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The map label for this gene is hemH [H]

Identifier: 54293419

GI number: 54293419

Start: 511792

End: 512787

Strand: Reverse

Name: hemH [H]

Synonym: lpl0468

Alternate gene names: 54293419

Gene position: 512787-511792 (Counterclockwise)

Preceding gene: 54293420

Following gene: 54293418

Centisome position: 15.33

GC content: 39.46

Gene sequence:

>996_bases
ATGAGACGTGGTTTATTACTGTTAAATCTTGGCACTCCCGATAATGCGGATATCAGGGCGGTAAAGTTATATTTGCGTGA
ATTTCTTACCGACAAAAGAGTAATAGACTTACCAACTATCCCGCGCTATATCCTGGTATATTGTTTGATCTTACCCTTTA
GATCGCCAAAATCAGCCCAGGCTTACCAATCAATATGGACTGAAAAAGGATCTCCACTTTTGTATCATAGCCAAAATCTA
GTGACAAAGTTACAGTCCGCACTTAAGGATGAGTACAAAATTGCTTTGGGAATGCGCTATGGAACTCCATCAATTACAAC
AGCACTTGCAGAATTAAAAGATTGCCATTCCCTTACCATTTTACCCTTATTTCCTCAATATTCTTCTGCTGCTACAGGTT
CAGCCATTGAAAAAACCTTATCCTATTTGGCAAACCAGGAAATTATTCCATCAATTAAAATCATTCGAGATTTCTACCAA
AGACCAGAATACATCCAGGCGCAAGCTAAAATTATGAAGCCTTATATTAAAGACAATTTCCACGTTCTTTTTAGCTACCA
CGGAATTCCCGAACGGCATATTCACAAAAGCGGGTGCGATACGCTTTGCCCCCAAACATGCACACCCATATACGATAAAA
ATCAAGCCTGTTATAGGGCTCAATGCTATCAGACCAGTCTATTACTGGCAAAAGAATTGCAATTAGGCACTCACCAATAC
ACAACCGCCTTCCAATCCAGACTTGGGAAAACTCCATGGATAAAACCTTATACCGATGAAATTTTTGCCGAACTAATAAG
CAAAGGAATTAAAAACATTGTGGTCTCCTGCCCATCTTTTGTCGCAGATTGCCTGGAAACTCTTGAGGAAATAGGAATTC
GCGCAAAAGAACAGTGGGAAAAACTTGGCGGTGAGCAATTTATATTAACTCCTTGCATGAACGATCATCCTGAGTGGATC
AAAGCAATTCAAAGTATTGTTAACGAGCAATTTTAA

Upstream 100 bases:

>100_bases
GCGATAAACTATTAAGCGCGGCAGTATAACTAATATTTATGCTGCTGCGTCCATCAACTTGAGGTATTATGTCCTTCATT
TTATAACTGGACTTTAGCTG

Downstream 100 bases:

>100_bases
CCCGCCGTCTTACTGATTTCACCATCGGCAGTCATAATAAAATTATGTTTCGCATTAAATATTTATTGCAAAACAATAAA
TATTTAATAAAATACGCATG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MRRGLLLLNLGTPDNADIRAVKLYLREFLTDKRVIDLPTIPRYILVYCLILPFRSPKSAQAYQSIWTEKGSPLLYHSQNL
VTKLQSALKDEYKIALGMRYGTPSITTALAELKDCHSLTILPLFPQYSSAATGSAIEKTLSYLANQEIIPSIKIIRDFYQ
RPEYIQAQAKIMKPYIKDNFHVLFSYHGIPERHIHKSGCDTLCPQTCTPIYDKNQACYRAQCYQTSLLLAKELQLGTHQY
TTAFQSRLGKTPWIKPYTDEIFAELISKGIKNIVVSCPSFVADCLETLEEIGIRAKEQWEKLGGEQFILTPCMNDHPEWI
KAIQSIVNEQF

Sequences:

>Translated_331_residues
MRRGLLLLNLGTPDNADIRAVKLYLREFLTDKRVIDLPTIPRYILVYCLILPFRSPKSAQAYQSIWTEKGSPLLYHSQNL
VTKLQSALKDEYKIALGMRYGTPSITTALAELKDCHSLTILPLFPQYSSAATGSAIEKTLSYLANQEIIPSIKIIRDFYQ
RPEYIQAQAKIMKPYIKDNFHVLFSYHGIPERHIHKSGCDTLCPQTCTPIYDKNQACYRAQCYQTSLLLAKELQLGTHQY
TTAFQSRLGKTPWIKPYTDEIFAELISKGIKNIVVSCPSFVADCLETLEEIGIRAKEQWEKLGGEQFILTPCMNDHPEWI
KAIQSIVNEQF
>Mature_331_residues
MRRGLLLLNLGTPDNADIRAVKLYLREFLTDKRVIDLPTIPRYILVYCLILPFRSPKSAQAYQSIWTEKGSPLLYHSQNL
VTKLQSALKDEYKIALGMRYGTPSITTALAELKDCHSLTILPLFPQYSSAATGSAIEKTLSYLANQEIIPSIKIIRDFYQ
RPEYIQAQAKIMKPYIKDNFHVLFSYHGIPERHIHKSGCDTLCPQTCTPIYDKNQACYRAQCYQTSLLLAKELQLGTHQY
TTAFQSRLGKTPWIKPYTDEIFAELISKGIKNIVVSCPSFVADCLETLEEIGIRAKEQWEKLGGEQFILTPCMNDHPEWI
KAIQSIVNEQF

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Escherichia coli, GI1786681, Length=331, Percent_Identity=38.0664652567976, Blast_Score=221, Evalue=5e-59,
Organism=Drosophila melanogaster, GI17864156, Length=353, Percent_Identity=25.7790368271955, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 37817; Mature: 37817

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRGLLLLNLGTPDNADIRAVKLYLREFLTDKRVIDLPTIPRYILVYCLILPFRSPKSAQ
CCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHCCCCCCHHH
AYQSIWTEKGSPLLYHSQNLVTKLQSALKDEYKIALGMRYGTPSITTALAELKDCHSLTI
HHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHCCCEEE
LPLFPQYSSAATGSAIEKTLSYLANQEIIPSIKIIRDFYQRPEYIQAQAKIMKPYIKDNF
EEECCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCE
HVLFSYHGIPERHIHKSGCDTLCPQTCTPIYDKNQACYRAQCYQTSLLLAKELQLGTHQY
EEEEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHH
TTAFQSRLGKTPWIKPYTDEIFAELISKGIKNIVVSCPSFVADCLETLEEIGIRAKEQWE
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHH
KLGGEQFILTPCMNDHPEWIKAIQSIVNEQF
HCCCCEEEEECCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRRGLLLLNLGTPDNADIRAVKLYLREFLTDKRVIDLPTIPRYILVYCLILPFRSPKSAQ
CCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHCCCCCCHHH
AYQSIWTEKGSPLLYHSQNLVTKLQSALKDEYKIALGMRYGTPSITTALAELKDCHSLTI
HHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHCCCEEE
LPLFPQYSSAATGSAIEKTLSYLANQEIIPSIKIIRDFYQRPEYIQAQAKIMKPYIKDNF
EEECCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCE
HVLFSYHGIPERHIHKSGCDTLCPQTCTPIYDKNQACYRAQCYQTSLLLAKELQLGTHQY
EEEEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHH
TTAFQSRLGKTPWIKPYTDEIFAELISKGIKNIVVSCPSFVADCLETLEEIGIRAKEQWE
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHH
KLGGEQFILTPCMNDHPEWIKAIQSIVNEQF
HCCCCEEEEECCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA