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The map label for this gene is arpA [H]

Identifier: 54026850

GI number: 54026850

Start: 5090627

End: 5091274

Strand: Reverse

Name: arpA [H]

Synonym: nfa48760

Alternate gene names: 54026850

Gene position: 5091274-5090627 (Counterclockwise)

Preceding gene: 54026851

Following gene: 54026849

Centisome position: 84.56

GC content: 66.51

Gene sequence:

>648_bases
ATGGCTAGGCAAGCGCGCGCGGAGATCACCCGCGATTCCGTCCTGGCGGGCGCTGCCGATGTCTTTCTGCGCTTGGGTTA
CGCGAACGCGAGCCTCAGCGAGATCATCGCGCAGTCCAATGTCACCAAGGGCGCCTTGTACTTTCACTTCGGTTCGAAGG
AAGAACTGGCCCGCGCGGTCGTCGACCAGGGCAACGAGCGGCTGATCAGCTCCTGCCAGGGATTCTTCGATCCCCGGGTG
CCCGCGCTGGAAGCCTGCATCGGCATCACCTACGTCGTGGCCGATCTGTCCATGAACGACCCGATGGTGGGCGCGATGCT
CAAGCTCACCCACCAGATCGGCGACTACCGGGGCGCGCAGGGCGACAACATCTCCAAGACCTGGGGCGAGACCTACCGGC
TGCTCGCCGAGCGGGCCATCGCCCAGGGCGACCTCGAGCCCGATCTCGACCCGGAGGTGGTCGGGCTGCTGCTGCACGAG
GTGACCGCCGGTGTGCACATCGTCGCGGTCGGCACCGAATCGATCGACCAGATGGCCACCCGGATGGAACGGGCCTGGCA
CTACCTGCTGCCCGCCCTGGTTCCGGCCGAGAAGCTGTCGTACTTCCGGGAATTCGCCGCGCGACGGTTGCGGCGCTACG
TCCCCTGA

Upstream 100 bases:

>100_bases
TTCACCCATCCTCTGGGTGCTGTTCGGGCGGTATGTCGGTCTACTTCGGGATGTCGGTCTACTTCAGGATGGCTGGTTTC
AGGAATGACAGGCGGATCTG

Downstream 100 bases:

>100_bases
GCCGCCGCGGACCCGCAGGCCGGGCAGGCGCGGAGACGCCGCGTGCGACGCGGACGGTGGGGGAGCGGGGTGGCAAGGGG
GCCGGGGGCGGTGATTAGAC

Product: putative transcriptional regulator

Products: NA

Alternate protein names: A-factor-binding protein [H]

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MARQARAEITRDSVLAGAADVFLRLGYANASLSEIIAQSNVTKGALYFHFGSKEELARAVVDQGNERLISSCQGFFDPRV
PALEACIGITYVVADLSMNDPMVGAMLKLTHQIGDYRGAQGDNISKTWGETYRLLAERAIAQGDLEPDLDPEVVGLLLHE
VTAGVHIVAVGTESIDQMATRMERAWHYLLPALVPAEKLSYFREFAARRLRRYVP

Sequences:

>Translated_215_residues
MARQARAEITRDSVLAGAADVFLRLGYANASLSEIIAQSNVTKGALYFHFGSKEELARAVVDQGNERLISSCQGFFDPRV
PALEACIGITYVVADLSMNDPMVGAMLKLTHQIGDYRGAQGDNISKTWGETYRLLAERAIAQGDLEPDLDPEVVGLLLHE
VTAGVHIVAVGTESIDQMATRMERAWHYLLPALVPAEKLSYFREFAARRLRRYVP
>Mature_214_residues
ARQARAEITRDSVLAGAADVFLRLGYANASLSEIIAQSNVTKGALYFHFGSKEELARAVVDQGNERLISSCQGFFDPRVP
ALEACIGITYVVADLSMNDPMVGAMLKLTHQIGDYRGAQGDNISKTWGETYRLLAERAIAQGDLEPDLDPEVVGLLLHEV
TAGVHIVAVGTESIDQMATRMERAWHYLLPALVPAEKLSYFREFAARRLRRYVP

Specific function: Represses adpA expression by binding to the promoter region in the absence of A-factor, causing repression of streptomycin production and of sporulation [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 23695; Mature: 23564

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARQARAEITRDSVLAGAADVFLRLGYANASLSEIIAQSNVTKGALYFHFGSKEELARAV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEEECCHHHHHHHH
VDQGNERLISSCQGFFDPRVPALEACIGITYVVADLSMNDPMVGAMLKLTHQIGDYRGAQ
HHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCC
GDNISKTWGETYRLLAERAIAQGDLEPDLDPEVVGLLLHEVTAGVHIVAVGTESIDQMAT
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEEECHHHHHHHHH
RMERAWHYLLPALVPAEKLSYFREFAARRLRRYVP
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ARQARAEITRDSVLAGAADVFLRLGYANASLSEIIAQSNVTKGALYFHFGSKEELARAV
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEEECCHHHHHHHH
VDQGNERLISSCQGFFDPRVPALEACIGITYVVADLSMNDPMVGAMLKLTHQIGDYRGAQ
HHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCC
GDNISKTWGETYRLLAERAIAQGDLEPDLDPEVVGLLLHEVTAGVHIVAVGTESIDQMAT
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEEECHHHHHHHHH
RMERAWHYLLPALVPAEKLSYFREFAARRLRRYVP
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7592371; 9813285; 2502536; 2111804; 9220006; 10540289; 9098075 [H]