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The map label for this gene is napA [H]

Identifier: 54293783

GI number: 54293783

Start: 954741

End: 956180

Strand: Direct

Name: napA [H]

Synonym: lpl0839

Alternate gene names: 54293783

Gene position: 954741-956180 (Clockwise)

Preceding gene: 54293782

Following gene: 54293784

Centisome position: 28.54

GC content: 39.44

Gene sequence:

>1440_bases
ATGAGTAATTCAAAATGGTGGTTTCTTTTAGTCTTTTTCATTCCTGCTATTACTTTTGCATCTGAGGGGGGAGAGCATTC
AGATCCAGTCACATCTGTTCTTCTGGGTGTTACTACTATTTTATTTTTAGCTATTGTTGGTCGTTATTTAGCCAGGCTCC
TTAATCAACCTGGCGTTCTTGGTGAATTACTGATAGGGATGATAGTTGGGAATCTCTCTTACTTTTTCGGAAGTGAATTA
GTGGTAATTCTTCGCGAAGGCTCTGCCATTTATGATGTTGTCAAAGAAATGTTAGCAGGAATTTCTTTAAATCAGGCGGT
AACTGATGTTATCCATAATTCCTATTATGCTAACCAGGTCATTCATGCCTTAAGTGGGGCAGAGGGAACGGAATATCTTA
AGATTGCCTATGTCGTTGATATTTTTTCACGTTATGGCGTCATATTTCTTCTGTTTATGGTTGGGCTTGAGACGTCTCTT
TCTGATTTAAAGAAAACTGGCAAAGAATCCATTCTCGTTGCGGTGATCGGTATCGTTGCGCCAATGATTTTAGGATTTGC
AGTGGCTTGTTTTATCATACCCAACTCAAATTACAAGATTAATTTATTTATCGGTGCTACCTTGAGTGCGACCAGTATTG
GTATTACAGCGAGTGTTCTTAAAGAGATGAATAAACTGAGTACACGAGAAGCAAGAACAATTCTTGGTGCGGCTACTTTG
GATGATATTTTAGGCCTGATTATTTTGGCGGTAGTCAGCAGTATAGTTATCAGTGGTGCTGTAAGTATCATGGTTGTAAT
GAAAATTATCATTTTAGCCCTACTGTTTTTCATTGGTACCTTGTTTATAGGGCCTTTTGTACTTCGGAAGGCAGTCGATT
TATTTCGTTTTCTGGAGCCTTGGGAATCCAAATTATTTATCTCATTCCTTTTTATTATGGCATTAGCCTGGTTGGCTTCA
TTTATACAGTTGGCGGCTATAATTGGTGCTTTTGCTGCGGGTGTCATTTTGCACGACGACTATTTTGGAGAGCAAAAAGA
CCATCATAAAGATCATCGCAGTATTCATCATTTGGTATCTCCCTTGGAAACTATATTGGCTCCTATGTTTTTTACTCTCA
TTGGGATACAGGTTAAGTTAGAAACTTTTTATGATTGGAATGTCATTGTTTTAGCGGGAGGCTTATCCGTAGCGGCTATT
CTTGGCAAGCTGCTTAGTGGCTTAGGCGCTAATCGACGGGATGATAGGCTGCTCATTGGCATAGGAATGCTGCCTCGTGG
AGAGGTAGGTTTGGTTTTTGCTTCTATTGGCAGAACTATAGGCGTAATAAGTGATAATCTGTTTACCGCAATTGTATTGA
TGATCATGATCACAACCTTTATTGCGCCACCTTTATTAAAGATGCGATATGCCAGACCAAAAGAGGATAGGAATGCATGA

Upstream 100 bases:

>100_bases
CTGTTAGTAATAGAACTACTTGTGATGGTATGGTGTTGCAATTCAAAATTCCCTTGCATTTGGGAGTAAGCAGCTTATTA
AGCTTATAGGATAAAGCGGT

Downstream 100 bases:

>100_bases
ATAATGTTTTATCGCAAGTTACATTTGATGTAAAACGTGCTTTGCAAGAGGACGTGGGCAACGGTGATGTTACTGCGGCT
TTGTTGCCTCAGCAGCTGAT

Product: hypothetical protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MSNSKWWFLLVFFIPAITFASEGGEHSDPVTSVLLGVTTILFLAIVGRYLARLLNQPGVLGELLIGMIVGNLSYFFGSEL
VVILREGSAIYDVVKEMLAGISLNQAVTDVIHNSYYANQVIHALSGAEGTEYLKIAYVVDIFSRYGVIFLLFMVGLETSL
SDLKKTGKESILVAVIGIVAPMILGFAVACFIIPNSNYKINLFIGATLSATSIGITASVLKEMNKLSTREARTILGAATL
DDILGLIILAVVSSIVISGAVSIMVVMKIIILALLFFIGTLFIGPFVLRKAVDLFRFLEPWESKLFISFLFIMALAWLAS
FIQLAAIIGAFAAGVILHDDYFGEQKDHHKDHRSIHHLVSPLETILAPMFFTLIGIQVKLETFYDWNVIVLAGGLSVAAI
LGKLLSGLGANRRDDRLLIGIGMLPRGEVGLVFASIGRTIGVISDNLFTAIVLMIMITTFIAPPLLKMRYARPKEDRNA

Sequences:

>Translated_479_residues
MSNSKWWFLLVFFIPAITFASEGGEHSDPVTSVLLGVTTILFLAIVGRYLARLLNQPGVLGELLIGMIVGNLSYFFGSEL
VVILREGSAIYDVVKEMLAGISLNQAVTDVIHNSYYANQVIHALSGAEGTEYLKIAYVVDIFSRYGVIFLLFMVGLETSL
SDLKKTGKESILVAVIGIVAPMILGFAVACFIIPNSNYKINLFIGATLSATSIGITASVLKEMNKLSTREARTILGAATL
DDILGLIILAVVSSIVISGAVSIMVVMKIIILALLFFIGTLFIGPFVLRKAVDLFRFLEPWESKLFISFLFIMALAWLAS
FIQLAAIIGAFAAGVILHDDYFGEQKDHHKDHRSIHHLVSPLETILAPMFFTLIGIQVKLETFYDWNVIVLAGGLSVAAI
LGKLLSGLGANRRDDRLLIGIGMLPRGEVGLVFASIGRTIGVISDNLFTAIVLMIMITTFIAPPLLKMRYARPKEDRNA
>Mature_478_residues
SNSKWWFLLVFFIPAITFASEGGEHSDPVTSVLLGVTTILFLAIVGRYLARLLNQPGVLGELLIGMIVGNLSYFFGSELV
VILREGSAIYDVVKEMLAGISLNQAVTDVIHNSYYANQVIHALSGAEGTEYLKIAYVVDIFSRYGVIFLLFMVGLETSLS
DLKKTGKESILVAVIGIVAPMILGFAVACFIIPNSNYKINLFIGATLSATSIGITASVLKEMNKLSTREARTILGAATLD
DILGLIILAVVSSIVISGAVSIMVVMKIIILALLFFIGTLFIGPFVLRKAVDLFRFLEPWESKLFISFLFIMALAWLASF
IQLAAIIGAFAAGVILHDDYFGEQKDHHKDHRSIHHLVSPLETILAPMFFTLIGIQVKLETFYDWNVIVLAGGLSVAAIL
GKLLSGLGANRRDDRLLIGIGMLPRGEVGLVFASIGRTIGVISDNLFTAIVLMIMITTFIAPPLLKMRYARPKEDRNA

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6322367, Length=410, Percent_Identity=25.1219512195122, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 52178; Mature: 52047

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSKWWFLLVFFIPAITFASEGGEHSDPVTSVLLGVTTILFLAIVGRYLARLLNQPGVL
CCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
GELLIGMIVGNLSYFFGSELVVILREGSAIYDVVKEMLAGISLNQAVTDVIHNSYYANQV
HHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
IHALSGAEGTEYLKIAYVVDIFSRYGVIFLLFMVGLETSLSDLKKTGKESILVAVIGIVA
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
PMILGFAVACFIIPNSNYKINLFIGATLSATSIGITASVLKEMNKLSTREARTILGAATL
HHHHHHHHHHHEEECCCEEEEEEEECEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DDILGLIILAVVSSIVISGAVSIMVVMKIIILALLFFIGTLFIGPFVLRKAVDLFRFLEP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WESKLFISFLFIMALAWLASFIQLAAIIGAFAAGVILHDDYFGEQKDHHKDHRSIHHLVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHH
PLETILAPMFFTLIGIQVKLETFYDWNVIVLAGGLSVAAILGKLLSGLGANRRDDRLLIG
HHHHHHHHHHHHHHHHHEEEEEEECCEEEEEECCHHHHHHHHHHHHHCCCCCCCCEEEEE
IGMLPRGEVGLVFASIGRTIGVISDNLFTAIVLMIMITTFIAPPLLKMRYARPKEDRNA
ECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SNSKWWFLLVFFIPAITFASEGGEHSDPVTSVLLGVTTILFLAIVGRYLARLLNQPGVL
CCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
GELLIGMIVGNLSYFFGSELVVILREGSAIYDVVKEMLAGISLNQAVTDVIHNSYYANQV
HHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
IHALSGAEGTEYLKIAYVVDIFSRYGVIFLLFMVGLETSLSDLKKTGKESILVAVIGIVA
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
PMILGFAVACFIIPNSNYKINLFIGATLSATSIGITASVLKEMNKLSTREARTILGAATL
HHHHHHHHHHHEEECCCEEEEEEEECEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DDILGLIILAVVSSIVISGAVSIMVVMKIIILALLFFIGTLFIGPFVLRKAVDLFRFLEP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WESKLFISFLFIMALAWLASFIQLAAIIGAFAAGVILHDDYFGEQKDHHKDHRSIHHLVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHH
PLETILAPMFFTLIGIQVKLETFYDWNVIVLAGGLSVAAILGKLLSGLGANRRDDRLLIG
HHHHHHHHHHHHHHHHHEEEEEEECCEEEEEECCHHHHHHHHHHHHHCCCCCCCCEEEEE
IGMLPRGEVGLVFASIGRTIGVISDNLFTAIVLMIMITTFIAPPLLKMRYARPKEDRNA
ECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]