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The map label for this gene is hutH [H]

Identifier: 54294266

GI number: 54294266

Start: 1489185

End: 1490705

Strand: Direct

Name: hutH [H]

Synonym: lpl1331

Alternate gene names: 54294266

Gene position: 1489185-1490705 (Clockwise)

Preceding gene: 54294265

Following gene: 54294267

Centisome position: 44.51

GC content: 40.76

Gene sequence:

>1521_bases
ATGTCAGAACATTTTATATTGCAGCCCGGGCAATTATCGCTACTTTCTATTAAGCAAATTTTAGATGAGGGTCAATCTTG
TGTTCTTGCTGAGAGCGCTTTTGAATTAATAAACGCTTCTCATCAAACTGTTAGAAAAGTAATTGATGAAAAGAAAACTG
TATATGGAATCAATACAGGTTTTGGTTCTCTGGCGAATCAGACCATTTCTGCAGATTGTTTGAAGGAGTTGCAGCGTAAT
ATTGTGCTTTCTCATGCTTGTGGAACGGGTAAATTATTGCCGGATGACGTGGTAGCCTTGATTTTGCTTTTGAAAATTAA
TAATTTGTCTCAAGGATATTCCGGAGTTAGGCTGGAATTAATTAATGCGTTGATTGCTTTGTTTAATCATAAAGTATATC
CATGCATTCCCTCTAAGGGTTCGGTAGGTGCGTCCGGAGATTTAGTCCCGCTTGCGCATTTGTCTTTGCCTTTGTTAGGG
GAAGGCGAAGTAAGACATCAAGGTCAGTTGATCAGTGCTGAGGAAGGACTAAAACTGGCTGGATTGAAACCGCTTGAATT
GGAAGCTAAAGAAGGATTAGCACTGCTTAATGGCTTACAGGTATCTACCGCTTTAGCTTTGTCAGCTCTGTTTATTAGTG
AGACATTGTTTGAAACTGCGATTATTTCCGGCAGTTTATCAGTAGATGCTGCCAGCGGGAGTGATGTCCCCTTTGATGAC
AGAATACACCAAACTCGAGGACATCAAGCTCAAATTTCTGCTGCCAGTATGTACAGAAATTTATTGGCAGGTAGTCAAAT
TCGAGAGTCACACAGGCATTGTAATCGTGTTCAGGACCCTTATTCTTTAAGATGTCAGCCACAAATCATGGGTGCAGTTC
TTCATCAGATGCAGTTTGTTGGACAAACTCTCCAAGTAGAGGCCAATGCAATTTCTGATAATCCTCTCGTTTTTGCAGAG
CAGGGGGATATTTTGTCTGGGGGAAATTTTCATGGTGAAATCATCGCAATGGCTGCTGACAATTTAGCATTGGCATTGTC
CGAGATAGGAGGTAGTGCAGAACGGCGAATCGCTTTATTAATTGATAAAAATTTTAGTGGATTGCCTGCTTTCCTGGTTA
GAGAAAGCGGCTTAAATTCAGGGTTTATGATTGCCCATGTTACTGCCGCCTCCTGTGCCAGTGATAACAAAGCACTTGCT
CATCCGCACTCCGTTGATAGTTTGCCTACCTCGGCAAATCAGGAAGATCATGTTTCTATGGCAACTAGCGCAGCACGTCG
ATTGCATGAAATGATCGATAATACTTCAACAATTCTTGCTATTGAGTTATTGGCAGCTTGTCAAGGGCTGGAGTTTCATA
AACCTCTAAAGACATCACCGCAATTGGACAAAATTTATCAAAGCGTAAGAAGCGTGGTTAAAGAGTATGATAAAGATCGC
TATTTTGCACCTGATATAGAAAAAATTAAAAAGAAGATTTTGGATAAAGAATTCTCATTGCTCACACTCACGAACGAATA
G

Upstream 100 bases:

>100_bases
GGGGTAATGAGGCATGCTGATGCAGGTTATCAAATTGCCAGGCAATGTGCCAAAGAGAACTCGCTTTGGCTACCCATGGA
ATCTTAAAAGGAGCCTGTTT

Downstream 100 bases:

>100_bases
CAGGAAAAATACAATGGAATTGATGGCAGAATTTCTAACTTTGCATCAACAACACAAAAACAATCCTTATCCTTCTTTGT
CTGAAAGAAAAAAATTGCTG

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MSEHFILQPGQLSLLSIKQILDEGQSCVLAESAFELINASHQTVRKVIDEKKTVYGINTGFGSLANQTISADCLKELQRN
IVLSHACGTGKLLPDDVVALILLLKINNLSQGYSGVRLELINALIALFNHKVYPCIPSKGSVGASGDLVPLAHLSLPLLG
EGEVRHQGQLISAEEGLKLAGLKPLELEAKEGLALLNGLQVSTALALSALFISETLFETAIISGSLSVDAASGSDVPFDD
RIHQTRGHQAQISAASMYRNLLAGSQIRESHRHCNRVQDPYSLRCQPQIMGAVLHQMQFVGQTLQVEANAISDNPLVFAE
QGDILSGGNFHGEIIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAFLVRESGLNSGFMIAHVTAASCASDNKALA
HPHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELLAACQGLEFHKPLKTSPQLDKIYQSVRSVVKEYDKDR
YFAPDIEKIKKKILDKEFSLLTLTNE

Sequences:

