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The map label for this gene is uvrD [H]

Identifier: 54026969

GI number: 54026969

Start: 5211240

End: 5213768

Strand: Reverse

Name: uvrD [H]

Synonym: nfa49950

Alternate gene names: 54026969

Gene position: 5213768-5211240 (Counterclockwise)

Preceding gene: 54026971

Following gene: 54026968

Centisome position: 86.59

GC content: 69.71

Gene sequence:

>2529_bases
ATGGACATGACGGTGGTTCCCCAGACGACGGCTCCCCAGACGACGCCGGCCGGCCGTTCGCTGGCCGAGCAAGCACAGCA
GCGCGCCGACGACCAGGCCCGACGCCGCGCCGACCGCGATCGGCAGCGGGCCGAACAGGTCGAGCGCCTGCTCGACGGCC
TCAACCCGCAGCAGCGGGCCGCGGTGGTCCACGCGGGCTCGCCGCTGTTGATCGTCGCGGGCGCGGGCTCGGGCAAGACC
GCGGTGCTCACCCGGCGCATCGCCTACCTGCTCGCCGCACGGGACGTCTCGCCCGGCCAGATCCTGGCGATCACCTTCAC
CAACAAGGCCGCCGCGGAGATGCGGGAGCGCGTCACGGGGCTGGTCGGCCCGCGCGCGGCCACCATGTGGGTGTCGACCT
TCCATTCCAGTTGCGTGCGGATCCTGCGCATGCAGGCGGCGCTGCTGCCCGGCCTGAATTCCAATTTCTCCATCTACGAC
GCCGACGATTCGCGGCGATTGCTGACCATGATCAGCCGCGATCTGGATATCGACACCAAGAAATACTCCGCGCGGCTGCT
GGTCACGGCCATCTCCAATCTCAAGAACGAGCTGATCGGCCCGGAGCAGGCTAGCGCCGACGCCGAGTCCGACGAATCCG
AGTTGCCCGGCCTGGTGGCCCGCGTCTACACCGAATACCAGCGCAGGCTGCGCGCGGCGAACGCGCTGGATTTCGACGAC
CTGATCGGCGAGACCGTCGCCCTGTTGCAGAACCACCCGCAGGTCGCCGAGTACTACCGCCGCCGGTTCCGGCACGTGCT
GGTCGACGAGTACCAGGACACCAACCACGCGCAGTACGTGCTGGTGCGCGAACTCGTCGGACATCACAGCGCGGCGGACG
ACACCGAGGACGCGGTGCCGCCGAGCGAACTGTGCGTGGTGGGCGACGCCGACCAGTCGATCTACGCCTTCCGCGGGGCG
ACCATCCGCAACATCGAGGAATTCGAGCGCGATTTCCCCGACGCGGAGACCATTCTGCTCGAGCAGAACTACCGCTCCAC
CCAGAACATCCTGTCCGCCGCCAACGCGGTGATCGCCCGCAACGAGGGCAGGCGCGAGAAGCGGCTGTGGACCGATTCGG
GCGAGGGCGACCTGATCGTCGGCTACGTCGCCGACAACGAGCACGACGAGGCCTCCTTCGTCGCCAGGGAGATCGATCGC
CTGGTCGACCAGGGCGAGGCGAACTACGGCGACGTCGCGGTGTTCTATCGCACCAACAACAACTCCCGTGCGCTGGAGGA
GATCTTCATCCGCATGGGGCTGCCGTACAAGGTGGTCGGCGGCGTGCGCTTCTACGAGCGCAAGGAGGTCCGCGACATCG
TGGCCTACCTGCGGGTGCTGGAGAACCCCGACGACGCGGTCAGCCTGCGCCGCATTCTCAACACCCCGCGCCGCGGTATC
GGTGACCGGGCCGAAGCCTGCGTCGCGGTGCACGCCGAACAGCGCGGCATCGGTTTCGCCGCCGCGCTGCGCGACGCCGC
CGAGGGCAAGGTGGCACTGCTCAACACCCGTGCCCAGCGCGCCATCGCCGGGTTCCTCGACCTGCTCGAAGAGATCCGGG
CCGCCGGTGAGCAGGCCGACGCCGACTTCCCCGATGTCGGCAACGTGGTGGAAGCGGTGCTCGACCGCACCGGCTACCGC
GCCGAACTGGAAGCCTCCGACGATCCGCAGGACGGCGCCCGGCTCGACAACCTGAACGAACTGGTCAGCGTGGCACGGGA
ATTCAGCTCCGAGGCCTACAACAACGCGGTCGCCGCCCGCGAGGAGGGCATCCTGCCCGAACAGGCCGAGGGTGAACCCG
ATCCCGGCTCGCTGGCGGCCTTCCTCGAGCGGGTCTCGCTGGTCGCCGACACCGACCAGATCCCCGACGAGGGCGCCGGG
GTGGTCACCATGATGACCCTGCACACCGCCAAGGGCCTGGAGTTCCCGGTGGTCTTCGTGACCGGCTGGGAGGACGGGCA
GTTCCCGCACATGCGCGCGCTGGGCGATCCCACCGAGCTGGCCGAGGAACGCAGGCTCGCCTACGTCGGCATCACCCGGG
CCAGGCAGCGGCTGTATCTGACCCGGGCGGTGGTCCGCTCCGGCTGGGGCCAGCCGGTGTCGAACCCGGAATCCCGGTTC
CTGCAGGAGATTCCCGACCACCTGATCGAGTGGCGCAGGCTGGAGCCTTCGCCCGCCACCCGCGGCATCCGTAAGCGTGG
CGGCGACGAGGGGCTGGAGCGGGACTGGACCCGCGGTGACGGCTGGTCCGAGCCGCGTCCCGGGGTGCGCGACCGCGGTC
CGCGCCGGCCCGCGCCGGGCGGGGCGAGCCGCAACAACACCAATCTGGTGCTCGCCGTGGGCGACCGGGTCAGCGACGAC
AAGTACGGGCTGGGCCGGGTGGTCGCCGCCGACGGGTTCGGGCCGCTGGCCACCGTCACGATCGATTTCGGCACGGCGGG
CAAGATCCGGCTCATCCCGCAGTACAGCCGGACCCTGGTCAAGCTCTGA

Upstream 100 bases:

>100_bases
CTGATCATGTGCCCAGTCTGCCACGGGTCCTGAGCGATGCAAAACATGTGATGGCGGGGGCTTCGCCCCTGTCGGTGGGC
GCCGGTAGCGTGGATGGGCA

Downstream 100 bases:

>100_bases
CGGGCTGGGTAGCGTCGGGGCCGTGGAAAGCCTCGCACAGCACCTGGTGTGGTTCCTTCCGATGCTCTGGCTCGGCATGG
TGGTCGCCATCTCGTTCCTC

Product: putative ATP-dependent DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 842; Mature: 842

Protein sequence:

>842_residues
MDMTVVPQTTAPQTTPAGRSLAEQAQQRADDQARRRADRDRQRAEQVERLLDGLNPQQRAAVVHAGSPLLIVAGAGSGKT
AVLTRRIAYLLAARDVSPGQILAITFTNKAAAEMRERVTGLVGPRAATMWVSTFHSSCVRILRMQAALLPGLNSNFSIYD
ADDSRRLLTMISRDLDIDTKKYSARLLVTAISNLKNELIGPEQASADAESDESELPGLVARVYTEYQRRLRAANALDFDD
LIGETVALLQNHPQVAEYYRRRFRHVLVDEYQDTNHAQYVLVRELVGHHSAADDTEDAVPPSELCVVGDADQSIYAFRGA
TIRNIEEFERDFPDAETILLEQNYRSTQNILSAANAVIARNEGRREKRLWTDSGEGDLIVGYVADNEHDEASFVAREIDR
LVDQGEANYGDVAVFYRTNNNSRALEEIFIRMGLPYKVVGGVRFYERKEVRDIVAYLRVLENPDDAVSLRRILNTPRRGI
GDRAEACVAVHAEQRGIGFAAALRDAAEGKVALLNTRAQRAIAGFLDLLEEIRAAGEQADADFPDVGNVVEAVLDRTGYR
AELEASDDPQDGARLDNLNELVSVAREFSSEAYNNAVAAREEGILPEQAEGEPDPGSLAAFLERVSLVADTDQIPDEGAG
VVTMMTLHTAKGLEFPVVFVTGWEDGQFPHMRALGDPTELAEERRLAYVGITRARQRLYLTRAVVRSGWGQPVSNPESRF
LQEIPDHLIEWRRLEPSPATRGIRKRGGDEGLERDWTRGDGWSEPRPGVRDRGPRRPAPGGASRNNTNLVLAVGDRVSDD
KYGLGRVVAADGFGPLATVTIDFGTAGKIRLIPQYSRTLVKL

Sequences:

>Translated_842_residues
MDMTVVPQTTAPQTTPAGRSLAEQAQQRADDQARRRADRDRQRAEQVERLLDGLNPQQRAAVVHAGSPLLIVAGAGSGKT
AVLTRRIAYLLAARDVSPGQILAITFTNKAAAEMRERVTGLVGPRAATMWVSTFHSSCVRILRMQAALLPGLNSNFSIYD
ADDSRRLLTMISRDLDIDTKKYSARLLVTAISNLKNELIGPEQASADAESDESELPGLVARVYTEYQRRLRAANALDFDD
LIGETVALLQNHPQVAEYYRRRFRHVLVDEYQDTNHAQYVLVRELVGHHSAADDTEDAVPPSELCVVGDADQSIYAFRGA
TIRNIEEFERDFPDAETILLEQNYRSTQNILSAANAVIARNEGRREKRLWTDSGEGDLIVGYVADNEHDEASFVAREIDR
LVDQGEANYGDVAVFYRTNNNSRALEEIFIRMGLPYKVVGGVRFYERKEVRDIVAYLRVLENPDDAVSLRRILNTPRRGI
GDRAEACVAVHAEQRGIGFAAALRDAAEGKVALLNTRAQRAIAGFLDLLEEIRAAGEQADADFPDVGNVVEAVLDRTGYR
AELEASDDPQDGARLDNLNELVSVAREFSSEAYNNAVAAREEGILPEQAEGEPDPGSLAAFLERVSLVADTDQIPDEGAG
VVTMMTLHTAKGLEFPVVFVTGWEDGQFPHMRALGDPTELAEERRLAYVGITRARQRLYLTRAVVRSGWGQPVSNPESRF
LQEIPDHLIEWRRLEPSPATRGIRKRGGDEGLERDWTRGDGWSEPRPGVRDRGPRRPAPGGASRNNTNLVLAVGDRVSDD
KYGLGRVVAADGFGPLATVTIDFGTAGKIRLIPQYSRTLVKL
>Mature_842_residues
MDMTVVPQTTAPQTTPAGRSLAEQAQQRADDQARRRADRDRQRAEQVERLLDGLNPQQRAAVVHAGSPLLIVAGAGSGKT
AVLTRRIAYLLAARDVSPGQILAITFTNKAAAEMRERVTGLVGPRAATMWVSTFHSSCVRILRMQAALLPGLNSNFSIYD
ADDSRRLLTMISRDLDIDTKKYSARLLVTAISNLKNELIGPEQASADAESDESELPGLVARVYTEYQRRLRAANALDFDD
LIGETVALLQNHPQVAEYYRRRFRHVLVDEYQDTNHAQYVLVRELVGHHSAADDTEDAVPPSELCVVGDADQSIYAFRGA
TIRNIEEFERDFPDAETILLEQNYRSTQNILSAANAVIARNEGRREKRLWTDSGEGDLIVGYVADNEHDEASFVAREIDR
LVDQGEANYGDVAVFYRTNNNSRALEEIFIRMGLPYKVVGGVRFYERKEVRDIVAYLRVLENPDDAVSLRRILNTPRRGI
GDRAEACVAVHAEQRGIGFAAALRDAAEGKVALLNTRAQRAIAGFLDLLEEIRAAGEQADADFPDVGNVVEAVLDRTGYR
AELEASDDPQDGARLDNLNELVSVAREFSSEAYNNAVAAREEGILPEQAEGEPDPGSLAAFLERVSLVADTDQIPDEGAG
VVTMMTLHTAKGLEFPVVFVTGWEDGQFPHMRALGDPTELAEERRLAYVGITRARQRLYLTRAVVRSGWGQPVSNPESRF
LQEIPDHLIEWRRLEPSPATRGIRKRGGDEGLERDWTRGDGWSEPRPGVRDRGPRRPAPGGASRNNTNLVLAVGDRVSDD
KYGLGRVVAADGFGPLATVTIDFGTAGKIRLIPQYSRTLVKL

Specific function: Has Both Atpase And Helicase Activities. Unwinds DNA Duplexes With 3' To 5' Polarity With Respect To The Bound Strand And Initiates Unwinding Most Effectively When A Single-Stranded Region Is Present. Involved In The Post-Incision Events Of Nucleotide Exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=791, Percent_Identity=38.3059418457649, Blast_Score=484, Evalue=1e-138,
Organism=Escherichia coli, GI48994965, Length=684, Percent_Identity=37.5730994152047, Blast_Score=376, Evalue=1e-105,
Organism=Escherichia coli, GI1787196, Length=350, Percent_Identity=29.4285714285714, Blast_Score=109, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6322369, Length=768, Percent_Identity=28.2552083333333, Blast_Score=238, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6324477, Length=471, Percent_Identity=23.1422505307856, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 92978; Mature: 92978

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMTVVPQTTAPQTTPAGRSLAEQAQQRADDQARRRADRDRQRAEQVERLLDGLNPQQRA
CCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHE
AVVHAGSPLLIVAGAGSGKTAVLTRRIAYLLAARDVSPGQILAITFTNKAAAEMRERVTG
EEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHH
LVGPRAATMWVSTFHSSCVRILRMQAALLPGLNSNFSIYDADDSRRLLTMISRDLDIDTK
HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCH
KYSARLLVTAISNLKNELIGPEQASADAESDESELPGLVARVYTEYQRRLRAANALDFDD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LIGETVALLQNHPQVAEYYRRRFRHVLVDEYQDTNHAQYVLVRELVGHHSAADDTEDAVP
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCC
PSELCVVGDADQSIYAFRGATIRNIEEFERDFPDAETILLEQNYRSTQNILSAANAVIAR
CCCEEEEECCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCC
NEGRREKRLWTDSGEGDLIVGYVADNEHDEASFVAREIDRLVDQGEANYGDVAVFYRTNN
CCCCHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECC
NSRALEEIFIRMGLPYKVVGGVRFYERKEVRDIVAYLRVLENPDDAVSLRRILNTPRRGI
CCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
GDRAEACVAVHAEQRGIGFAAALRDAAEGKVALLNTRAQRAIAGFLDLLEEIRAAGEQAD
CCHHHHEEEEEHHHCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCC
ADFPDVGNVVEAVLDRTGYRAELEASDDPQDGARLDNLNELVSVAREFSSEAYNNAVAAR
CCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHH
EEGILPEQAEGEPDPGSLAAFLERVSLVADTDQIPDEGAGVVTMMTLHTAKGLEFPVVFV
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEHHCCCCCCCEEEE
TGWEDGQFPHMRALGDPTELAEERRLAYVGITRARQRLYLTRAVVRSGWGQPVSNPESRF
ECCCCCCCCCHHHCCCHHHHHHHHCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
LQEIPDHLIEWRRLEPSPATRGIRKRGGDEGLERDWTRGDGWSEPRPGVRDRGPRRPAPG
HHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GASRNNTNLVLAVGDRVSDDKYGLGRVVAADGFGPLATVTIDFGTAGKIRLIPQYSRTLV
CCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCEEECCHHHHHHH
KL
CC
>Mature Secondary Structure
MDMTVVPQTTAPQTTPAGRSLAEQAQQRADDQARRRADRDRQRAEQVERLLDGLNPQQRA
CCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHE
AVVHAGSPLLIVAGAGSGKTAVLTRRIAYLLAARDVSPGQILAITFTNKAAAEMRERVTG
EEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHH
LVGPRAATMWVSTFHSSCVRILRMQAALLPGLNSNFSIYDADDSRRLLTMISRDLDIDTK
HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCH
KYSARLLVTAISNLKNELIGPEQASADAESDESELPGLVARVYTEYQRRLRAANALDFDD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LIGETVALLQNHPQVAEYYRRRFRHVLVDEYQDTNHAQYVLVRELVGHHSAADDTEDAVP
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCC
PSELCVVGDADQSIYAFRGATIRNIEEFERDFPDAETILLEQNYRSTQNILSAANAVIAR
CCCEEEEECCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCC
NEGRREKRLWTDSGEGDLIVGYVADNEHDEASFVAREIDRLVDQGEANYGDVAVFYRTNN
CCCCHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECC
NSRALEEIFIRMGLPYKVVGGVRFYERKEVRDIVAYLRVLENPDDAVSLRRILNTPRRGI
CCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
GDRAEACVAVHAEQRGIGFAAALRDAAEGKVALLNTRAQRAIAGFLDLLEEIRAAGEQAD
CCHHHHEEEEEHHHCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCC
ADFPDVGNVVEAVLDRTGYRAELEASDDPQDGARLDNLNELVSVAREFSSEAYNNAVAAR
CCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHH
EEGILPEQAEGEPDPGSLAAFLERVSLVADTDQIPDEGAGVVTMMTLHTAKGLEFPVVFV
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEHHCCCCCCCEEEE
TGWEDGQFPHMRALGDPTELAEERRLAYVGITRARQRLYLTRAVVRSGWGQPVSNPESRF
ECCCCCCCCCHHHCCCHHHHHHHHCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
LQEIPDHLIEWRRLEPSPATRGIRKRGGDEGLERDWTRGDGWSEPRPGVRDRGPRRPAPG
HHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GASRNNTNLVLAVGDRVSDDKYGLGRVVAADGFGPLATVTIDFGTAGKIRLIPQYSRTLV
CCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCEEECCHHHHHHH
KL
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]