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The map label for this gene is mmgC [H]

Identifier: 54293844

GI number: 54293844

Start: 1010810

End: 1011964

Strand: Direct

Name: mmgC [H]

Synonym: lpl0900

Alternate gene names: 54293844

Gene position: 1010810-1011964 (Clockwise)

Preceding gene: 54293841

Following gene: 54293845

Centisome position: 30.21

GC content: 42.16

Gene sequence:

>1155_bases
ATGCATTTTAATTTCACTGATGAACATTTGGCATTTCGAGAAATGGCCTCCGAGTTTGCTCGTAACAAACTGGCTCCAAT
GGCAGATTTCTGGGATGAACAAGGTTACTTTCCAATCGAAATTTTAAGAGAAGCGGCGCAATTAGGTATGGCGGGAATGG
TAGTCCGCGAAGATATAGGAGGTGCTCAGCTCTCTCGTCTGGATGCAGCACTCATCTTTGAACAACTCGCTACGGGCTGT
ATTCCAACAAGCGCATATCTCTCCATCCATAATATGGTCGCTTCATTGGTCGACCGCTATGGCAGCCAAGAGATTCGCAA
GAAATGGGGGCCAAAATTAACCAGTATGGAAGTGATAGCCAGTTATTGTCTTACAGAGCCAGAATCCGGATCTGATGCAG
CCTCTTTAAAAACTCGCGCGGTAAAAGAGGGTGAATATTATGTTCTTAATGGTGCGAAAGCATTCATATCGGGTGGAAGT
GTTAGTGATGTGTATTTATGTATGGTACGTACTGGCGATGAATCTCATCATGGCATCAGTTGTTTGTTAATTGAAAAGAA
TACTCCTGGTCTGACATTTGGCAAACTGGAGAAAAAATTAGGTTGGCGAAATCAGCCAACTTGTATGCTATATTTTGAAA
ATTGTCGTGTGCCCATTGCCAATCGTGTTGGTGAAGAAGGTATGGGTTTTAAAATTGCACTGAATGCCTTAAACGGAGGG
AGAGTAAATATTGCTTCCTGCTCATTGGGAGGGGCTCTTGCTTGCCTGCGAATGAGTCAATCTTATATGCATGAGCGCAA
ACAGTTTGGAAAACCTTTAACTCAGATGCAAGCTCTTCGTTTTTATTTTTCGGATATGTTAACAGATTATGAAGCGGCAA
GGCTGATGGTTTATAGGGCTGCAGCAGCAATGGATAATGATGCCCCCAATGCGCCAATGTATTGTGCGATGGGCAAGCGC
TTGGCTACAGATGTCGCATTTCGTATTAGTGATAAAGCCATGCAATTGCACGGAGGTTATGGCTACCTGAGAGATTATCA
AATTGAAAGAATATTTAGAGATTTAAGAGTTCATCAGATTCTTGAAGGGACTAATGAAATCATGCGTGAAATTATAGCGA
AAGCAAGTTTGGATGAAGAGTATTTTATAGAGTAA

Upstream 100 bases:

>100_bases
TTATCTTTCCTGGGCGCTAAAAATTCGCAATAATATCATTTTTTAAGAAAGCGTCATAAATAAATCCAATGACTAAAATC
AATAAATCTAAGGATGGTCT

Downstream 100 bases:

>100_bases
TCATAGGGGATTATTGATGAATTTAATTGAACAGGATATAGATAATAACGGAATCTTAACTTTAACTTTGAATAGGCCAG
AGAAGCTCAATGCTTTAAGC

Product: hypothetical protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MHFNFTDEHLAFREMASEFARNKLAPMADFWDEQGYFPIEILREAAQLGMAGMVVREDIGGAQLSRLDAALIFEQLATGC
IPTSAYLSIHNMVASLVDRYGSQEIRKKWGPKLTSMEVIASYCLTEPESGSDAASLKTRAVKEGEYYVLNGAKAFISGGS
VSDVYLCMVRTGDESHHGISCLLIEKNTPGLTFGKLEKKLGWRNQPTCMLYFENCRVPIANRVGEEGMGFKIALNALNGG
RVNIASCSLGGALACLRMSQSYMHERKQFGKPLTQMQALRFYFSDMLTDYEAARLMVYRAAAAMDNDAPNAPMYCAMGKR
LATDVAFRISDKAMQLHGGYGYLRDYQIERIFRDLRVHQILEGTNEIMREIIAKASLDEEYFIE

Sequences:

>Translated_384_residues
MHFNFTDEHLAFREMASEFARNKLAPMADFWDEQGYFPIEILREAAQLGMAGMVVREDIGGAQLSRLDAALIFEQLATGC
IPTSAYLSIHNMVASLVDRYGSQEIRKKWGPKLTSMEVIASYCLTEPESGSDAASLKTRAVKEGEYYVLNGAKAFISGGS
VSDVYLCMVRTGDESHHGISCLLIEKNTPGLTFGKLEKKLGWRNQPTCMLYFENCRVPIANRVGEEGMGFKIALNALNGG
RVNIASCSLGGALACLRMSQSYMHERKQFGKPLTQMQALRFYFSDMLTDYEAARLMVYRAAAAMDNDAPNAPMYCAMGKR
LATDVAFRISDKAMQLHGGYGYLRDYQIERIFRDLRVHQILEGTNEIMREIIAKASLDEEYFIE
>Mature_384_residues
MHFNFTDEHLAFREMASEFARNKLAPMADFWDEQGYFPIEILREAAQLGMAGMVVREDIGGAQLSRLDAALIFEQLATGC
IPTSAYLSIHNMVASLVDRYGSQEIRKKWGPKLTSMEVIASYCLTEPESGSDAASLKTRAVKEGEYYVLNGAKAFISGGS
VSDVYLCMVRTGDESHHGISCLLIEKNTPGLTFGKLEKKLGWRNQPTCMLYFENCRVPIANRVGEEGMGFKIALNALNGG
RVNIASCSLGGALACLRMSQSYMHERKQFGKPLTQMQALRFYFSDMLTDYEAARLMVYRAAAAMDNDAPNAPMYCAMGKR
LATDVAFRISDKAMQLHGGYGYLRDYQIERIFRDLRVHQILEGTNEIMREIIAKASLDEEYFIE

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7656849, Length=375, Percent_Identity=53.0666666666667, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI4501859, Length=387, Percent_Identity=36.9509043927649, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI4557233, Length=371, Percent_Identity=38.2749326145553, Blast_Score=252, Evalue=5e-67,
Organism=Homo sapiens, GI4557231, Length=381, Percent_Identity=32.8083989501312, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI187960098, Length=381, Percent_Identity=32.8083989501312, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI21361497, Length=376, Percent_Identity=34.3085106382979, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI4501857, Length=375, Percent_Identity=32, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI4557235, Length=380, Percent_Identity=30, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI76496475, Length=380, Percent_Identity=30, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI226958412, Length=378, Percent_Identity=31.4814814814815, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI226958414, Length=341, Percent_Identity=32.258064516129, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI4503943, Length=379, Percent_Identity=28.7598944591029, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI7669494, Length=354, Percent_Identity=28.8135593220339, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI211971008, Length=292, Percent_Identity=30.8219178082192, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI48976061, Length=292, Percent_Identity=30.8219178082192, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI38505218, Length=393, Percent_Identity=25.9541984732824, Blast_Score=112, Evalue=7e-25,
Organism=Escherichia coli, GI1786223, Length=386, Percent_Identity=28.4974093264249, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI87081958, Length=346, Percent_Identity=28.6127167630058, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI87082384, Length=288, Percent_Identity=28.8194444444444, Blast_Score=92, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17533517, Length=371, Percent_Identity=46.900269541779, Blast_Score=372, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17534899, Length=378, Percent_Identity=35.7142857142857, Blast_Score=254, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI17569725, Length=380, Percent_Identity=34.7368421052632, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=30.9711286089239, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17508101, Length=380, Percent_Identity=32.8947368421053, Blast_Score=218, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI17506239, Length=379, Percent_Identity=32.4538258575198, Blast_Score=215, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI71985184, Length=381, Percent_Identity=31.2335958005249, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17538396, Length=385, Percent_Identity=33.7662337662338, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI71990804, Length=263, Percent_Identity=36.8821292775665, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17551932, Length=380, Percent_Identity=28.6842105263158, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17505929, Length=380, Percent_Identity=28.1578947368421, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71985192, Length=327, Percent_Identity=29.0519877675841, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=34.7826086956522, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=28.8321167883212, Blast_Score=144, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17534353, Length=377, Percent_Identity=27.5862068965517, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17562446, Length=288, Percent_Identity=29.5138888888889, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17531909, Length=247, Percent_Identity=28.7449392712551, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI86563383, Length=318, Percent_Identity=27.0440251572327, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI86563381, Length=318, Percent_Identity=27.0440251572327, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17531913, Length=182, Percent_Identity=29.6703296703297, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24660351, Length=376, Percent_Identity=34.5744680851064, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI21356377, Length=377, Percent_Identity=34.2175066312997, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24666513, Length=372, Percent_Identity=34.9462365591398, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24646207, Length=377, Percent_Identity=35.5437665782493, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI281363737, Length=340, Percent_Identity=34.4117647058824, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI21355753, Length=386, Percent_Identity=31.6062176165803, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI19920834, Length=383, Percent_Identity=26.3707571801567, Blast_Score=131, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 42984; Mature: 42984

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
7.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFNFTDEHLAFREMASEFARNKLAPMADFWDEQGYFPIEILREAAQLGMAGMVVREDIG
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHCCC
GAQLSRLDAALIFEQLATGCIPTSAYLSIHNMVASLVDRYGSQEIRKKWGPKLTSMEVIA
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHH
SYCLTEPESGSDAASLKTRAVKEGEYYVLNGAKAFISGGSVSDVYLCMVRTGDESHHGIS
HHHCCCCCCCCCHHHHHHHHCCCCCEEEEECCEEEECCCCCCEEEEEEEECCCCCCCCEE
CLLIEKNTPGLTFGKLEKKLGWRNQPTCMLYFENCRVPIANRVGEEGMGFKIALNALNGG
EEEEECCCCCCCHHHHHHHCCCCCCCEEEEEEECCCCCHHHHCCCCCCCEEEEEEECCCC
RVNIASCSLGGALACLRMSQSYMHERKQFGKPLTQMQALRFYFSDMLTDYEAARLMVYRA
EEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAAMDNDAPNAPMYCAMGKRLATDVAFRISDKAMQLHGGYGYLRDYQIERIFRDLRVHQI
HHHCCCCCCCCCEEHHHCHHHHHHHHHEECCHHHEEECCCCCHHHHHHHHHHHHHHHHHH
LEGTNEIMREIIAKASLDEEYFIE
HHHHHHHHHHHHHHHCCCHHHCCC
>Mature Secondary Structure
MHFNFTDEHLAFREMASEFARNKLAPMADFWDEQGYFPIEILREAAQLGMAGMVVREDIG
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHCCC
GAQLSRLDAALIFEQLATGCIPTSAYLSIHNMVASLVDRYGSQEIRKKWGPKLTSMEVIA
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHH
SYCLTEPESGSDAASLKTRAVKEGEYYVLNGAKAFISGGSVSDVYLCMVRTGDESHHGIS
HHHCCCCCCCCCHHHHHHHHCCCCCEEEEECCEEEECCCCCCEEEEEEEECCCCCCCCEE
CLLIEKNTPGLTFGKLEKKLGWRNQPTCMLYFENCRVPIANRVGEEGMGFKIALNALNGG
EEEEECCCCCCCHHHHHHHCCCCCCCEEEEEEECCCCCHHHHCCCCCCCEEEEEEECCCC
RVNIASCSLGGALACLRMSQSYMHERKQFGKPLTQMQALRFYFSDMLTDYEAARLMVYRA
EEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAAMDNDAPNAPMYCAMGKRLATDVAFRISDKAMQLHGGYGYLRDYQIERIFRDLRVHQI
HHHCCCCCCCCCEEHHHCHHHHHHHHHEECCHHHEEECCCCCHHHHHHHHHHHHHHHHHH
LEGTNEIMREIIAKASLDEEYFIE
HHHHHHHHHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]