESVLAEDWNYLTNQIVLGQLETLNSSSGEYL
EEECCCCCCCCCCCHHCCCCEEECCCCCHHHHHHHHHHHHHHHHEEEEHHHCCCCCCCEE
QVRPKAANGKSLCYGYDPEGNRIRTLPRGFYLRSCFTSVILSQS
EEEECCCCCCEEEEEECCCCCEEEECCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MILALKNKPPKNEKELLEQCQRIEGLSFAQLALELGLFTPVNPVHRKGWVGQALELALGA
CEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHCCC
DAKNESLPDFKHLGIELKTIPINKSGKPAESTFIVSIPLLTIHQQSWESSQCYAKLKKVL
CCCCCCCCCHHHCCEEEEEEECCCCCCCCCCEEEEEEEEEEEECCCCCCHHHHHHHHHEE
WIPIEGDTDIPFPHRRIGCGFLWSPNKDQESVLAEDWNYLTNQIVLGQLETLNSSSGEYL
EEECCCCCCCCCCCHHCCCCEEECCCCCHHHHHHHHHHHHHHHHEEEEHHHCCCCCCCEE
QVRPKAANGKSLCYGYDPEGNRIRTLPRGFYLRSCFTSVILSQS
EEEECCCCCCEEEEEECCCCCEEEECCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA