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The map label for this gene is prlC [H]

Identifier: 54293103

GI number: 54293103

Start: 172914

End: 174971

Strand: Direct

Name: prlC [H]

Synonym: lpl0141

Alternate gene names: 54293103

Gene position: 172914-174971 (Clockwise)

Preceding gene: 54293102

Following gene: 54293104

Centisome position: 5.17

GC content: 44.36

Gene sequence:

>2058_bases
ATGTTATGCTTTCAAAAAAATTACATGATGGAAAGGTATAACATGTCGACCACAGTTGGATTACCGCAATTTAGCCATAT
AGAAGTTGAACATTTCAAATCCCATCTTGATGCTTTATTAAAAAACCATCTCGAGGAAATTGACAGGTTGCTTAAAGAAA
ATCACCACTACACCTGGGATAATTTAATTTATCCTTTAGATAGTCTGTCTGATGAGCTTGAGCGTTTTTGGTCTCCTTTT
GCACACATGCATGCGGTGATGGATTCTGAGGCAATACGTGAATCCTATGAGGCGTGTTTGCCCTTGCTGTCTGCCTATGA
TGCAGCGATTGGGCATAATCAAGACTTGTATGAGGCCATTAAATCGATAGATCAGCATTCCCTTAATCCTGCCCAGAAAA
AAATTATTGCAGACAACATACAGGATTTTGAGTTATCAGGAGTTGCTTTATCCAAGGCGAATAAAAAGCGTTTTGAAGCC
ATTCAATCGAGACTGGCCGAATTATCCAGCAAATTCGAAAACAATGTGTTGGATGCGACCCATGCCTACACTATTCATAT
CACCGAAGCAGAACGTTTGGCCGGATTACCCGAGCACGCTTTAAATACGGCAAAAGAATTGGCGCATGAGAAGGGGCTGG
ATGGCTTTGTTTTAACACTCGAATACCCTTGTTTTCAGGCCGTCATTACGCATGCCGAAGACCGGGCTTTGCGCGAAGAA
ATGTATCGGGCTTACGTCACCAGAGCCTCAGATCAAGGCCCTAATGCAGGAACCTTTGATAATACTCCGCTGATTGATGA
AATTCTGTCCTTGCGCCATGAAAAAGCCGAGCTTTTAGGGTTTAATAATTTTGCCGAGTTATCCCTGGCGACCAAGATGG
CGGCCTCGACCAATCAAGTCACTGAATTTATTTATGATTTGATCAGCAGAACTCGTGACAAGGGTAAGGCTGAATTTAGG
CAACTTGAACTGTTTGCACAGGATAAATTCAATCTAAACCCCGTAAACCCATGGGACGTTGCTTATCTTTCTGAAAAAAG
AAGGCAAGATTTGTATTCCTTATCTCAAGAGGAGTTACGACCTTATTTCCCACAACCTAAAGTGATGCAAGGTTTGTTTG
CGATTGTCAAAAAGCTCTTTGGTATGAGTATCGAGGAGATTGAGGGCGTGGATGTTTGGCATAAGGACGTTCAATGCTAT
TGCATAGTCGATGAATCCAATCAAACGCGCGGGTACATTTACACGGATTTGTTTGCCAGACCGCACAAGCGCAATGGTGC
CTGGATGGACTCCATGCAAAGCCGCAGAAAACTCGAGGATGGCACAGTTCAATTACCCATTGCAACCTTGACTTGCAATT
TTGCCAAGCCTTCTGCAAACAGACCCGCCATGTTATCGCACGATGAAGTGGTGACTTTGTTTCACGAGTTTGGTCATTGC
CTGCATCACGTTTTGACTCAAGTCGATTACCTTGGCGGCTCAGGAATTAATGGCGTGGAATGGGATGCGGTGGAATTACC
CAGCCAATTTTTCGAAAACTGGTGCTGGGATGAGCATGCATTGTCTTTACTGACTTCGCACGTGGATACAGGGGAAACCT
TGCCTTCCGCATTGTACGAGCGCTTGATTGCCGCTAAAAATTTTCAATCCGCCATGGCCATGTTAAGACAGATGGAATTC
GCCTTGTTTGATTTTCGCATTCACCAGGAATATCAGGCAGGTAAAGCGTTATTTGTCCCAAATATTCTGGCGGATGTCCG
TTCTAAAACCAGTGTTGTACCTATTGTTCCTTATAATCGTTTTCAGCACAGTTTCTCGCATATTTTTGGGGGTGGCTACG
CCGCTGGTTATTACAGTTACATGTGGGCAGAAGTATTATCCAGCGATGCCTTTGCGCGCTTTGAGGAGGAAGGTATTTTC
AACCCCAAAACCGGGCATGACTTTTTGAAATCCATCTTGGAGGCAGGCGGCTCAAGAAAAGCAGCCGATGCTTTCGTTGA
ATTCCGAGGGAGACCCGCGACGATTGATGCTTTGCTGCGCCATAATGGGATTTTATAA

Upstream 100 bases:

>100_bases
AGACGATGAAGTGGGGGAGTTAATCCCAACATCCGCCTTTAATTGATTACTGTACTTTGCTGTTTCACAGCGGATAAAGT
ATAGAGACTAATTCAATTGA

Downstream 100 bases:

>100_bases
AAACAGGACTTACGAAACTCCCAATCTTGTTGTTAAAAACTATTGTGTTTTGACCTTGAGGGGCTGTAAGTCCTGAAAAT
TTATTCGGTATGCTGGCGGG

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 685; Mature: 685

Protein sequence:

>685_residues
MLCFQKNYMMERYNMSTTVGLPQFSHIEVEHFKSHLDALLKNHLEEIDRLLKENHHYTWDNLIYPLDSLSDELERFWSPF
AHMHAVMDSEAIRESYEACLPLLSAYDAAIGHNQDLYEAIKSIDQHSLNPAQKKIIADNIQDFELSGVALSKANKKRFEA
IQSRLAELSSKFENNVLDATHAYTIHITEAERLAGLPEHALNTAKELAHEKGLDGFVLTLEYPCFQAVITHAEDRALREE
MYRAYVTRASDQGPNAGTFDNTPLIDEILSLRHEKAELLGFNNFAELSLATKMAASTNQVTEFIYDLISRTRDKGKAEFR
QLELFAQDKFNLNPVNPWDVAYLSEKRRQDLYSLSQEELRPYFPQPKVMQGLFAIVKKLFGMSIEEIEGVDVWHKDVQCY
CIVDESNQTRGYIYTDLFARPHKRNGAWMDSMQSRRKLEDGTVQLPIATLTCNFAKPSANRPAMLSHDEVVTLFHEFGHC
LHHVLTQVDYLGGSGINGVEWDAVELPSQFFENWCWDEHALSLLTSHVDTGETLPSALYERLIAAKNFQSAMAMLRQMEF
ALFDFRIHQEYQAGKALFVPNILADVRSKTSVVPIVPYNRFQHSFSHIFGGGYAAGYYSYMWAEVLSSDAFARFEEEGIF
NPKTGHDFLKSILEAGGSRKAADAFVEFRGRPATIDALLRHNGIL

Sequences:

>Translated_685_residues
MLCFQKNYMMERYNMSTTVGLPQFSHIEVEHFKSHLDALLKNHLEEIDRLLKENHHYTWDNLIYPLDSLSDELERFWSPF
AHMHAVMDSEAIRESYEACLPLLSAYDAAIGHNQDLYEAIKSIDQHSLNPAQKKIIADNIQDFELSGVALSKANKKRFEA
IQSRLAELSSKFENNVLDATHAYTIHITEAERLAGLPEHALNTAKELAHEKGLDGFVLTLEYPCFQAVITHAEDRALREE
MYRAYVTRASDQGPNAGTFDNTPLIDEILSLRHEKAELLGFNNFAELSLATKMAASTNQVTEFIYDLISRTRDKGKAEFR
QLELFAQDKFNLNPVNPWDVAYLSEKRRQDLYSLSQEELRPYFPQPKVMQGLFAIVKKLFGMSIEEIEGVDVWHKDVQCY
CIVDESNQTRGYIYTDLFARPHKRNGAWMDSMQSRRKLEDGTVQLPIATLTCNFAKPSANRPAMLSHDEVVTLFHEFGHC
LHHVLTQVDYLGGSGINGVEWDAVELPSQFFENWCWDEHALSLLTSHVDTGETLPSALYERLIAAKNFQSAMAMLRQMEF
ALFDFRIHQEYQAGKALFVPNILADVRSKTSVVPIVPYNRFQHSFSHIFGGGYAAGYYSYMWAEVLSSDAFARFEEEGIF
NPKTGHDFLKSILEAGGSRKAADAFVEFRGRPATIDALLRHNGIL
>Mature_685_residues
MLCFQKNYMMERYNMSTTVGLPQFSHIEVEHFKSHLDALLKNHLEEIDRLLKENHHYTWDNLIYPLDSLSDELERFWSPF
AHMHAVMDSEAIRESYEACLPLLSAYDAAIGHNQDLYEAIKSIDQHSLNPAQKKIIADNIQDFELSGVALSKANKKRFEA
IQSRLAELSSKFENNVLDATHAYTIHITEAERLAGLPEHALNTAKELAHEKGLDGFVLTLEYPCFQAVITHAEDRALREE
MYRAYVTRASDQGPNAGTFDNTPLIDEILSLRHEKAELLGFNNFAELSLATKMAASTNQVTEFIYDLISRTRDKGKAEFR
QLELFAQDKFNLNPVNPWDVAYLSEKRRQDLYSLSQEELRPYFPQPKVMQGLFAIVKKLFGMSIEEIEGVDVWHKDVQCY
CIVDESNQTRGYIYTDLFARPHKRNGAWMDSMQSRRKLEDGTVQLPIATLTCNFAKPSANRPAMLSHDEVVTLFHEFGHC
LHHVLTQVDYLGGSGINGVEWDAVELPSQFFENWCWDEHALSLLTSHVDTGETLPSALYERLIAAKNFQSAMAMLRQMEF
ALFDFRIHQEYQAGKALFVPNILADVRSKTSVVPIVPYNRFQHSFSHIFGGGYAAGYYSYMWAEVLSSDAFARFEEEGIF
NPKTGHDFLKSILEAGGSRKAADAFVEFRGRPATIDALLRHNGIL

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=611, Percent_Identity=30.278232405892, Blast_Score=287, Evalue=2e-77,
Organism=Homo sapiens, GI14149738, Length=614, Percent_Identity=30.9446254071661, Blast_Score=264, Evalue=3e-70,
Organism=Homo sapiens, GI156105687, Length=607, Percent_Identity=27.5123558484349, Blast_Score=207, Evalue=3e-53,
Organism=Escherichia coli, GI1789913, Length=672, Percent_Identity=50.1488095238095, Blast_Score=707, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=671, Percent_Identity=28.9120715350224, Blast_Score=269, Evalue=6e-73,
Organism=Caenorhabditis elegans, GI32565901, Length=564, Percent_Identity=23.758865248227, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71999758, Length=591, Percent_Identity=23.6886632825719, Blast_Score=114, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319793, Length=588, Percent_Identity=28.7414965986395, Blast_Score=241, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6322715, Length=703, Percent_Identity=24.0398293029872, Blast_Score=136, Evalue=9e-33,
Organism=Drosophila melanogaster, GI21356111, Length=674, Percent_Identity=25.6676557863501, Blast_Score=246, Evalue=4e-65,
Organism=Drosophila melanogaster, GI20129717, Length=599, Percent_Identity=24.3739565943239, Blast_Score=169, Evalue=5e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 78183; Mature: 78183

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLCFQKNYMMERYNMSTTVGLPQFSHIEVEHFKSHLDALLKNHLEEIDRLLKENHHYTWD
CCEECHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
NLIYPLDSLSDELERFWSPFAHMHAVMDSEAIRESYEACLPLLSAYDAAIGHNQDLYEAI
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
KSIDQHSLNPAQKKIIADNIQDFELSGVALSKANKKRFEAIQSRLAELSSKFENNVLDAT
HHHHHCCCCHHHHHHHHCCCCCCEECCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
HAYTIHITEAERLAGLPEHALNTAKELAHEKGLDGFVLTLEYPCFQAVITHAEDRALREE
CEEEEEEECHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHH
MYRAYVTRASDQGPNAGTFDNTPLIDEILSLRHEKAELLGFNNFAELSLATKMAASTNQV
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
TEFIYDLISRTRDKGKAEFRQLELFAQDKFNLNPVNPWDVAYLSEKRRQDLYSLSQEELR
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHCC
PYFPQPKVMQGLFAIVKKLFGMSIEEIEGVDVWHKDVQCYCIVDESNQTRGYIYTDLFAR
CCCCCHHHHHHHHHHHHHHHCCCHHHHCCCHHCCCCCEEEEEEECCCCCCCEEEEHHHCC
PHKRNGAWMDSMQSRRKLEDGTVQLPIATLTCNFAKPSANRPAMLSHDEVVTLFHEFGHC
CCCCCCCHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
LHHVLTQVDYLGGSGINGVEWDAVELPSQFFENWCWDEHALSLLTSHVDTGETLPSALYE
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHH
RLIAAKNFQSAMAMLRQMEFALFDFRIHQEYQAGKALFVPNILADVRSKTSVVPIVPYNR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHCCCCEEEECCCHH
FQHSFSHIFGGGYAAGYYSYMWAEVLSSDAFARFEEEGIFNPKTGHDFLKSILEAGGSRK
HHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCH
AADAFVEFRGRPATIDALLRHNGIL
HHHHHHHHCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MLCFQKNYMMERYNMSTTVGLPQFSHIEVEHFKSHLDALLKNHLEEIDRLLKENHHYTWD
CCEECHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
NLIYPLDSLSDELERFWSPFAHMHAVMDSEAIRESYEACLPLLSAYDAAIGHNQDLYEAI
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
KSIDQHSLNPAQKKIIADNIQDFELSGVALSKANKKRFEAIQSRLAELSSKFENNVLDAT
HHHHHCCCCHHHHHHHHCCCCCCEECCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
HAYTIHITEAERLAGLPEHALNTAKELAHEKGLDGFVLTLEYPCFQAVITHAEDRALREE
CEEEEEEECHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHH
MYRAYVTRASDQGPNAGTFDNTPLIDEILSLRHEKAELLGFNNFAELSLATKMAASTNQV
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
TEFIYDLISRTRDKGKAEFRQLELFAQDKFNLNPVNPWDVAYLSEKRRQDLYSLSQEELR
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHCC
PYFPQPKVMQGLFAIVKKLFGMSIEEIEGVDVWHKDVQCYCIVDESNQTRGYIYTDLFAR
CCCCCHHHHHHHHHHHHHHHCCCHHHHCCCHHCCCCCEEEEEEECCCCCCCEEEEHHHCC
PHKRNGAWMDSMQSRRKLEDGTVQLPIATLTCNFAKPSANRPAMLSHDEVVTLFHEFGHC
CCCCCCCHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
LHHVLTQVDYLGGSGINGVEWDAVELPSQFFENWCWDEHALSLLTSHVDTGETLPSALYE
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHH
RLIAAKNFQSAMAMLRQMEFALFDFRIHQEYQAGKALFVPNILADVRSKTSVVPIVPYNR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHCCCCEEEECCCHH
FQHSFSHIFGGGYAAGYYSYMWAEVLSSDAFARFEEEGIFNPKTGHDFLKSILEAGGSRK
HHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCH
AADAFVEFRGRPATIDALLRHNGIL
HHHHHHHHCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]