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The map label for this gene is kefC [H]

Identifier: 54294450

GI number: 54294450

Start: 1691388

End: 1692560

Strand: Direct

Name: kefC [H]

Synonym: lpl1519

Alternate gene names: 54294450

Gene position: 1691388-1692560 (Clockwise)

Preceding gene: 54294449

Following gene: 54294451

Centisome position: 50.55

GC content: 38.7

Gene sequence:

>1173_bases
ATGCATGATGGCTCTGTATTTTACACTATATTTCTTATATTTGCTGGAGCTGCTTTTTTTTCTACCTTGGTATTGTACAC
CAAACAGTCATTATTGGTTGCTTATATAACACTTGGTGCTATCTTAGGTCCTTGGGGATTCAAGCTTGTATCCGATGTGA
CGGTTGTCAAACAGATAGGTGACATCGGAATAGTATTCTTGCTTTTCTTATTAGGTTTGCATTTGCAGCCCCAGAATTTG
ATTCATATGCTAAGAAAAGTAACCTGGATTGCAATCGTAAGCTCAATTCTGTTTGCTGCACTTGCCTACGGAATTGGCAG
ATGGTTTGGCCTCACGGTGACTGAGTCCTTGATATTGGGCGGAGCCATGATGTTTTCAAGTACTATTATTGGCTTGAAAT
TATTACCAACAACCATTTTACATCACCAGCATACTGGTGAAGTCATGATTAGCGTACTCCTAATGCAGGACGTTATAGCC
ATAGTGCTTTTGATATTACTTAATAGTGCCCATCAGGATGGGAACCTGTCAATCAATGATTTCATCCTGGTTATTATCGC
GCTACCGGCCCTGTGCTTGTTCTCTTTTTTATTTGAAAGATACATCCTGATAAAACTGCTGGCACGTTTTGATAGAACTC
AGGAATACGTTTTTCTACTCTCCATAGGATGGTGTTTGGGGATATCCGTTTTAGCACAAACAATAGGCTTATCAGAAGAT
ATTGGCGCTTTTATAGCAGGAGTAGCTTTGGCATCAAGCCCAATTTCATTGTTTATTGCTGAAAGTTTAAAGCCATTAAG
AGATTTTTTCCTTGTCATGTTCTTTTTTTCGATAGGTGCTACTTTTAATTTTGGATTTGGAGCTCAGGTAGTTATCCCGG
CGGTGATATTAGCAACATTGATACTGATTATTAAGCCGTTGCTATTTTATATATTGCTTGCCCGTTCTGGTGAGAAAAAA
CAAGTGGCAAAAGAAGTAGGAATTCGCTTGGGGCAGGGGAGTGAGTTTTCTTTATTGGTTGCGAGCATCGCTTTGAGTGC
AAATCTGATTTCAGAAGTCGCCTCCAATTTAATCCAGGCAACTACTATTTTAACTTTTATCGTTTCATCGTATCTTGTTG
TATTGAAATATCCAACACCTATAGCTTTATCTGAAAAAATGCGTAAGGATTAA

Upstream 100 bases:

>100_bases
TTATTAATAAACAATAATTAATAGCTAATTAATAGATTAATGGATAAAATTGGCTTTATAATTCAATTTTAACTACCTTT
TCTTAAGAGGTATTCAATCG

Downstream 100 bases:

>100_bases
TCAAATGAAATTACTGGTAATAGTATTATGCTTGCTCAGTGAGCGGTTTTTAATCCATTCAGTGTCCTATCAGCGATTTT
CCTGGTTTAATAACTACTGC

Product: hypothetical protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MHDGSVFYTIFLIFAGAAFFSTLVLYTKQSLLVAYITLGAILGPWGFKLVSDVTVVKQIGDIGIVFLLFLLGLHLQPQNL
IHMLRKVTWIAIVSSILFAALAYGIGRWFGLTVTESLILGGAMMFSSTIIGLKLLPTTILHHQHTGEVMISVLLMQDVIA
IVLLILLNSAHQDGNLSINDFILVIIALPALCLFSFLFERYILIKLLARFDRTQEYVFLLSIGWCLGISVLAQTIGLSED
IGAFIAGVALASSPISLFIAESLKPLRDFFLVMFFFSIGATFNFGFGAQVVIPAVILATLILIIKPLLFYILLARSGEKK
QVAKEVGIRLGQGSEFSLLVASIALSANLISEVASNLIQATTILTFIVSSYLVVLKYPTPIALSEKMRKD

Sequences:

>Translated_390_residues
MHDGSVFYTIFLIFAGAAFFSTLVLYTKQSLLVAYITLGAILGPWGFKLVSDVTVVKQIGDIGIVFLLFLLGLHLQPQNL
IHMLRKVTWIAIVSSILFAALAYGIGRWFGLTVTESLILGGAMMFSSTIIGLKLLPTTILHHQHTGEVMISVLLMQDVIA
IVLLILLNSAHQDGNLSINDFILVIIALPALCLFSFLFERYILIKLLARFDRTQEYVFLLSIGWCLGISVLAQTIGLSED
IGAFIAGVALASSPISLFIAESLKPLRDFFLVMFFFSIGATFNFGFGAQVVIPAVILATLILIIKPLLFYILLARSGEKK
QVAKEVGIRLGQGSEFSLLVASIALSANLISEVASNLIQATTILTFIVSSYLVVLKYPTPIALSEKMRKD
>Mature_390_residues
MHDGSVFYTIFLIFAGAAFFSTLVLYTKQSLLVAYITLGAILGPWGFKLVSDVTVVKQIGDIGIVFLLFLLGLHLQPQNL
IHMLRKVTWIAIVSSILFAALAYGIGRWFGLTVTESLILGGAMMFSSTIIGLKLLPTTILHHQHTGEVMISVLLMQDVIA
IVLLILLNSAHQDGNLSINDFILVIIALPALCLFSFLFERYILIKLLARFDRTQEYVFLLSIGWCLGISVLAQTIGLSED
IGAFIAGVALASSPISLFIAESLKPLRDFFLVMFFFSIGATFNFGFGAQVVIPAVILATLILIIKPLLFYILLARSGEKK
QVAKEVGIRLGQGSEFSLLVASIALSANLISEVASNLIQATTILTFIVSSYLVVLKYPTPIALSEKMRKD

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=349, Percent_Identity=26.647564469914, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1786232, Length=363, Percent_Identity=26.9972451790634, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1789749, Length=371, Percent_Identity=27.2237196765499, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1786685, Length=366, Percent_Identity=27.8688524590164, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 42609; Mature: 42609

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDGSVFYTIFLIFAGAAFFSTLVLYTKQSLLVAYITLGAILGPWGFKLVSDVTVVKQIG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
DIGIVFLLFLLGLHLQPQNLIHMLRKVTWIAIVSSILFAALAYGIGRWFGLTVTESLILG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAMMFSSTIIGLKLLPTTILHHQHTGEVMISVLLMQDVIAIVLLILLNSAHQDGNLSIND
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
FILVIIALPALCLFSFLFERYILIKLLARFDRTQEYVFLLSIGWCLGISVLAQTIGLSED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
IGAFIAGVALASSPISLFIAESLKPLRDFFLVMFFFSIGATFNFGFGAQVVIPAVILATL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
ILIIKPLLFYILLARSGEKKQVAKEVGIRLGQGSEFSLLVASIALSANLISEVASNLIQA
HHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TTILTFIVSSYLVVLKYPTPIALSEKMRKD
HHHHHHHHHHHHHHHCCCCCHHHHHHHCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA