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The map label for this gene is fadA9 [H]

Identifier: 54026579

GI number: 54026579

Start: 4792811

End: 4794103

Strand: Reverse

Name: fadA9 [H]

Synonym: nfa46060

Alternate gene names: 54026579

Gene position: 4794103-4792811 (Counterclockwise)

Preceding gene: 54026580

Following gene: 54026572

Centisome position: 79.62

GC content: 71.85

Gene sequence:

>1293_bases
ATGGCTTCCACCGCCTCTCGGCGCGCCGTGATCGTGGCGGGTGCGCGCACCCCGTTCGTGCGCGCCTTCACCGACTTCAC
GAAGATGGACTCGATCGCGCTCGCCGACGCCGCCGTGCGCGGCCTGCTCGAGCGCACCGCACTGCCCGGCGACCAGGTGC
AGGCGATCGTCTGGGGCGGGGTGATCCTGCCCAGCGCCGCGCCCAACATCGCGCGCGAGATCGCCCTGGACCTGAAGCTC
GACCCCGGCTGCGAGGGGCACACCGTCACGCGGGCGTGCGCGTCCGGACTCCAGGCCGTCACCACCGCGGCCGCCGCCAT
CGAACGCGGCGAATACGACGTGATGATCGCCGGCGGCAGCGATTCCACCTCCAACGCCGAGATCAAGCTGCCGCAGAAGC
TGGTGCACGCCGGGGCGCCGATCGCGCTCGGCAAGCCCAAGCTCAAGGACTATCTGTCGGCGGCCGCGCAGCTGGCGCCG
TTCACCGACATCCTGCCGAGCAGGCCGCGCATCGCCGAACGCACCACCGGCGAGGTGATGGGGGAGTCCGCCGAGAAGAT
GGCCCGCATCCACGGCATCGGCCGCGCCGAACAGGACGAGTTCGCCGCGCGCTCGCACCATCGGGCCGCCGCCGCGATCG
AATCCGGCCGCTTCGACGACGAGGTGCTGCGGGTGCGCACCCCCGACGGCGCCGAGATCAGCCGCGACGGGCTGGTGCGC
GCCGATACCAGCGTCGAGAAGCTGGCCCGGTTGAAGCCGGTCTTCGCCGAGGGCGGCACCGTCACCGCGGGCAATGCCAG
CCCCCTCACCGACGGCGCCTCGGCGGTGCTGCTGATGAGCGAGGAACGTGCCCGCGCCCTCGGCTACCGCCCGTTGGCCG
CCTTCCGGTCCTGGAGCTATGTCAGCGTCGATCCCACCGACCAGGTGCTCATCGGCCCCGCGATCTCGATGCCCCGGGCC
TTGGACGCAGCGGGCATGACGCTGGCCGACGTGGACCTGGTCGACATCCACGAGGCGTTCGCCGCGCAGACGCTGTCGGT
GCTGAGCGCCCTCGCCAGCGACGAGTGGGCCAAGACCCGCCTGGACCGCGACACCGCCGTCGGCGAAGTCGACATCGACA
AGCTCAACGTGCACGGCGGCTCGGTCTCGCTGGGCCATCCGTTCGGGGCGACCGGTGCGCGGATGGTCACCACCATGGCC
AACGAACTCGCCCGCTCCGACAAGCAGACCGCACTGCTCGGCATCTGCGCGGCGGGCGGCATCGGCGCCTCGGCGGTACT
GGAACGCGTCTGA

Upstream 100 bases:

>100_bases
GCGGGCCGGTCGCATGTCCGGGTTCCGGGCAAACCCTGGCCGCGCTTCTTACTTCAGAGTAAGTTCAGGGGAGCTGTTCG
ATGTGGGAAAGGGAATTCCG

Downstream 100 bases:

>100_bases
GCCGGTCCGGGCGAGCGGGGTGGCGGGCCGGTGGTAGCACGCCACCGGACCGCCGCACGGCCGCGGCCGTCGGGTCAGGC
TCGGGCGGCCGGTGCGCCGC

Product: putative acyl-CoA thiolase

Products: NA

Alternate protein names: ACSs; Acetyl-CoA acyltransferase; Acyl-CoA ligase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MASTASRRAVIVAGARTPFVRAFTDFTKMDSIALADAAVRGLLERTALPGDQVQAIVWGGVILPSAAPNIAREIALDLKL
DPGCEGHTVTRACASGLQAVTTAAAAIERGEYDVMIAGGSDSTSNAEIKLPQKLVHAGAPIALGKPKLKDYLSAAAQLAP
FTDILPSRPRIAERTTGEVMGESAEKMARIHGIGRAEQDEFAARSHHRAAAAIESGRFDDEVLRVRTPDGAEISRDGLVR
ADTSVEKLARLKPVFAEGGTVTAGNASPLTDGASAVLLMSEERARALGYRPLAAFRSWSYVSVDPTDQVLIGPAISMPRA
LDAAGMTLADVDLVDIHEAFAAQTLSVLSALASDEWAKTRLDRDTAVGEVDIDKLNVHGGSVSLGHPFGATGARMVTTMA
NELARSDKQTALLGICAAGGIGASAVLERV

Sequences:

>Translated_430_residues
MASTASRRAVIVAGARTPFVRAFTDFTKMDSIALADAAVRGLLERTALPGDQVQAIVWGGVILPSAAPNIAREIALDLKL
DPGCEGHTVTRACASGLQAVTTAAAAIERGEYDVMIAGGSDSTSNAEIKLPQKLVHAGAPIALGKPKLKDYLSAAAQLAP
FTDILPSRPRIAERTTGEVMGESAEKMARIHGIGRAEQDEFAARSHHRAAAAIESGRFDDEVLRVRTPDGAEISRDGLVR
ADTSVEKLARLKPVFAEGGTVTAGNASPLTDGASAVLLMSEERARALGYRPLAAFRSWSYVSVDPTDQVLIGPAISMPRA
LDAAGMTLADVDLVDIHEAFAAQTLSVLSALASDEWAKTRLDRDTAVGEVDIDKLNVHGGSVSLGHPFGATGARMVTTMA
NELARSDKQTALLGICAAGGIGASAVLERV
>Mature_429_residues
ASTASRRAVIVAGARTPFVRAFTDFTKMDSIALADAAVRGLLERTALPGDQVQAIVWGGVILPSAAPNIAREIALDLKLD
PGCEGHTVTRACASGLQAVTTAAAAIERGEYDVMIAGGSDSTSNAEIKLPQKLVHAGAPIALGKPKLKDYLSAAAQLAPF
TDILPSRPRIAERTTGEVMGESAEKMARIHGIGRAEQDEFAARSHHRAAAAIESGRFDDEVLRVRTPDGAEISRDGLVRA
DTSVEKLARLKPVFAEGGTVTAGNASPLTDGASAVLLMSEERARALGYRPLAAFRSWSYVSVDPTDQVLIGPAISMPRAL
DAAGMTLADVDLVDIHEAFAAQTLSVLSALASDEWAKTRLDRDTAVGEVDIDKLNVHGGSVSLGHPFGATGARMVTTMAN
ELARSDKQTALLGICAAGGIGASAVLERV

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=41.5094339622642, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI4501853, Length=432, Percent_Identity=34.2592592592593, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI167614485, Length=434, Percent_Identity=32.258064516129, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI4557237, Length=427, Percent_Identity=31.3817330210773, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI148539872, Length=428, Percent_Identity=29.4392523364486, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI194353979, Length=106, Percent_Identity=38.6792452830189, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1788683, Length=400, Percent_Identity=41.75, Blast_Score=301, Evalue=5e-83,
Organism=Escherichia coli, GI87082165, Length=423, Percent_Identity=36.1702127659575, Blast_Score=231, Evalue=7e-62,
Organism=Escherichia coli, GI1788554, Length=427, Percent_Identity=34.192037470726, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI48994986, Length=434, Percent_Identity=34.7926267281106, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI1787663, Length=438, Percent_Identity=33.7899543378995, Blast_Score=182, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17551802, Length=427, Percent_Identity=43.0913348946136, Blast_Score=305, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI133906874, Length=430, Percent_Identity=31.1627906976744, Blast_Score=184, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI25147385, Length=432, Percent_Identity=29.6296296296296, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17535921, Length=433, Percent_Identity=28.175519630485, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17535917, Length=434, Percent_Identity=24.1935483870968, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6325229, Length=436, Percent_Identity=31.651376146789, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6322031, Length=341, Percent_Identity=32.8445747800587, Blast_Score=172, Evalue=9e-44,
Organism=Drosophila melanogaster, GI17137578, Length=428, Percent_Identity=41.8224299065421, Blast_Score=299, Evalue=3e-81,
Organism=Drosophila melanogaster, GI24655093, Length=424, Percent_Identity=30.4245283018868, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24640423, Length=426, Percent_Identity=32.3943661971831, Blast_Score=178, Evalue=5e-45,
Organism=Drosophila melanogaster, GI17648125, Length=433, Percent_Identity=30.4849884526559, Blast_Score=168, Evalue=6e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012806
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 44861; Mature: 44730

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASTASRRAVIVAGARTPFVRAFTDFTKMDSIALADAAVRGLLERTALPGDQVQAIVWGG
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
VILPSAAPNIAREIALDLKLDPGCEGHTVTRACASGLQAVTTAAAAIERGEYDVMIAGGS
EECCCCCCHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
DSTSNAEIKLPQKLVHAGAPIALGKPKLKDYLSAAAQLAPFTDILPSRPRIAERTTGEVM
CCCCCCEEECHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCHHHHCHHHHH
GESAEKMARIHGIGRAEQDEFAARSHHRAAAAIESGRFDDEVLRVRTPDGAEISRDGLVR
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCEE
ADTSVEKLARLKPVFAEGGTVTAGNASPLTDGASAVLLMSEERARALGYRPLAAFRSWSY
CCCHHHHHHHHCHHHCCCCEEECCCCCCCCCCCCEEEEEECHHHHHHCCCHHHHHCCCCE
VSVDPTDQVLIGPAISMPRALDAAGMTLADVDLVDIHEAFAAQTLSVLSALASDEWAKTR
EEECCCCCEEECCCCCCCCHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LDRDTAVGEVDIDKLNVHGGSVSLGHPFGATGARMVTTMANELARSDKQTALLGICAAGG
CCCCCCCCEEECEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCC
IGASAVLERV
CCHHHHHHCC
>Mature Secondary Structure 
ASTASRRAVIVAGARTPFVRAFTDFTKMDSIALADAAVRGLLERTALPGDQVQAIVWGG
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
VILPSAAPNIAREIALDLKLDPGCEGHTVTRACASGLQAVTTAAAAIERGEYDVMIAGGS
EECCCCCCHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
DSTSNAEIKLPQKLVHAGAPIALGKPKLKDYLSAAAQLAPFTDILPSRPRIAERTTGEVM
CCCCCCEEECHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCHHHHCHHHHH
GESAEKMARIHGIGRAEQDEFAARSHHRAAAAIESGRFDDEVLRVRTPDGAEISRDGLVR
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCEE
ADTSVEKLARLKPVFAEGGTVTAGNASPLTDGASAVLLMSEERARALGYRPLAAFRSWSY
CCCHHHHHHHHCHHHCCCCEEECCCCCCCCCCCCEEEEEECHHHHHHCCCHHHHHCCCCE
VSVDPTDQVLIGPAISMPRALDAAGMTLADVDLVDIHEAFAAQTLSVLSALASDEWAKTR
EEECCCCCEEECCCCCCCCHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LDRDTAVGEVDIDKLNVHGGSVSLGHPFGATGARMVTTMANELARSDKQTALLGICAAGG
CCCCCCCCEEECEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCC
IGASAVLERV
CCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA