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The map label for this gene is drrB [H]

Identifier: 54027488

GI number: 54027488

Start: 5841147

End: 5841911

Strand: Reverse

Name: drrB [H]

Synonym: nfa55140

Alternate gene names: 54027488

Gene position: 5841911-5841147 (Counterclockwise)

Preceding gene: 54027489

Following gene: 54027484

Centisome position: 97.02

GC content: 67.97

Gene sequence:

>765_bases
ATGAGCGCGACCGCACTCACCGATTCGATGACCATGCTGCGGCGCAACCTCGTGCACGCCAAGCGCTACCCGAGCATGGT
GTTCAGCGTCGTGCTGATGCCGGTGGTGCTGTTGCTGGTGTTCGTGTTCGTCTTCGGCGGCGCGCTGGAGAAGTCCTCCG
GCGGCAACTACATCGACTACCTCACCCCAGGCATGCTGCTGATGATCCCGGCCTACCTCACCGCCTCGGTGGCCGTCTCG
GTCTCCACCGACGTCACCAAGGGCATCGTCAACCGGTTCCGCACCATGGCGATCGCGCCCTCGTCGATGCTCACCGGGCA
CGTCTTCGGCACGGTGCTGCTCGGCATGCTCGGCACCGTGGTGATGATGGCGGTGGCGTTCCTGGTCGGCTGGCGGCCGC
AGGCGAACCCGCTGGAATGGCTGGCCGTGTTCGGTCTGCTCGTCCTGCTGGTGTTCGCCCTGGCCTGGTTGTCGGTCGCG
CTGGGACTGCTCTCGCCCAACCCCGAGGCCGCCAGCAACGCCGTCTTCCCGGTCATCATGCTGCCCTTCCTCGGCAGCGG
CCTGGTCGCCACCGACACCATGCCGGTCGGCATGCGCCAGTTCGCCGAGTACCAGCCCTTCACCCCGATCACCGAGACCG
TGCGCGGGCTGCTGATGGGCACCGAGATCGGCGGCCAGGGCATCGCCGCGCTGGCCTGGTGTGTCGGGCTCGGACTCGCC
GGCTACCTCTGGTCGGCGCGGATCTTCGCCAAGCAGGCGGGCTGA

Upstream 100 bases:

>100_bases
AGGTCGACGGATTGTCCGTGCACACCCCCACCCTCGACGACGTCTTCCTCACCCTCACCGGCGCACCGACCGCCGACACC
ACCTCGAAGGAGGCCCTGCG

Downstream 100 bases:

>100_bases
TCACCCCGCCGCGCGACGACATGCCCCACGGGTACGCACCCGTGGGGCATGTTCTCGTGCGCCGGGGCGGTCACACGTCG
CCGGTGAGCAGCACCCGGTT

Product: putative ABC transporter membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MSATALTDSMTMLRRNLVHAKRYPSMVFSVVLMPVVLLLVFVFVFGGALEKSSGGNYIDYLTPGMLLMIPAYLTASVAVS
VSTDVTKGIVNRFRTMAIAPSSMLTGHVFGTVLLGMLGTVVMMAVAFLVGWRPQANPLEWLAVFGLLVLLVFALAWLSVA
LGLLSPNPEAASNAVFPVIMLPFLGSGLVATDTMPVGMRQFAEYQPFTPITETVRGLLMGTEIGGQGIAALAWCVGLGLA
GYLWSARIFAKQAG

Sequences:

>Translated_254_residues
MSATALTDSMTMLRRNLVHAKRYPSMVFSVVLMPVVLLLVFVFVFGGALEKSSGGNYIDYLTPGMLLMIPAYLTASVAVS
VSTDVTKGIVNRFRTMAIAPSSMLTGHVFGTVLLGMLGTVVMMAVAFLVGWRPQANPLEWLAVFGLLVLLVFALAWLSVA
LGLLSPNPEAASNAVFPVIMLPFLGSGLVATDTMPVGMRQFAEYQPFTPITETVRGLLMGTEIGGQGIAALAWCVGLGLA
GYLWSARIFAKQAG
>Mature_253_residues
SATALTDSMTMLRRNLVHAKRYPSMVFSVVLMPVVLLLVFVFVFGGALEKSSGGNYIDYLTPGMLLMIPAYLTASVAVSV
STDVTKGIVNRFRTMAIAPSSMLTGHVFGTVLLGMLGTVVMMAVAFLVGWRPQANPLEWLAVFGLLVLLVFALAWLSVAL
GLLSPNPEAASNAVFPVIMLPFLGSGLVATDTMPVGMRQFAEYQPFTPITETVRGLLMGTEIGGQGIAALAWCVGLGLAG
YLWSARIFAKQAG

Specific function: Part of the ABC transporter complex drrAB involved in daunorubicin and doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000412
- InterPro:   IPR013525 [H]

Pfam domain/function: PF01061 ABC2_membrane [H]

EC number: NA

Molecular weight: Translated: 27012; Mature: 26881

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: PS51012 ABC_TM2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
6.3 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHCCC
>Mature Secondary Structure 
SATALTDSMTMLRRNLVHAKRYPSMVFSVVLMPVVLLLVFVFVFGGALEKSSGGNYIDY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHH
LTPGMLLMIPAYLTASVAVSVSTDVTKGIVNRFRTMAIAPSSMLTGHVFGTVLLGMLGTV
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
VMMAVAFLVGWRPQANPLEWLAVFGLLVLLVFALAWLSVALGLLSPNPEAASNAVFPVIM
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHH
LPFLGSGLVATDTMPVGMRQFAEYQPFTPITETVRGLLMGTEIGGQGIAALAWCVGLGLA
HHHHCCCCEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
GYLWSARIFAKQAG
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1924314 [H]