| Definition | Legionella pneumophila str. Lens, complete genome. |
|---|---|
| Accession | NC_006369 |
| Length | 3,345,687 |
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The map label for this gene is ftsI [H]
Identifier: 54293891
GI number: 54293891
Start: 1058128
End: 1059789
Strand: Direct
Name: ftsI [H]
Synonym: lpl0947
Alternate gene names: 54293891
Gene position: 1058128-1059789 (Clockwise)
Preceding gene: 54293890
Following gene: 54293892
Centisome position: 31.63
GC content: 40.43
Gene sequence:
>1662_bases ATGAAAAAAACACACCATTTTGCCAGGCTGGTTACTGTCGCTGTTTTTTTCTCTTTGATTTTGGCTATTTTGATATGGAG AATGGTTGATCTCACTGTTCTGCATCGACAATTTTTGCAGGGCCAGGGTGATGCGCGCAGCATCCGAGTTATAGATATTC CTGCCTATCGAGGTATGATTACCGATAGAAATGGTACTCCGCTTGCTGTGAGCACACCTGTTGAATCGGTTTGGGTCAAT CCAAAGGAATTTTCTCCGGATGAAGAACAATTTATGCAGTTAGCTAAATACCTGAATTTGGCACCTAAAGAATTAAGTAG AAAAATTGTCCGGGCTGAAAGTCGGGAGTTTGTTTATTTACAAAGACAGTTACCTCCACCCCTTTCGAAAAAGATCGAAG CTTTAAAAATCCCAGGTGTTAATTTTCAAAAAGAATTCAAACGTTATTATCCAGATTCAGATAGTATTTCCCCATTAATT GGATTTACCAATGTCGATGATCAAGGATTGGAGGGGATTGAGCTGGCTTATCAAGATTGGCTTATGGGAGTCGTTGGTAA AAAAAGAGTAATCAAAGATCGATTAGGACGAGTTGTCGAAGATCTGGGAGTTTTGAAGGAACCACGCCCGGGACATGAGT TAACTTTGAGTATAGATAGACGACTACAATATTTAGCTTATAGCGAATTAGGTAAAACAGTCGAAGAGTTTTCTGCTAAA TCCGGGTCTGTAGTTGTAATCGATGCTGAAAATGGCGAGATCCTGGCTGTGGCTAATGTTCCATCTTATAATCCTAACGC ACGTGGGCATTATGATAAGGAAACCTACCGCAACAGAGCCTTCACCGATACTTTCGAGCCTGGGTCTGTCATTAAATCAT TCAGTATCGCCAGTGCATTGGAAACAGGCTTATTTACTCCGGATACCATTATTGATACTAATCCAGGATGGATGACTGTT CATGGCCGAACAGTAAGAGATATCCATAATTATGGTGTTTTAGATGTTACCGGAATATTACAACATTCCAGTAATGTGGG TGTTACAAAAATGGTATTATCCACTCCAGCTGAGCAATTAATCGGGTTTTTGCAAAAATGTGGTTTTGGGCAACGCTCTG AGTTGGCATACCCGGGTGAAAGTGAAGGAGGCATAGTAAAAGCCAAGGATGCAAACCCATTCGTTTTAGCCACATTAGGT TTCGGTTATGGTTTGTCTGTTACTGCACTGCAATTGGCTAAAGCCAATTTAATTTTTGCAAATAAAGGACGATTAATACC TGTGACTTTGATTCACAATGATACCCCCAGTAATGGCATTCAAGTGATGGAACCTAAAACCGCTGAAAATGTATTATTAA TGATGGAAGCGGTAATGAATAAGGGTACAGGTAAGGGAGCAAGGGTTCCTGGTTATAGAGTAGCTGGAAAAACTGGAACA GCACGAGTTGCCGGAAAGAATGGATATAAAGACAGGAAATACACAGCCAGTTTTATTGGGATAGCACCAGTTTCCAAACC AAAATTTGTAGTTGTTGTTATTATTCATGAACCTTCACGAAAGGGTTATTATGCTGCCTCTGTGGCAGGACCTTTATTTG CGAAAGTCATGTCAGGTGCTTTACGCTTATTCAATATTCCTACTGATGAGCCAGTTAGTTAA
Upstream 100 bases:
>100_bases TATGTTTAACTCTAAGGTAATTTTGAGGAAGAGGCTTCAAGTATATTTTCACTAATTTATTGTTGCGTGCATAGTTAATA CTATTTATGAGTAGTCATAT
Downstream 100 bases:
>100_bases AGAGAATAGGAGCCAATTTTGTGAAACTAACCCAATTATTAGAACCGTGGATTAAAAGGGACATTATTGATGGCACTGTT AGTGACATAAAAAATGACAG
Product: peptidoglycan synthetase FtsI precursor
Products: NA
Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]
Number of amino acids: Translated: 553; Mature: 553
Protein sequence:
>553_residues MKKTHHFARLVTVAVFFSLILAILIWRMVDLTVLHRQFLQGQGDARSIRVIDIPAYRGMITDRNGTPLAVSTPVESVWVN PKEFSPDEEQFMQLAKYLNLAPKELSRKIVRAESREFVYLQRQLPPPLSKKIEALKIPGVNFQKEFKRYYPDSDSISPLI GFTNVDDQGLEGIELAYQDWLMGVVGKKRVIKDRLGRVVEDLGVLKEPRPGHELTLSIDRRLQYLAYSELGKTVEEFSAK SGSVVVIDAENGEILAVANVPSYNPNARGHYDKETYRNRAFTDTFEPGSVIKSFSIASALETGLFTPDTIIDTNPGWMTV HGRTVRDIHNYGVLDVTGILQHSSNVGVTKMVLSTPAEQLIGFLQKCGFGQRSELAYPGESEGGIVKAKDANPFVLATLG FGYGLSVTALQLAKANLIFANKGRLIPVTLIHNDTPSNGIQVMEPKTAENVLLMMEAVMNKGTGKGARVPGYRVAGKTGT ARVAGKNGYKDRKYTASFIGIAPVSKPKFVVVVIIHEPSRKGYYAASVAGPLFAKVMSGALRLFNIPTDEPVS
Sequences:
>Translated_553_residues MKKTHHFARLVTVAVFFSLILAILIWRMVDLTVLHRQFLQGQGDARSIRVIDIPAYRGMITDRNGTPLAVSTPVESVWVN PKEFSPDEEQFMQLAKYLNLAPKELSRKIVRAESREFVYLQRQLPPPLSKKIEALKIPGVNFQKEFKRYYPDSDSISPLI GFTNVDDQGLEGIELAYQDWLMGVVGKKRVIKDRLGRVVEDLGVLKEPRPGHELTLSIDRRLQYLAYSELGKTVEEFSAK SGSVVVIDAENGEILAVANVPSYNPNARGHYDKETYRNRAFTDTFEPGSVIKSFSIASALETGLFTPDTIIDTNPGWMTV HGRTVRDIHNYGVLDVTGILQHSSNVGVTKMVLSTPAEQLIGFLQKCGFGQRSELAYPGESEGGIVKAKDANPFVLATLG FGYGLSVTALQLAKANLIFANKGRLIPVTLIHNDTPSNGIQVMEPKTAENVLLMMEAVMNKGTGKGARVPGYRVAGKTGT ARVAGKNGYKDRKYTASFIGIAPVSKPKFVVVVIIHEPSRKGYYAASVAGPLFAKVMSGALRLFNIPTDEPVS >Mature_553_residues MKKTHHFARLVTVAVFFSLILAILIWRMVDLTVLHRQFLQGQGDARSIRVIDIPAYRGMITDRNGTPLAVSTPVESVWVN PKEFSPDEEQFMQLAKYLNLAPKELSRKIVRAESREFVYLQRQLPPPLSKKIEALKIPGVNFQKEFKRYYPDSDSISPLI GFTNVDDQGLEGIELAYQDWLMGVVGKKRVIKDRLGRVVEDLGVLKEPRPGHELTLSIDRRLQYLAYSELGKTVEEFSAK SGSVVVIDAENGEILAVANVPSYNPNARGHYDKETYRNRAFTDTFEPGSVIKSFSIASALETGLFTPDTIIDTNPGWMTV HGRTVRDIHNYGVLDVTGILQHSSNVGVTKMVLSTPAEQLIGFLQKCGFGQRSELAYPGESEGGIVKAKDANPFVLATLG FGYGLSVTALQLAKANLIFANKGRLIPVTLIHNDTPSNGIQVMEPKTAENVLLMMEAVMNKGTGKGARVPGYRVAGKTGT ARVAGKNGYKDRKYTASFIGIAPVSKPKFVVVVIIHEPSRKGYYAASVAGPLFAKVMSGALRLFNIPTDEPVS
Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]
COG id: COG0768
COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2
Gene ontology:
Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI1786272, Length=547, Percent_Identity=40.2193784277879, Blast_Score=403, Evalue=1e-113, Organism=Escherichia coli, GI1786854, Length=596, Percent_Identity=25.3355704697987, Blast_Score=134, Evalue=2e-32,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR005311 - InterPro: IPR001460 [H]
Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]
EC number: =2.4.1.129 [H]
Molecular weight: Translated: 60884; Mature: 60884
Theoretical pI: Translated: 9.83; Mature: 9.83
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.2 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 2.4 %Cys+Met (Translated Protein) 0.2 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 2.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKKTHHFARLVTVAVFFSLILAILIWRMVDLTVLHRQFLQGQGDARSIRVIDIPAYRGMI CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEE TDRNGTPLAVSTPVESVWVNPKEFSPDEEQFMQLAKYLNLAPKELSRKIVRAESREFVYL ECCCCCCEEEECCHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEE QRQLPPPLSKKIEALKIPGVNFQKEFKRYYPDSDSISPLIGFTNVDDQGLEGIELAYQDW ECCCCCCHHHCCCEEECCCCCHHHHHHHHCCCCCCCCCEEEECCCCCCCCCHHHHHHHHH LMGVVGKKRVIKDRLGRVVEDLGVLKEPRPGHELTLSIDRRLQYLAYSELGKTVEEFSAK HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCC SGSVVVIDAENGEILAVANVPSYNPNARGHYDKETYRNRAFTDTFEPGSVIKSFSIASAL CCCEEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHH ETGLFTPDTIIDTNPGWMTVHGRTVRDIHNYGVLDVTGILQHSSNVGVTKMVLSTPAEQL HHCCCCCCCEEECCCCEEEECCCHHHHHHCCCCEEEHHHHHCCCCCCHHHHHHHCCHHHH IGFLQKCGFGQRSELAYPGESEGGIVKAKDANPFVLATLGFGYGLSVTALQLAKANLIFA HHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHCEEEEE NKGRLIPVTLIHNDTPSNGIQVMEPKTAENVLLMMEAVMNKGTGKGARVPGYRVAGKTGT CCCCEEEEEEEECCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCC ARVAGKNGYKDRKYTASFIGIAPVSKPKFVVVVIIHEPSRKGYYAASVAGPLFAKVMSGA EEECCCCCCCCCCEEEEEEEECCCCCCCEEEEEEEECCCCCCEEEEHHHHHHHHHHHHCC LRLFNIPTDEPVS EEEEECCCCCCCC >Mature Secondary Structure MKKTHHFARLVTVAVFFSLILAILIWRMVDLTVLHRQFLQGQGDARSIRVIDIPAYRGMI CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEE TDRNGTPLAVSTPVESVWVNPKEFSPDEEQFMQLAKYLNLAPKELSRKIVRAESREFVYL ECCCCCCEEEECCHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEE QRQLPPPLSKKIEALKIPGVNFQKEFKRYYPDSDSISPLIGFTNVDDQGLEGIELAYQDW ECCCCCCHHHCCCEEECCCCCHHHHHHHHCCCCCCCCCEEEECCCCCCCCCHHHHHHHHH LMGVVGKKRVIKDRLGRVVEDLGVLKEPRPGHELTLSIDRRLQYLAYSELGKTVEEFSAK HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCC SGSVVVIDAENGEILAVANVPSYNPNARGHYDKETYRNRAFTDTFEPGSVIKSFSIASAL CCCEEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHH ETGLFTPDTIIDTNPGWMTVHGRTVRDIHNYGVLDVTGILQHSSNVGVTKMVLSTPAEQL HHCCCCCCCEEECCCCEEEECCCHHHHHHCCCCEEEHHHHHCCCCCCHHHHHHHCCHHHH IGFLQKCGFGQRSELAYPGESEGGIVKAKDANPFVLATLGFGYGLSVTALQLAKANLIFA HHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHCEEEEE NKGRLIPVTLIHNDTPSNGIQVMEPKTAENVLLMMEAVMNKGTGKGARVPGYRVAGKTGT CCCCEEEEEEEECCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCC ARVAGKNGYKDRKYTASFIGIAPVSKPKFVVVVIIHEPSRKGYYAASVAGPLFAKVMSGA EEECCCCCCCCCCEEEEEEEECCCCCCCEEEEEEEECCCCCCEEEEHHHHHHHHHHHHCC LRLFNIPTDEPVS EEEEECCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]