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The map label for this gene is mazG [H]

Identifier: 54026848

GI number: 54026848

Start: 5086173

End: 5086868

Strand: Reverse

Name: mazG [H]

Synonym: nfa48740

Alternate gene names: 54026848

Gene position: 5086868-5086173 (Counterclockwise)

Preceding gene: 54026849

Following gene: 54026843

Centisome position: 84.48

GC content: 73.28

Gene sequence:

>696_bases
ATGAGCACCGAACGCGCCGACGTCGACCTGGTGTCCGCGGGGCTCGCGGGCGCCGTCGAGGTGATGGACCGGCTGTGGAG
CTTCGGCGGCTGGGAGGTCACCCAGACCCACGACTCGCTGCGCCCGTACCTGCTCGAGGAAACCTACGAACTGCTCGACG
CCATCGGCCACGGCGACGCCGAGACCATCAAGGAGGAACTGGGCGATCTGCTGTTGCAGGTGCTGTTCCACTCCCGGATC
GCCGAGGCCGCGGGCGAATTCACCGTGCACGACGTCGCCGCCGCGCTGGTCGCCAAGCTGGTGAACCGCAGCCCGCACCT
GGTCGAAGCCGCCATCGACCCCGGCGCGTCGCGGGAGGAGAAGATCGCCGCGCAGGAACGCGCCTGGCAGGAGCGCAAGT
CCGCGGAGAAGACCCGCCGCTCCTGCCTCGACGGGATCGCGCCGGCGCAGCCCGCCCTCGCCCTCGCCGAGAAGGTCGTC
GCGCGCAGCCGCGCCGCGGGGCTGCCCGACGACCTGGTGCCCGGCGAACTGCGCGTGGTCCACCTCGGTGGGCCGGACAG
CGCCGAGGAACGGTTGCGCAAGGACACGCTGGCCTTCGCCGCGCGGATTCGCGCGGCCGAGGACGCCGCCGAAGCCGAGC
GCGGGGCGCGGGCGCCGTTGGCCGAGGCCGACTGGCGGCGGTACTGGCCGAGCTGA

Upstream 100 bases:

>100_bases
TGCAGCTGCTCCAGTTCGTCGCCGATCTGCTGCTGGCACTGGACGGCAAGGCGCAGGGCGCGGTGGACCTGACGGTGGCG
ACCGAGGCCACGGCGCACCG

Downstream 100 bases:

>100_bases
GCGGGCGGTCAGCCCGGTAGCACCGAGTCCAGGTCGGCGGCCAGCGTCCGCGCGATGCCGGTGGCGACGGTGCTCAGCTC
GGCAGTCGGGACCGGCTCCG

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MSTERADVDLVSAGLAGAVEVMDRLWSFGGWEVTQTHDSLRPYLLEETYELLDAIGHGDAETIKEELGDLLLQVLFHSRI
AEAAGEFTVHDVAAALVAKLVNRSPHLVEAAIDPGASREEKIAAQERAWQERKSAEKTRRSCLDGIAPAQPALALAEKVV
ARSRAAGLPDDLVPGELRVVHLGGPDSAEERLRKDTLAFAARIRAAEDAAEAERGARAPLAEADWRRYWPS

Sequences:

>Translated_231_residues
MSTERADVDLVSAGLAGAVEVMDRLWSFGGWEVTQTHDSLRPYLLEETYELLDAIGHGDAETIKEELGDLLLQVLFHSRI
AEAAGEFTVHDVAAALVAKLVNRSPHLVEAAIDPGASREEKIAAQERAWQERKSAEKTRRSCLDGIAPAQPALALAEKVV
ARSRAAGLPDDLVPGELRVVHLGGPDSAEERLRKDTLAFAARIRAAEDAAEAERGARAPLAEADWRRYWPS
>Mature_230_residues
STERADVDLVSAGLAGAVEVMDRLWSFGGWEVTQTHDSLRPYLLEETYELLDAIGHGDAETIKEELGDLLLQVLFHSRIA
EAAGEFTVHDVAAALVAKLVNRSPHLVEAAIDPGASREEKIAAQERAWQERKSAEKTRRSCLDGIAPAQPALALAEKVVA
RSRAAGLPDDLVPGELRVVHLGGPDSAEERLRKDTLAFAARIRAAEDAAEAERGARAPLAEADWRRYWPS

Specific function: Required to maintain the full capacity of the mycobacteria to respond to oxidative stress via the degradation of the oxidation-induced damaged nucleotides. It hydrolyzes all canonical (d)NTPs, as well as the mutagenic dUTP and 8-oxo-7,8- dihydro-2'-deoxyg

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=138, Percent_Identity=37.6811594202899, Blast_Score=96, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 25132; Mature: 25001

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTERADVDLVSAGLAGAVEVMDRLWSFGGWEVTQTHDSLRPYLLEETYELLDAIGHGDA
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCH
ETIKEELGDLLLQVLFHSRIAEAAGEFTVHDVAAALVAKLVNRSPHLVEAAIDPGASREE
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEHHCCCCCCHHH
KIAAQERAWQERKSAEKTRRSCLDGIAPAQPALALAEKVVARSRAAGLPDDLVPGELRVV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEE
HLGGPDSAEERLRKDTLAFAARIRAAEDAAEAERGARAPLAEADWRRYWPS
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCC
>Mature Secondary Structure 
STERADVDLVSAGLAGAVEVMDRLWSFGGWEVTQTHDSLRPYLLEETYELLDAIGHGDA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCH
ETIKEELGDLLLQVLFHSRIAEAAGEFTVHDVAAALVAKLVNRSPHLVEAAIDPGASREE
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEHHCCCCCCHHH
KIAAQERAWQERKSAEKTRRSCLDGIAPAQPALALAEKVVARSRAAGLPDDLVPGELRVV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEE
HLGGPDSAEERLRKDTLAFAARIRAAEDAAEAERGARAPLAEADWRRYWPS
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]