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The map label for this gene is fbiC

Identifier: 54026726

GI number: 54026726

Start: 4962947

End: 4965544

Strand: Reverse

Name: fbiC

Synonym: nfa47520

Alternate gene names: 54026726

Gene position: 4965544-4962947 (Counterclockwise)

Preceding gene: 54026729

Following gene: 54026725

Centisome position: 82.47

GC content: 71.59

Gene sequence:

>2598_bases
ATGATCGAGGGCGTGACCGAGCTAGCGACCCCGAACGTCCCGCCCGCTCCGCCCTCCCCGTCGGCGATGCGCCGGGCGTT
GCGCCGGGCGCGCGACGGGGTGAGCCTCAACCTCGACGAAGCCGTCGTGCTGCTGCACGCCCGCGGCGACGACCTGGCCG
ACCTGTGCCGCAGCGCCGCCCGGGTACGCGACGCCGGGCTCGAGTCGGCGGGCCGGCCCGGCACCATCACCTATTCGCGC
AACGTCTTCATCCCGCTGACCCGGCTGTGCCGGGACCGCTGTCACTACTGCACCTTCGTCACGGTGCCCGGCAAGCTGCG
GGCCGAGGGCAAGGGCATGTTCCTCGAGCCCGACGAGGTGCTCGACATCGCCCGCCGCGGCGCCGCCCTCGGCTGCAAGG
AGGCGCTGTTCACCCTCGGCGACCGGCCCGAGGACCGCTGGCCGGAGGCCGCGCAGTGGCTCGACGAACGCGGCTACGAC
TCCACGCTGGACTACCTGCGCGCCGTCTCGATCCTGGTGCTCGAGGAAACCGGCCTGCTGCCCCACCTCAACCCCGGTGT
GATGAGCTGGGCGGAGATCGCTCGGCTCAAGCCGGTCGCCCAGTCGATGGGCATGATGCTGGAGACCACCGCCACCCGGC
TGTTCACCGAGAAGGGGCAATGCCACCACGGCAGCCCCGACAAGGACCCGGCGGTGCGGCTGCGCGCCATCACCGACGCG
GGCAGGCTCTCGGTGCCCTACACCACCGGCATCCTGGTCGGCATCGGCGAGACGCTCACCGAGCGGGCCGAGTCGATCAT
GGCGATCCGCAAGCAGCACAAGGCCTTCGGGCACATCCAGGAGGTGATCGTCCAGAACTTCCGCGCCAAGGACGACACCG
CCATGCGCGATGCCCCCGACGCAGGCTTCGACGAGTTCCGGGCCACCATCGCCGTCACCCGCCTGCTGCTCGGGCCGGAC
GTGCCGGTGCAGGCGCCGCCGAACCTCGTCTCCCAGCAGGAGTGCCTGGCGCTGATCGAGGCGGGCATCGACGACTGGGG
CGGGGTCTCCCCGGTGACGCCGGACCACGTGAACCCGGAGCGGCCGTGGCCGAACCTGGACACCCTGCGCGAGCTCACCG
AGGCCAGCGGCTTCACCCTGGTCGAGCGCACCTCGGCGCACCCGAAGTACGTGCGGGCGGGCAATCCGTGGATCGACCCG
CGCATCGGCGCCCACGTCGCCGCGCTCACCGACCCGGTGACCGGCCTGGCGAAGGCCGACGCGCTGCCGGTGGGTCTGCC
CTGGCAGGAGCCGGACGAGTCGTGGGAGTCGGCGGGCCGCACCGACCTCAACATCGCCATCGACACCGAGGGCCGCAACA
CCGAGGCGCGCAGCGACGCCGCCCTCGGACAGGACGTGGTCGGCGCCTTCGGCGACTGGGACACCATCCGCGAGCAGGTC
CGCGACCTGGCCGTGAACGCGCCCGAACGGCTGGACTCCGACGTGCTCGCCGCGCTGCGCGCCGCCGAACGCGACCCGGC
GGGGCTCTCCGACGATCAATACCTGGCGCTGGCCACCGCCGACGGCGCCGAACTCGACGCGGTCGCCGCGCTGGCCGACC
AGTTGCGCCGGGACACCGTCGGCGACGACGTGACCTATGTCGTCAACCGCAACATCAACTTCACCAACATCTGTTACACC
GGTTGCCGGTTCTGCGCGTTCGCCCAGCGCAAGGGCGACGCCGACGCGTTCACGCTGTCCACCGAGGAGGTCGCCGACCG
CGCCTGGGAGGCCTACGTCGACGGCGCCACCGAGGTCTGCATGCAGGGCGGCATCGACCCCGACCTGCCGGTGACCGGGT
ACGCGGATCTGGTGCGGGCGGTGAAGCGGCGGGTGCCCTCGATGCACGTGCACGCGTTCAGCCCGATGGAGATCGTCAAC
GGCGCCTCCCGCGGCGGCGAGAGCATCGCCGACTGGCTGACCGCGCTCAAGGAGGCGGGCCTGGACACCATCCCGGGCAC
CGCCGCCGAGATCCTCGACGACGAGGTGCGCTGGGTGCTCACCAAGGGCAAGCTGCCCAGCTCGGCCTGGATCGAGGTGA
TCACCACCGCGCACCGCGTCGGGCTGCGGTCCAGCTCGACGATGATGTACGGGCACGTGGACAATCCGAGCCACTGGGTC
GGCCATCTGCGCGTGCTGCGCGGAATCCAGGACGAGACAGGCGGTTTCACCGAATTCGTGCTGCTGCCGTTCGTGCACCA
GAGCGCGCCGCTGTATTTGGCGGGCGCGGCGCGGCCCGGCCCGACCATCCGCGACAACCGGGCCGCCCACGCGCTGGCGC
GGATCATGCTGCACGGGCGGATCGACAATATCCAGACCAGCTGGGTCAAGCTCGGCATCGCGGGTACCCGGGTGATGTTG
CAGGGTGGCGCCAACGATCTGGGCGGCACGCTGATGGAGGAGACCATCTCGCGCATGGCCGGGTCGCAGCACGGTTCGGC
GAAGACCGTGGCCGAGCTGGCCGAGATCGCCGAGGGCATCGGCAGGCCGGTGCGCGAACGCACCACCGTCTACGGCCGGG
TGGACCGGCGGCCCGCGCCGATCGTGCCGGTCGGCTGA

Upstream 100 bases:

>100_bases
CCGTGACCGGCCGGTCGTGAGCGTCGCCCCCACCCCGGGGATCGGCACCGCTAGGCTCGGTCGGACGCACTGGAGGGAGA
CAGTCCAGGATGGTTAGCGC

Downstream 100 bases:

>100_bases
ACCGAAGCGACCCACGTGAATCCGGGTGAGTTAGGGCAGGCTGACCCGGAGTAACGTGGGTGCTCGGGATAGGGTTTCGC
GTGGCGGATCATCCCCGCAG

Product: FO synthase

Products: NA

Alternate protein names: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase

Number of amino acids: Translated: 865; Mature: 865

Protein sequence:

>865_residues
MIEGVTELATPNVPPAPPSPSAMRRALRRARDGVSLNLDEAVVLLHARGDDLADLCRSAARVRDAGLESAGRPGTITYSR
NVFIPLTRLCRDRCHYCTFVTVPGKLRAEGKGMFLEPDEVLDIARRGAALGCKEALFTLGDRPEDRWPEAAQWLDERGYD
STLDYLRAVSILVLEETGLLPHLNPGVMSWAEIARLKPVAQSMGMMLETTATRLFTEKGQCHHGSPDKDPAVRLRAITDA
GRLSVPYTTGILVGIGETLTERAESIMAIRKQHKAFGHIQEVIVQNFRAKDDTAMRDAPDAGFDEFRATIAVTRLLLGPD
VPVQAPPNLVSQQECLALIEAGIDDWGGVSPVTPDHVNPERPWPNLDTLRELTEASGFTLVERTSAHPKYVRAGNPWIDP
RIGAHVAALTDPVTGLAKADALPVGLPWQEPDESWESAGRTDLNIAIDTEGRNTEARSDAALGQDVVGAFGDWDTIREQV
RDLAVNAPERLDSDVLAALRAAERDPAGLSDDQYLALATADGAELDAVAALADQLRRDTVGDDVTYVVNRNINFTNICYT
GCRFCAFAQRKGDADAFTLSTEEVADRAWEAYVDGATEVCMQGGIDPDLPVTGYADLVRAVKRRVPSMHVHAFSPMEIVN
GASRGGESIADWLTALKEAGLDTIPGTAAEILDDEVRWVLTKGKLPSSAWIEVITTAHRVGLRSSSTMMYGHVDNPSHWV
GHLRVLRGIQDETGGFTEFVLLPFVHQSAPLYLAGAARPGPTIRDNRAAHALARIMLHGRIDNIQTSWVKLGIAGTRVML
QGGANDLGGTLMEETISRMAGSQHGSAKTVAELAEIAEGIGRPVRERTTVYGRVDRRPAPIVPVG

Sequences:

>Translated_865_residues
MIEGVTELATPNVPPAPPSPSAMRRALRRARDGVSLNLDEAVVLLHARGDDLADLCRSAARVRDAGLESAGRPGTITYSR
NVFIPLTRLCRDRCHYCTFVTVPGKLRAEGKGMFLEPDEVLDIARRGAALGCKEALFTLGDRPEDRWPEAAQWLDERGYD