>Translated_506_residues
MSEHFILQPGQLSLLSIKQILDEGQSCVLAESAFELINASHQTVRKVIDEKKTVYGINTGFGSLANQTISADCLKELQRN
IVLSHACGTGKLLPDDVVALILLLKINNLSQGYSGVRLELINALIALFNHKVYPCIPSKGSVGASGDLVPLAHLSLPLLG
EGEVRHQGQLISAEEGLKLAGLKPLELEAKEGLALLNGLQVSTALALSALFISETLFETAIISGSLSVDAASGSDVPFDD
RIHQTRGHQAQISAASMYRNLLAGSQIRESHRHCNRVQDPYSLRCQPQIMGAVLHQMQFVGQTLQVEANAISDNPLVFAE
QGDILSGGNFHGEIIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAFLVRESGLNSGFMIAHVTAASCASDNKALA
HPHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELLAACQGLEFHKPLKTSPQLDKIYQSVRSVVKEYDKDR
YFAPDIEKIKKKILDKEFSLLTLTNE
>Mature_505_residues
SEHFILQPGQLSLLSIKQILDEGQSCVLAESAFELINASHQTVRKVIDEKKTVYGINTGFGSLANQTISADCLKELQRNI
VLSHACGTGKLLPDDVVALILLLKINNLSQGYSGVRLELINALIALFNHKVYPCIPSKGSVGASGDLVPLAHLSLPLLGE
GEVRHQGQLISAEEGLKLAGLKPLELEAKEGLALLNGLQVSTALALSALFISETLFETAIISGSLSVDAASGSDVPFDDR
IHQTRGHQAQISAASMYRNLLAGSQIRESHRHCNRVQDPYSLRCQPQIMGAVLHQMQFVGQTLQVEANAISDNPLVFAEQ
GDILSGGNFHGEIIAMAADNLALALSEIGGSAERRIALLIDKNFSGLPAFLVRESGLNSGFMIAHVTAASCASDNKALAH
PHSVDSLPTSANQEDHVSMATSAARRLHEMIDNTSTILAIELLAACQGLEFHKPLKTSPQLDKIYQSVRSVVKEYDKDRY
FAPDIEKIKKKILDKEFSLLTLTNE

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=474, Percent_Identity=47.6793248945148, Blast_Score=432, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17567831, Length=498, Percent_Identity=44.1767068273092, Blast_Score=382, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 54587; Mature: 54456

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHFILQPGQLSLLSIKQILDEGQSCVLAESAFELINASHQTVRKVIDEKKTVYGINTG
CCCCEECCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCC
FGSLANQTISADCLKELQRNIVLSHACGTGKLLPDDVVALILLLKINNLSQGYSGVRLEL
CHHHHCCHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHH
INALIALFNHKVYPCIPSKGSVGASGDLVPLAHLSLPLLGEGEVRHQGQLISAEEGLKLA
HHHHHHHHCCCCEECCCCCCCCCCCCCEEEHHHCCCCCCCCCCCCCCCCEEECCCCCEEC
GLKPLELEAKEGLALLNGLQVSTALALSALFISETLFETAIISGSLSVDAASGSDVPFDD
CCCCCCCCHHCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCH
RIHQTRGHQAQISAASMYRNLLAGSQIRESHRHCNRVQDPYSLRCQPQIMGAVLHQMQFV
HHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
GQTLQVEANAISDNPLVFAEQGDILSGGNFHGEIIAMAADNLALALSEIGGSAERRIALL
CCCEEEEEEECCCCCEEEEECCCEECCCCCCCEEEEEECCCHHHHHHHHCCCCCCEEEEE
IDKNFSGLPAFLVRESGLNSGFMIAHVTAASCASDNKALAHPHSVDSLPTSANQEDHVSM
EECCCCCCCHHHEECCCCCCCEEEEEEEHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHH
ATSAARRLHEMIDNTSTILAIELLAACQGLEFHKPLKTSPQLDKIYQSVRSVVKEYDKDR
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
YFAPDIEKIKKKILDKEFSLLTLTNE
CCCCCHHHHHHHHHCCCCEEEEEECC
>Mature Secondary Structure 
SEHFILQPGQLSLLSIKQILDEGQSCVLAESAFELINASHQTVRKVIDEKKTVYGINTG
CCCEECCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCC
FGSLANQTISADCLKELQRNIVLSHACGTGKLLPDDVVALILLLKINNLSQGYSGVRLEL
CHHHHCCHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHH
INALIALFNHKVYPCIPSKGSVGASGDLVPLAHLSLPLLGEGEVRHQGQLISAEEGLKLA
HHHHHHHHCCCCEECCCCCCCCCCCCCEEEHHHCCCCCCCCCCCCCCCCEEECCCCCEEC
GLKPLELEAKEGLALLNGLQVSTALALSALFISETLFETAIISGSLSVDAASGSDVPFDD
CCCCCCCCHHCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCH
RIHQTRGHQAQISAASMYRNLLAGSQIRESHRHCNRVQDPYSLRCQPQIMGAVLHQMQFV
HHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
GQTLQVEANAISDNPLVFAEQGDILSGGNFHGEIIAMAADNLALALSEIGGSAERRIALL
CCCEEEEEEECCCCCEEEEECCCEECCCCCCCEEEEEECCCHHHHHHHHCCCCCCEEEEE
IDKNFSGLPAFLVRESGLNSGFMIAHVTAASCASDNKALAHPHSVDSLPTSANQEDHVSM
EECCCCCCCHHHEECCCCCCCEEEEEEEHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHH
ATSAARRLHEMIDNTSTILAIELLAACQGLEFHKPLKTSPQLDKIYQSVRSVVKEYDKDR
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
YFAPDIEKIKKKILDKEFSLLTLTNE
CCCCCHHHHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA