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The map label for this gene is gltA [H]

Identifier: 54294301

GI number: 54294301

Start: 1522870

End: 1524141

Strand: Reverse

Name: gltA [H]

Synonym: lpl1366

Alternate gene names: 54294301

Gene position: 1524141-1522870 (Counterclockwise)

Preceding gene: 54294321

Following gene: 54294299

Centisome position: 45.56

GC content: 39.47

Gene sequence:

>1272_bases
ATGACTCAAAAGACAGCGAAACTCAGCATCGATGGGCAAGAGACGATTGATTTACCAATCTATACTCCCACCTTAGGTAA
TGATGTGATTGATATTACCCAGCTTGGTTCACATGGCGTCTTTACCTTTGATCAAGGTTTTTTATCAACTGCCTCCTGTG
AATCAAAAATCACCTATATTGATGGGGATAAAGGCATTTTGTTGTATAGGGGTTATCCTATAGAACAATTGGCAGAAAAA
AAGGACTTTCTTGATGTAAGTTATTTATTACTCAATGGAGAACTACCTAACAAAGAAGAAAAGAAAGCTTTCGTTAGTCT
GATCAACAATCATACTATGGTTCATCAGCAAATGTACCAGTTTTTAAATGGGTTCAGGCGTGACGCTCACCCAATGGCTA
TAATGGTTGGAATTGTGGGGGCTTTGTCTGCTTTTTATCATGAATCCATGGATTTGAATAACGCACAAGACCGTTTTATT
TCCGCAATCAGACTGGTTGCTAAAATGCCTACTTTAGCCGCAATGAGTTATAAATACTCCATTGGCATGCCCTACATGTA
TCCTAAAAATAAAATGTCTTATGCAGAAAATTTTCTTCACATGATGTTTGGTGTTCCATCCGAAGATACTACGCCAGATC
CAGTATTGGTAAGAGCTATGGATACTATTTTTATTCTACATGCTGATCATGAACAAAATGCATCTACATCGACAGTACGT
CTGGCAGGCTCTACCGGAGCTAACCCCTTTGCGTGTATTTCAGCTGGTATAGGGGCTTTATGGGGACCAGCTCATGGTGG
AGCGAATGAAGCCTGCTTAAATATGCTAAAAGAAATAGGCGATGTGAGTCGCATCGATCATTACATTAAACGAGCCAAAG
ATAAAAATGATCCATTCCGTTTAATGGGTTTTGGGCACAGGGTCTATAAAAGCTATGATCCAAGAGCAAAAGTAATGCGT
AAGACCTGTTATGATGTATTAGAAGCCGTTGGAGCAAAAGACGCACCTTTATTTAAATTAGCAATGGAACTTGAACGTAT
TGCTCTTGAAGATGAATATTTCATTGAGAAAAAACTCTACCCGAATGTAGACTTTTACTCAGGATTGACTTTAAGCGCTA
TTGGAATACCAACCAATATGTTCACAGTGATATTTGCTCTAGCCCGCACTGTTGGATGGATGAGTCACTGGATGGAAATG
GTAGCCACCAAGTCACGCATTGGCAGACCTCGCCAATTGTATACTGGTGAAAAAATTCGTGACGTAAAATAA

Upstream 100 bases:

>100_bases
AAAATTACGTTTAATTTGACTGTATGTTGTCATTTTTATATAGTTCCGCGCACTAACGCAATTATGAATGCTTAAAGCAT
GTAAATAATCAGGAGAAGCA

Downstream 100 bases:

>100_bases
AAAATCCAATGTGTTAATCAGTAGCTTGTATTAAACTATAATACGAGCTACTGCAATCTAATTTAATTGCACCAATTTAA
ATATAAGACCAGCCTATGCA

Product: citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MTQKTAKLSIDGQETIDLPIYTPTLGNDVIDITQLGSHGVFTFDQGFLSTASCESKITYIDGDKGILLYRGYPIEQLAEK
KDFLDVSYLLLNGELPNKEEKKAFVSLINNHTMVHQQMYQFLNGFRRDAHPMAIMVGIVGALSAFYHESMDLNNAQDRFI
SAIRLVAKMPTLAAMSYKYSIGMPYMYPKNKMSYAENFLHMMFGVPSEDTTPDPVLVRAMDTIFILHADHEQNASTSTVR
LAGSTGANPFACISAGIGALWGPAHGGANEACLNMLKEIGDVSRIDHYIKRAKDKNDPFRLMGFGHRVYKSYDPRAKVMR
KTCYDVLEAVGAKDAPLFKLAMELERIALEDEYFIEKKLYPNVDFYSGLTLSAIGIPTNMFTVIFALARTVGWMSHWMEM
VATKSRIGRPRQLYTGEKIRDVK

Sequences:

>Translated_423_residues
MTQKTAKLSIDGQETIDLPIYTPTLGNDVIDITQLGSHGVFTFDQGFLSTASCESKITYIDGDKGILLYRGYPIEQLAEK
KDFLDVSYLLLNGELPNKEEKKAFVSLINNHTMVHQQMYQFLNGFRRDAHPMAIMVGIVGALSAFYHESMDLNNAQDRFI
SAIRLVAKMPTLAAMSYKYSIGMPYMYPKNKMSYAENFLHMMFGVPSEDTTPDPVLVRAMDTIFILHADHEQNASTSTVR
LAGSTGANPFACISAGIGALWGPAHGGANEACLNMLKEIGDVSRIDHYIKRAKDKNDPFRLMGFGHRVYKSYDPRAKVMR
KTCYDVLEAVGAKDAPLFKLAMELERIALEDEYFIEKKLYPNVDFYSGLTLSAIGIPTNMFTVIFALARTVGWMSHWMEM
VATKSRIGRPRQLYTGEKIRDVK
>Mature_422_residues
TQKTAKLSIDGQETIDLPIYTPTLGNDVIDITQLGSHGVFTFDQGFLSTASCESKITYIDGDKGILLYRGYPIEQLAEKK
DFLDVSYLLLNGELPNKEEKKAFVSLINNHTMVHQQMYQFLNGFRRDAHPMAIMVGIVGALSAFYHESMDLNNAQDRFIS
AIRLVAKMPTLAAMSYKYSIGMPYMYPKNKMSYAENFLHMMFGVPSEDTTPDPVLVRAMDTIFILHADHEQNASTSTVRL
AGSTGANPFACISAGIGALWGPAHGGANEACLNMLKEIGDVSRIDHYIKRAKDKNDPFRLMGFGHRVYKSYDPRAKVMRK
TCYDVLEAVGAKDAPLFKLAMELERIALEDEYFIEKKLYPNVDFYSGLTLSAIGIPTNMFTVIFALARTVGWMSHWMEMV
ATKSRIGRPRQLYTGEKIRDVK

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=389, Percent_Identity=26.7352185089974, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1786939, Length=423, Percent_Identity=64.0661938534279, Blast_Score=588, Evalue=1e-169,
Organism=Escherichia coli, GI1786527, Length=357, Percent_Identity=32.2128851540616, Blast_Score=162, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17555174, Length=404, Percent_Identity=25.4950495049505, Blast_Score=109, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6319850, Length=358, Percent_Identity=28.2122905027933, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324328, Length=356, Percent_Identity=27.8089887640449, Blast_Score=106, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6325257, Length=400, Percent_Identity=26.5, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24640126, Length=415, Percent_Identity=26.0240963855422, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24640124, Length=415, Percent_Identity=26.0240963855422, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI21356863, Length=397, Percent_Identity=26.7002518891688, Blast_Score=102, Evalue=6e-22,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 47491; Mature: 47360

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQKTAKLSIDGQETIDLPIYTPTLGNDVIDITQLGSHGVFTFDQGFLSTASCESKITYI
CCCCCEEEEECCCCEEECEEECCCCCCCCEEHEECCCCCCEEECCCCCCCCCCCCEEEEE
DGDKGILLYRGYPIEQLAEKKDFLDVSYLLLNGELPNKEEKKAFVSLINNHTMVHQQMYQ
ECCCCEEEECCCCHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHH
FLNGFRRDAHPMAIMVGIVGALSAFYHESMDLNNAQDRFISAIRLVAKMPTLAAMSYKYS
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHEEEEE
IGMPYMYPKNKMSYAENFLHMMFGVPSEDTTPDPVLVRAMDTIFILHADHEQNASTSTVR
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHEEEEEEEEEECCCCCCCCCCEEE
LAGSTGANPFACISAGIGALWGPAHGGANEACLNMLKEIGDVSRIDHYIKRAKDKNDPFR
EECCCCCCHHHHHHHCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
LMGFGHRVYKSYDPRAKVMRKTCYDVLEAVGAKDAPLFKLAMELERIALEDEYFIEKKLY
EEECCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCC
PNVDFYSGLTLSAIGIPTNMFTVIFALARTVGWMSHWMEMVATKSRIGRPRQLYTGEKIR
CCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHC
DVK
CCC
>Mature Secondary Structure 
TQKTAKLSIDGQETIDLPIYTPTLGNDVIDITQLGSHGVFTFDQGFLSTASCESKITYI
CCCCEEEEECCCCEEECEEECCCCCCCCEEHEECCCCCCEEECCCCCCCCCCCCEEEEE
DGDKGILLYRGYPIEQLAEKKDFLDVSYLLLNGELPNKEEKKAFVSLINNHTMVHQQMYQ
ECCCCEEEECCCCHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHH
FLNGFRRDAHPMAIMVGIVGALSAFYHESMDLNNAQDRFISAIRLVAKMPTLAAMSYKYS
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHEEEEE
IGMPYMYPKNKMSYAENFLHMMFGVPSEDTTPDPVLVRAMDTIFILHADHEQNASTSTVR
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHEEEEEEEEEECCCCCCCCCCEEE
LAGSTGANPFACISAGIGALWGPAHGGANEACLNMLKEIGDVSRIDHYIKRAKDKNDPFR
EECCCCCCHHHHHHHCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
LMGFGHRVYKSYDPRAKVMRKTCYDVLEAVGAKDAPLFKLAMELERIALEDEYFIEKKLY
EEECCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCC
PNVDFYSGLTLSAIGIPTNMFTVIFALARTVGWMSHWMEMVATKSRIGRPRQLYTGEKIR
CCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHC
DVK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1756983; 12704232; 7698664 [H]