STLDYLRAVSILVLEETGLLPHLNPGVMSWAEIARLKPVAQSMGMMLETTATRLFTEKGQCHHGSPDKDPAVRLRAITDA
GRLSVPYTTGILVGIGETLTERAESIMAIRKQHKAFGHIQEVIVQNFRAKDDTAMRDAPDAGFDEFRATIAVTRLLLGPD
VPVQAPPNLVSQQECLALIEAGIDDWGGVSPVTPDHVNPERPWPNLDTLRELTEASGFTLVERTSAHPKYVRAGNPWIDP
RIGAHVAALTDPVTGLAKADALPVGLPWQEPDESWESAGRTDLNIAIDTEGRNTEARSDAALGQDVVGAFGDWDTIREQV
RDLAVNAPERLDSDVLAALRAAERDPAGLSDDQYLALATADGAELDAVAALADQLRRDTVGDDVTYVVNRNINFTNICYT
GCRFCAFAQRKGDADAFTLSTEEVADRAWEAYVDGATEVCMQGGIDPDLPVTGYADLVRAVKRRVPSMHVHAFSPMEIVN
GASRGGESIADWLTALKEAGLDTIPGTAAEILDDEVRWVLTKGKLPSSAWIEVITTAHRVGLRSSSTMMYGHVDNPSHWV
GHLRVLRGIQDETGGFTEFVLLPFVHQSAPLYLAGAARPGPTIRDNRAAHALARIMLHGRIDNIQTSWVKLGIAGTRVML
QGGANDLGGTLMEETISRMAGSQHGSAKTVAELAEIAEGIGRPVRERTTVYGRVDRRPAPIVPVG
>Mature_865_residues
MIEGVTELATPNVPPAPPSPSAMRRALRRARDGVSLNLDEAVVLLHARGDDLADLCRSAARVRDAGLESAGRPGTITYSR
NVFIPLTRLCRDRCHYCTFVTVPGKLRAEGKGMFLEPDEVLDIARRGAALGCKEALFTLGDRPEDRWPEAAQWLDERGYD
STLDYLRAVSILVLEETGLLPHLNPGVMSWAEIARLKPVAQSMGMMLETTATRLFTEKGQCHHGSPDKDPAVRLRAITDA
GRLSVPYTTGILVGIGETLTERAESIMAIRKQHKAFGHIQEVIVQNFRAKDDTAMRDAPDAGFDEFRATIAVTRLLLGPD
VPVQAPPNLVSQQECLALIEAGIDDWGGVSPVTPDHVNPERPWPNLDTLRELTEASGFTLVERTSAHPKYVRAGNPWIDP
RIGAHVAALTDPVTGLAKADALPVGLPWQEPDESWESAGRTDLNIAIDTEGRNTEARSDAALGQDVVGAFGDWDTIREQV
RDLAVNAPERLDSDVLAALRAAERDPAGLSDDQYLALATADGAELDAVAALADQLRRDTVGDDVTYVVNRNINFTNICYT
GCRFCAFAQRKGDADAFTLSTEEVADRAWEAYVDGATEVCMQGGIDPDLPVTGYADLVRAVKRRVPSMHVHAFSPMEIVN
GASRGGESIADWLTALKEAGLDTIPGTAAEILDDEVRWVLTKGKLPSSAWIEVITTAHRVGLRSSSTMMYGHVDNPSHWV
GHLRVLRGIQDETGGFTEFVLLPFVHQSAPLYLAGAARPGPTIRDNRAAHALARIMLHGRIDNIQTSWVKLGIAGTRVML
QGGANDLGGTLMEETISRMAGSQHGSAKTVAELAEIAEGIGRPVRERTTVYGRVDRRPAPIVPVG

