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The map label for this gene is galK [H]

Identifier: 54026478

GI number: 54026478

Start: 4670583

End: 4671791

Strand: Reverse

Name: galK [H]

Synonym: nfa45050

Alternate gene names: 54026478

Gene position: 4671791-4670583 (Counterclockwise)

Preceding gene: 54026480

Following gene: 54026477

Centisome position: 77.59

GC content: 75.85

Gene sequence:

>1209_bases
TTGCCCGGGTTCGTCTCCTCGGCGTGCCGCCCTGCGCGGGTCGGGGCGGGGCGCGCCCGGGCCGCGGCGCACAATGGGCC
GGTGGTGGATACGTGGGTGGCGCCGGGGCGGGTCAACATCATCGGCGAGCACACCGATTACAACGACGGATACGTCCTGC
CGATCGCGTTGCCGCTGGTCACCCGGTGCGCCGCGCGGGTGACGGCGCAGCCGGTGGTGCGGGTGCGCTCGCGGCAACGG
CCGGACGAGCCGGTGCGGGCCGAACTCGACGCCATCGACGCCGTGCGGACGCAGGTGCCGGGCTGGGCCCGCTACGTGCT
CGGCGTGGTCGGTGAATTCGTCCGGCGCGGGCACCCGGTGGGCGGACTCGACCTCGAGGTGGACGGCGCGGTGCCGATCG
GGGCGGGGCTGTCGAGTTCGGCCGCGCTGTCCTGTTCGGTGGCGTTGGCGCTGCGCGACCTGTTCGCGCCCCAGCTGAGC
GAGCGCGAGCTGATCGATGTCGCACGGGCGGCCGAGAACGACTACGCGGGCGCGCCCACCGGCGTGCTCGACCAGTCCGC
CGCGGTGCTGTGCACCGCGGGGCACGCGCTGTTCCTGGACGTCCGCCGATTCACCGGCGCCGCACCCGGAACCGACCCCG
GCTACCGGCAGATCCCCTTCGACCTCGCCCGGTCCGGCCTGACGCTGCTGGTGATCGACACCCGCGAGGCGCACGAACAC
GCCGGTGGCGGCTACGCCGAGCGCCGCGCCCAGTGCGAGGCGGCCGCGGCGGCGCTCGGCGTGGCCGCACTGCGCGACGT
GGTGGTGCCCGGCGAGCTCGGCCGGATCGAGGATCCGGTGGTGCGCAGGCGCGCCCGGCACGTGGTCACCGAGAACGCCC
GCGTGCTCGCGGTCGCCGAGACCCTGCGCAGCGGCGCCGATCCGCGGGAGATCGGCCCGATCCTGACCGCCGGGCACGCG
TCGCTGCGCGACGACTTCGAGGTCTCCACCCCCGCGCTGGATCTCGTCGTGGACGCGGCACTCGCCGCGGGCGCCCACGG
TGCCCGCATGGTGGGCGGCGGGTTCGGCGGCAGCGCCATCGCCCTGGTCGAGAGCGGGCAGGCCGACGCCGTCGCCGCGG
CCGTCGAGCGACGACTCGGCAGTGCCGGACATCGCGCCCCGCGGACCTTCACCGTCGTCCCGGCCGCGGGGGCACACCGG
GAGAACTGA

Upstream 100 bases:

>100_bases
GCTACGAGCGGATGGTCCCGGGCGGGCGCTGCACGTCCGGTCACCGAGACCTGGACAACTGATCCGATGATCGCACGGAA
CCGGGGTCCGCCGGGATGGT

Downstream 100 bases:

>100_bases
CGGCGCACGCGGGATGAACGGCCGCGCAACACCGGACCGTCCGGGGGACTCGCTGTTTCGGTTCGCCCCGGATCGCGGCC
GGGGAGTGCGACAATCACGC

Product: putative galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MPGFVSSACRPARVGAGRARAAAHNGPVVDTWVAPGRVNIIGEHTDYNDGYVLPIALPLVTRCAARVTAQPVVRVRSRQR
PDEPVRAELDAIDAVRTQVPGWARYVLGVVGEFVRRGHPVGGLDLEVDGAVPIGAGLSSSAALSCSVALALRDLFAPQLS
ERELIDVARAAENDYAGAPTGVLDQSAAVLCTAGHALFLDVRRFTGAAPGTDPGYRQIPFDLARSGLTLLVIDTREAHEH
AGGGYAERRAQCEAAAAALGVAALRDVVVPGELGRIEDPVVRRRARHVVTENARVLAVAETLRSGADPREIGPILTAGHA
SLRDDFEVSTPALDLVVDAALAAGAHGARMVGGGFGGSAIALVESGQADAVAAAVERRLGSAGHRAPRTFTVVPAAGAHR
EN

Sequences:

>Translated_402_residues
MPGFVSSACRPARVGAGRARAAAHNGPVVDTWVAPGRVNIIGEHTDYNDGYVLPIALPLVTRCAARVTAQPVVRVRSRQR
PDEPVRAELDAIDAVRTQVPGWARYVLGVVGEFVRRGHPVGGLDLEVDGAVPIGAGLSSSAALSCSVALALRDLFAPQLS
ERELIDVARAAENDYAGAPTGVLDQSAAVLCTAGHALFLDVRRFTGAAPGTDPGYRQIPFDLARSGLTLLVIDTREAHEH
AGGGYAERRAQCEAAAAALGVAALRDVVVPGELGRIEDPVVRRRARHVVTENARVLAVAETLRSGADPREIGPILTAGHA
SLRDDFEVSTPALDLVVDAALAAGAHGARMVGGGFGGSAIALVESGQADAVAAAVERRLGSAGHRAPRTFTVVPAAGAHR
EN
>Mature_401_residues
PGFVSSACRPARVGAGRARAAAHNGPVVDTWVAPGRVNIIGEHTDYNDGYVLPIALPLVTRCAARVTAQPVVRVRSRQRP
DEPVRAELDAIDAVRTQVPGWARYVLGVVGEFVRRGHPVGGLDLEVDGAVPIGAGLSSSAALSCSVALALRDLFAPQLSE
RELIDVARAAENDYAGAPTGVLDQSAAVLCTAGHALFLDVRRFTGAAPGTDPGYRQIPFDLARSGLTLLVIDTREAHEHA
GGGYAERRAQCEAAAAALGVAALRDVVVPGELGRIEDPVVRRRARHVVTENARVLAVAETLRSGADPREIGPILTAGHAS
LRDDFEVSTPALDLVVDAALAAGAHGARMVGGGFGGSAIALVESGQADAVAAAVERRLGSAGHRAPRTFTVVPAAGAHRE
N

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=356, Percent_Identity=39.0449438202247, Blast_Score=201, Evalue=9e-52,
Organism=Homo sapiens, GI4503897, Length=425, Percent_Identity=27.5294117647059, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI48527957, Length=425, Percent_Identity=27.5294117647059, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1786972, Length=385, Percent_Identity=36.1038961038961, Blast_Score=211, Evalue=8e-56,
Organism=Saccharomyces cerevisiae, GI6319494, Length=249, Percent_Identity=31.7269076305221, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320212, Length=249, Percent_Identity=29.3172690763052, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24661292, Length=404, Percent_Identity=26.4851485148515, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21355577, Length=404, Percent_Identity=26.4851485148515, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24661285, Length=404, Percent_Identity=26.4851485148515, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 41690; Mature: 41558

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGFVSSACRPARVGAGRARAAAHNGPVVDTWVAPGRVNIIGEHTDYNDGYVLPIALPLV
CCCCHHHCCCCCCCCCCHHHHHCCCCCEEEEEECCCEEEEEECCCCCCCCEEEEEHHHHH
TRCAARVTAQPVVRVRSRQRPDEPVRAELDAIDAVRTQVPGWARYVLGVVGEFVRRGHPV
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCC
GGLDLEVDGAVPIGAGLSSSAALSCSVALALRDLFAPQLSERELIDVARAAENDYAGAPT
CCEEEEECCCCEECCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCC
GVLDQSAAVLCTAGHALFLDVRRFTGAAPGTDPGYRQIPFDLARSGLTLLVIDTREAHEH
CCCCCCCEEEEECCCEEEEEHHHHCCCCCCCCCCCCCCCHHHHHCCCEEEEEECHHHHHH
AGGGYAERRAQCEAAAAALGVAALRDVVVPGELGRIEDPVVRRRARHVVTENARVLAVAE
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEHH
TLRSGADPREIGPILTAGHASLRDDFEVSTPALDLVVDAALAAGAHGARMVGGGFGGSAI
HHHCCCCHHHHCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCEE
ALVESGQADAVAAAVERRLGSAGHRAPRTFTVVPAAGAHREN
EEEECCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCC
>Mature Secondary Structure 
PGFVSSACRPARVGAGRARAAAHNGPVVDTWVAPGRVNIIGEHTDYNDGYVLPIALPLV
CCCHHHCCCCCCCCCCHHHHHCCCCCEEEEEECCCEEEEEECCCCCCCCEEEEEHHHHH
TRCAARVTAQPVVRVRSRQRPDEPVRAELDAIDAVRTQVPGWARYVLGVVGEFVRRGHPV
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCC
GGLDLEVDGAVPIGAGLSSSAALSCSVALALRDLFAPQLSERELIDVARAAENDYAGAPT
CCEEEEECCCCEECCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCC
GVLDQSAAVLCTAGHALFLDVRRFTGAAPGTDPGYRQIPFDLARSGLTLLVIDTREAHEH
CCCCCCCEEEEECCCEEEEEHHHHCCCCCCCCCCCCCCCHHHHHCCCEEEEEECHHHHHH
AGGGYAERRAQCEAAAAALGVAALRDVVVPGELGRIEDPVVRRRARHVVTENARVLAVAE
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEHH
TLRSGADPREIGPILTAGHASLRDDFEVSTPALDLVVDAALAAGAHGARMVGGGFGGSAI
HHHCCCCHHHHCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCEE
ALVESGQADAVAAAVERRLGSAGHRAPRTFTVVPAAGAHREN
EEEECCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]