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The map label for this gene is wzt [H]

Identifier: 54293758

GI number: 54293758

Start: 920989

End: 922413

Strand: Direct

Name: wzt [H]

Synonym: lpl0814

Alternate gene names: 54293758

Gene position: 920989-922413 (Clockwise)

Preceding gene: 54293757

Following gene: 54293759

Centisome position: 27.53

GC content: 37.19

Gene sequence:

>1425_bases
ATGAGTTGGTCTATTCGTATTGAAAACCTTTCCAAACAATATCGGATTGGTAGTACTACTACAACCGCAGCAGAGCTGAT
TAATGAAAAATTGAGAAAATTTCTTTTATTACTGGATTTTAAAAAAAGGAATCGATTTTCATCCGATAAGCCACTGCCTT
CATCCATTGCACAAGAAGGTAGAACTGTAGTCGATGCAAGTCAAATTAGCCCGGAATATCCCAATCATTTCTGGGCTTTG
CGGGATATTAATCTTGAAATCAAGGCAGGGGAGCGGCTTGGTATAGTAGGACAAAATGGTTGCGGTAAGAGCACATTATT
AAAAATTCTATCACGTATTGTTTCTCCAACCGAAGGGTTATTCCGATTTAGGGGGCGCTTAATCAGTTTGTTGGAAATCG
GTACAGGATTTCATGGTGAACTGACTGGACGTGAAAATATTTTTTTAAATGGCACTATTATGGGAATGAAAACCCATGAA
ATTAAAAATCGACTCAATCAAATTATTGAATTTTCTGAATTGGGATCAATGATAGATACTCCTGTCAAGCGCTACTCTTC
AGGAATGTATATCCGCTTGGCATTTGCTGTAGCTGCTCATTTGGAGTCTGAAATCCTTATAGTTGATGAAGTGTTAGCGG
TAGGTGATGCAGCATTTCAACGCAAGTGTACGGAAAAAATGCTGGATTTAGCAAATCAGGGAAGAACTTTATTATTTGTC
AGTCACGATATGGAAACCGTGAATCGAATTTGTAATAGAGCCATACGAATGTCGCATGGCAGAATTGTCGGTGACAGTAA
ATTTGATACAAGTGCAGCAAGCAAAAGTTCAGTCATGGATATCACTCGCGACTATCTCCGCTCAGGAGCGAAATATAAAT
CGGAACAAGTTTGGCCTAGTGATAAGCCAATGATATTTTTAAATTCCCTTAAGCTTAACCGGGTTAGATTGATAGATTAC
GACAATAAAGTTCGTTCTAATTTTAATTTAAATGAAACTATTGTTGTTGAAATAGATTTTACAATTATTAAAGAAACATA
CCCTTTTAATATTCATCTTTATCTTAAGGACAGCTCTGGGCGTGTGATATTTGTGTCAATGGATAATCATGCCTGGCAAT
CTAAGAAAGTACGCCCATTAGGAAATTATACCGAACGATGTACTTTGTATTCACCCTTATTAAACATTGGCGATTATCAT
ATTGATATTGAATTTTGGCCAGGTAATGCTTTGGAAAACCGATTGGTAGTCAATTCAGTAGTCAGCTTCGAGCTGAAAGA
TGGAGCTGTAAATGAGGGGGTAAGAGGCAATTGGGCTTCTGATTGGCCAAACTCATTGATTAGACCACAGTTGGATTGGA
GTATTTCGACAAATAAGAAACAGGATCTTGTTTTAAAAGATCATGAATTAGTCACTGAAAAGTAA

Upstream 100 bases:

>100_bases
CACCTACTATAATAATGACATTATCTGGTATGGCAATTATAACTTTCCTTGTGGGGCTTGTTGCATTTCATCACATGGAG
CATAAGGTCGTTGATATTTT

Downstream 100 bases:

>100_bases
TCAACATGAACAAATATGGTGGTGCAATCATTTTACTCTCTTTTCCCCATCAATTAATTCATGCTCTTGCAGCATTATTT
ACTGATAGAGAGCAGCGCAG

Product: ABC transporter of LPS O-antigen, Wzt

Products: ADP; phosphate; S2O32- [Cytoplasm]; SO42- [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MSWSIRIENLSKQYRIGSTTTTAAELINEKLRKFLLLLDFKKRNRFSSDKPLPSSIAQEGRTVVDASQISPEYPNHFWAL
RDINLEIKAGERLGIVGQNGCGKSTLLKILSRIVSPTEGLFRFRGRLISLLEIGTGFHGELTGRENIFLNGTIMGMKTHE
IKNRLNQIIEFSELGSMIDTPVKRYSSGMYIRLAFAVAAHLESEILIVDEVLAVGDAAFQRKCTEKMLDLANQGRTLLFV
SHDMETVNRICNRAIRMSHGRIVGDSKFDTSAASKSSVMDITRDYLRSGAKYKSEQVWPSDKPMIFLNSLKLNRVRLIDY
DNKVRSNFNLNETIVVEIDFTIIKETYPFNIHLYLKDSSGRVIFVSMDNHAWQSKKVRPLGNYTERCTLYSPLLNIGDYH
IDIEFWPGNALENRLVVNSVVSFELKDGAVNEGVRGNWASDWPNSLIRPQLDWSISTNKKQDLVLKDHELVTEK

Sequences:

>Translated_474_residues
MSWSIRIENLSKQYRIGSTTTTAAELINEKLRKFLLLLDFKKRNRFSSDKPLPSSIAQEGRTVVDASQISPEYPNHFWAL
RDINLEIKAGERLGIVGQNGCGKSTLLKILSRIVSPTEGLFRFRGRLISLLEIGTGFHGELTGRENIFLNGTIMGMKTHE
IKNRLNQIIEFSELGSMIDTPVKRYSSGMYIRLAFAVAAHLESEILIVDEVLAVGDAAFQRKCTEKMLDLANQGRTLLFV
SHDMETVNRICNRAIRMSHGRIVGDSKFDTSAASKSSVMDITRDYLRSGAKYKSEQVWPSDKPMIFLNSLKLNRVRLIDY
DNKVRSNFNLNETIVVEIDFTIIKETYPFNIHLYLKDSSGRVIFVSMDNHAWQSKKVRPLGNYTERCTLYSPLLNIGDYH
IDIEFWPGNALENRLVVNSVVSFELKDGAVNEGVRGNWASDWPNSLIRPQLDWSISTNKKQDLVLKDHELVTEK
>Mature_473_residues
SWSIRIENLSKQYRIGSTTTTAAELINEKLRKFLLLLDFKKRNRFSSDKPLPSSIAQEGRTVVDASQISPEYPNHFWALR
DINLEIKAGERLGIVGQNGCGKSTLLKILSRIVSPTEGLFRFRGRLISLLEIGTGFHGELTGRENIFLNGTIMGMKTHEI
KNRLNQIIEFSELGSMIDTPVKRYSSGMYIRLAFAVAAHLESEILIVDEVLAVGDAAFQRKCTEKMLDLANQGRTLLFVS
HDMETVNRICNRAIRMSHGRIVGDSKFDTSAASKSSVMDITRDYLRSGAKYKSEQVWPSDKPMIFLNSLKLNRVRLIDYD
NKVRSNFNLNETIVVEIDFTIIKETYPFNIHLYLKDSSGRVIFVSMDNHAWQSKKVRPLGNYTERCTLYSPLLNIGDYHI
DIEFWPGNALENRLVVNSVVSFELKDGAVNEGVRGNWASDWPNSLIRPQLDWSISTNKKQDLVLKDHELVTEK

Specific function: May form an ATP-driven O-antigen export apparatus, in association with RfbA [H]

COG id: COG1134

COG function: function code GM; ABC-type polysaccharide/polyol phosphate transport system, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI31657092, Length=223, Percent_Identity=29.5964125560538, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI27436953, Length=237, Percent_Identity=24.0506329113924, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI153792144, Length=202, Percent_Identity=23.7623762376238, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI47078218, Length=195, Percent_Identity=28.2051282051282, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI45446740, Length=195, Percent_Identity=28.2051282051282, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI27262624, Length=207, Percent_Identity=25.6038647342995, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI27262626, Length=207, Percent_Identity=25.6038647342995, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI6005701, Length=192, Percent_Identity=22.9166666666667, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI27477115, Length=205, Percent_Identity=26.8292682926829, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI105990541, Length=193, Percent_Identity=26.4248704663212, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI21536376, Length=204, Percent_Identity=26.4705882352941, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI30795238, Length=198, Percent_Identity=24.2424242424242, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI42741659, Length=270, Percent_Identity=22.962962962963, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI27881501, Length=198, Percent_Identity=24.2424242424242, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1788761, Length=198, Percent_Identity=28.7878787878788, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786398, Length=203, Percent_Identity=28.0788177339901, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI48994943, Length=262, Percent_Identity=25.9541984732824, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1790467, Length=193, Percent_Identity=30.0518134715026, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87081709, Length=193, Percent_Identity=26.9430051813472, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786319, Length=234, Percent_Identity=25.2136752136752, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789032, Length=203, Percent_Identity=24.6305418719212, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788225, Length=205, Percent_Identity=27.8048780487805, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI87081791, Length=196, Percent_Identity=24.4897959183673, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786253, Length=226, Percent_Identity=27.8761061946903, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87081782, Length=246, Percent_Identity=22.3577235772358, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787547, Length=204, Percent_Identity=26.9607843137255, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788210, Length=206, Percent_Identity=31.0679611650485, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1789672, Length=225, Percent_Identity=25.7777777777778, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI48995001, Length=242, Percent_Identity=24.3801652892562, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1786703, Length=204, Percent_Identity=27.4509803921569, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788897, Length=222, Percent_Identity=23.8738738738739, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787029, Length=210, Percent_Identity=26.6666666666667, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790525, Length=211, Percent_Identity=27.9620853080569, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786653, Length=251, Percent_Identity=27.4900398406374, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1788540, Length=272, Percent_Identity=26.8382352941176, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1786803, Length=200, Percent_Identity=26.5, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1786872, Length=226, Percent_Identity=26.9911504424779, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI1790739, Length=204, Percent_Identity=24.5098039215686, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI1787105, Length=209, Percent_Identity=24.4019138755981, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI1788450, Length=267, Percent_Identity=23.5955056179775, Blast_Score=62, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI193202349, Length=230, Percent_Identity=26.9565217391304, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193209708, Length=201, Percent_Identity=27.8606965174129, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115533608, Length=208, Percent_Identity=23.5576923076923, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17565586, Length=226, Percent_Identity=23.0088495575221, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71983523, Length=195, Percent_Identity=26.1538461538462, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71983516, Length=195, Percent_Identity=26.1538461538462, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71983510, Length=195, Percent_Identity=26.1538461538462, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321121, Length=264, Percent_Identity=25.7575757575758, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI116007184, Length=201, Percent_Identity=24.3781094527363, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221500365, Length=201, Percent_Identity=24.3781094527363, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24666092, Length=216, Percent_Identity=25, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24650853, Length=179, Percent_Identity=27.9329608938547, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: 3.6.3.25 [C]

Molecular weight: Translated: 53943; Mature: 53811

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWSIRIENLSKQYRIGSTTTTAAELINEKLRKFLLLLDFKKRNRFSSDKPLPSSIAQEG
CCEEEEECCCCCCEECCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCHHHHHCC
RTVVDASQISPEYPNHFWALRDINLEIKAGERLGIVGQNGCGKSTLLKILSRIVSPTEGL
CEEEEHHHCCCCCCCCEEEEEEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHCCCHHHH
FRFRGRLISLLEIGTGFHGELTGRENIFLNGTIMGMKTHEIKNRLNQIIEFSELGSMIDT
HHHHHHHHHHHHHCCCCCCEECCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
PVKRYSSGMYIRLAFAVAAHLESEILIVDEVLAVGDAAFQRKCTEKMLDLANQGRTLLFV
HHHHHCCCCEEEEHHHHHHHCCCCEEEEHHHHHHCHHHHHHHHHHHHHHHHCCCCEEEEE
SHDMETVNRICNRAIRMSHGRIVGDSKFDTSAASKSSVMDITRDYLRSGAKYKSEQVWPS
ECCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
DKPMIFLNSLKLNRVRLIDYDNKVRSNFNLNETIVVEIDFTIIKETYPFNIHLYLKDSSG
CCCEEEEECCCCCEEEEEECCCHHHCCCCCCCEEEEEEEEEEEEECCCEEEEEEEECCCC
RVIFVSMDNHAWQSKKVRPLGNYTERCTLYSPLLNIGDYHIDIEFWPGNALENRLVVNSV
CEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEEEE
VSFELKDGAVNEGVRGNWASDWPNSLIRPQLDWSISTNKKQDLVLKDHELVTEK
EEEEECCCCCCCCCCCCCCCCCCHHHCCCCCCEEECCCCCCCEEEECCHHHCCC
>Mature Secondary Structure 
SWSIRIENLSKQYRIGSTTTTAAELINEKLRKFLLLLDFKKRNRFSSDKPLPSSIAQEG
CEEEEECCCCCCEECCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCHHHHHCC
RTVVDASQISPEYPNHFWALRDINLEIKAGERLGIVGQNGCGKSTLLKILSRIVSPTEGL
CEEEEHHHCCCCCCCCEEEEEEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHCCCHHHH
FRFRGRLISLLEIGTGFHGELTGRENIFLNGTIMGMKTHEIKNRLNQIIEFSELGSMIDT
HHHHHHHHHHHHHCCCCCCEECCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
PVKRYSSGMYIRLAFAVAAHLESEILIVDEVLAVGDAAFQRKCTEKMLDLANQGRTLLFV
HHHHHCCCCEEEEHHHHHHHCCCCEEEEHHHHHHCHHHHHHHHHHHHHHHHCCCCEEEEE
SHDMETVNRICNRAIRMSHGRIVGDSKFDTSAASKSSVMDITRDYLRSGAKYKSEQVWPS
ECCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
DKPMIFLNSLKLNRVRLIDYDNKVRSNFNLNETIVVEIDFTIIKETYPFNIHLYLKDSSG
CCCEEEEECCCCCEEEEEECCCHHHCCCCCCCEEEEEEEEEEEEECCCEEEEEEEECCCC
RVIFVSMDNHAWQSKKVRPLGNYTERCTLYSPLLNIGDYHIDIEFWPGNALENRLVVNSV
CEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEEEE
VSFELKDGAVNEGVRGNWASDWPNSLIRPQLDWSISTNKKQDLVLKDHELVTEK
EEEEECCCCCCCCCCCCCCCCCCHHHCCCCCCEEECCCCCCCEEEECCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S2O32- [Periplasm]; H2O; SO42- [Periplasm]; ATP [C]

Specific reaction: ATP + S2O32- [Periplasm] + H2O = ADP + phosphate + S2O32- [Cytoplasm] SO42- [Periplasm] + H2O + ATP = SO42- [Cytoplasm] + phosphate + ADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8626291 [H]