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The map label for this gene is cbs [H]

Identifier: 54026806

GI number: 54026806

Start: 5046193

End: 5047581

Strand: Reverse

Name: cbs [H]

Synonym: nfa48320

Alternate gene names: 54026806

Gene position: 5047581-5046193 (Counterclockwise)

Preceding gene: 54026810

Following gene: 54026805

Centisome position: 83.83

GC content: 70.34

Gene sequence:

>1389_bases
ATGCGCATCGCGGATCACGTCGTGGACCTCATCGGCAACACGCCCCTGGTCCGGCTCAACAATGTCGTCGGCCCGAACGC
GGGCCTGGTCGCCGCCAAGATCGAGTACCTCAACCCCGGCGGCAGCTCGAAGGACCGGATCGCGGTGAAGATGATCGACG
CCGCGGAGAAGTCCGGCCAGCTGAAGCCGGGCGGCACCATTGTCGAGCCGACCTCCGGCAACACCGGCGTGGGTCTCGCG
CTGGTGGCGCAGCAGCGCGGCTACAAGTGCGTGTTCGTCTGCCCGGACAAAGTCTCCGAGGACAAGCGCAACGTGCTGCG
CGCCTACGGCGCCGAGGTGGTGGTCTGCCCGACCGCGGTCCCGCCGGATCACCCGGACAGCTACTACAGCGTCTCCGATC
GGCTCGTCCGCGAGATCGACGGTGCGTGGAAGCCCGACCAGTACTCCAACCCGGGCGGCCCGGAGAGCCATTACGAGACC
ACCGGCCCGGAGATCTGGCGCGACACCGACGGCCGGGTGACCCACTTCGTCGCGGGCGTCGGTACCGGCGGCACCATCAC
CGGCGCGGGCCGCTACCTCAAGGAGGTCTCCGGCGGGAAGGTGCGCGTCATCGGCGCCGACCCGGAAGGCTCGGTCTACT
CCGGCGGCAGTGGCAGGCCCTACCTGGTGGAGGGCGTCGGCGAGGACTTCTGGCCCTCCGCCTACGACCCGGCCGTGCCG
GACGAGATCATCGCCGTCTCCGACGCCGACTCCTTCGAGATGACCCGCAGGCTGGCCCGGGAGGAGGGCCTGCTGGTCGG
CGGCTCCTGCGGCATGGCCGTGGTGGCCGCGATCGAGGTCGCGCGGCGGGATCCGGACGCCGTGGTGGTCGTGCTGCTGC
CCGACGGCGGCCGCGGCTACCTGTCGAAGATCTTCAACGACCAGTGGATGAGCTCCTACGGCTTCCTGCGCACCCGCCTG
GACGGCAGCCCCGAGCCGCTGGTGGGTGACGTGCTGCGCGGTAAGTCCGGCGAGCTGCCCGACCTGGTGCACACCCACCC
GTCGGAGACGTTGCGCGACGCGATCGAGATCCTGCGCGAATACGGCGTCTCGCAGATGCCGGTGGTCGGTGCCGAGCCGC
CGGTGATGGCGGGCGAGGTGCAGGGCAGCGTCACCGAGCGCGACCTGCTCTCGGCGGTGTTCGAGGGCCGCGCGCATCTC
ACCGATTCGGTGGCCCAGCACATGAGCCCGTCGTTCCCGCTGATCGGTTCCGGCGAGCCGATCTCGGCGGCGACCAAGGC
GCTGTCGGACACCGACGCGCTGATGGTGGTCGAGGACGGCAAGCCGGTCGGCGTCATCACCCGGCACGATCTGCTCGGTT
TCCTCAGCACCGGCAGCGTCGGCCACTGA

Upstream 100 bases:

>100_bases
GCGCGCGCCCGGCCTCCGGCGCGCCGCCGCGGGGTGTCGTGCCGACCCGCTGAGGCGACGTGCGCGAACTCACAGCGGGG
CCTTCTGCAACGATGGGGCT

Downstream 100 bases:

>100_bases
GGCTCGACGGCCCTTTCCATTCCGGACGGTGAATTCCGCGCGGAAATACTACTACTGATTTCGGCTAATTGTTCGCAATC
CGAGGGTTAGCCCAGCATCA

Product: putative cystathionine beta-synthase

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MRIADHVVDLIGNTPLVRLNNVVGPNAGLVAAKIEYLNPGGSSKDRIAVKMIDAAEKSGQLKPGGTIVEPTSGNTGVGLA
LVAQQRGYKCVFVCPDKVSEDKRNVLRAYGAEVVVCPTAVPPDHPDSYYSVSDRLVREIDGAWKPDQYSNPGGPESHYET
TGPEIWRDTDGRVTHFVAGVGTGGTITGAGRYLKEVSGGKVRVIGADPEGSVYSGGSGRPYLVEGVGEDFWPSAYDPAVP
DEIIAVSDADSFEMTRRLAREEGLLVGGSCGMAVVAAIEVARRDPDAVVVVLLPDGGRGYLSKIFNDQWMSSYGFLRTRL
DGSPEPLVGDVLRGKSGELPDLVHTHPSETLRDAIEILREYGVSQMPVVGAEPPVMAGEVQGSVTERDLLSAVFEGRAHL
TDSVAQHMSPSFPLIGSGEPISAATKALSDTDALMVVEDGKPVGVITRHDLLGFLSTGSVGH

Sequences:

>Translated_462_residues
MRIADHVVDLIGNTPLVRLNNVVGPNAGLVAAKIEYLNPGGSSKDRIAVKMIDAAEKSGQLKPGGTIVEPTSGNTGVGLA
LVAQQRGYKCVFVCPDKVSEDKRNVLRAYGAEVVVCPTAVPPDHPDSYYSVSDRLVREIDGAWKPDQYSNPGGPESHYET
TGPEIWRDTDGRVTHFVAGVGTGGTITGAGRYLKEVSGGKVRVIGADPEGSVYSGGSGRPYLVEGVGEDFWPSAYDPAVP
DEIIAVSDADSFEMTRRLAREEGLLVGGSCGMAVVAAIEVARRDPDAVVVVLLPDGGRGYLSKIFNDQWMSSYGFLRTRL
DGSPEPLVGDVLRGKSGELPDLVHTHPSETLRDAIEILREYGVSQMPVVGAEPPVMAGEVQGSVTERDLLSAVFEGRAHL
TDSVAQHMSPSFPLIGSGEPISAATKALSDTDALMVVEDGKPVGVITRHDLLGFLSTGSVGH
>Mature_462_residues
MRIADHVVDLIGNTPLVRLNNVVGPNAGLVAAKIEYLNPGGSSKDRIAVKMIDAAEKSGQLKPGGTIVEPTSGNTGVGLA
LVAQQRGYKCVFVCPDKVSEDKRNVLRAYGAEVVVCPTAVPPDHPDSYYSVSDRLVREIDGAWKPDQYSNPGGPESHYET
TGPEIWRDTDGRVTHFVAGVGTGGTITGAGRYLKEVSGGKVRVIGADPEGSVYSGGSGRPYLVEGVGEDFWPSAYDPAVP
DEIIAVSDADSFEMTRRLAREEGLLVGGSCGMAVVAAIEVARRDPDAVVVVLLPDGGRGYLSKIFNDQWMSSYGFLRTRL
DGSPEPLVGDVLRGKSGELPDLVHTHPSETLRDAIEILREYGVSQMPVVGAEPPVMAGEVQGSVTERDLLSAVFEGRAHL
TDSVAQHMSPSFPLIGSGEPISAATKALSDTDALMVVEDGKPVGVITRHDLLGFLSTGSVGH

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=478, Percent_Identity=40.5857740585774, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI295821200, Length=478, Percent_Identity=40.5857740585774, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI4557415, Length=478, Percent_Identity=40.5857740585774, Blast_Score=304, Evalue=1e-82,
Organism=Escherichia coli, GI2367138, Length=304, Percent_Identity=39.8026315789474, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1788754, Length=322, Percent_Identity=39.1304347826087, Blast_Score=187, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17534315, Length=330, Percent_Identity=46.3636363636364, Blast_Score=238, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI25147552, Length=328, Percent_Identity=43.2926829268293, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17562970, Length=304, Percent_Identity=42.7631578947368, Blast_Score=222, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI32566674, Length=277, Percent_Identity=45.8483754512635, Blast_Score=221, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI17535051, Length=298, Percent_Identity=41.2751677852349, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI115535073, Length=330, Percent_Identity=41.8181818181818, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17561720, Length=280, Percent_Identity=45.3571428571429, Blast_Score=198, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI32566672, Length=217, Percent_Identity=38.7096774193548, Blast_Score=139, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6321594, Length=504, Percent_Identity=34.3253968253968, Blast_Score=266, Evalue=5e-72,
Organism=Saccharomyces cerevisiae, GI6321449, Length=330, Percent_Identity=35.1515151515151, Blast_Score=154, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24643623, Length=483, Percent_Identity=35.1966873706004, Blast_Score=251, Evalue=8e-67,
Organism=Drosophila melanogaster, GI20129101, Length=483, Percent_Identity=35.1966873706004, Blast_Score=251, Evalue=8e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 48825; Mature: 48825

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIADHVVDLIGNTPLVRLNNVVGPNAGLVAAKIEYLNPGGSSKDRIAVKMIDAAEKSGQ
CCHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEEEECCCCCCCCEEEEEEEEHHHHCCC
LKPGGTIVEPTSGNTGVGLALVAQQRGYKCVFVCPDKVSEDKRNVLRAYGAEVVVCPTAV
CCCCCEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECCCC
PPDHPDSYYSVSDRLVREIDGAWKPDQYSNPGGPESHYETTGPEIWRDTDGRVTHFVAGV
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEEEEEEC
GTGGTITGAGRYLKEVSGGKVRVIGADPEGSVYSGGSGRPYLVEGVGEDFWPSAYDPAVP
CCCCCCCHHHHHHHHCCCCEEEEEECCCCCCEECCCCCCCEEEECCCCCCCCCCCCCCCC
DEIIAVSDADSFEMTRRLAREEGLLVGGSCGMAVVAAIEVARRDPDAVVVVLLPDGGRGY
CCEEEECCCCHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCCCHH
LSKIFNDQWMSSYGFLRTRLDGSPEPLVGDVLRGKSGELPDLVHTHPSETLRDAIEILRE
HHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHCCCCCCCCCHHHCCCHHHHHHHHHHHHH
YGVSQMPVVGAEPPVMAGEVQGSVTERDLLSAVFEGRAHLTDSVAQHMSPSFPLIGSGEP
CCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCC
ISAATKALSDTDALMVVEDGKPVGVITRHDLLGFLSTGSVGH
HHHHHHHHCCCCEEEEEECCCCEEEEEHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRIADHVVDLIGNTPLVRLNNVVGPNAGLVAAKIEYLNPGGSSKDRIAVKMIDAAEKSGQ
CCHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEEEECCCCCCCCEEEEEEEEHHHHCCC
LKPGGTIVEPTSGNTGVGLALVAQQRGYKCVFVCPDKVSEDKRNVLRAYGAEVVVCPTAV
CCCCCEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECCCC
PPDHPDSYYSVSDRLVREIDGAWKPDQYSNPGGPESHYETTGPEIWRDTDGRVTHFVAGV
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEEEEEEC
GTGGTITGAGRYLKEVSGGKVRVIGADPEGSVYSGGSGRPYLVEGVGEDFWPSAYDPAVP
CCCCCCCHHHHHHHHCCCCEEEEEECCCCCCEECCCCCCCEEEECCCCCCCCCCCCCCCC
DEIIAVSDADSFEMTRRLAREEGLLVGGSCGMAVVAAIEVARRDPDAVVVVLLPDGGRGY
CCEEEECCCCHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCCCHH
LSKIFNDQWMSSYGFLRTRLDGSPEPLVGDVLRGKSGELPDLVHTHPSETLRDAIEILRE
HHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHCCCCCCCCCHHHCCCHHHHHHHHHHHHH
YGVSQMPVVGAEPPVMAGEVQGSVTERDLLSAVFEGRAHLTDSVAQHMSPSFPLIGSGEP
CCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCC
ISAATKALSDTDALMVVEDGKPVGVITRHDLLGFLSTGSVGH
HHHHHHHHCCCCEEEEEECCCCEEEEEHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]