Specific function: Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO)

COG id: COG1060

COG function: function code HR; Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the radical SAM superfamily. CofH family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FBIC_NOCFA (Q5YQD7)

Other databases:

- EMBL:   AP006618
- RefSeq:   YP_120968.1
- ProteinModelPortal:   Q5YQD7
- GeneID:   3111177
- GenomeReviews:   AP006618_GR
- KEGG:   nfa:nfa47520
- NMPDR:   fig|247156.1.peg.4571
- HOGENOM:   HBG335564
- OMA:   RAGIDDW
- ProtClustDB:   PRK09234
- BioCyc:   NFAR247156:NFA47520-MONOMER
- HAMAP:   MF_01611
- HAMAP:   MF_01612
- InterPro:   IPR013785
- InterPro:   IPR019940
- InterPro:   IPR006638
- InterPro:   IPR019939
- InterPro:   IPR020050
- InterPro:   IPR007197
- Gene3D:   G3DSA:3.20.20.70
- SMART:   SM00729
- TIGRFAMs:   TIGR00423
- TIGRFAMs:   TIGR03550
- TIGRFAMs:   TIGR03551

Pfam domain/function: PF04055 Radical_SAM

EC number: NA

Molecular weight: Translated: 93768; Mature: 93768

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEGVTELATPNVPPAPPSPSAMRRALRRARDGVSLNLDEAVVLLHARGDDLADLCRSAA
CCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCEEEEEEECCCCHHHHHHHHH
RVRDAGLESAGRPGTITYSRNVFIPLTRLCRDRCHYCTFVTVPGKLRAEGKGMFLEPDEV
HHHHHCCCCCCCCCEEEECCCEEEEHHHHHHHHCCEEEEEECCCCEEECCCCCEECHHHH
LDIARRGAALGCKEALFTLGDRPEDRWPEAAQWLDERGYDSTLDYLRAVSILVLEETGLL
HHHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCC
PHLNPGVMSWAEIARLKPVAQSMGMMLETTATRLFTEKGQCHHGSPDKDPAVRLRAITDA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCC
GRLSVPYTTGILVGIGETLTERAESIMAIRKQHKAFGHIQEVIVQNFRAKDDTAMRDAPD
CCEECCHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCC
AGFDEFRATIAVTRLLLGPDVPVQAPPNLVSQQECLALIEAGIDDWGGVSPVTPDHVNPE
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
RPWPNLDTLRELTEASGFTLVERTSAHPKYVRAGNPWIDPRIGAHVAALTDPVTGLAKAD
CCCCCHHHHHHHHHCCCCEEEECCCCCCCEEECCCCCCCCCCCCCHHHHHCCHHHHHHCC
ALPVGLPWQEPDESWESAGRTDLNIAIDTEGRNTEARSDAALGQDVVGAFGDWDTIREQV
CCCCCCCCCCCCHHHHHCCCCEEEEEEECCCCCCCCHHHHHHCHHHHHCCCCHHHHHHHH
RDLAVNAPERLDSDVLAALRAAERDPAGLSDDQYLALATADGAELDAVAALADQLRRDTV
HHHHCCCHHHCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCC
GDDVTYVVNRNINFTNICYTGCRFCAFAQRKGDADAFTLSTEEVADRAWEAYVDGATEVC
CCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHCCHHHHH
MQGGIDPDLPVTGYADLVRAVKRRVPSMHVHAFSPMEIVNGASRGGESIADWLTALKEAG
HHCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHCCCCCCHHHHHHHHHHHHHCC
LDTIPGTAAEILDDEVRWVLTKGKLPSSAWIEVITTAHRVGLRSSSTMMYGHVDNPSHWV
CCCCCCCHHHHHCCHHHEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHH
GHLRVLRGIQDETGGFTEFVLLPFVHQSAPLYLAGAARPGPTIRDNRAAHALARIMLHGR
HHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCC
IDNIQTSWVKLGIAGTRVMLQGGANDLGGTLMEETISRMAGSQHGSAKTVAELAEIAEGI
CCCCEECCEEEEECCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
GRPVRERTTVYGRVDRRPAPIVPVG
CCCHHHHHHHEEECCCCCCCCCCCC
>Mature Secondary Structure
MIEGVTELATPNVPPAPPSPSAMRRALRRARDGVSLNLDEAVVLLHARGDDLADLCRSAA
CCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCEEEEEEECCCCHHHHHHHHH
RVRDAGLESAGRPGTITYSRNVFIPLTRLCRDRCHYCTFVTVPGKLRAEGKGMFLEPDEV
HHHHHCCCCCCCCCEEEECCCEEEEHHHHHHHHCCEEEEEECCCCEEECCCCCEECHHHH
LDIARRGAALGCKEALFTLGDRPEDRWPEAAQWLDERGYDSTLDYLRAVSILVLEETGLL
HHHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCC
PHLNPGVMSWAEIARLKPVAQSMGMMLETTATRLFTEKGQCHHGSPDKDPAVRLRAITDA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCC
GRLSVPYTTGILVGIGETLTERAESIMAIRKQHKAFGHIQEVIVQNFRAKDDTAMRDAPD
CCEECCHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCC
AGFDEFRATIAVTRLLLGPDVPVQAPPNLVSQQECLALIEAGIDDWGGVSPVTPDHVNPE
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
RPWPNLDTLRELTEASGFTLVERTSAHPKYVRAGNPWIDPRIGAHVAALTDPVTGLAKAD
CCCCCHHHHHHHHHCCCCEEEECCCCCCCEEECCCCCCCCCCCCCHHHHHCCHHHHHHCC
ALPVGLPWQEPDESWESAGRTDLNIAIDTEGRNTEARSDAALGQDVVGAFGDWDTIREQV
CCCCCCCCCCCCHHHHHCCCCEEEEEEECCCCCCCCHHHHHHCHHHHHCCCCHHHHHHHH
RDLAVNAPERLDSDVLAALRAAERDPAGLSDDQYLALATADGAELDAVAALADQLRRDTV
HHHHCCCHHHCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCC
GDDVTYVVNRNINFTNICYTGCRFCAFAQRKGDADAFTLSTEEVADRAWEAYVDGATEVC
CCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHCCHHHHH
MQGGIDPDLPVTGYADLVRAVKRRVPSMHVHAFSPMEIVNGASRGGESIADWLTALKEAG
HHCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHCCCCCCHHHHHHHHHHHHHCC
LDTIPGTAAEILDDEVRWVLTKGKLPSSAWIEVITTAHRVGLRSSSTMMYGHVDNPSHWV
CCCCCCCHHHHHCCHHHEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHH
GHLRVLRGIQDETGGFTEFVLLPFVHQSAPLYLAGAARPGPTIRDNRAAHALARIMLHGR
HHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCC
IDNIQTSWVKLGIAGTRVMLQGGANDLGGTLMEETISRMAGSQHGSAKTVAELAEIAEGI
CCCCEECCEEEEECCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
GRPVRERTTVYGRVDRRPAPIVPVG
CCCHHHHHHHEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA