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The map label for this gene is ubiH [H]

Identifier: 54293043

GI number: 54293043

Start: 92901

End: 94103

Strand: Direct

Name: ubiH [H]

Synonym: lpl0080

Alternate gene names: 54293043

Gene position: 92901-94103 (Clockwise)

Preceding gene: 54293042

Following gene: 54293044

Centisome position: 2.78

GC content: 42.98

Gene sequence:

>1203_bases
GTGGCGAATAAAGAGACTGATATACTGATTATTGGTGGTGGTTTGACTGGTGCAAGCTTATCCCTGGCTCTGCAGGGATT
AGGTTTCTCTGTCACGTTAGTAGAATCCAGGCCATACAGCGATAAGGTAAATCCTGATTTTGATGCTCGCTCATTGGCGT
TGTCGCCTGCAAGTCAACGTATATTGGCAATGCTGGGAGTTTGGGAGATTCTCAAAGAATATACAACACCAATTCATATG
ATTCATGTTTCTGATCAGCATCGCTTTGGGGTTTCTCGTTTGCAAGGCGAAAAAAATAGTCCTTTGGGCTATGTGGTAGA
AATGCAATACATCAACAGGGCTTTGAGTATTCTAATCAATAAAGAACAGTTGTTAGCTCCTGCGGTTTTAAAATCCATCG
ATTTTAACAATTCTACTGCTGCTGTCGCCCATGGCGACGATATGATTTCTATCCGGGCTCAATTAATTGTCGCGGCCGAT
GGGACGGAATCGATGACTCGCCACCTCTGTAATCTGCCAGTCAAAATCAAAGATTATGCTCAAGACGCTATTGTCGCCAA
TGTGGGCCTGATAAAACCTCATGGTAATCGTGCCTTTGAGAGATTTACGCCTAATGGTCCTCTTGCATTATTGCCTATGA
TGAATGACAAAATGTCATTGGTATGGGCATCAAAGCCTGAAGAAGCAAAACGGTTAGTGATGTTGAGTGATGGTGATTTT
TTGCGAGAACTGCAAACTGCTTTTGGGTATAGGTTAGGACGATTTGGTAAAGTAGGAAAGCGATACTCTTATCCCCTGAA
ACAAGTTTTAATGCCCCAGCAAACCAAATGGCCTGTTGTTTTTGTTGGTAATGCCGCTCACACTTTGCATCCAGTTGCGG
GTCAGGGGTTTAACTTGGGTTTAAGAGATATTGCGGCGTTGGCACAATGCATCAGCCAAAAGGGATTAAATCCACAGATG
TTGGAGCATTATTTGAAATTGCGAGCACATGATCAGCAAATGATTACCTGGCTAACAGACGGTTTGATACATCTATTTAC
GAGTCGTTTACCCGGTATGGGAGTAGCGCGTAACCTTGGATTGCTGGCACTTGATAATATACCGGCATTAAAAAATTTAT
TAGCGCGATATGCGCGGGGTTTTGGCGGAATTACTCCTGATTTGGTTTGTGAAATTGCATTAAGTGCAGGAGAATTTCAA
TGA

Upstream 100 bases:

>100_bases
GGTGTACGTATAGAAGATGATATTCTGGTAACCAGGGCAGGATATGAGGTATTGACCGGTGACTTACCTGTTAATGTAGA
TGATATTGAGGCTTTGATGC

Downstream 100 bases:

>100_bases
GCCAACATTTTGATGTACTTGTCATTGGAGGTGGGATTGTTGGCTTGACAGCAGCTTTAGCAATGGCCCAACGCCATTAT
ACTGTTGCTGTTATCGATGC

Product: hypothetical protein

Products: H2O; 2-octaprenyl-6-methoxy-1,4-benzoquinone [C]

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MANKETDILIIGGGLTGASLSLALQGLGFSVTLVESRPYSDKVNPDFDARSLALSPASQRILAMLGVWEILKEYTTPIHM
IHVSDQHRFGVSRLQGEKNSPLGYVVEMQYINRALSILINKEQLLAPAVLKSIDFNNSTAAVAHGDDMISIRAQLIVAAD
GTESMTRHLCNLPVKIKDYAQDAIVANVGLIKPHGNRAFERFTPNGPLALLPMMNDKMSLVWASKPEEAKRLVMLSDGDF
LRELQTAFGYRLGRFGKVGKRYSYPLKQVLMPQQTKWPVVFVGNAAHTLHPVAGQGFNLGLRDIAALAQCISQKGLNPQM
LEHYLKLRAHDQQMITWLTDGLIHLFTSRLPGMGVARNLGLLALDNIPALKNLLARYARGFGGITPDLVCEIALSAGEFQ

Sequences:

>Translated_400_residues
MANKETDILIIGGGLTGASLSLALQGLGFSVTLVESRPYSDKVNPDFDARSLALSPASQRILAMLGVWEILKEYTTPIHM
IHVSDQHRFGVSRLQGEKNSPLGYVVEMQYINRALSILINKEQLLAPAVLKSIDFNNSTAAVAHGDDMISIRAQLIVAAD
GTESMTRHLCNLPVKIKDYAQDAIVANVGLIKPHGNRAFERFTPNGPLALLPMMNDKMSLVWASKPEEAKRLVMLSDGDF
LRELQTAFGYRLGRFGKVGKRYSYPLKQVLMPQQTKWPVVFVGNAAHTLHPVAGQGFNLGLRDIAALAQCISQKGLNPQM
LEHYLKLRAHDQQMITWLTDGLIHLFTSRLPGMGVARNLGLLALDNIPALKNLLARYARGFGGITPDLVCEIALSAGEFQ
>Mature_399_residues
ANKETDILIIGGGLTGASLSLALQGLGFSVTLVESRPYSDKVNPDFDARSLALSPASQRILAMLGVWEILKEYTTPIHMI
HVSDQHRFGVSRLQGEKNSPLGYVVEMQYINRALSILINKEQLLAPAVLKSIDFNNSTAAVAHGDDMISIRAQLIVAADG
TESMTRHLCNLPVKIKDYAQDAIVANVGLIKPHGNRAFERFTPNGPLALLPMMNDKMSLVWASKPEEAKRLVMLSDGDFL
RELQTAFGYRLGRFGKVGKRYSYPLKQVLMPQQTKWPVVFVGNAAHTLHPVAGQGFNLGLRDIAALAQCISQKGLNPQML
EHYLKLRAHDQQMITWLTDGLIHLFTSRLPGMGVARNLGLLALDNIPALKNLLARYARGFGGITPDLVCEIALSAGEFQ

Specific function: Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967305, Length=403, Percent_Identity=25.3101736972705, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI32967307, Length=272, Percent_Identity=28.6764705882353, Blast_Score=96, Evalue=7e-20,
Organism=Escherichia coli, GI1789274, Length=394, Percent_Identity=36.2944162436548, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI1789273, Length=396, Percent_Identity=32.5757575757576, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1786883, Length=398, Percent_Identity=30.6532663316583, Blast_Score=161, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI25146631, Length=440, Percent_Identity=26.1363636363636, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI19920760, Length=400, Percent_Identity=26, Blast_Score=105, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971
- InterPro:   IPR011295 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.- [C]

Molecular weight: Translated: 43903; Mature: 43772

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS01304 UBIH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANKETDILIIGGGLTGASLSLALQGLGFSVTLVESRPYSDKVNPDFDARSLALSPASQR
CCCCCCCEEEEECCCCCCHHHHEEECCCEEEEEEECCCCCCCCCCCCCCHHEEECHHHHH
ILAMLGVWEILKEYTTPIHMIHVSDQHRFGVSRLQGEKNSPLGYVVEMQYINRALSILIN
HHHHHHHHHHHHHHCCCEEEEEECCCCHHCHHHHCCCCCCCCEEEEEHHHHHHHHHHHCC
KEQLLAPAVLKSIDFNNSTAAVAHGDDMISIRAQLIVAADGTESMTRHLCNLPVKIKDYA
HHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEEEEEEEECCHHHHHHHHHCCCEEEHHHH
QDAIVANVGLIKPHGNRAFERFTPNGPLALLPMMNDKMSLVWASKPEEAKRLVMLSDGDF
HHHHHEECEEECCCCCCHHHHCCCCCCEEEEEECCCCEEEEECCCCCCCCEEEEECCCHH
LRELQTAFGYRLGRFGKVGKRYSYPLKQVLMPQQTKWPVVFVGNAAHTLHPVAGQGFNLG
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCEEEECCCCCEECCCCCCCCCCC
LRDIAALAQCISQKGLNPQMLEHYLKLRAHDQQMITWLTDGLIHLFTSRLPGMGVARNLG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCC
LLALDNIPALKNLLARYARGFGGITPDLVCEIALSAGEFQ
EEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure 
ANKETDILIIGGGLTGASLSLALQGLGFSVTLVESRPYSDKVNPDFDARSLALSPASQR
CCCCCCEEEEECCCCCCHHHHEEECCCEEEEEEECCCCCCCCCCCCCCHHEEECHHHHH
ILAMLGVWEILKEYTTPIHMIHVSDQHRFGVSRLQGEKNSPLGYVVEMQYINRALSILIN
HHHHHHHHHHHHHHCCCEEEEEECCCCHHCHHHHCCCCCCCCEEEEEHHHHHHHHHHHCC
KEQLLAPAVLKSIDFNNSTAAVAHGDDMISIRAQLIVAADGTESMTRHLCNLPVKIKDYA
HHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEEEEEEEECCHHHHHHHHHCCCEEEHHHH
QDAIVANVGLIKPHGNRAFERFTPNGPLALLPMMNDKMSLVWASKPEEAKRLVMLSDGDF
HHHHHEECEEECCCCCCHHHHCCCCCCEEEEEECCCCEEEEECCCCCCCCEEEEECCCHH
LRELQTAFGYRLGRFGKVGKRYSYPLKQVLMPQQTKWPVVFVGNAAHTLHPVAGQGFNLG
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCEEEECCCCCEECCCCCCCCCCC
LRDIAALAQCISQKGLNPQMLEHYLKLRAHDQQMITWLTDGLIHLFTSRLPGMGVARNLG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCC
LLALDNIPALKNLLARYARGFGGITPDLVCEIALSAGEFQ
EEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-octaprenyl-6-methoxyphenol; O2 [C]

Specific reaction: 2-octaprenyl-6-methoxyphenol + O2 = H2O + 2-octaprenyl-6-methoxy-1,4-benzoquinone [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1339425; 9278503 [H]