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The map label for this gene is adhc1 [H]

Identifier: 54293595

GI number: 54293595

Start: 698786

End: 699832

Strand: Reverse

Name: adhc1 [H]

Synonym: lpl0647

Alternate gene names: 54293595

Gene position: 699832-698786 (Counterclockwise)

Preceding gene: 54293596

Following gene: 54293593

Centisome position: 20.92

GC content: 42.88

Gene sequence:

>1047_bases
ATGTCAGAAACTATTGGTTATGCTGCCCACAAAGCGGGAGCCCCTTTAAAACCTTTCACTTTTGAACGCCGCCCTGTTGG
TGCACACGACGTAGCAATTGATATTCTATTTTGTGGTATCTGTCATTCCGATTTGCATCAAGTCAATAATGATTGGGCAG
GAGCGTTCTATCCTATGGTTCCTGGACATGAAATCATTGGACGAGTCAAGGAGGTAGGACATCAAGTCCACCGGTTCAAA
GCAGGAGATTTAGTGGGCGTTGGCTGTATGGTTGACTCCTGCCGTCAATGCACCTATTGCCATCAGAATGAAGAACAATA
TTGTAAATCCGGCGCAACCTACACCTATAACAGTCAAGACAATCATCTGGGAGGGGTGACTTACGGGGGATATTCCAAGC
ATGTTGTCGTCACGGAAGATTTTGTATTAAAAATTGATGAATCACTTGATCCTGCCGCCGCCGCACCATTGCTCTGTGCC
GGAATAACCACTTACTCCCCCTTGAAAAGGGCTAAAGTAGGTAAAATGAGTAAAGTAGGAATCGTTGGCCTGGGTGGCTT
AGGACATATGGCAGTCAAATTAGCCCGTGCCATGGGGGCTTATGTGACTGTATTTACCACTTCTATAAACAAGATAAAAG
CGGGTAAAGATTTGGGAGCTCATGATGTTGTCTTGTCTACCGACAGCAATGTCATGCAAACACTGGCCAATCAATATGAT
TTTATTCTTGATACTGTTTCTGCCAAACATGATCTTGGCCAATATTTAAACCTTCTTAAAGTGGATGGACAACTAACCCA
GGTTGGGCTTCCATCAGATCCACTTGAAGTTACCATGTTTCCTGTTATTTTAAAGAGACTGAGCATTAACGGCTCATTGA
TTGGCGGCATTAAAGAGACACAAGAAGTTTTGGATTTTTGCGCCAGGCATGGGATCACCGCAGACATTGAATTAATAAAA
ATGCATGAAGTAAATTCTGCCTATGAAAGACTGCTAAAAGGAGATGTGAAATATCGATTTGTTATCGATATGTCAACCTT
GGATTAA

Upstream 100 bases:

>100_bases
TAATGAGGGAGTTTAGATAAACTGAACAACCGAATTAAAAACATTTTCTAACAAAGAGATTGGGGGGTATGCCCTGATTA
TAATTTTTTAAGGACAAAAA

Downstream 100 bases:

>100_bases
ATGAACCAGGTATAAAAGGTCTCCAGTTGGCCTTTTATACCGCGGAGCAAATATTATTCCTGGTTTTTGATCTTGGGGAA
AACTTTAATTTTGGTTATAA

Product: hypothetical protein

Products: NA

Alternate protein names: Ms-ADHC 1 [H]

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MSETIGYAAHKAGAPLKPFTFERRPVGAHDVAIDILFCGICHSDLHQVNNDWAGAFYPMVPGHEIIGRVKEVGHQVHRFK
AGDLVGVGCMVDSCRQCTYCHQNEEQYCKSGATYTYNSQDNHLGGVTYGGYSKHVVVTEDFVLKIDESLDPAAAAPLLCA
GITTYSPLKRAKVGKMSKVGIVGLGGLGHMAVKLARAMGAYVTVFTTSINKIKAGKDLGAHDVVLSTDSNVMQTLANQYD
FILDTVSAKHDLGQYLNLLKVDGQLTQVGLPSDPLEVTMFPVILKRLSINGSLIGGIKETQEVLDFCARHGITADIELIK
MHEVNSAYERLLKGDVKYRFVIDMSTLD

Sequences:

>Translated_348_residues
MSETIGYAAHKAGAPLKPFTFERRPVGAHDVAIDILFCGICHSDLHQVNNDWAGAFYPMVPGHEIIGRVKEVGHQVHRFK
AGDLVGVGCMVDSCRQCTYCHQNEEQYCKSGATYTYNSQDNHLGGVTYGGYSKHVVVTEDFVLKIDESLDPAAAAPLLCA
GITTYSPLKRAKVGKMSKVGIVGLGGLGHMAVKLARAMGAYVTVFTTSINKIKAGKDLGAHDVVLSTDSNVMQTLANQYD
FILDTVSAKHDLGQYLNLLKVDGQLTQVGLPSDPLEVTMFPVILKRLSINGSLIGGIKETQEVLDFCARHGITADIELIK
MHEVNSAYERLLKGDVKYRFVIDMSTLD
>Mature_347_residues
SETIGYAAHKAGAPLKPFTFERRPVGAHDVAIDILFCGICHSDLHQVNNDWAGAFYPMVPGHEIIGRVKEVGHQVHRFKA
GDLVGVGCMVDSCRQCTYCHQNEEQYCKSGATYTYNSQDNHLGGVTYGGYSKHVVVTEDFVLKIDESLDPAAAAPLLCAG
ITTYSPLKRAKVGKMSKVGIVGLGGLGHMAVKLARAMGAYVTVFTTSINKIKAGKDLGAHDVVLSTDSNVMQTLANQYDF
ILDTVSAKHDLGQYLNLLKVDGQLTQVGLPSDPLEVTMFPVILKRLSINGSLIGGIKETQEVLDFCARHGITADIELIKM
HEVNSAYERLLKGDVKYRFVIDMSTLD

Specific function: Prefers aldehydes over alcohols [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71565152, Length=323, Percent_Identity=27.5541795665635, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4501933, Length=353, Percent_Identity=28.6118980169972, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4501929, Length=353, Percent_Identity=28.0453257790368, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI34577061, Length=354, Percent_Identity=28.2485875706215, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI71565154, Length=239, Percent_Identity=28.4518828451883, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4501939, Length=235, Percent_Identity=27.2340425531915, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI156523966, Length=235, Percent_Identity=27.2340425531915, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786518, Length=341, Percent_Identity=55.425219941349, Blast_Score=353, Evalue=1e-98,
Organism=Escherichia coli, GI87082401, Length=344, Percent_Identity=34.593023255814, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI87081918, Length=312, Percent_Identity=28.525641025641, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1788075, Length=286, Percent_Identity=24.8251748251748, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790045, Length=277, Percent_Identity=25.9927797833935, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI226510992, Length=343, Percent_Identity=26.2390670553936, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788407, Length=276, Percent_Identity=26.8115942028986, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788073, Length=265, Percent_Identity=26.4150943396226, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790718, Length=272, Percent_Identity=25.7352941176471, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87082125, Length=221, Percent_Identity=27.1493212669683, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=338, Percent_Identity=30.4733727810651, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17562584, Length=344, Percent_Identity=28.1976744186047, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17562582, Length=343, Percent_Identity=27.9883381924198, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI25146526, Length=363, Percent_Identity=26.4462809917355, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71997431, Length=365, Percent_Identity=26.3013698630137, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562876, Length=343, Percent_Identity=23.6151603498542, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17565904, Length=337, Percent_Identity=25.2225519287834, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17562878, Length=197, Percent_Identity=28.9340101522843, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=346, Percent_Identity=35.8381502890173, Blast_Score=179, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6319949, Length=346, Percent_Identity=34.971098265896, Blast_Score=179, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6323729, Length=333, Percent_Identity=29.7297297297297, Blast_Score=145, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6323961, Length=326, Percent_Identity=29.7546012269939, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6319621, Length=334, Percent_Identity=27.8443113772455, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324486, Length=327, Percent_Identity=28.4403669724771, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6320033, Length=359, Percent_Identity=27.8551532033426, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322619, Length=282, Percent_Identity=29.4326241134752, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319955, Length=282, Percent_Identity=29.4326241134752, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319258, Length=285, Percent_Identity=24.5614035087719, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17737897, Length=230, Percent_Identity=30.4347826086957, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17737895, Length=365, Percent_Identity=24.9315068493151, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17137530, Length=249, Percent_Identity=28.9156626506024, Blast_Score=78, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.2 [H]

Molecular weight: Translated: 37863; Mature: 37732

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00059 ADH_ZINC ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETIGYAAHKAGAPLKPFTFERRPVGAHDVAIDILFCGICHSDLHQVNNDWAGAFYPMV
CCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCC
PGHEIIGRVKEVGHQVHRFKAGDLVGVGCMVDSCRQCTYCHQNEEQYCKSGATYTYNSQD
CCHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHCCCHHHHHHCCCCEEECCCC
NHLGGVTYGGYSKHVVVTEDFVLKIDESLDPAAAAPLLCAGITTYSPLKRAKVGKMSKVG
CCCCCEEECCCCCEEEEECCEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHCCCCCCCC
IVGLGGLGHMAVKLARAMGAYVTVFTTSINKIKAGKDLGAHDVVLSTDSNVMQTLANQYD
EEEECCHHHHHHHHHHHHCCEEEEEEECHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHH
FILDTVSAKHDLGQYLNLLKVDGQLTQVGLPSDPLEVTMFPVILKRLSINGSLIGGIKET
HHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCEECCHHHH
QEVLDFCARHGITADIELIKMHEVNSAYERLLKGDVKYRFVIDMSTLD
HHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHCCCCEEEEEEEECCCC
>Mature Secondary Structure 
SETIGYAAHKAGAPLKPFTFERRPVGAHDVAIDILFCGICHSDLHQVNNDWAGAFYPMV
CCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCC
PGHEIIGRVKEVGHQVHRFKAGDLVGVGCMVDSCRQCTYCHQNEEQYCKSGATYTYNSQD
CCHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHCCCHHHHHHCCCCEEECCCC
NHLGGVTYGGYSKHVVVTEDFVLKIDESLDPAAAAPLLCAGITTYSPLKRAKVGKMSKVG
CCCCCEEECCCCCEEEEECCEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHCCCCCCCC
IVGLGGLGHMAVKLARAMGAYVTVFTTSINKIKAGKDLGAHDVVLSTDSNVMQTLANQYD
EEEECCHHHHHHHHHHHHCCEEEEEEECHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHH
FILDTVSAKHDLGQYLNLLKVDGQLTQVGLPSDPLEVTMFPVILKRLSINGSLIGGIKET
HHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCEECCHHHH
QEVLDFCARHGITADIELIKMHEVNSAYERLLKGDVKYRFVIDMSTLD
HHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHCCCCEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11257547 [H]