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The map label for this gene is gcsB [H]

Identifier: 54293075

GI number: 54293075

Start: 134426

End: 135880

Strand: Reverse

Name: gcsB [H]

Synonym: lpl0113

Alternate gene names: 54293075

Gene position: 135880-134426 (Counterclockwise)

Preceding gene: 54293076

Following gene: 54293074

Centisome position: 4.06

GC content: 43.64

Gene sequence:

>1455_bases
ATGTTGATTTTTGAATTATCTAAAACTGGTCGCCAGGCAAAAGCTCAAATACCCAGAGCAGTAAGCAAAAACTATTCAAT
ACCCGAAGAATTTCAACGAAAGTCGCGCCCAAGATTGCCGGCCTGCTCCGAATTGCAAGTGGTAAGACACTTTACCTGCC
TTTCCCAAAAGAATTTTTCCATAGATACCAATTTTTATCCTTTGGGCTCATGTACCATGAAATACAATCCCCGGGGTGTT
CATAAAGCAGCTTCGCTTCCCGGTTTTATAAATCGCCATCCGTTAGCCATGGACAATGAAAGCCAGGGATTTCTGGAAAC
TCTTTATAAATTACAAAATTATATTTCTGAAATTACGGGGATGCCCGGTGTTTCGCTAACTCCAATGGCAGGTTCACAGG
GAGAATTTGCCGGAGTCGCCATGATTAAAGCCTATCACCAGTCTCGTGGCGACACCGCCCGAGATGAAATTCTCATTCCA
GATGCGGCGCATGGAACAAACCCCGCCTCTGCCGTGATGTGTGGCTTCAAAGTAGTAGAAATAGCTACCGCTCCGGACGG
TGACATTGATCTTGACGAATTAAAAAGAAAAGTAGGCCCCAGGACTGCCGGAATTATGCTAACTAACCCCTCTACTTTGG
GATTATTTATGCGTCAGATAAAAGAAATAGCCAGTCTTGTACATCAGGCCGGGGGATTATTATACTACGATGGTGCTAAT
CTCAATGCTATTTTAGGTAAAGTAAGACCTGGTGACATGGGTTTTGATGTCATGCATCTTAATTTACATAAAACATTTGC
TACACCTCACGGGGGTGGCGGTCCTGGCGCTGGCCCTGTTGCTGTTGGCAAACGCCTTATTCCTTACATGCCCTTACCTG
TAGTGAAAAAAACCGACTCCGGATATCACTGGGCAACTCGCCAGGATTATCCACAAAGTATAGGAAGATTATCGTGCTTT
ATGGGTAATGCCGGCATTTTATTACGTGCTTATTTTTATATGCTTGTCCTTGGTAAAGAAGGCCTATTGCGCGTATCAGA
GTTCGCAACACTTAATGCCAATTATTTACTTAAAGAATTGACTAAAGTGGGCTACACAGCAGCCTATCCTGACAGGCGTG
CATCGCATGAATTTATTCTCACTTTAAATTCCGAAAAGAAAAATTATGACGTGACTGCCATGGATTTTGCAAAAAGGTTA
TTGGACTATGGGGTTCATGCCCCCACTACTTATTTCCCTTTACTAGTACCGGAATGCCTGTTGATTGAACCGCCCGAAAC
AGAAAGCAAAGAGGAATTGGATGCTTTTGTAGCCGTGATGAAAACCATTCGCGAAGAAGCTAGCAAACAACCTGATATAC
TCAAAGCTGCGCCCCACACTTTACCAGTCAAAAGACTGGATGATGTGAAAGCGGCTCGCGAACTGGATTTAAATTATTTT
GCAACTCACGAGTAA

Upstream 100 bases:

>100_bases
ATTATTTAGCAGAAATTGCTGAGTATCAATTTATCGAGTTTACTCCAGTAAAACACAGGAATGAACTCAAGGAACTTATT
CAAAAAACGGAAGGCAAATT

Downstream 100 bases:

>100_bases
CCAGTACAACAGATTTTTCCAATTTTAGCGCAGCAGCTTTCTTTTGATGACAGTTGCTGCGTTTTATGACGACCAATCTT
CTCTCACCAAAATGTGTGAG

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MLIFELSKTGRQAKAQIPRAVSKNYSIPEEFQRKSRPRLPACSELQVVRHFTCLSQKNFSIDTNFYPLGSCTMKYNPRGV
HKAASLPGFINRHPLAMDNESQGFLETLYKLQNYISEITGMPGVSLTPMAGSQGEFAGVAMIKAYHQSRGDTARDEILIP
DAAHGTNPASAVMCGFKVVEIATAPDGDIDLDELKRKVGPRTAGIMLTNPSTLGLFMRQIKEIASLVHQAGGLLYYDGAN
LNAILGKVRPGDMGFDVMHLNLHKTFATPHGGGGPGAGPVAVGKRLIPYMPLPVVKKTDSGYHWATRQDYPQSIGRLSCF
MGNAGILLRAYFYMLVLGKEGLLRVSEFATLNANYLLKELTKVGYTAAYPDRRASHEFILTLNSEKKNYDVTAMDFAKRL
LDYGVHAPTTYFPLLVPECLLIEPPETESKEELDAFVAVMKTIREEASKQPDILKAAPHTLPVKRLDDVKAARELDLNYF
ATHE

Sequences:

>Translated_484_residues
MLIFELSKTGRQAKAQIPRAVSKNYSIPEEFQRKSRPRLPACSELQVVRHFTCLSQKNFSIDTNFYPLGSCTMKYNPRGV
HKAASLPGFINRHPLAMDNESQGFLETLYKLQNYISEITGMPGVSLTPMAGSQGEFAGVAMIKAYHQSRGDTARDEILIP
DAAHGTNPASAVMCGFKVVEIATAPDGDIDLDELKRKVGPRTAGIMLTNPSTLGLFMRQIKEIASLVHQAGGLLYYDGAN
LNAILGKVRPGDMGFDVMHLNLHKTFATPHGGGGPGAGPVAVGKRLIPYMPLPVVKKTDSGYHWATRQDYPQSIGRLSCF
MGNAGILLRAYFYMLVLGKEGLLRVSEFATLNANYLLKELTKVGYTAAYPDRRASHEFILTLNSEKKNYDVTAMDFAKRL
LDYGVHAPTTYFPLLVPECLLIEPPETESKEELDAFVAVMKTIREEASKQPDILKAAPHTLPVKRLDDVKAARELDLNYF
ATHE
>Mature_484_residues
MLIFELSKTGRQAKAQIPRAVSKNYSIPEEFQRKSRPRLPACSELQVVRHFTCLSQKNFSIDTNFYPLGSCTMKYNPRGV
HKAASLPGFINRHPLAMDNESQGFLETLYKLQNYISEITGMPGVSLTPMAGSQGEFAGVAMIKAYHQSRGDTARDEILIP
DAAHGTNPASAVMCGFKVVEIATAPDGDIDLDELKRKVGPRTAGIMLTNPSTLGLFMRQIKEIASLVHQAGGLLYYDGAN
LNAILGKVRPGDMGFDVMHLNLHKTFATPHGGGGPGAGPVAVGKRLIPYMPLPVVKKTDSGYHWATRQDYPQSIGRLSCF
MGNAGILLRAYFYMLVLGKEGLLRVSEFATLNANYLLKELTKVGYTAAYPDRRASHEFILTLNSEKKNYDVTAMDFAKRL
LDYGVHAPTTYFPLLVPECLLIEPPETESKEELDAFVAVMKTIREEASKQPDILKAAPHTLPVKRLDDVKAARELDLNYF
ATHE

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=434, Percent_Identity=41.4746543778802, Blast_Score=276, Evalue=4e-74,
Organism=Escherichia coli, GI1789269, Length=414, Percent_Identity=41.7874396135266, Blast_Score=284, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17535605, Length=433, Percent_Identity=40.8775981524249, Blast_Score=271, Evalue=4e-73,
Organism=Caenorhabditis elegans, GI32564013, Length=394, Percent_Identity=40.8629441624365, Blast_Score=245, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6323843, Length=462, Percent_Identity=41.991341991342, Blast_Score=301, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24645648, Length=434, Percent_Identity=42.8571428571429, Blast_Score=293, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 53426; Mature: 53426

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIFELSKTGRQAKAQIPRAVSKNYSIPEEFQRKSRPRLPACSELQVVRHFTCLSQKNFS
CEEEEECCCCCHHHHHCCHHHHCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCE
IDTNFYPLGSCTMKYNPRGVHKAASLPGFINRHPLAMDNESQGFLETLYKLQNYISEITG
ECCCEEECCCEEEEECCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
MPGVSLTPMAGSQGEFAGVAMIKAYHQSRGDTARDEILIPDAAHGTNPASAVMCGFKVVE
CCCCEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCHHHHHHHCEEEEE
IATAPDGDIDLDELKRKVGPRTAGIMLTNPSTLGLFMRQIKEIASLVHQAGGLLYYDGAN
EEECCCCCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCEEEECCCC
LNAILGKVRPGDMGFDVMHLNLHKTFATPHGGGGPGAGPVAVGKRLIPYMPLPVVKKTDS
CEEHEECCCCCCCCCEEEEEEEEHEECCCCCCCCCCCCHHHHHHHHCCCCCCCCEEECCC
GYHWATRQDYPQSIGRLSCFMGNAGILLRAYFYMLVLGKEGLLRVSEFATLNANYLLKEL
CCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEHHHHHHCCHHHHHHHH
TKVGYTAAYPDRRASHEFILTLNSEKKNYDVTAMDFAKRLLDYGVHAPTTYFPLLVPECL
HHHCCEECCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHCCCCE
LIEPPETESKEELDAFVAVMKTIREEASKQPDILKAAPHTLPVKRLDDVKAARELDLNYF
EECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCEE
ATHE
ECCC
>Mature Secondary Structure
MLIFELSKTGRQAKAQIPRAVSKNYSIPEEFQRKSRPRLPACSELQVVRHFTCLSQKNFS
CEEEEECCCCCHHHHHCCHHHHCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCE
IDTNFYPLGSCTMKYNPRGVHKAASLPGFINRHPLAMDNESQGFLETLYKLQNYISEITG
ECCCEEECCCEEEEECCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
MPGVSLTPMAGSQGEFAGVAMIKAYHQSRGDTARDEILIPDAAHGTNPASAVMCGFKVVE
CCCCEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCHHHHHHHCEEEEE
IATAPDGDIDLDELKRKVGPRTAGIMLTNPSTLGLFMRQIKEIASLVHQAGGLLYYDGAN
EEECCCCCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCEEEECCCC
LNAILGKVRPGDMGFDVMHLNLHKTFATPHGGGGPGAGPVAVGKRLIPYMPLPVVKKTDS
CEEHEECCCCCCCCCEEEEEEEEHEECCCCCCCCCCCCHHHHHHHHCCCCCCCCEEECCC
GYHWATRQDYPQSIGRLSCFMGNAGILLRAYFYMLVLGKEGLLRVSEFATLNANYLLKEL
CCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEHHHHHHCCHHHHHHHH
TKVGYTAAYPDRRASHEFILTLNSEKKNYDVTAMDFAKRLLDYGVHAPTTYFPLLVPECL
HHHCCEECCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHCCCCE
LIEPPETESKEELDAFVAVMKTIREEASKQPDILKAAPHTLPVKRLDDVKAARELDLNYF
EECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCEE
ATHE
ECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA