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The map label for this gene is lexA1

Identifier: 54027192

GI number: 54027192

Start: 5511956

End: 5512606

Strand: Reverse

Name: lexA1

Synonym: nfa52180

Alternate gene names: 54027192

Gene position: 5512606-5511956 (Counterclockwise)

Preceding gene: 54027193

Following gene: 54027184

Centisome position: 91.55

GC content: 72.35

Gene sequence:

>651_bases
GTGACCGACTACGACTTCGAGCATCTCGACACCTCGGCGCTGCCGGTGCGGCAGCGGCGGATCCTGGAGGTCATCCGGGA
CTGGGTGGTCGAGCACGGGTACGCGCCGAGCACCCGGCAGATCGGTGCCGCGGTCGGTCTGCGCTCGATGTCGTCGGTCG
CCCGGCATCTGCGCAGCCTCGAGGAGCGCGGGTTCCTGCGGCGGGGGGAGGGGGTGGCGCGGCCGATCGATGTGCGGCTG
TTCCTGCACGGCACGGCCGCCGCGGCGCCCAGCGAGGACGCGGTGACCGTGCCGGTGGTGGGCGACATCGCCGCGGGCGC
ACCGATCCTGGCCGAGGAACACACCGACGACCTGCTCACCCTGCCGCGCGAACTGGTCGGCCGCGGCACCGTGTTCGCGC
TGCGCGTGCGCGGCGACTCCATGATCGACGCCGCCATCTGCGACGGCGACACCGTCGTGGTGCGCAGCCAGCGGGAGGCG
AACTCGGGCGACATCGTGGCCGCCATGATCGGCGAGGAGGCCACCGTCAAGGTCTTCCGCCGCCGCAACGGCCACGTCCT
GCTGGAACCCCGCAACCCCGCCTACGACGTGATCGACGGCGACGAGGCCGTCATCCTCGGCAAGGTCGTCTCGGTGCTGC
GCCGGATCTGA

Upstream 100 bases:

>100_bases
GTCACCACCGAACTGTTCGACCTCATCGGCACCCAGACACCCGCGACCTGACCGGCCGCTGACTCGTGCCGGTCCACCGC
ACCCGCCTAACATCTCCCGG

Downstream 100 bases:

>100_bases
ATCCTCACGCCCGGTCGAGGCGGCGCAGTTGTTCGGCGACGTCGAACTGGGCGGGCGGCCAGTCCAGCTGGAACGTGGAC
AGTGCGTCGATGAGCAGTTC

Product: LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MTDYDFEHLDTSALPVRQRRILEVIRDWVVEHGYAPSTRQIGAAVGLRSMSSVARHLRSLEERGFLRRGEGVARPIDVRL
FLHGTAAAAPSEDAVTVPVVGDIAAGAPILAEEHTDDLLTLPRELVGRGTVFALRVRGDSMIDAAICDGDTVVVRSQREA
NSGDIVAAMIGEEATVKVFRRRNGHVLLEPRNPAYDVIDGDEAVILGKVVSVLRRI

Sequences:

>Translated_216_residues
MTDYDFEHLDTSALPVRQRRILEVIRDWVVEHGYAPSTRQIGAAVGLRSMSSVARHLRSLEERGFLRRGEGVARPIDVRL
FLHGTAAAAPSEDAVTVPVVGDIAAGAPILAEEHTDDLLTLPRELVGRGTVFALRVRGDSMIDAAICDGDTVVVRSQREA
NSGDIVAAMIGEEATVKVFRRRNGHVLLEPRNPAYDVIDGDEAVILGKVVSVLRRI
>Mature_215_residues
TDYDFEHLDTSALPVRQRRILEVIRDWVVEHGYAPSTRQIGAAVGLRSMSSVARHLRSLEERGFLRRGEGVARPIDVRLF
LHGTAAAAPSEDAVTVPVVGDIAAGAPILAEEHTDDLLTLPRELVGRGTVFALRVRGDSMIDAAICDGDTVVVRSQREAN
SGDIVAAMIGEEATVKVFRRRNGHVLLEPRNPAYDVIDGDEAVILGKVVSVLRRI

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family

Homologues:

Organism=Escherichia coli, GI1790476, Length=187, Percent_Identity=32.0855614973262, Blast_Score=98, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LEXA1_NOCFA (Q5YP21)

Other databases:

- EMBL:   AP006618
- RefSeq:   YP_121434.1
- ProteinModelPortal:   Q5YP21
- SMR:   Q5YP21
- MEROPS:   S24.001
- GeneID:   3110706
- GenomeReviews:   AP006618_GR
- KEGG:   nfa:nfa52180
- NMPDR:   fig|247156.1.peg.5014
- HOGENOM:   HBG679610
- OMA:   ITNHINA
- ProtClustDB:   PRK00215
- BioCyc:   NFAR247156:NFA52180-MONOMER
- BRENDA:   3.4.21.88
- GO:   GO:0006508
- GO:   GO:0006350
- HAMAP:   MF_00015
- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991
- Gene3D:   G3DSA:2.10.109.10
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00726
- TIGRFAMs:   TIGR00498

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24; SSF51306 Pept_S24_S26_C

EC number: =3.4.21.88

Molecular weight: Translated: 23535; Mature: 23404

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: ACT_SITE 140-140 ACT_SITE 177-177

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDYDFEHLDTSALPVRQRRILEVIRDWVVEHGYAPSTRQIGAAVGLRSMSSVARHLRSL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EERGFLRRGEGVARPIDVRLFLHGTAAAAPSEDAVTVPVVGDIAAGAPILAEEHTDDLLT
HHCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCEEEEEECCCCCCCCEEECCCCCHHHH
LPRELVGRGTVFALRVRGDSMIDAAICDGDTVVVRSQREANSGDIVAAMIGEEATVKVFR
HHHHHHCCCCEEEEEECCCCEEEEEEECCCEEEEECCCCCCCCCEEEEECCCHHHHHHHH
RRNGHVLLEPRNPAYDVIDGDEAVILGKVVSVLRRI
CCCCEEEECCCCCCEEEECCCCEEHHHHHHHHHHCC
>Mature Secondary Structure 
TDYDFEHLDTSALPVRQRRILEVIRDWVVEHGYAPSTRQIGAAVGLRSMSSVARHLRSL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EERGFLRRGEGVARPIDVRLFLHGTAAAAPSEDAVTVPVVGDIAAGAPILAEEHTDDLLT
HHCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCEEEEEECCCCCCCCEEECCCCCHHHH
LPRELVGRGTVFALRVRGDSMIDAAICDGDTVVVRSQREANSGDIVAAMIGEEATVKVFR
HHHHHHCCCCEEEEEECCCCEEEEEEECCCEEEEECCCCCCCCCEEEEECCCHHHHHHHH
RRNGHVLLEPRNPAYDVIDGDEAVILGKVVSVLRRI
CCCCEEEECCCCCCEEEECCCCEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA