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The map label for this gene is mcl1 [H]

Identifier: 54026689

GI number: 54026689

Start: 4926995

End: 4927942

Strand: Reverse

Name: mcl1 [H]

Synonym: nfa47160

Alternate gene names: 54026689

Gene position: 4927942-4926995 (Counterclockwise)

Preceding gene: 54026699

Following gene: 54026688

Centisome position: 81.84

GC content: 70.68

Gene sequence:

>948_bases
ATGAAGCCACGCCGCTCGGTCCTGGCCGTGCCAGGCAGCAATCCGAAGATGATCGAGAAGGCCAAGGGACTGCCCGTCGA
CGAGGTGTTCCTCGATCTGGAGGATGCCGTCGCGCCGGTCGCCAAGGCCGCGGCGCGGGCCAACATCGTGGCGGCGCTGA
ACGAGCCGGGCTGGGGCGAGCAGCTGCGGGTGGTGCGGGTCAACGACTGGACCACCCAGTGGACCTACAGCGACGTCATC
ACCGTGGTGGAGGGCGCGGGCGCGGCGCTCGATGCCGTCCTGCTGCCCAAGGTGACCGACGCCGGTCAGGTGCGGGCGCT
GGATCTGCTGTTGAGCCAGCTCGAGCGCACCTGTGGGCTCGAGGTCGGCCGCATCGGCATCGAACCGCAGCTGGAGAACG
CCCTCGGCCTGCGCAACATCGACGAGATCGCCACCGCGAGCCCGCGCGTGCAGGCGCTGGTCTTCGGGCCCGCCGATTTC
ATGGCCAGCGTCAACATGCGCACGCTGGTGGTCGGCGAGCAGCCGGAGGGCTACGACACCGGCGACGCCTACCACCACAT
CCTGATGACCATCCTGCTCACCGCCCGGGCGCACGGGTTGCAGGCGATCGACGGGCCGTACCTGCAGATCCGCGATCTCG
ACGGCTTCCGCCGCGCCGCCGCCCGCACCGCCGCGCTCGGCTTCGACGGCAAATGGGTGCTGCACCCCACCCAGATCGAG
GCCGCCAACGAGATCTTCAGCCCGCGCCAGGCCGATTACGACCGCGCCGAGGAGATCCTCGAGGCCTACGCCTACTACAC
CTCCGGCGCGGGCGGTGCCCGCGGCGCGGTGATGCTCGGCGAGGAGATGATCGACGAGGCGAGCGCCAAGATGGCGGCCG
TCATCGCGGAGAAGGGGCGCGCGGCCGGGATGCGGCGCACCACCGCGTTCACCCCGCCCCGTGACTGA

Upstream 100 bases:

>100_bases
CCACCAGGCCGGCGAGCCTGGCGACGTACACCCTGGTAGCTGCCATGCTTGCCAGGCTAGAGGTTTGCGGGCCGGTGGTC
GCCGTGACACAGGAGGGTTT

Downstream 100 bases:

>100_bases
ATCGGACACCCCGATCACCGCCTGCACCACCGCGGGCGACGGGCCTGCGCCCATAATGGACCTATGACGAACCCACTGGG
GAACGCGAACAACCCGCGGG

Product: putative lyase

Products: NA

Alternate protein names: (3S)-malyl-CoA/beta-methylmalyl-CoA lyase; L-malyl-CoA/beta-methylmalyl-CoA lyase [H]

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MKPRRSVLAVPGSNPKMIEKAKGLPVDEVFLDLEDAVAPVAKAAARANIVAALNEPGWGEQLRVVRVNDWTTQWTYSDVI
TVVEGAGAALDAVLLPKVTDAGQVRALDLLLSQLERTCGLEVGRIGIEPQLENALGLRNIDEIATASPRVQALVFGPADF
MASVNMRTLVVGEQPEGYDTGDAYHHILMTILLTARAHGLQAIDGPYLQIRDLDGFRRAAARTAALGFDGKWVLHPTQIE
AANEIFSPRQADYDRAEEILEAYAYYTSGAGGARGAVMLGEEMIDEASAKMAAVIAEKGRAAGMRRTTAFTPPRD

Sequences:

>Translated_315_residues
MKPRRSVLAVPGSNPKMIEKAKGLPVDEVFLDLEDAVAPVAKAAARANIVAALNEPGWGEQLRVVRVNDWTTQWTYSDVI
TVVEGAGAALDAVLLPKVTDAGQVRALDLLLSQLERTCGLEVGRIGIEPQLENALGLRNIDEIATASPRVQALVFGPADF
MASVNMRTLVVGEQPEGYDTGDAYHHILMTILLTARAHGLQAIDGPYLQIRDLDGFRRAAARTAALGFDGKWVLHPTQIE
AANEIFSPRQADYDRAEEILEAYAYYTSGAGGARGAVMLGEEMIDEASAKMAAVIAEKGRAAGMRRTTAFTPPRD
>Mature_315_residues
MKPRRSVLAVPGSNPKMIEKAKGLPVDEVFLDLEDAVAPVAKAAARANIVAALNEPGWGEQLRVVRVNDWTTQWTYSDVI
TVVEGAGAALDAVLLPKVTDAGQVRALDLLLSQLERTCGLEVGRIGIEPQLENALGLRNIDEIATASPRVQALVFGPADF
MASVNMRTLVVGEQPEGYDTGDAYHHILMTILLTARAHGLQAIDGPYLQIRDLDGFRRAAARTAALGFDGKWVLHPTQIE
AANEIFSPRQADYDRAEEILEAYAYYTSGAGGARGAVMLGEEMIDEASAKMAAVIAEKGRAAGMRRTTAFTPPRD

Specific function: Catalyzes the reversible condensation of glyoxylate and acetyl-CoA to L-malyl-CoA and the reversible condensation of glyoxylate and propionyl-CoA to beta-methylmalyl-CoA [H]

COG id: COG2301

COG function: function code G; Citrate lyase beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family [H]

Homologues:

Organism=Homo sapiens, GI45545437, Length=311, Percent_Identity=32.7974276527331, Blast_Score=120, Evalue=1e-27,
Organism=Escherichia coli, GI87081764, Length=304, Percent_Identity=31.9078947368421, Blast_Score=135, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17557458, Length=298, Percent_Identity=30.8724832214765, Blast_Score=95, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR011206
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: =4.1.3.24 [H]

Molecular weight: Translated: 33905; Mature: 33905

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPRRSVLAVPGSNPKMIEKAKGLPVDEVFLDLEDAVAPVAKAAARANIVAALNEPGWGE
CCCCCCEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCC
QLRVVRVNDWTTQWTYSDVITVVEGAGAALDAVLLPKVTDAGQVRALDLLLSQLERTCGL
CEEEEEEECCCCEEEHHHHHHHHCCCCCHHHHEECCCCCCCCHHHHHHHHHHHHHHHHCC
EVGRIGIEPQLENALGLRNIDEIATASPRVQALVFGPADFMASVNMRTLVVGEQPEGYDT
EECCCCCCCCHHHHCCCCCHHHHHCCCCCEEEEEECCHHHHHCCCEEEEEECCCCCCCCC
GDAYHHILMTILLTARAHGLQAIDGPYLQIRDLDGFRRAAARTAALGFDGKWVLHPTQIE
CHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEECCHHHH
AANEIFSPRQADYDRAEEILEAYAYYTSGAGGARGAVMLGEEMIDEASAKMAAVIAEKGR
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCC
AAGMRRTTAFTPPRD
CCCCCCCCCCCCCCC
>Mature Secondary Structure
MKPRRSVLAVPGSNPKMIEKAKGLPVDEVFLDLEDAVAPVAKAAARANIVAALNEPGWGE
CCCCCCEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCC
QLRVVRVNDWTTQWTYSDVITVVEGAGAALDAVLLPKVTDAGQVRALDLLLSQLERTCGL
CEEEEEEECCCCEEEHHHHHHHHCCCCCHHHHEECCCCCCCCHHHHHHHHHHHHHHHHCC
EVGRIGIEPQLENALGLRNIDEIATASPRVQALVFGPADFMASVNMRTLVVGEQPEGYDT
EECCCCCCCCHHHHCCCCCHHHHHCCCCCEEEEEECCHHHHHCCCEEEEEECCCCCCCCC
GDAYHHILMTILLTARAHGLQAIDGPYLQIRDLDGFRRAAARTAALGFDGKWVLHPTQIE
CHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEECCHHHH
AANEIFSPRQADYDRAEEILEAYAYYTSGAGGARGAVMLGEEMIDEASAKMAAVIAEKGR
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCC
AAGMRRTTAFTPPRD
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA