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The map label for this gene is moeA2 [H]

Identifier: 54026926

GI number: 54026926

Start: 5170198

End: 5171454

Strand: Reverse

Name: moeA2 [H]

Synonym: nfa49520

Alternate gene names: 54026926

Gene position: 5171454-5170198 (Counterclockwise)

Preceding gene: 54026927

Following gene: 54026925

Centisome position: 85.89

GC content: 72.47

Gene sequence:

>1257_bases
ATGCGCTCGGTTGAGGATCAGCAGATCAAGGTGACCGCGGCGGCGGTCGCACCACGGCCGGTCCGCGTCGCGATCTCCGA
GGCCCAGGGCCTGCTGTGCGCCGAGGACGTGGTCACCGAGCGCCCGCTGCCCGGTTTCGACCAGGCCGCGATCGACGGTT
ACGCGGTGCGCAGTGTCGATGTCGCGGCCGCGGGCTCCGACATCCGCGACGAGGACGGCGAACTCGTCGACCTCACCCTG
CCGGTGGTGGGGGAGGTCGTGGCGGGCTCGCGCCAGCCGATCCGGCTGCAACCGCGCCAGACCGTGCGGGTGGACACCGG
CGCCCCGCTGCCCACCCTCGCCGACGCGGTGCTGCCGCTGGACTTCACCGATGGCGGCCGGGCCAGGATCAAGGTGTTCG
AGCCGGTGCGTTCGGGCGACTACGTGCGCCGCATCGGCGACGACGTGCAGCCCGGTGACGTGGCGGTGCGGGCAGGCACG
ATCATCGGCCCGGCCCAGGTGGGTCTGCTGGCCGCCGTCGGCCAGGACAAGGTGCTGGTGCATCCGCGCCCGCGGCTGTC
GGTGATCGCCGTCGGCGGCGAGCTCATCGACATCGACCGCACCCCCGGCCCCGGCCAGGTCTACGACGTCAACTCGTATG
CGCTGGCCGCCGCGGCCAGGGATGCGGGCGCCGACGTGAACCGGGTCGGCATCGTCAGCACCGATCCGCGCCGGCTGCGC
GACGTGGTCGAGGGCCAGCTGGTGCGCTCGGAGGTCGTGGTGATCGCGGGCGCGGTCGGCGGCTGGGCCTCCGAACAGGT
CCGCGAGGCGCTCGAGGGCCTGGGGGAACTCGAGATCGCGCGGGTCGCCATGCATCCCGGGTCGGTGCAGGGCTTCGGGC
GGCTCGGCCGCGACGAGGTGCCGACCTTCCTGCTGCCCGCCAACCCGGTGGGCGCGCTGGTGGTCTTCGAGGTGATGGTG
CGCCCGCTCATCCGCATCGCGCTCGGCCGCAGGCACCCCATGCGCCGCGTCATCCGGGCCAGGACGATCACCCCGATCAG
CTCGATGGCCGGTCGCAAGGGCTATCTGCGCGCGCAGTTGATGCGCGACGAGTCGACCGGTGAATACCTGGTGCAGCCGC
TCGGCGGCGCGGCGGGCTCCTCGCACCTGCTGGCCACCCTGGCCGAGGCGAACAGTCTGATCATCGTCGATCCGGACGAC
ACCGAGATCAGGACCGGCGACGAAGTGCAGGTCGCGTTTCTCTCCCAACGCGGCTGA

Upstream 100 bases:

>100_bases
CGCCAGCCGTGCACCGTCGGGTACCAATGGTGCAGGCGAACGCGGCCCGTCCGGGACAGGTGATCGCGGACAGGTAGCGG
AGAGGATCAGGAAGGGCTGG

Downstream 100 bases:

>100_bases
ACCGTGGAGAGCATGAACGTGTTCCGGGCGACGCAGCACCCCGGATGGCCCGCCCGACTCGGCCCGGTGCGCGTCGCGGC
CGGACAGATCACCCTGCGGC

Product: putative molybdopterin biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase 1 [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MRSVEDQQIKVTAAAVAPRPVRVAISEAQGLLCAEDVVTERPLPGFDQAAIDGYAVRSVDVAAAGSDIRDEDGELVDLTL
PVVGEVVAGSRQPIRLQPRQTVRVDTGAPLPTLADAVLPLDFTDGGRARIKVFEPVRSGDYVRRIGDDVQPGDVAVRAGT
IIGPAQVGLLAAVGQDKVLVHPRPRLSVIAVGGELIDIDRTPGPGQVYDVNSYALAAAARDAGADVNRVGIVSTDPRRLR
DVVEGQLVRSEVVVIAGAVGGWASEQVREALEGLGELEIARVAMHPGSVQGFGRLGRDEVPTFLLPANPVGALVVFEVMV
RPLIRIALGRRHPMRRVIRARTITPISSMAGRKGYLRAQLMRDESTGEYLVQPLGGAAGSSHLLATLAEANSLIIVDPDD
TEIRTGDEVQVAFLSQRG

Sequences:

>Translated_418_residues
MRSVEDQQIKVTAAAVAPRPVRVAISEAQGLLCAEDVVTERPLPGFDQAAIDGYAVRSVDVAAAGSDIRDEDGELVDLTL
PVVGEVVAGSRQPIRLQPRQTVRVDTGAPLPTLADAVLPLDFTDGGRARIKVFEPVRSGDYVRRIGDDVQPGDVAVRAGT
IIGPAQVGLLAAVGQDKVLVHPRPRLSVIAVGGELIDIDRTPGPGQVYDVNSYALAAAARDAGADVNRVGIVSTDPRRLR
DVVEGQLVRSEVVVIAGAVGGWASEQVREALEGLGELEIARVAMHPGSVQGFGRLGRDEVPTFLLPANPVGALVVFEVMV
RPLIRIALGRRHPMRRVIRARTITPISSMAGRKGYLRAQLMRDESTGEYLVQPLGGAAGSSHLLATLAEANSLIIVDPDD
TEIRTGDEVQVAFLSQRG
>Mature_418_residues
MRSVEDQQIKVTAAAVAPRPVRVAISEAQGLLCAEDVVTERPLPGFDQAAIDGYAVRSVDVAAAGSDIRDEDGELVDLTL
PVVGEVVAGSRQPIRLQPRQTVRVDTGAPLPTLADAVLPLDFTDGGRARIKVFEPVRSGDYVRRIGDDVQPGDVAVRAGT
IIGPAQVGLLAAVGQDKVLVHPRPRLSVIAVGGELIDIDRTPGPGQVYDVNSYALAAAARDAGADVNRVGIVSTDPRRLR
DVVEGQLVRSEVVVIAGAVGGWASEQVREALEGLGELEIARVAMHPGSVQGFGRLGRDEVPTFLLPANPVGALVVFEVMV
RPLIRIALGRRHPMRRVIRARTITPISSMAGRKGYLRAQLMRDESTGEYLVQPLGGAAGSSHLLATLAEANSLIIVDPDD
TEIRTGDEVQVAFLSQRG

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=403, Percent_Identity=28.7841191066998, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI10880983, Length=403, Percent_Identity=28.7841191066998, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1787049, Length=376, Percent_Identity=30.5851063829787, Blast_Score=152, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI25147659, Length=357, Percent_Identity=29.1316526610644, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17562606, Length=415, Percent_Identity=22.8915662650602, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17136978, Length=355, Percent_Identity=25.9154929577465, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24638841, Length=355, Percent_Identity=25.9154929577465, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44298; Mature: 44298

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSVEDQQIKVTAAAVAPRPVRVAISEAQGLLCAEDVVTERPLPGFDQAAIDGYAVRSVD
CCCCCCCEEEEEEEECCCCCEEEEEECCCCCEEHHHHHHCCCCCCCCHHHCCCEEEEEEE
VAAAGSDIRDEDGELVDLTLPVVGEVVAGSRQPIRLQPRQTVRVDTGAPLPTLADAVLPL
EEECCCCCCCCCCCEEEEEHHHHHHHHCCCCCCEEECCCCEEEECCCCCCHHHHHHEEEE
DFTDGGRARIKVFEPVRSGDYVRRIGDDVQPGDVAVRAGTIIGPAQVGLLAAVGQDKVLV
EECCCCCEEEEEECCCCCCCHHHHHCCCCCCCCEEEEECCEECHHHHHEEEECCCCEEEE
HPRPRLSVIAVGGELIDIDRTPGPGQVYDVNSYALAAAARDAGADVNRVGIVSTDPRRLR
CCCCCEEEEEECCEEEEECCCCCCCEEEECCCCEEEEHHHCCCCCCCEEEEEECCHHHHH
DVVEGQLVRSEVVVIAGAVGGWASEQVREALEGLGELEIARVAMHPGSVQGFGRLGRDEV
HHHHHHHEEEEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCHHCCCCCCCC
PTFLLPANPVGALVVFEVMVRPLIRIALGRRHPMRRVIRARTITPISSMAGRKGYLRAQL
CEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHCCCCCCEEEEE
MRDESTGEYLVQPLGGAAGSSHLLATLAEANSLIIVDPDDTEIRTGDEVQVAFLSQRG
ECCCCCCCEEEEECCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MRSVEDQQIKVTAAAVAPRPVRVAISEAQGLLCAEDVVTERPLPGFDQAAIDGYAVRSVD
CCCCCCCEEEEEEEECCCCCEEEEEECCCCCEEHHHHHHCCCCCCCCHHHCCCEEEEEEE
VAAAGSDIRDEDGELVDLTLPVVGEVVAGSRQPIRLQPRQTVRVDTGAPLPTLADAVLPL
EEECCCCCCCCCCCEEEEEHHHHHHHHCCCCCCEEECCCCEEEECCCCCCHHHHHHEEEE
DFTDGGRARIKVFEPVRSGDYVRRIGDDVQPGDVAVRAGTIIGPAQVGLLAAVGQDKVLV
EECCCCCEEEEEECCCCCCCHHHHHCCCCCCCCEEEEECCEECHHHHHEEEECCCCEEEE
HPRPRLSVIAVGGELIDIDRTPGPGQVYDVNSYALAAAARDAGADVNRVGIVSTDPRRLR
CCCCCEEEEEECCEEEEECCCCCCCEEEECCCCEEEEHHHCCCCCCCEEEEEECCHHHHH
DVVEGQLVRSEVVVIAGAVGGWASEQVREALEGLGELEIARVAMHPGSVQGFGRLGRDEV
HHHHHHHEEEEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCHHCCCCCCCC
PTFLLPANPVGALVVFEVMVRPLIRIALGRRHPMRRVIRARTITPISSMAGRKGYLRAQL
CEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHCCCCCCEEEEE
MRDESTGEYLVQPLGGAAGSSHLLATLAEANSLIIVDPDDTEIRTGDEVQVAFLSQRG
ECCCCCCCEEEEECCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]